Saturation Biopsy for Prostate Cancer

A saturation biopsy can be used to help diagnose a patient with prostate cancer. Designed to retrieve more tissue samples from a tumor site than a standard biopsy, this option provides pathologists with a more extensive selection of cells to test for the presence of cancer.

Whereas a standard biopsy typically retrieves just 12 to 14 tissue samples, a saturation biopsy can retrieve 20 or more samples at one time. This, in turn, yields a number of benefits, such as:

  • Improved sampling of the anterior (rear) zone of the prostate gland, where cancer can otherwise go undetected
  • A reduction in false negative diagnoses (cancers that are improperly categorized as noncancerous)
  • Enhanced ability to detect the grade of the cancer (this can be more difficult with limited biopsy material)
  • Improved ability to identify tumors that are eligible for cryoablation therapy

To perform a saturation biopsy, a surgeon will insert a needle through the rectum or peritoneum while the patient is under general anesthesia in an operating room. The needle will then be used to carefully remove a selection of cells from various locations throughout the prostate. Recovery times and complication rates are similar (and typically minimal) for both saturation and conventional biopsies.

At Moffitt Cancer Center, the saturation biopsy is just one of the diagnostic prostate cancer surgery procedures that we use. A multispecialty team will assess each patient’s needs to determine which lab tests are most likely to result in a prompt and accurate diagnosis.

Regardless of the technique used to obtain a tissue sample, our pathologists are highly skilled at detecting signs of cancer in prostate specimens. Because our biopsies are completed and analyzed in the same location, we can accelerate the evaluation process and quickly place our patients on the path to proper treatment.

To learn more about a saturation biopsy or any of the other diagnostic techniques that we use to detect and grade prostate cancer, call 1-888-663-3488 or request to schedule an appointment online.