Basic Science Research

Basic science research at Moffitt Cancer Center involves lab work that addresses the genome, cells, and biology of cancers, as well as the surrounding tissues, which can impact the nature of the cancer and its potential to spread.  Basic science focuses understanding of the mechanisms and causes of cancer at a biological and molecular level.  While new knowledge may not be immediately translatable to new treatments and cures, over time the fundamental discoveries of basic science provide the foundation for better treatments and cures.

The Department of Drug Discovery is interdisciplinary and composed of faculty members with expertise in molecular and cellular biology, structural biology, chemistry and pharmacology. 

The Department of Immunology faculty members focus on interrogation of immune regulation in cancer with the goal of developing novel immune strategies to combat cancer. 

The Department of Metabolism and Physiology focuses on the characterization of cancer-related processes in their native state through the use of non-invasive techniques, including intravital microscopy, clinical grade imaging (PET/CT/MRI), and ex vivo live microscopy and metabolomics. 

The Department of Molecular Oncology faculty members shares common interests in understanding signal transduction pathways from the cell surface to the nucleus. They also aim to clarify the mechanisms by which a number of nuclear proteins control different cellular regulatory processes, such as gene expression and DNA replication. 

The Department of Tumor Biology conducts cutting-edge research on the molecular mechanisms underlying the growth and metastasis of tumors with an emphasis on identifying novel therapeutic strategies to combat human cancer.