Glioblastoma Treatment

Glioblastoma treatment often involves a combination of therapies. Neurosurgery (craniotomy) is usually one of the most important aspects of treatment, although it is rarely used alone. Because glioblastomas invade functioning brain, they cannot be removed in their entirety; only the mass-forming part of the tumor can be removed. Therefore, a craniotomy is performed with the goal of achieving a "maximal safe resection" – removing as much of the tumor as possible while preserving the patient’s brain function and sparing healthy tissues. Residual cancer cells are targeted with additional treatments, including chemotherapy and radiation therapy, after surgery. In some cases, investigational treatments are also available via a clinical trial. Moffitt Cancer Center has a robust clinical trials program and many of our glioblastoma patients are treated in clinical trials that provide them treatments that are not available elsewhere.

At Moffitt Cancer Center, a Neuro-Oncology specialty tumor board meets each week to review each patient’s case and determine if different glioblastoma treatment options should be considered, including new treatments in clinical trials.

The treatment options that we offer include:

  • Conventional and awake craniotomies, laser ablation and other procedures designed to remove glioblastoma tumors and alleviate pressure within the skull  
  • Radiation therapy, including intensity-modulated radiation therapy and stereotactic radiosurgery, which destroys cancerous cells with targeted beams of radiation
  • Chemotherapy, including oral and intravenous medications  
  • Biological therapies, immunotherapies, genetic therapies and hormone therapies, as well as clinical trials

At Moffitt, all of our patients receive tailored glioblastoma treatment recommendations based on the size, location and status (newly diagnosed or recurrent) of their tumors. Because we create treatment plans on a case-by-case basis, we can also account for factors such as a patient’s age and personal preferences. Additionally, we understand that every minute counts – especially with fast-growing cancers like glioblastomas. We expedite the path to treatment as much as possible so that our patients can focus on getting well. 

Referrals are not necessary to come to Moffitt. To learn more about our approach to glioblastoma treatment or to make an appointment with the experts in our Neuro-Oncology Program, call 1-888-663-3488 or submit a new patient registration form online.