Molecular Oncology

The Molecular Oncology Department faculty members share common interests in understanding signal transduction pathways from the cell surface to the nucleus. They also aim to clarify the mechanisms by which a number of nuclear proteins, APC complexes and non-coding RNAs control different cellular regulatory processes, such as gene expression and DNA replication. The members focus their research in understanding the basic biology of signal transduction and gene regulation and also in identifying and evaluating potential new drugs that target these pathways.

Examples of ongoing work include:

  • explaining mechanisms by which growth factor signals regulate the assembly and function of pre-DNA replication complexes
  • understanding the regulation of the p53 tumor suppressor and its associated proteins and identifying novel therapeutic strategies targeting the p53 pathway
  • defining the mechanisms of Akt and IKBKE kinases as well as ncRNA in human carcinogenesis
  • studying how transcription factor E2F influences cell cycle and proliferation
  • proteomic detection of candidate biomarkers
  • investigating the mechanisms regulating the proliferation and survival of normal and tumor cells
  • identifying oncogenes in acute myeloid leukemia
  • understanding the role of epigenetic modifications in human cancer
  • understanding the molecular mechanisms of melanoma metastasis and developing personalized therapies for melanoma
  • investigating how APC complexes are rewired in cells
  • targeting survival pathways and ncRNAs in human cancer

Molecular Oncology Department Members

Department Chair: 
Elsa Flores, PhD

Members: 
Mark G. Alexandrow, PhD
Jiandong Chen, PhD
W. Douglas Cress, PhD
Robert A. Gatenby, MD
Florian Karreth, PhD
Minjung Kim, PhD
John M. Koomen, PhD
Gary W. Reuther, PhD
Lixin Wan, PhD