Metabolism and Physiology Department Metrics

CLINICAL TRIAL 19989
Targeted Intra-arterial Gemcitabine vs. Continuation of IV Gemcitabine plus Nab-Paclitaxel following Induction with sequential IV Gemcitabine plus Nab-Paclitaxel and Radiotherapy for Locally Advanced Pancreatic Cancer
Condition: Gastrointestinal Tumor
Intervention: Gemzar (gemcitabine); Nab-paclitaxel (Abraxane); Xeloda (capecitabine); capecitabine (); gemcitabine ()

CLINICAL TRIAL 20832
A Phase II Study to Evaluate the Safety and Efficacy of Prostatic Artery Embolization in Patients with Localized Prostate Carcinoma and Obstructive Lower Urinary Tract Symptoms
Condition: Genitourinary
Intervention:

• Investigation of NRF2-Dependent Metabolic Liabilities
  Sponsor: Nat Institutes of Health
  PI:DeNicola, G.
• Investigation of NRF2-Dependent Metabolic Liabilities
  Sponsor: Nat Institutes of Health
  PI:DeNicola, G.
• Perturbing the Evolutionary Drivers of Targeted Therapy Resistance in NSCLC
  Sponsor: Amer Cancer Society
  PI:Marusyk, A.
• Imaging Acidosis and Immune Therapy in PDAC
  Sponsor: Nat Institutes of Health
  PI (Contact):Gillies, R.,PI (MPI):Pilon-Thomas, S.
• Therapeutic strategies for KEAP1/NRF2 mutant lung cancer
  Sponsor: Florida Biomedical Research Program (FBRP)
  PI:DeNicola, G.
• Exploiting Ecology and Evolution to Prevent Therapy Resistance in EGFR-Driven Lung Cancer
  Sponsor: Nat Institutes of Health
  PI:Marusyk, A.
• Metabolic basis of the NADPH-independent disulfide reductase system in mouse liver
  Sponsor: Nat Institutes of Health
  PI (MPI):DeNicola, G.
• Defining the Role of Metabolic Heterogeneity in Melanoma Dissemination and Therapy Escape
  Sponsor: Nat Institutes of Health
  PI:Smalley, I.
• Pyridine Nucleotides: Missing Link between Aging and Lung Cancer
  Sponsor: Florida Biomedical Research Program (FBRP)
  PI:DeNicola, G.,CO-PI:Gomes, A.
• Evolution of Evolability Under Targeted Therapies
  Sponsor: Moffitt Cancer Center
  PI:Marusyk, A.,CO-PI:Basanta Gutierrez, D.
• Conjugates for Detection of Breast Cancer Nodal Metastasis
  Sponsor: Moffitt Cancer Center
  PI:Morse, D.,CO-PI:Luca, V.
• Engineering Bispecific Nanobodies for Detection of Breast Cancer Nodal Metastasis
  Sponsor: US Army
  PI:Morse, D.
• Impact of extracellular glutathione catabolism on triple-negative breast cancer
  Sponsor: Nat Institutes of Health
  PI:DeNicola, G.
• A High Content Screening Platform for High Throughput, High Content Imaging and Analysis
  Sponsor: Nat Institutes of Health
  PI (Contact):McDonald, P.
• Defining and targeting the immune-suppressive metabolic microenvironment of leptomeningeal melanoma metastases
  Sponsor: Nat Institutes of Health
  PI:Smalley, I.
• Tumor-stroma metabolic crosstalk in melanoma brain metastases
  Sponsor: Melanoma Research Alliance (MRA)
  PI:Smalley, I.
• Ecology and Evolution of Breast Carcinogenesis
  Sponsor: Nat Institutes of Health
  PI (MPI):Silva, A.
• Sensitizing leptomeningeal melanoma to checkpoint inhibitor therapy
  Sponsor: Moffitt Cancer Center
  PI (Contact):Smalley, I.
• IND Enabling Studies for Rare Skin Cancer Targeted Alpha Particle Therapy
  Sponsor: Moffitt Cancer Center
  PI:Morse, D.

• Yoon SJ, Combs JA, Falzone A, Prieto-Farigua N, Caldwell S, Ackerman HD, Flores ER, DeNicola GM. Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors. Cancer Res. 2023 May.83(9):1426-1442. Pubmedid: 36862034. Pmcid: PMC10152234.
• Ilter D, Drapela S, Schild T, Ward NP, Adhikari E, Low V, Asara J, Oskarsson T, Lau EK, DeNicola GM, McReynolds MR, Gomes AP. NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023 May.61:102627. Pubmedid: 36841051. Pmcid: PMC9982641.
• DeBlasi JM, Falzone A, Caldwell S, Prieto-Farigua N, Prigge JR, Schmidt EE, Chio IIC, Karreth FA, DeNicola GM. Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression. Cancer Res. 2023 Apr. Pubmedid: 37062029.
• Torrente L, DeNicola GM. GAPDH redox redux-rewiring pentose phosphate flux. Nat Metab. 2023 Apr.5(4):538-539. Pubmedid: 37024755.
• Khaled ML, Tarhini AA, Forsyth PA, Smalley I, Piña Y. Leptomeningeal Disease (LMD) in Patients with Melanoma Metastases. Cancers (Basel). 2023 Mar.15(6). Pubmedid: 36980770. Pmcid: PMC10047692.
• Dutta T, Kapoor N, Mathew M, Chakraborty SS, Ward NP, Prieto-Farigua N, Falzone A, DeLany JP, Smith SR, Coen PM, DeNicola GM, Gardell SJ. Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans. Cell Rep. 2023 Mar.42(3):112218. Pubmedid: 36897780.
• Ravi H, Arias-Lorza AM, Costello JR, Han HS, Jeong DK, Klinz SG, Sachdev JC, Korn RL, Raghunand N. Pretherapy Ferumoxytol-enhanced MRI to Predict Response to Liposomal Irinotecan in Metastatic Breast Cancer. Radiol Imaging Cancer. 2023 Mar.5(2):e220022. Pubmedid: 36734848. Pmcid: PMC10077095.
• Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Duncan R, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith Z, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Glutathione supports lipid abundance in vivo. bioRxiv. 2023 Feb. Pubmedid: 36798186. Pmcid: PMC9934595.
• Miroshnychenko D, Miti T, Miller A, Kumar P, Laurie M, Bui MM, Altrock PM, Basanta D, Marusyk A. Paracrine enhancement of tumor cell proliferation provides indirect stroma-mediated chemoresistance via acceleration of tumor recovery between chemotherapy cycles. bioRxiv. 2023 Feb. Pubmedid: 36798328. Pmcid: PMC9934626.
• Van Oss SB, Parikh SB, Coelho NC, Wacholder A, Belashov I, Zdancewicz S, Michaca M, Xu J, Kang YP, Ward NP, Yoon SJ, McCourt KM, McKee J, Ideker T, VanDemark AP, DeNicola GM, Carvunis AR. On the illusion of auxotrophy: met15Δ yeast cells can grow on inorganic sulfur, thanks to the previously uncharacterized homocysteine synthase Yll058w. J Biol Chem. 2022 Dec.298(12):102697. Pubmedid: 36379252. Pmcid: PMC9763685.
• Sriramareddy SN, Faião-Flores F, Emmons MF, Saha B, Chellappan S, Wyatt C, Smalley I, Licht JD, Durante MA, Harbour JW, Smalley KSM. HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma. Cancer Gene Ther. 2022 Dec.29(12):1840-1846. Pubmedid: 35332245. Pmcid: PMC9508287.
• Morris BB, Smith JP, Zhang Q, Jiang Z, Hampton OA, Churchman ML, Arnold SM, Owen DH, Gray JE, Dillon PM, Soliman HH, Stover DG, Colman H, Chakravarti A, Shain KH, Silva AS, Villano JL, Vogelbaum MA, Borges VF, Akerley WL, Gentzler RD, Hall RD, Matsen CB, Ulrich CM, Post AR, Nix DA, Singer EA, Larner JM, Stukenberg PT, Jones DR, Mayo MW. Replicative Instability Drives Cancer Progression. Biomolecules. 2022 Oct.12(11). Pubmedid: 36358918. Pmcid: PMC9688014.
• Pezacki AT, Matier CD, Gu X, Kummelstedt E, Bond SE, Torrente L, Jordan-Sciutto KL, DeNicola GM, Su TA, Brady DC, Chang CJ. Oxidation state-specific fluorescent copper sensors reveal oncogene-driven redox changes that regulate labile copper(II) pools. Proc Natl Acad Sci U S A. 2022 Oct.119(43):e2202736119. Pubmedid: 36252013. Pmcid: PMC9621372.
• Law V, Chen Z, Vena F, Smalley I, Macaulay R, Evernden BR, Tran N, Pina Y, Puskas J, Caceres G, Bayle S, Johnson J, Liu JKC, Etame A, Vogelbaum M, Rodriguez P, Duckett D, Czerniecki B, Chen A, Smalley KSM, Forsyth PA. A preclinical model of patient-derived cerebrospinal fluid circulating tumor cells for experimental therapeutics in leptomeningeal disease from melanoma. Neurooncol. 2022 Oct.24(10):1673-1686. Pubmedid: 35213727. Pmcid: PMC9527526.
• Smalley I, Smalley KSM. Space Is the Place: Mapping the Cell-Cell Interactions That Predict Immunotherapy Responses in Melanoma. Cancer Res. 2022 Sep.82(18):3198-3200. Pubmedid: 36111402.
• Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM. Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer. Cancer Discov. 2022 Sep.12(9):2198-2219. Pubmedid: 35771494. Pmcid: PMC9444964.
• Remsing Rix LL, Sumi NJ, Hu Q, Desai B, Bryant AT, Li X, Welsh EA, Fang B, Kinose F, Kuenzi BM, Chen YA, Antonia SJ, Lovly CM, Koomen JM, Haura EB, Marusyk A, Rix U. IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells. Sci Signal. 2022 Aug.15(747):eabj5879. Pubmedid: 35973030. Pmcid: PMC9528501.
• Ward NP, DeNicola GM. Long-sought mediator of vitamin K recycling discovered. Nature. 2022 Aug.608(7924):673-674. Pubmedid: 35922487.
• Jiang C, Ward NP, Prieto-Farigua N, Kang YP, Thalakola A, Teng M, DeNicola GM. Corrigendum to "A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer" [Redox Biol. 54 (2022) 102358]. Redox Biol. 2022 Aug.54:102393. Pubmedid: 35794066. Pmcid: PMC9287741.
• Jiang Q, Sudalagunta P, Silva MC, Canevarolo RR, Zhao X, Ahmed KT, Alugubelli RR, DeAvila G, Tungesvik A, Perez L, Gatenby R, Gillies R, Baz R, Meads MB, Shain KH, Silva AS, Zhang W. CancerCellTracker: a brightfield time-lapse microscopy framework for cancer drug sensitivity estimation. Bioinformatics. 2022 Aug.38(16):4002-4010. Pubmedid: 35751591.
• Jiang C, Ward NP, Prieto-Farigua N, Kang YP, Thalakola A, Teng M, DeNicola GM. A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer. Redox Biol. 2022 Aug.54:102358. Pubmedid: 35667246. Pmcid: PMC9168196.
• Somarelli JA, DeGregori J, Gerlinger M, Heng HH, Marusyk A, Welch DR, Laukien FH. Questions to guide cancer evolution as a framework for furthering progress in cancer research and sustainable patient outcomes. Med Oncol. 2022 Jul.39(9):137. Pubmedid: 35781581. Pmcid: PMC9252949.
• Farrokhian N, Maltas J, Dinh M, Durmaz A, Ellsworth P, Hitomi M, McClure E, Marusyk A, Kaznatcheev A, Scott JG. Measuring competitive exclusion in non-small cell lung cancer. Sci Adv. 2022 Jul.8(26):eabm7212. Pubmedid: 35776787.
• Abou DS, Zerkel P, Robben J, McLaughlin M, Hazlehurst T, Morse D, Wadas TJ, Pandya DN, Oyama R, Gaehle G, Nickels ML, Thorek DLJ. Radiopharmaceutical Quality Control Considerations for Accelerator-Produced Actinium Therapies. Cancer Biother Radiopharm. 2022 Jun.37(5):355-363. Pubmedid: 35695807. Pmcid: PMC9242709.
• Wang X, Li Y, Li Z, Lin S, Wang H, Sun J, Lan C, Wu L, Sun D, Huang C, Singh PK, Hempel N, Trebak M, DeNicola GM, Hao J, Yang S. Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer. Cancer Res. 2022 Jun.82(12):2254-2268. Pubmedid: 35413105. Pmcid: PMC9203979.
• Vander Velde R, Shaffer S, Marusyk A. Integrating mutational and nonmutational mechanisms of acquired therapy resistance within the Darwinian paradigm. Trends Cancer. 2022 Jun.8(6):456-466. Pubmedid: 35307314.
• Li J, Smalley I, Chen Z, Wu JY, Phadke MS, Teer JK, Nguyen T, Karreth FA, Koomen JM, Sarnaik AA, Zager JS, Khushalani NI, Tarhini AA, Sondak VK, Rodriguez PC, Messina JL, Chen YA, Smalley KSM. Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy. Clin Cancer Res. 2022 May.28(10):2131-2146. Pubmedid: 35247927. Pmcid: PMC9106889.