Our Approach to Blood & Bone Marrow Transplant Procedures
At Moffitt Cancer Center, we understand that a blood and bone marrow transplant is a complicated procedure and that it requires a great deal of commitment on the part of the patient and his or her caretaker. As a result, we’re here to provide comprehensive support to all of our transplant recipients, every step of the way.
We realize that a blood and bone marrow transplant is not right for everyone. Our team will work one-on-one with every patient to help determine if a transplant is the best option for his or her specific situation. For instance, patients with the following conditions may benefit from a stem cell transplant:
- Leukemia (acute or chronic)
- Lymphoma (Hodgkin or non-Hodgkin)
- Multiple myeloma
- Multiple sclerosis
- Myelodysplastic syndromes
- Myeloproliferative neoplasms
- Paroxysmal nocturnal hemoglobinuria (PNH)
- Primary amyloidosis
- Severe anaplastic anemia (SAA)
- Testicular cancer
- Waldenstrom’s macroglobulinemia
- Essential thrombocytosis (ET)
- Ewing’s sarcoma
When determining whether a patient is a good candidate for a blood and bone marrow transplant, Moffitt’s transplant team will also evaluate his or her age, individual care needs and medical history. During this process, we will also consider the various transplant techniques – autologous, in which the stem cells are taken from the patient’s own blood; allogenic, in which the stem cells are collected from a donor; or syngeneic, in which the stem cells are obtained from an identical twin; to determine which blood or bone marrow transplant procedure would be most appropriate for the patient.
If an allogenic or syngeneic transplant is the best option, we will run extensive DNA testing with any potential donor to ensure that the donor’s stem cells and white blood cells will be an appropriate match for the patient. With siblings, the chance is higher that the human leukocyte antigen (HLA) will match than with unrelated donors. However, if the transplant recipient does not have a sibling (or does not match with their sibling), Moffitt can search for a suitable volunteer donor through the National Marrow Donor Program. Currently, more than half of our allogenic transplants are arranged with a volunteer donor, although an HLA match must still be obtained. Moffitt will also screen potential donors to ensure they are able to tolerate a stem cell harvest, and that they do not have any active infections or other complications that might negatively impact their ability to donate.
When a patient is approved for a blood or bone marrow transplant procedure, Moffitt’s experienced physicians, nurses, lab technicians, transplant coordinators, dietitians and other medical professionals will work together to provide quality diagnosis and treatment, as well as individualized guidance at every phase of the transplant process. This approach helps us achieve the most positive outcomes possible, while helping to enhance each patient’s quality of life.