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When non-Hodgkin lymphoma comes back after treatment is completed, it is called a recurrence. Many types of non-Hodgkin lymphoma respond favorably to treatment, but it’s still important for people who have achieved partial or total remission to be aware of the potential for a recurrence. Because most recurrent lymphomas are diagnosed within the first two years of entering remission, a follow-up schedule typically includes frequent visits during this time period, with the frequency reduced gradually as more time passes.

To check for signs of a potential non-Hodgkin lymphoma recurrence, physicians may perform:

  • Visual examinations of the lymph nodes
  • CT scans or PET/CT scans
  • Routine bloodwork

Survivors of non-Hodgkin lymphoma are also advised to remain aware of any potential symptoms, such as unexplained fever, night sweats or swelling of the lymph nodes in the neck or underarms, and to schedule an appointment with an oncologist if any unusual changes develop.

Treatment for recurrent non-Hodgkin lymphoma is usually slightly different than treatment for an initial diagnosis. For instance, as compared to standard chemotherapy, high-dose chemotherapy followed by stem cell transplantation may produce a better outcome for recurrent non-Hodgkin lymphoma. The addition of targeted immunotherapies may help as well.

At Moffitt Cancer Center, our goal is to provide each patient with the best possible outcome and quality of life, regardless of the type and stage of the cancer. Using evidence-based best practices for non-Hodgkin lymphoma diagnosis and treatment, we’re committed to providing patients with the best options for their unique needs, as well as comprehensive supportive care throughout their recoveries.

If you’re concerned about a potential non-Hodgkin lymphoma recurrence and would like to request an appointment at Moffitt Cancer Center, call 1-888-663-3488 or submit a new patient registration form online. You can consult with our hematologists and oncologists with or without a physician’s referral.