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5-ALA Guided Tumor Resection for Glioblastoma Removal

Moffitt Cancer Center is firmly positioned at the forefront of brain cancer treatment. To facilitate the removal of a glioblastoma - a highly aggressive form of glioma brain cancer - the neurosurgeons in our Neuro-Oncology Program offer an advanced procedure known as 5-ALA fluorescence-guided tumor resection.

Approved by the FDA for brain cancer surgery, 5-ALA technology involves the use of a drug (5-aminolevulinic acid), which is given a few hours before the procedure, and a special microscope equipped with a fluorescence filter. During the 5-ALA guided tumor resection, the cancerous cells take on a luminescent pink color, becoming more visible to the surgeon and therefore easier to precisely remove.

The intricacies of glioblastoma removal

Unlike a solid tumor, a glioblastoma is a diffuse and infiltrative cancer (envision a milk splatter). Many glioblastomas spread extensively throughout multiple regions of the brain. Therefore, glioblastoma removal is highly challenging in that a surgeon must be able to differentiate and capture cancerous cells that have become intermingled with healthy tissues. Using 5-ALA visualization technology, a surgeon can obtain a more complete resection, which can lead to a better outcome and quality of life for the patient.

In addition to working in a state-of-the-art facility and having groundbreaking technology at their fingertips, Moffitt’s neurosurgeons perform a high volume of glioblastoma removal surgeries. As such, they have acquired extensive expertise in treating even the most challenging types of brain cancer.

If you have questions about 5-ALA guided tumor resection or would like to discuss your glioblastoma removal options with a neuro-oncologist at Moffitt, you can request an appointment by calling 1-888-663-3488 or completing our new patient registration form online.