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Nam Tran, MD, PhD
Cancer Focus: Brain Cancer , Glioblastoma , Meningioma , Spinal Tumor
Dr. Nam Tran is a neuro-oncology surgeon at Moffitt Cancer Center and assistant professor of oncology and neurosurgery at the University of South Florida College of Medicine. Dr. Tran completed his fellowship training at Moffitt, following a residency in neurosurgery at Medical College of Virginia. He was chief resident his final year. Prior to that, he was affiliated for several years with the University of California-Irvine, where he received a Ph.D. in neuroscience and served as an assistant project scientist. Dr. Tran’s research interests include regulation of the blood brain barrier, tumor and trauma-associated cerebral edema, central nervous system malignancies and spine biomechanics. He has received advanced training in minimally invasive spine techniques and artificial disc replacement surgery. Dr. Tran has a strong commitment to community service. During medical school at the University of Arizona, he coordinated the Bethany House Women’s & Children’s Center Health Clinic and Primavera Indigent Health Clinic. More recently, he worked with the Guatemala Ministry of Health to establish medical missions to Guatemala City. In 2008, he was asked to speak about spina bifida at the Second International Symposium on Neural Tube Defects at the College of Physicians and Surgeons in Guatemala. Dr. Tran is fluent in Vietnamese and English.
Education & Training
- Neurological Surgery
- H Lee Moffitt Cancer Center & Research Institute - Neuro-Oncology
- Virginia Commonwealth University - Neurosurgery
- University of Arizona College of Medicine - MD
- Law V, Baldwin M, Ramamoorthi G, Kodumudi K, Tran N, Smalley I, Duckett D, Kalinski P, Czerniecki B, Smalley KSM, Forsyth PA. A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease. J Vis Exp. 2021 Jan.(167). Pubmedid: 33586709.
- Vogelbaum MA, Kroll D, Etame A, Tran N, Liu J, Ford A, Sparr E, Kim Y, Forsyth P, Sahebjam S, Mokhtari S, Peguero E, Macaulay R. A Prospective Validation Study of the First 3D Digital Exoscope for Visualization of 5-ALA-Induced Fluorescence in High-Grade Gliomas. World Neurosurg. 2021 Feb. Pubmedid: 33561551.
- Di L, Wang CP, Tang J, Macaulay R, Tran N. Sarcoidosis-Lymphoma Syndrome Presenting As Bony Vertebral Metastasis: A Case Report and Literature Review. Cureus. 2021 Feb.13(2):e13227. Pubmedid: 33728177. Pmcid: PMC7946476.
- Di L, Huang K, Kesayan T, Kroll D, Baz RC, Macaulay RJ, Tran ND. Multiple myeloma presenting as an intramedullary spinal cord tumor: a case report and review of the literature. J Med Case Rep. 2020 Oct.14(1):189. Pubmedid: 33059729. Pmcid: PMC7566029.
- Levy J, Hopkins T, Morris J, Tran ND, David E, Massari F, Farid H, Vogel A, O'Connell WG, Sunenshine P, Dixon R, Gangi A, von der Höh N, Bagla S. Radiofrequency Ablation for the Palliative Treatment of Bone Metastases: Outcomes from the Multicenter OsteoCool Tumor Ablation Post-Market Study (OPuS One Study) in 100 Patients. J Vasc Interv Radiol. 2020 Nov.31(11):1745-1752. Pubmedid: 33129427.
- Sahebjam S, Forsyth PA, Tran ND, Arrington JA, Macaulay R, Etame AB, Walko CM, Boyle T, Peguero EN, Jaglal M, Mokhtari S, Enderling H, Raghunand N, Gatewood T, Long W, Dzierzeski JL, Evernden B, Robinson T, Wicklund MC, Kim S, Thompson ZJ, Chen DT, Chinnaiyan P, Yu HM. Hypofractionated Stereotactic Re-Irradiation with Pembrolizumab and Bevacizumab in Patients with Recurrent High Grade Gliomas: Results from a Phase 1 Study. Neurooncol. 2020 Nov. Pubmedid: 33173935.
- Scherr CL, Nam K, Augusto B, Kasting ML, Caldwell M, Lee MC, Meade CD, Pal T, Quinn GP, Vadaparampil ST. A Framework for Pilot Testing Health Risk Video Narratives. Health Commun. 2020 Jun.35(7):832-841. Pubmedid: 30999777. Pmcid: PMC6800594.
- Figura NB, Rizk VT, Mohammadi H, Evernden B, Mokhtari S, Yu HM, Robinson TJ, Etame AB, Tran ND, Liu J, Washington I, Diaz R, Czerniecki BJ, Soliman H, Han HS, Sahebjam S, Forsyth PA, Ahmed KA. Clinical outcomes of breast leptomeningeal disease treated with intrathecal trastuzumab, intrathecal chemotherapy, or whole brain radiation therapy. Breast Cancer Res Treat. 2019 Jun.175(3):781-788. Pubmedid: 30859348.
- Figura NB, Potluri TK, Mohammadi H, Oliver DE, Arrington JA, Robinson TJ, Etame AB, Tran ND, Liu JK, Soliman H, Forsyth PA, Sahebjam S, Yu HM, Han HS, Ahmed KA. CDK 4/6 inhibitors and stereotactic radiation in the management of hormone receptor positive breast cancer brain metastases. J Neurooncol. 2019 Aug.144(3):583-589. Pubmedid: 31399935.
- B Figura N, Long W, Yu M, Robinson TJ, Mokhtari S, Etame AB, Tran ND, Diaz R, Soliman H, S Han H, Sahebjam S, Forsyth PA, Ahmed KA. Intrathecal trastuzumab in the management of HER2+ breast leptomeningeal disease: a single institution experience. Breast Cancer Res Treat. 2018 Jun.169(2):391-396. Pubmedid: 29392582.
- Sahebjam S, Forsyth PA, Smalley KS, Tran ND. Experimental Treatments for Leptomeningeal Metastases From Solid Malignancies. Cancer Control. 2017 Jan.24(1):42-46. Pubmedid: 28178711.
- Sahebjam S, Stallworth DG, Mokhtari S, Tran ND, Arrington JA. Assessing Response of High-Grade Gliomas to Immune Checkpoint Inhibitors. Cancer Control. 2017 Apr.24(2):180-186. Pubmedid: 28441372.
- Grabau M, Gajanan G, Nanjappa S, Bohra C, Tran N, Vrionis F, Greene J. Neurological Symptoms in a Cancer Patient With Osler-Weber-Rendu Syndrome: Brain Abscess or Metastasis?. Infect Dis Clin Prac. 2016 May.24(3):138-142.
- Kothari N, Mellon E, Hoffe SE, Frakes J, Shridhar R, Pimiento J, Meredith K, Tran ND, Saeed N, Almhanna K. Outcomes in patients with brain metastasis from esophageal carcinoma. J Gastrointest Oncol. 2016 Aug.7(4):562-569. Pubmedid: 27563446. Pmcid: PMC4963374.
- Seydafkan S, Shibata D, Sanchez J, Tran ND, Leon M, Coppola D. Pathology Report: Presacral Noncommunicating Enteric Duplication Cyst. Cancer Control. 2016 Apr.23(2):170-174. Pubmedid: 27218796.
- Nabors LB, Portnow J, Ammirati M, Baehring J, Brem H, Brown P, Butowski N, Chamberlain MC, Fenstermaker RA, Friedman A, Gilbert MR, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Lawson R, Loeffler JS, Lovely MP, Moots PL, Mrugala MM, Newton HB, Parney I, Raizer JJ, Recht L, Shonka N, Shrieve DC, Sills AK, Swinnen LJ, Tran D, Tran N, Vrionis FD, Weiss S, Wen PY, McMillian N, Engh AM. Central Nervous System Cancers, Version 1.2015. J Natl Compr Canc Ne. 2015 Oct.13(10):1191-1202. Pubmedid: 26483059.
- Wallace AN, Robinson CG, Meyer J, Tran ND, Gangi A, Callstrom MR, Chao ST, Van Tine BA, Morris JM, Bruel BM, Long J, Timmerman RD, Buchowski JM, Jennings JW. The Metastatic Spine Disease Multidisciplinary Working Group Algorithms. Oncologist. 2015 Oct.20(10):1205-1215. Pubmedid: 26354526. Pmcid: PMC4591956.
- Lawn S, Krishna N, Pisklakova A, Qu X, Fenstermacher DA, Fournier M, Vrionis FD, Tran N, Chan JA, Kenchappa RS, Forsyth PA. Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells. J Biol Chem. 2015 Feb.290(6):3814-3824. Pubmedid: 25538243. Pmcid: PMC4319045.
- Stupp R, Taillibert S, Kanner AA, Kesari S, Steinberg DM, Toms SA, Taylor LP, Lieberman F, Silvani A, Fink KL, Barnett GH, Zhu JJ, Henson JW, Engelhard HH, Chen TC, Tran DD, Sroubek J, Tran ND, Hottinger AF, Landolfi J, Desai R, Caroli M, Kew Y, Honnorat J, Idbaih A, Kirson ED, Weinberg U, Palti Y, Hegi ME, Ram Z. Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial. Jama. 2015 Dec.314(23):2535-2543. Pubmedid: 26670971.
- Toloza E, Cheng A, Coppola D, Shan Y, Moodie C, Garrett J, Krblich D, Tran N, Altiok S, Smith P. Metastatic Non-small Cell Lung Cancer Masquerading as Metastatic Renal Cell Cancer: A Case Report. Chest. 2014 Mar.145(3 Suppl):317A. Pubmedid: 24638364.
- Anchala PR, Irving WD, Hillen TJ, Friedman MV, Georgy BA, Coldwell DM, Tran ND, Vrionis FD, Brook A, Jennings JW. Treatment of metastatic spinal lesions with a navigational bipolar radiofrequency ablation device: a multicenter retrospective study. Pain Physician. 2014 Jul.17(4):317-327. Pubmedid: 25054391.
- Nabors LB, Ammirati M, Bierman PJ, Brem H, Butowski N, Chamberlain MC, Deangelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Holdhoff M, Junck L, Lawson R, Loeffler JS, Maor MH, Moots PL, Morrison T, Mrugala MM, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK, Tran D, Tran N, Vrionis FD, Wen PY, McMillian N, Ho M. Central nervous system cancers. J Natl Compr Canc Ne. 2013 Sep.11(9):1114-1151. Pubmedid: 24029126. Pmcid: PMC4124889.
- Kenchappa RS, Tran N, Rao NG, Smalley KS, Gibney GT, Sondak VK, Forsyth PA. Novel treatments for melanoma brain metastases. Cancer Control. 2013 Oct.20(4):298-306. Pubmedid: 24077406.
- Kochany JZ, Tran ND, Sarria JE. Increasing back and radicular pain 2 years following intrathecal pump implantation with review of arachnoiditis. Pain Med. 2013 Nov.14(11):1658-1663. Pubmedid: 23889758.
- Setzer M, Eleraky M, Johnson WM, Aghayev K, Tran ND, Vrionis FD. Biomechanical comparison of anterior cervical spine instrumentation techniques with and without supplemental posterior fusion after different corpectomy and discectomy combinations: Laboratory investigation. J Neurosurg Spine. 2012 Jun.16(6):579-584. Pubmedid: 22423633.
- Eleraky M, Papanastassiou I, Setzer M, Baaj AA, Tran ND, Vrionis FD. Balloon kyphoplasty in the treatment of metastatic tumors of the upper thoracic spine. J Neurosurg Spine. 2011 Mar.14(3):372-376. Pubmedid: 21250808.
- Eleraky M, Papanastassiou I, Tran ND, Dakwar E, Vrionis FD. Comparison of polymethylmethacrylate versus expandable cage in anterior vertebral column reconstruction after posterior extracavitary corpectomy in lumbar and thoraco-lumbar metastatic spine tumors. Eur Spine J. 2011 Aug.20(8):1363-1370. Pubmedid: 21390557. Pmcid: PMC3175854.
- Kim JA, Tran ND, Li Z, Yang F, Zhou W, Fisher MJ. Brain endothelial hemostasis regulation by pericytes. J Cereb Blood Flow Metab. 2006 Feb.26(2):209-217. Pubmedid: 16015279.
- Kim JA, Tran ND, Zhou W, Fisher M. Dipyridamole enhances tissue plasminogen activator release by brain capillary endothelial cells. Thromb Res. 2005.115(5):435-438. Pubmedid: 15733978.
- Kim JA, Tran ND, Berliner JA, Fisher MJ. Minimally oxidized low-density lipoprotein regulates hemostasis factors of brain capillary endothelial cells. J Neurol Sci. 2004 Feb.217(2):135-141. Pubmedid: 14706215.
- Kim JA, Tran ND, Wang SJ, Fisher MJ. Astrocyte regulation of human brain capillary endothelial fibrinolysis. Thromb Res. 2003.112(3):159-165. Pubmedid: 14967413.
- Zhang J, Tan Z, Tran ND. Chemical hypoxia-ischemia induces apoptosis in cerebromicrovascular endothelial cells. Brain Res. 2000 Sep.877(2):134-140. Pubmedid: 10986325.
- Tran ND, Correale J, Schreiber SS, Fisher M. Transforming growth factor-beta mediates astrocyte-specific regulation of brain endothelial anticoagulant factors. Stroke. 1999 Aug.30(8):1671-1678. Pubmedid: 10436120.
- Tran ND, Schreiber SS, Fisher M. Astrocyte regulation of endothelial tissue plasminogen activator in a blood-brain barrier model. J Cereb Blood Flow Metab. 1998 Dec.18(12):1316-1324. Pubmedid: 9850144.
- Wang L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. Rat brain capillary thrombomodulin: structure and function. Thromb Res. 1998 Dec.92(5):213-219. Pubmedid: 9851812.
- Tran ND, Wang L, Schreiber SS, Zlokovic B, Fisher M. Measurement of thrombomodulin mRNA expression in brain capillaries by polymerase chain reaction. Thromb Res. 1998 Aug.91(4):191-197. Pubmedid: 9736422.
- Wang L, Tran ND, Kittaka M, Fisher MJ, Schreiber SS, Zlokovic BV. Thrombomodulin expression in bovine brain capillaries. Anticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms. Arterioscler Thromb Vasc Biol. 1997 Nov.17(11):3139-3146. Pubmedid: 9409303.
- Sakhi S, Gilmore W, Tran ND, Schreiber SS. p53-deficient mice are protected against adrenalectomy-induced apoptosis. Neuroreport. 1996 Dec.8(1):233-235. Pubmedid: 9051787.
- Tran ND, Wong VL, Schreiber SS, Bready JV, Fisher M. Regulation of brain capillary endothelial thrombomodulin mRNA expression. Stroke. 1996 Dec.27(12):2304-2310. Pubmedid: 8969798.
- Silverman RB, Tran N, Sinha RK, Neuhaus FC. The oxazolidinone antibacterial agent DuP 105 does not act on cell wall biosynthesis or on a beta-lactamase. Biochem Biophys Res Commun. 1993 Sep.195(2):1077-1080. Pubmedid: 8373386.
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