Robert <span>J.</span> Gillies, PhD
Researcher

Robert J. Gillies, PhD

Academic Rank: Senior Member

Overview

Discipline

    • Cancer Imaging and Metabolism
    • Diagnostic Imaging and Interventional Radiology
    • Cancer Chemoprevention Research Interest Group
    • Melanoma Research Center of Excellence
    • Myeloma
    • Cancer Imaging and Technology
    • Center for Infection Research in Cancer
    • Cancer Biology and Evolution Program
    • Lung Cancer Center of Excellence
    • Chemical Biology and Molecular Medicine Program

Education & Training

    • University of California, Davis, PhD - Zoology
    • Yale University, Fellow - Molecular biophysics
Research

The work of Dr. Gillies has impacted all 3 aims of the ET program, with the majority focused on Aim 1: Define & characterize deregulated pathways with therapeutic relevance in subsets of human cancers. Work in this area has examined two different pathways: 1) cell surface proteins that can be targeted by imaging or therapy, and 2) energy metabolic pathways and their sequelae. Dr. Gillies and colleagues have identified targetable cell surface receptors in pancreatic, melanoma and breast cancers.  For agents designed to be applied locally, Dr. Gillies and colleagues have looked for single protein targets that are expressed in the cancer or pre-cancer, that are not expressed in normal not adjacent-normal tissues.  These can be targeted with homomultivalent ligands (hoMVLs) coupled to dyes or nanoparticles.  For agents designed to be applied systemically, they have interrogated the gene expression arrays looking for combinations of cell surface receptors that can be targeted with heteromultivalent ligands (htMVLs).  Recently, Dr. Gillies and colleagues have identified both hoMVL and htMVL targets in pancreatic cancers and melanomas, and have identified hoMVL targets for breast cancer in lymph nodes.

Publications

  • Permuth JB, Chen DT, Yoder SJ, Li J, Smith AT, Choi JW, Kim J, Balagurunathan Y, Jiang K, Coppola D, Centeno BA, Klapman J, Hodul P, Karreth FA, Trevino JG, Merchant N, Magliocco A, Malafa MP, Gillies R. Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas. Sci Rep. 2017 Sep;7(1):10484. Pubmedid: 28874676. Pmcid: PMC5585319.
  • Li Q, Kim J, Balagurunathan Y, Qi J, Liu Y, Latifi K, Moros EG, Schabath MB, Ye Z, Gillies RJ, Dilling TJ. CT imaging features associated with recurrence in non-small cell lung cancer patients after stereotactic body radiotherapy. Radiat Oncol. 2017 Sep;12(1):158. Pubmedid: 28946909. Pmcid: PMC5613447.
  • Damaghi M, Gillies R. Phenotypic changes of acid-adapted cancer cells push them toward aggressiveness in their evolution in the tumor microenvironment. Cell Cycle. 2017 Oct;16(19):1739-1743. Pubmedid: 27635863. Pmcid: PMC5628657.
  • Zhou M, Scott J, Chaudhury B, Hall L, Goldgof D, Yeom KW, Iv M, Ou Y, Kalpathy-Cramer J, Napel S, Gillies R, Gevaert O, Gatenby R. Radiomics in Brain Tumor: Image Assessment, Quantitative Feature Descriptors, and Machine-Learning Approaches. Ajnr Am J Neuroradiol. 2017 Oct. Pubmedid: 28982791.
  • Bailey DL, Pichler BJ, Gückel B, Antoch G, Barthel H, Bhujwalla ZM, Biskup S, Biswal S, Bitzer M, Boellaard R, Braren RF, Brendle C, Brindle K, Chiti A, la Fougère C, Gillies R, Goh V, Goyen M, Hacker M, Heukamp L, Knudsen GM, Krackhardt AM, Law I, Morris JC, Nikolaou K, Nuyts J, Ordonez AA, Pantel K, Quick HH, Riklund K, Sabri O, Sattler B, Troost EGC, Zaiss M, Zender L, Beyer T. Combined PET/MRI: Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tübingen, Germany. Mol Imaging Biol. 2017 Oct. Pubmedid: 28971346.
  • Li Q, Balagurunathan Y, Liu Y, Qi J, Schabath MB, Ye Z, Gillies RJ. Comparison Between Radiological Semantic Features and Lung-RADS in Predicting Malignancy of Screen-Detected Lung Nodules in the National Lung Screening Trial. Clin Lung Cancer. 2017 Oct. Pubmedid: 29137847.
  • Russell S, Wojtkowiak J, Neilson A, Gillies RJ. Metabolic Profiling of healthy and cancerous tissues in 2D and 3D. Sci Rep. 2017 Nov;7(1):15285. Pubmedid: 29127321. Pmcid: PMC5681543.
  • Ibrahim-Hashim A, Robertson-Tessi M, Enrizues-Navas P, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson AR, Gillies RJ, Gatenby RA. Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res. 2017 May;77(9):2242-2254. Pubmedid: 28249898.
  • Caudell JJ, Torres-Roca JF, Gillies RJ, Enderling H, Kim S, Rishi A, Moros EG, Harrison LB. The future of personalised radiotherapy for head and neck cancer. Lancet Oncol. 2017 May;18(5):e266-e273. Pubmedid: 28456586.
  • Shafiq-Ul-Hassan M, Zhang GG, Latifi K, Ullah G, Hunt DC, Balagurunathan Y, Abdalah MA, Schabath MB, Goldgof DG, Mackin D, Court LE, Gillies RJ, Moros EG. Intrinsic dependencies of CT radiomic features on voxel size and number of gray levels. Med Phys. 2017 Mar;44(3):1050-1062. Pubmedid: 28112418. Pmcid: PMC5462462.
  • O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC. Imaging biomarker roadmap for cancer studies. Nat Rev Clin Oncol. 2017 Mar;14(3):169-186. Pubmedid: 27725679. Pmcid: PMC5378302.
  • Liu Y, Balagurunathan Y, Atwater T, Antic S, Li Q, Walker RC, Smith G, Massion PP, Schabath MB, Gillies RJ. Radiological Image Traits Predictive of Cancer Status in Pulmonary Nodules. Clin Cancer Res. 2017 Mar;23(6):1442-1449. Pubmedid: 27663588. Pmcid: PMC5527551.
  • Avnet S, Di Pompo G, Chano T, Errani C, Ibrahim-Hashim A, Gillies RJ, Donati DM, Baldini N. Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation. Int J Cancer. 2017 Mar;140(6):1331-1345. Pubmedid: 27888521. Pmcid: PMC5272857.
  • Yip SSF, Liu Y, Parmar C, Li Q, Liu S, Qu F, Ye Z, Gillies RJ, Aerts HJWL. Associations between radiologist-defined semantic and automatically computed radiomic features in non-small cell lung cancer. Sci Rep. 2017 Jun;7(1):3519. Pubmedid: 28615677. Pmcid: PMC5471260.
  • Silva AS, Silva MC, Sudalagunta P, Distler AI, Jacobson T, Collins A, Nguyen T, Song J, Chen DT, Chen L, Cubitt CL, Baz R, Perez L, Rebatchouk D, Dalton W, Greene J, Gatenby RA, Gillies RJ, Sontag E, Meads MB, Shain K. An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma. Cancer Res. 2017 Jun;77(12):3336-3351. Pubmedid: 28400475.
  • Ibrahim-Hashim A, Abrahams D, Enriquez-Navas PM, Luddy K, Gatenby RA, Gillies RJ. Tris-base buffer: a promising new inhibitor for cancer progression and metastasis. Cancer Med. 2017 Jul;6(7):1720-1729. Pubmedid: 28556628. Pmcid: PMC5504318.
  • Grossmann P, Stringfield O, El-Hachem N, Bui MM, Rios Velazquez E, Parmar C, Leijenaar RT, Haibe-Kains B, Lambin P, Gillies R, Aerts HJ. Defining the biological basis of radiomic phenotypes in lung cancer. Elife. 2017 Jul;6. Pubmedid: 28731408. Pmcid: PMC5590809.
  • Rios Velazquez E, Parmar C, Liu Y, Coroller TP, Cruz G, Stringfield O, Ye Z, Makrigiorgos GM, Fennessy FMM, Mak RH, Gillies RJ, Quackenbush J, Aerts H. Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer. Cancer Res. 2017 Jul;77(14):3922-3930. Pubmedid: 28566328. Pmcid: PMC5528160.
  • Baldini N, De Milito A, Feron O, Gillies RJ, Michiels C, Otto AM, Pastoreková S, Pedersen SF, Porporato PE, Sonveaux P, Supuran CT, Avnet S. Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer. Front Pharmacol. 2017 Jul;8:411. Pubmedid: 28725193. Pmcid: PMC5496414.
  • Zhou M, Chaudhury B, Hall LO, Goldgof DB, Gillies RJ, Gatenby RA. Identifying spatial imaging biomarkers of glioblastoma multiforme for survival group prediction. J Magn Reson Imaging. 2017 Jul;46(1):115-123. Pubmedid: 27678245.
  • Beichel RR, Smith BJ, Bauer C, Ulrich EJ, Ahmadvand P, Budzevich MM, Gillies RJ, Goldgof D, Grkovski M, Hamarneh G, Huang Q, Kinahan PE, Laymon CM, Mountz JM, Muzi JP, Muzi M, Nehmeh S, Oborski MJ, Tan Y, Zhao B, Sunderland JJ, Buatti JM. Multi-site quality and variability analysis of 3D FDG PET segmentations based on phantom and clinical image data. Med Phys. 2017 Feb;44(2):479-496. Pubmedid: 28205306.
  • Lemma S, Di Pompo G, Porporato PE, Sboarina M, Russell S, Gillies RJ, Baldini N, Sonveaux P, Avnet S. MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases. Biochim Biophys Acta. 2017 Dec;1863(12):3254-3264. Pubmedid: 28866133.
  • Chang YC, Ackerstaff E, Tschudi Y, Jimenez B, Foltz W, Fisher C, Lilge L, Cho H, Carlin S, Gillies RJ, Balagurunathan Y, Yechieli RL, Subhawong T, Turkbey B, Pollack A, Stoyanova R. Delineation of Tumor Habitats based on Dynamic Contrast Enhanced MRI. Sci Rep. 2017 Aug;7(1):9746. Pubmedid: 28851989. Pmcid: PMC5575347.
  • Liu Y, Wang H, Li Q, McGettigan MJ, Balagurunathan Y, Garcia AL, Thompson ZJ, Heine JJ, Ye Z, Gillies RJ, Schabath MB. Radiologic Features of Small Pulmonary Nodules and Lung Cancer Risk in the National Lung Screening Trial: A Nested Case-Control Study. Radiology. 2017 Aug;161458. Pubmedid: 28837413.
  • Li Q, Kim J, Balagurunathan Y, Liu Y, Latifi K, Stringfield O, Garcia A, Moros EG, Dilling TJ, Schabath MB, Ye Z, Gillies RJ. Imaging features from pretreatment CT scans are associated with clinical outcomes in nonsmall-cell lung cancer patients treated with stereotactic body radiotherapy. Med Phys. 2017 Aug;44(8):4341-4349. Pubmedid: 28464316. Pmcid: PMC5553698.
  • Di Pompo G, Lemma S, Canti L, Rucci N, Ponzetti M, Errani C, Donati DM, Russell S, Gillies R, Chano T, Baldini N, Avnet S. Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma. Oncotarget. 2017 Aug;8(33):54478-54496. Pubmedid: 28903357. Pmcid: PMC5589596.
  • Di Pompo G, Lemma S, Canti L, Rucci N, Ponzetti M, Errani C, Donati DM, Russell S, Gillies R, Chano T, Baldini N, Avnet S. Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma. Oncotarget. 2017 Apr. Pubmedid: 28467965.
  • Liu Y, Kim J, Balagurunathan Y, Li Q, Garcia AL, Stringfield O, Ye Z, Gillies RJ. Radiomic Features Are Associated With EGFR Mutation Status in Lung Adenocarcinomas. Clin Lung Cancer. 2016 Sep;17(5):441-448.e6. Pubmedid: 27017476. Pmcid: PMC5548419.
  • Bailey DL, Pichler BJ, Gückel B, Barthel H, Beer AJ, Botnar R, Gillies R, Goh V, Gotthardt M, Hicks RJ, Lanzenberger R, la Fougere C, Lentschig M, Nekolla SG, Niederdraenk T, Nikolaou K, Nuyts J, Olego D, Riklund KÅ, Signore A, Schäfers M, Sossi V, Suminski M, Veit-Haibach P, Umutlu L, Wissmeyer M, Beyer T. Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; Tübingen, Germany. Mol Imaging Biol. 2016 Oct;18(5):637-650. Pubmedid: 27534971. Pmcid: PMC5010606.
  • Gillies RJ, Beyer T. PET and MRI: Is the Whole Greater than the Sum of Its Parts?. Cancer Res. 2016 Nov;76(21):6163-6166. Pubmedid: 27729326. Pmcid: PMC5408508.
  • Wang H, Schabath MB, Liu Y, Han Y, Li Q, Gillies RJ, Ye Z. Clinical and CT characteristics of surgically resected lung adenocarcinomas harboring ALK rearrangements or EGFR mutations. Eur J Radiol. 2016 Nov;85(11):1934-1940. Pubmedid: 27776643. Pmcid: PMC5123695.
  • Zhang X, Wojtkowiak JW, Martinez GV, Cornnell HH, Hart CP, Baker AF, Gillies R. MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts. PLoS One. 2016 May;11(5):e0155289. Pubmedid: 27227903. Pmcid: PMC4882075.
  • Huang X, Xiao X, Gillies RJ, Tian H. Design and automated production of 11C-alpha-methyl-l-tryptophan (11C-AMT). Nucl Med Biol. 2016 May;43(5):303-308. Pubmedid: 27150033.
  • Pilon-Thomas S, Kodumudi KN, El-Kenawi AE, Russell S, Weber AM, Luddy K, Damaghi M, Wojtkowiak JW, Mulé JJ, Ibrahim-Hashim A, Gillies RJ. Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy. Cancer Res. 2016 Mar;76(6):1381-1390. Pubmedid: 26719539. Pmcid: PMC4829106.
  • Lloyd MC, Cunningham JJ, Bui MM, Gillies RJ, Brown JS, Gatenby RA. Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces. Cancer Res. 2016 Jun;76(11):3136-3144. Pubmedid: 27009166. Pmcid: PMC5384728.
  • Liu Y, Kim J, Qu F, Liu S, Wang H, Balagurunathan Y, Ye Z, Gillies RJ. CT Features Associated with Epidermal Growth Factor Receptor Mutation Status in Patients with Lung Adenocarcinoma. Radiology. 2016 Jul;280(1):271-280. Pubmedid: 26937803. Pmcid: PMC4934516.
  • Damaghi M, Gillies RJ. Lysosomal protein relocation as an adaptation mechanism to extracellular acidosis. Cell Cycle. 2016 Jul;15(13):1659-1660. Pubmedid: 27097301. Pmcid: PMC5036926.
  • Wang H, Schabath MB, Liu Y, Stringfield O, Balagurunathan Y, Heine JJ, Eschrich SA, Ye Z, Gillies RJ. Association Between Computed Tomographic Features and Kirsten Rat Sarcoma Viral Oncogene Mutations in Patients With Stage I Lung Adenocarcinoma and Their Prognostic Value. Clin Lung Cancer. 2016 Jul;17(4):271-278. Pubmedid: 26712103. Pmcid: PMC4887405.
  • Yankeelov TE, Mankoff DA, Schwartz LH, Lieberman FS, Buatti JM, Mountz JM, Erickson BJ, Fennessy FM, Huang W, Kalpathy-Cramer J, Wahl RL, Linden HM, Kinahan PE, Zhao B, Hylton NM, Gillies RJ, Clarke L, Nordstrom R, Rubin DL. Quantitative Imaging in Cancer Clinical Trials. Clin Cancer Res. 2016 Jan;22(2):284-290. Pubmedid: 26773162. Pmcid: PMC4717912.
  • Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer. Sci Transl Med. 2016 Feb;8(327):327ra24. Pubmedid: 26912903. Pmcid: PMC4962860.
  • et al., Gillies, R. Radiomics: Images Are More than Pictures, They Are Data. Radiology. 2016 Feb;278(2):563-577. Pubmedid: 26579733. Pmcid: PMC4734157.
  • Kalpathy-Cramer J, Mamomov A, Zhao B, Lu L, Cherezov D, Napel S, Echegaray S, Rubin D, McNitt-Gray M, Lo P, Sieren JC, Uthoff J, Dilger SK, Driscoll B, Yeung I, Hadjiiski L, Cha K, Balagurunathan Y, Gillies R, Goldgof D. Radiomics of Lung Nodules: A Multi-Institutional Study of Robustness and Agreement of Quantitative Imaging Features. Tomography. 2016 Dec;2(4):430-437. Pubmedid: 28149958. Pmcid: PMC5279995.
  • Paul R, Hawkins SH, Balagurunathan Y, Schabath MB, Gillies RJ, Hall LO, Goldgof DB. Deep Feature Transfer Learning in Combination with Traditional Features Predicts Survival Among Patients with Lung Adenocarcinoma. Tomography. 2016 Dec;2(4):388-395. Pubmedid: 28066809. Pmcid: PMC5218828.
  • Permuth JB, Choi J, Balarunathan Y, Kim J, Chen DT, Chen L, Orcutt S, Doepker MP, Gage K, Zhang G, Latifi K, Hoffe S, Jiang K, Coppola D, Centeno BA, Magliocco A, Li Q, Trevino J, Merchant N, Gillies R, Malafa M, On Behalf Of The Florida Pancreas Collaborative . Combining radiomic features with a miRNA classifier may improve prediction of malignant pathology for pancreatic intraductal papillary mucinous neoplasms. Oncotarget. 2016 Dec;7(52):85785-85797. Pubmedid: 27589689. Pmcid: PMC5349874.
  • Hawkins S, Wang H, Liu Y, Garcia A, Stringfield O, Krewer H, Li Q, Cherezov D, Gatenby RA, Balagurunathan Y, Goldgof D, Schabath MB, Hall L, Gillies RJ. Predicting Malignant Nodules from Screening CT Scans. J Thorac Oncol. 2016 Dec;11(12):2120-2128. Pubmedid: 27422797. Pmcid: PMC5545995.
  • Stoyanova R, Pollack A, Takhar M, Lynne C, Parra N, Lam LL, Alshalalfa M, Buerki C, Castillo R, Jorda M, Ashab HA, Kryvenko ON, Punnen S, Parekh DJ, Abramowitz MC, Gillies RJ, Davicioni E, Erho N, Ishkanian A. Association of multiparametric MRI quantitative imaging features with prostate cancer gene expression in MRI-targeted prostate biopsies. Oncotarget. 2016 Aug;7(33):53362-53376. Pubmedid: 27438142. Pmcid: PMC5288193.
  • Schabath MB, Massion PP, Thompson ZJ, Eschrich SA, Balagurunathan Y, Goldof D, Aberle DR, Gillies RJ. Differences in Patient Outcomes of Prevalence, Interval, and Screen-Detected Lung Cancers in the CT Arm of the National Lung Screening Trial. PLoS One. 2016 Aug;11(8):e0159880. Pubmedid: 27509046. Pmcid: PMC4980050.
  • Kalpathy-Cramer J, Zhao B, Goldgof D, Gu Y, Wang X, Yang H, Tan Y, Gillies R, Napel S. A Comparison of Lung Nodule Segmentation Algorithms: Methods and Results from a Multi-institutional Study. J Digit Imaging. 2016 Aug;29(4):476-487. Pubmedid: 26847203. Pmcid: PMC4942386.
  • Athelogou M, Kim HJ, Dima A, Obuchowski N, Peskin A, Gavrielides MA, Petrick N, Saiprasad G, Colditz Colditz D, Beaumont H, Oubel E, Tan Y, Zhao B, Kuhnigk JM, Moltz JH, Orieux G, Gillies RJ, Gu Y, Mantri N, Goldmacher G, Zhang L, Vega E, Bloom M, Jarecha R, Soza G, Tietjen C, Takeguchi T, Yamagata H, Peterson S, Masoud O, Buckler AJ. Algorithm Variability in the Estimation of Lung Nodule Volume From Phantom CT Scans: Results of the QIBA 3A Public Challenge. Acad Radiol. 2016 Aug;23(8):940-952. Pubmedid: 27215408.
  • Tafreshi NK, Lloyd MC, Proemsey JB, Bui MM, Kim J, Gillies RJ, Morse DL. Evaluation of CAIX and CAXII Expression in Breast Cancer at Varied O2 Levels: CAIX is the Superior Surrogate Imaging Biomarker of Tumor Hypoxia. Mol Imaging Biol. 2016 Apr;18(2):219-231. Pubmedid: 26276155. Pmcid: PMC4754166.
  • Schabath MB, Gillies RJ. Noninvasive Quantitative Imaging-based Biomarkers and Lung Cancer Screening. Am J Respir Crit Care Med. 2015 Sep;192(6):654-656. Pubmedid: 26371810. Pmcid: PMC5447294.
  • Chaudhury B, Zhou M, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ, Patel BK, Weinfurtner RJ, Drukteinis JS. Heterogeneity in intratumoral regions with rapid gadolinium washout correlates with estrogen receptor status and nodal metastasis. J Magn Reson Imaging. 2015 Nov;42(5):1421-1430. Pubmedid: 25884277. Pmcid: PMC5017794.
  • Wang H, Schabath MB, Liu Y, Berglund AE, Bloom GC, Kim J, Stringfield O, Eikman EA, Klippenstein DL, Heine JJ, Eschrich SA, Ye Z, Gillies RJ. Semiquantitative Computed Tomography Characteristics for Lung Adenocarcinoma and Their Association With Lung Cancer Survival. Clin Lung Cancer. 2015 Nov;16(6):e141-e163. Pubmedid: 26077095. Pmcid: PMC4609593.
  • Grove O, Berglund AE, Schabath MB, Aerts HJ, Dekker A, Wang H, Velazquez ER, Lambin P, Gu Y, Balagurunathan Y, Eikman E, Gatenby RA, Eschrich S, Gillies RJ. Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma. PLoS One. 2015 Mar;10(3):e0118261. Pubmedid: 25739030. Pmcid: PMC4349806.
  • Verduzco D, Lloyd M, Xu L, Ibrahim-Hashim A, Balagurunathan Y, Gatenby RA, Gillies RJ. Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance. PLoS One. 2015 Mar;10(3):e0120958. Pubmedid: 25811878. Pmcid: PMC4374837.
  • Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ. Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302. Cancer Metab. 2015 Jan;3(1):2. Pubmedid: 25635223. Pmcid: PMC4310189.
  • Kam Y, Das T, Tian H, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". Int J Cancer. 2015 Feb;136(4):E188-E196. Pubmedid: 25156304. Pmcid: PMC4262548.
  • Obuchowski NA, Reeves AP, Huang EP, Wang XF, Buckler AJ, Kim HJ, Barnhart HX, Jackson EF, Giger ML, Pennello G, Toledano AY, Kalpathy-Cramer J, Apanasovich TV, Kinahan PE, Myers KJ, Goldgof DB, Barboriak DP, Gillies RJ, Schwartz LH, Sullivan AD. Quantitative imaging biomarkers: a review of statistical methods for computer algorithm comparisons. Stat Methods Med Res. 2015 Feb;24(1):68-106. Pubmedid: 24919829. Pmcid: PMC4263694.
  • Damaghi M, Tafreshi NK, Lloyd MC, Sprung R, Estrella V, Wojtkowiak JW, Morse DL, Koomen JM, Bui MM, Gatenby RA, Gillies RJ. Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane. Nat Commun. 2015 Dec;6:8752. Pubmedid: 26658462. Pmcid: PMC4682176.
  • Stephen RM, Jha AK, Roe DJ, Trouard TP, Galons JP, Kupinski MA, Frey G, Cui H, Squire S, Pagel MD, Rodriguez JJ, Gillies RJ, Stopeck AT. Diffusion MRI with Semi-Automated Segmentation Can Serve as a Restricted Predictive Biomarker of the Therapeutic Response of Liver Metastasis. Magn Reson Imaging. 2015 Dec;33(10):1267-1273. Pubmedid: 26284600. Pmcid: PMC4658325.
  • Rajeshkumar NV, Dutta P, Yabuuchi S, de Wilde RF, Matrinez GV, Le A, Kamphorst JJ, Rabinowitz JD, Jain SK, Hidalgo M, Dang CV, Gillies RJ, Maitra A. Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function. Cancer Res. 2015 Aug;75(16):3355-3364. Pubmedid: 26113084. Pmcid: PMC4537812.
  • Leijenaar RT, Nalbantov G, Carvalho S, van Elmpt WJ, Troost EG, Boellaard R, Aerts HJ, Gillies RJ, Lambin P. The effect of SUV discretization in quantitative FDG-PET Radiomics: the need for standardized methodology in tumor texture analysis. Sci Rep. 2015 Aug;5:11075. Pubmedid: 26242464. Pmcid: PMC4525145.
  • Robertson-Tessi M, Gillies RJ, Gatenby RA, Anderson AR. Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes. Cancer Res. 2015 Apr;75(8):1567-1579. Pubmedid: 25878146. Pmcid: PMC4421891.
  • Huang X, Gillies RJ, Tian H. Synthesis of [(18) F] 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide (IDO5L): a novel potential PET probe for imaging of IDO1 expression. J Labelled Comp Radiopharm. 2015 Apr;58(4):156-162. Pubmedid: 25690452. Pmcid: PMC4655588.
  • Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC. Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302. PLoS One. 2014 Sep;9(9):e107995. Pubmedid: 25254649. Pmcid: PMC4177858.
  • Luhach I, Idiyatullin D, Lynch CC, Corum C, Martinez GV, Garwood M, Gillies RJ. Rapid ex vivo imaging of PAIII prostate to bone tumor with SWIFT-MRI. Magn Reson Med. 2014 Sep;72(3):858-863. Pubmedid: 24155275. Pmcid: PMC3997623.
  • Colen R, Foster I, Gatenby R, Giger ME, Gillies R, Gutman D, Heller M, Jain R, Madabhushi A, Madhavan S, Napel S, Rao A, Saltz J, Tatum J, Verhaak R, Whitman G. NCI Workshop Report: Clinical and Computational Requirements for Correlating Imaging Phenotypes with Genomics Signatures. Transl Oncol. 2014 Oct;7(5):556-569. Pubmedid: 25389451. Pmcid: PMC4225695.
  • Fernandes SM, Lee YS, Gillies RJ, Hruby VJ. Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor. Bioorg Med Chem. 2014 Nov;22(22):6360-6365. Pubmedid: 25438759. Pmcid: PMC4254589.
  • Oosterwijk E, Gillies RJ. Targeting ion transport in cancer. Philos Trans R Soc Lond B Biol Sci. 2014 Mar;369(1638):20130107. Pubmedid: 24493755. Pmcid: PMC3917361.
  • Epstein T, Xu L, Gillies RJ, Gatenby RA. Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane. Cancer Metab. 2014 Jun;2:7. Pubmedid: 24982758. Pmcid: PMC4060846.
  • Aerts HJ, Velazquez ER, Leijenaar RT, Parmar C, Grossmann P, Cavalho S, Bussink J, Monshouwer R, Haibe-Kains B, Rietveld D, Hoebers F, Rietbergen MM, Leemans CR, Dekker A, Quackenbush J, Gillies RJ, Lambin P. Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun. 2014 Jun;5:4006. Pubmedid: 24892406. Pmcid: PMC4059926.
  • Mountz JM, Yankeelov TE, Rubin DL, Buatti JM, Erikson BJ, Fennessy FM, Gillies RJ, Huang W, Jacobs MA, Kinahan PE, Laymon CM, Linden HM, Mankoff DA, Schwartz LH, Shim H, Wahl RL. Letter to cancer center directors: Progress in quantitative imaging as a means to predict and/or measure tumor response in cancer therapy trials. J Clin Oncol. 2014 Jul;32(19):2115-2116. Pubmedid: 24868025. Pmcid: PMC4861229.
  • Tafreshi NK, Lloyd MC, Bui MM, Gillies RJ, Morse DL. Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases. Subcell Biochem. 2014 Jan;75:221-254. Pubmedid: 24146382. Pmcid: PMC4282494.
  • Zhang X, Pagel MD, Baker AF, Gillies RJ. Reproducibility of magnetic resonance perfusion imaging. PLoS One. 2014 Feb;9(2):e89797. Pubmedid: 24587040. Pmcid: PMC3934952.
  • Zhou M, Hall L, Goldgof D, Russo R, Balagurunathan Y, Gillies R, Gatenby R. Radiologically defined ecological dynamics and clinical outcomes in glioblastoma multiforme: preliminary results. Transl Oncol. 2014 Feb;7(1):5-13. Pubmedid: 24772202. Pmcid: PMC3998688.
  • Balagurunathan Y, Gu Y, Wang H, Kumar V, Grove O, Hawkins S, Kim J, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ. Reproducibility and Prognosis of Quantitative Features Extracted from CT Images. Transl Oncol. 2014 Feb;7(1):72-87. Pubmedid: 24772210. Pmcid: PMC3998690.
  • Mignion L, Dutta P, Martinez GV, Foroutan P, Gillies RJ, Jordan BF. Monitoring chemotherapeutic response by hyperpolarized 13C-fumarate MRS and diffusion MRI. Cancer Res. 2014 Feb;74(3):686-694. Pubmedid: 24285723. Pmcid: PMC4461058.
  • Balagurunathan Y, Kumar V, Gu Y, Kim J, Wang H, Liu Y, Goldgof DB, Hall LO, Korn R, Zhao B, Schwartz LH, Basu S, Eschrich S, Gatenby RA, Gillies RJ. Test-retest reproducibility analysis of lung CT image features. J Digit Imaging. 2014 Dec;27(6):805-823. Pubmedid: 24990346. Pmcid: PMC4391075.
  • Bailey KM, Cornnell HH, Ibrahim-Hashim A, Wojtkowiak JW, Hart CP, Zhang X, Leos R, Martinez GV, Baker AF, Gillies RJ. Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer. PLoS One. 2014 Dec;9(12):e113586. Pubmedid: 25532146. Pmcid: PMC4273999.
  • Khramtsov VV, Gillies RJ. Janus-faced tumor microenvironment and redox. Antioxid Redox Signal. 2014 Aug;21(5):723-729. Pubmedid: 24512276. Pmcid: PMC4098816.
  • Aerts HJ, Velazquez ER, Leijenaar RT, Parmar C, Grossmann P, Carvalho S, Bussink J, Monshouwer R, Haibe-Kains B, Rietveld D, Hoebers F, Rietbergen MM, Leemans CR, Dekker A, Quackenbush J, Gillies RJ, Lambin P. Corrigendum: Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun. 2014 Aug;5:4644. Pubmedid: 25100327.
  • Lloyd MC, Alfarouk KO, Verduzco D, Bui MM, Gillies RJ, Ibrahim ME, Brown JS, Gatenby RA. Vascular measurements correlate with estrogen receptor status. BMC Cancer. 2014 Apr;14:279. Pubmedid: 24755315. Pmcid: PMC4012762.
  • Bailey KM, Wojtkowiak JW, Cornnell HH, Ribeiro MC, Balagurunathan Y, Hashim AI, Gillies RJ. Mechanisms of buffer therapy resistance. Neoplasia. 2014 Apr;16(4):354-64.e1. Pubmedid: 24862761. Pmcid: PMC4094835.
  • Dutta P, Martinez GV, Gillies RJ. A New Horizon of DNP technology: Application to In-vivo (13)C Magnetic Resonance Spectroscopy and Imaging. Biophys Rev. 2013 Sep;5(3):271-281. Pubmedid: 26491489. Pmcid: PMC4610403.
  • Martinez-Zaguilan R, Tompkins LS, Gillies RJ, Lynch RM. Simultaneous analysis of intracellular pH and Ca²⁺ from cell populations. Methods Mol Biol. 2013 Sep;937:253-271. Pubmedid: 23007592.
  • Alleti R, Vagner J, Dehigaspitiya DC, Moberg VE, Elshan NG, Tafreshi NK, Brabez N, Weber CS, Lynch RM, Hruby VJ, Gillies RJ, Morse DL, Mash EA. Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors. Bioorg Med Chem. 2013 Sep;21(17):5029-5038. Pubmedid: 23890524. Pmcid: PMC3773999.
  • Kreahling JM, Foroutan P, Reed D, Martinez G, Razabdouski T, Bui MM, Raghavan M, Letson D, Gillies RJ, Altiok S. Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas. PLoS One. 2013 Sep;8(3):e57523. Pubmedid: 23520471. Pmcid: PMC3592874.
  • Rothberg JM, Bailey KM, Wojtkowiak JW, Ben-Nun Y, Bogyo M, Weber E, Moin K, Blum G, Mattingly RR, Gillies RJ, Sloane BF. Acid-mediated tumor proteolysis: contribution of cysteine cathepsins. Neoplasia. 2013 Oct;15(10):1125-1137. Pubmedid: 24204192. Pmcid: PMC3819629.
  • Leijenaar RT, Carvalho S, Velazquez ER, van Elmpt WJ, Parmar C, Hoekstra OS, Hoekstra CJ, Boellaard R, Dekker AL, Gillies RJ, Aerts HJ, Lambin P. Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability. Acta Oncol. 2013 Oct;52(7):1391-1397. Pubmedid: 24047337. Pmcid: PMC4533992.
  • Carvalho S, Leijenaar RT, Velazquez ER, Oberije C, Parmar C, van Elmpt W, Reymen B, Troost EG, Oellers M, Dekker A, Gillies R, Aerts HJ, Lambin P. Prognostic value of metabolic metrics extracted from baseline positron emission tomography images in non-small cell lung cancer. Acta Oncol. 2013 Oct;52(7):1398-1404. Pubmedid: 24047338. Pmcid: PMC4464799.
  • Gatenby RA, Grove O, Gillies RJ. Quantitative imaging in cancer evolution and ecology. Radiology. 2013 Oct;269(1):8-15. Pubmedid: 24062559. Pmcid: PMC3781355.
  • Kim M, Gillies RJ, Rejniak KA. Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues. Front Oncol. 2013 Nov;3:278. Pubmedid: 24303366. Pmcid: PMC3831268.
  • Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res. 2013 Mar;73(5):1524-1535. Pubmedid: 23288510. Pmcid: PMC3594450.
  • Kumar V, Nath K, Berman CG, Kim J, Tanvetyanon T, Chiappori AA, Gatenby RA, Gillies RJ, Eikman EA. Variance of SUVs for FDG-PET/CT is greater in clinical practice than under ideal study settings. Clin Nucl Med. 2013 Mar;38(3):175-182. Pubmedid: 23354032. Pmcid: PMC3578161.
  • Gu Y, Kumar V, Hall LO, Goldgof DB, Li CY, Korn R, Bendtsen C, Velazquez ER, Dekker A, Aerts H, Lambin P, Li X, Tian J, Gatenby RA, Gillies RJ. Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach. Pattern Recognit. 2013 Mar;46(3):692-702. Pubmedid: 23459617. Pmcid: PMC3580869.
  • Dutta P, Le A, Jagt DL, Tsukamoto T, Martinez GV, Dang CV, Gillies RJ. Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors. Cancer Res. 2013 Jul;73(14):4190-4195. Pubmedid: 23722553. Pmcid: PMC3736580.
  • Foroutan P, Kreahling JM, Morse DL, Grove O, Lloyd MC, Reed D, Raghavan M, Altiok S, Martinez GV, Gillies RJ. Diffusion MRI and novel texture analysis in osteosarcoma xenotransplants predicts response to anti-checkpoint therapy. PLoS One. 2013 Dec;8(12):e82875. Pubmedid: 24358232. Pmcid: PMC3865096.
  • Damaghi M, Wojtkowiak JW, Gillies RJ. pH sensing and regulation in cancer. Front Physiol. 2013 Dec;4:370. Pubmedid: 24381558. Pmcid: PMC3865727.
  • Barkey NM, Preihs C, Cornnell HH, Martinez GV, Carie A, Vagner J, Xu L, Lloyd MC, Lynch VM, Hruby VJ, Sessler JL, Sill KN, Gillies RJ, Morse DL. Development and in vivo quantitative magnetic resonance imaging of polymer micelles targeted to the melanocortin 1 receptor. J Med Chem. 2013 Aug;56(16):6330-6338. Pubmedid: 23863078. Pmcid: PMC3807968.
  • Martinez GV, Navath S, Sewda K, Rao V, Foroutan P, Alleti R, Moberg VE, Ahad AM, Coppola D, Lloyd MC, Gillies RJ, Morse DL, Mash EA. Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract. Bioorg Med Chem Lett. 2013 Apr;23(7):2061-2064. Pubmedid: 23481651. Pmcid: PMC3602218.
  • Brabez N, Nguyen KL, Saunders K, Lacy R, Xu L, Gillies RJ, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment. Bioorg Med Chem Lett. 2013 Apr;23(8):2422-2425. Pubmedid: 23489620. Pmcid: PMC4007200.
  • Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013 Apr;3:1449. Pubmedid: 23618955. Pmcid: PMC3636513.
  • Tafreshi NK, Gillies RJ, Morse DL. Molecular imaging of breast cancer lymph node metastasis. Eur J Radiol. 2012 Sep;81 Suppl 1:S160-S161. Pubmedid: 23083574. Pmcid: PMC4529025.
  • Bailey KM, Wojtkowiak JW, Hashim AI, Gillies RJ. Targeting the metabolic microenvironment of tumors. Adv Pharmacol. 2012 Sep;65:63-107. Pubmedid: 22959024. Pmcid: PMC3796340.
  • Cárdenas-Rodríguez J, Li Y, Galons JP, Cornnell H, Gillies RJ, Pagel MD, Baker AF. Imaging biomarkers to monitor response to the hypoxia-activated prodrug TH-302 in the MiaPaCa2 flank xenograft model. Magn Reson Imaging. 2012 Sep;30(7):1002-1009. Pubmedid: 22554971. Pmcid: PMC3402593.
  • Cunningham J, Estrella V, Lloyd M, Gillies R, Frieden BR, Gatenby R. Intracellular electric field and pH optimize protein localization and movement. PLoS One. 2012 Sep;7(5):e36894. Pubmedid: 22623963. Pmcid: PMC3356409.
  • Gillies RJ, Flowers CI, Drukteinis JS, Gatenby RA. A unifying theory of carcinogenesis, and why targeted therapy doesn't work. Eur J Radiol. 2012 Sep;81 Suppl 1:S48-S50. Pubmedid: 23083599.
  • Wojtkowiak JW, Gillies RJ. Autophagy on acid. Autophagy. 2012 Nov;8(11):1688-1689. Pubmedid: 22874557. Pmcid: PMC3494602.
  • Rios Velazquez E, Aerts HJ, Gu Y, Goldgof DB, De Ruysscher D, Dekker A, Korn R, Gillies RJ, Lambin P. A semiautomatic CT-based ensemble segmentation of lung tumors: comparison with oncologists' delineations and with the surgical specimen. Radiother Oncol. 2012 Nov;105(2):167-173. Pubmedid: 23157978. Pmcid: PMC3749821.
  • Chinnaiyan P, Kensicki E, Bloom G, Prabhu A, Sarcar B, Kahali S, Eschrich S, Qu X, Forsyth P, Gillies R. The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism. Cancer Res. 2012 Nov;72(22):5878-5888. Pubmedid: 23026133. Pmcid: PMC4638418.
  • Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Forster K, Aerts HJ, Dekker A, Fenstermacher D, Goldgof DB, Hall LO, Lambin P, Balagurunathan Y, Gatenby RA, Gillies RJ. Radiomics: the process and the challenges. Magn Reson Imaging. 2012 Nov;30(9):1234-1248. Pubmedid: 22898692. Pmcid: PMC3563280.
  • Stephen RM, Pagel MD, Brown K, Baker AF, Meuillet EJ, Gillies RJ. Monitoring the development of xenograft triple-negative breast cancer models using diffusion-weighted magnetic resonance imaging. Exp Biol Med (Maywood). 2012 Nov;237(11):1273-1280. Pubmedid: 23239438. Pmcid: PMC4091981.
  • Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout RG, Granton P, Zegers CM, Gillies R, Boellard R, Dekker A, Aerts HJ. Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer. 2012 Mar;48(4):441-446. Pubmedid: 22257792. Pmcid: PMC4533986.
  • Martin NK, Robey IF, Gaffney EA, Gillies RJ, Gatenby RA, Maini PK. Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study. Brit J Cancer. 2012 Mar;106(7):1280-1287. Pubmedid: 22382688. Pmcid: PMC3314784.
  • Gillies RJ, Verduzco D, Gatenby RA. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer. 2012 Jun;12(7):487-493. Pubmedid: 22695393. Pmcid: PMC4122506.
  • D'Silva L, Pola A, Dutta P, Martinez GV, Sprenger P, Gillies RJ, Kuchel PW, Sendhil Velan S. Slow relaxation of longitudinal multispin orders in weakly and strongly coupled two-spin systems. Magn Reson Chem. 2012 Jun;50(6):443-448. Pubmedid: 22552892. Pmcid: PMC4573577.
  • Tafreshi NK, Bui MM, Bishop K, Lloyd MC, Enkemann SA, Lopez AS, Abrahams D, Carter WB, Vagner J, Gobmyer SR, Gillies RJ, Morse DL. Noninvasive detection of breast cancer lymph node metastasis using carbonic anhydrases IX and XII targeted imaging probes. Clin Cancer Res. 2012 Jan;18(1):207-219. Pubmedid: 22016510. Pmcid: PMC4130557.
  • Gillies RJ, Gelovani J. The World Molecular Imaging Society (WMIS). Mol Imaging Biol. 2012 Feb;14(1):1-3. Pubmedid: 22203242.
  • Silva AS, Kam Y, Khin ZP, Minton SE, Gillies RJ, Gatenby RA. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res. 2012 Dec;72(24):6362-6370. Pubmedid: 23066036. Pmcid: PMC3525750.
  • Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ. Heterobivalent ligands target cell-surface receptor combinations in vivo. Proc Natl Acad Sci U S A. 2012 Dec;109(52):21295-21300. Pubmedid: 23236171. Pmcid: PMC3535626.
  • Ribeiro MdLC, Silva AS, Bailey KM, Kumar NB, Sellers TA, Gatenby RA, Arig IH, Gillies RJ. Buffer Therapy for Cancer. J Nutr Food Sci. 2012 Aug;2:6. Pubmedid: 24371544. Pmcid: PMC3872072.
  • Ibrahim-Hashim A, Cornnell HH, Abrahams D, Lloyd M, Bui M, Gillies RJ, Gatenby RA. Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol. 2012 Aug;188(2):624-631. Pubmedid: 22704445. Pmcid: PMC3694604.
  • Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ. Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res. 2012 Aug;72(16):3938-3947. Pubmedid: 22719070. Pmcid: PMC3749826.
  • Huynh AS, Abrahams DF, Torres MS, Baldwin MK, Gillies RJ, Morse DL. Development of an orthotopic human pancreatic cancer xenograft model using ultrasound guided injection of cells. PLoS One. 2011 Sep;6(5):e20330. Pubmedid: 21647423. Pmcid: PMC3103544.
  • Brabez N, Lynch RM, Xu L, Gillies RJ, Chassaing G, Lavielle S, Hruby VJ. Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment. J Med Chem. 2011 Oct;54(20):7375-7384. Pubmedid: 21928837. Pmcid: PMC3521580.
  • Rao V, Alleti R, Xu L, Tafreshi NK, Morse DL, Gillies RJ, Mash EA. A sucrose-derived scaffold for multimerization of bioactive peptides. Bioorg Med Chem. 2011 Nov;19(21):6474-6482. Pubmedid: 21940174. Pmcid: PMC3197697.
  • Ibrahim-Hashim A, Wojtkowiak JW, de Lourdes Coelho Ribeiro M, Estrella V, Bailey KM, Cornnell HH, Gatenby RA, Gillies RJ. Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model. J Cancer Sci Ther. 2011 Nov;Suppl 1(4). Pubmedid: 24032073. Pmcid: PMC3768133.
  • Martin NK, Gaffney EA, Gatenby RA, Gillies RJ, Robey IF, Maini PK. A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system. Math Biosci. 2011 Mar;230(1):1-11. Pubmedid: 21167185. Pmcid: PMC3045481.
  • Hashim AI, Zhang X, Wojtkowiak JW, Martinez GV, Gillies RJ. Imaging pH and metastasis. Nmr Biomed. 2011 Jul;24(6):582-591. Pubmedid: 21387439. Pmcid: PMC3740268.
  • Josan JS, Handl HL, Sankaranarayanan R, Xu L, Lynch RM, Vagner J, Mash EA, Hruby VJ, Gillies RJ. Cell-specific targeting by heterobivalent ligands. Bioconjug Chem. 2011 Jul;22(7):1270-1278. Pubmedid: 21639139. Pmcid: PMC3381984.
  • Tafreshi NK, Enkemann SA, Bui MM, Lloyd MC, Abrahams D, Huynh AS, Kim J, Grobmyer SR, Carter WB, Vagner J, Gillies RJ, Morse DL. A mammaglobin-A targeting agent for noninvasive detection of breast cancer metastasis in lymph nodes. Cancer Res. 2011 Feb;71(3):1050-1059. Pubmedid: 21169406. Pmcid: PMC4130564.
  • Ibrahim Hashim A, Cornnell HH, Coelho Ribeiro Mde L, Abrahams D, Cunningham J, Lloyd M, Martinez GV, Gatenby RA, Gillies RJ. Reduction of metastasis using a non-volatile buffer. Clin Exp Metastas. 2011 Dec;28(8):841-849. Pubmedid: 21861189. Pmcid: PMC3213349.
  • Yamazato M, Ferreira AJ, Yamazato Y, Diez-Freire C, Yuan L, Gillies R, Raizada MK. Gene transfer of angiotensin-converting enzyme 2 in the nucleus tractus solitarius improves baroreceptor heart rate reflex in spontaneously hypertensive rats. J Renin Angiotensin Aldosterone Syst. 2011 Dec;12(4):456-461. Pubmedid: 21719524. Pmcid: PMC3375591.
  • Wojtkowiak JW, Verduzco D, Schramm KJ, Gillies RJ. Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm. 2011 Dec;8(6):2032-2038. Pubmedid: 21981633. Pmcid: PMC3230683.
  • Barkey NM, Tafreshi NK, Josan JS, De Silva CR, Sill KN, Hruby VJ, Gillies RJ, Morse DL, Vagner J. Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand. J Med Chem. 2011 Dec;54(23):8078-8084. Pubmedid: 22011200. Pmcid: PMC3302579.
  • Martinez GV, Zhang X, García-Martín ML, Morse DL, Woods M, Sherry AD, Gillies RJ. Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents. Nmr Biomed. 2011 Dec;24(10):1380-1391. Pubmedid: 21604311. Pmcid: PMC3693774.
  • Gatenby RA, Gillies RJ. Integrated imaging of cancer metabolism. Acad Radiol. 2011 Aug;18(8):929-931. Pubmedid: 21718952. Pmcid: PMC3753802.
  • Perfahl H, Byrne HM, Chen T, Estrella V, Alarcón T, Lapin A, Gatenby RA, Gillies RJ, Lloyd MC, Maini PK, Reuss M, Owen MR. Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions. PLoS One. 2011 Apr;6(4):e14790. Pubmedid: 21533234. Pmcid: PMC3076378.
  • Gatenby RA, Gillies RJ, Brown JS. Of cancer and cave fish. Nat Rev Cancer. 2011 04;11(4):237-238. Pubmedid: 21548400. Pmcid: PMC3971416.
  • Morse DL, Gillies RJ. Molecular imaging and targeted therapies. Biochem Pharmacol. 2010 Sep;80(5):731-738. Pubmedid: 20399197. Pmcid: PMC2925390.
  • Alleti R, Rao V, Xu L, Gillies RJ, Mash EA. A solanesol-derived scaffold for multimerization of bioactive peptides. J Org Chem. 2010 Sep;75(17):5895-5903. Pubmedid: 20701315. Pmcid: PMC2929268.
  • Morse DL, Balagurunathan Y, Hostetter G, Trissal M, Tafreshi NK, Burke N, Lloyd M, Enkemann S, Coppola D, Hruby VJ, Gillies RJ, Han H. Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray. Biochem Pharmacol. 2010 Sep;80(5):748-754. Pubmedid: 20510208. Pmcid: PMC2914681.
  • Morse DL, Hostetter G, Balagurunathan Y, Gillies RJ, Han H. Identification of pancreatic cancer-specific cell-surface markers for development of targeting ligands. Methods Mol Biol. 2010 Mar;624:195-210. Pubmedid: 20217597. Pmcid: PMC4010309.
  • De Silva CR, Vagner J, Lynch R, Gillies RJ, Hruby VJ. Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions. Anal Biochem. 2010 Mar;398(1):15-23. Pubmedid: 19852924. Pmcid: PMC2830854.
  • Gillies RJ, Anderson AR, Gatenby RA, Morse DL. The biology underlying molecular imaging in oncology: from genome to anatome and back again. Clin Radiol. 2010 Jul;65(7):517-521. Pubmedid: 20541651. Pmcid: PMC4009364.
  • Lee YS, Fernandes S, Kulkarani V, Mayorov A, Davis P, Ma SW, Brown K, Gillies RJ, Lai J, Porreca F, Hruby VJ. Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. Bioorg Med Chem Lett. 2010 Jul;20(14):4080-4084. Pubmedid: 20547453. Pmcid: PMC2917332.
  • Silva AS, Gatenby RA, Gillies RJ, Yunes JA. A quantitative theoretical model for the development of malignancy in ductal carcinoma in situ. J Theor Biol. 2010 Feb;262(4):601-613. Pubmedid: 19887072.
  • Gatenby RA, Gillies RJ, Brown JS. Evolutionary dynamics of cancer prevention. Nat Rev Cancer. 2010 Aug;10(8):526-527. Pubmedid: 21137109. Pmcid: PMC3744108.
  • Zhang X, Lin Y, Gillies RJ. Tumor pH and its measurement. J Nucl Med. 2010 Aug;51(8):1167-1170. Pubmedid: 20660380. Pmcid: PMC4351768.
  • Xu L, Vagner J, Alleti R, Rao V, Jagadish B, Morse DL, Hruby VJ, Gillies RJ, Mash EA. Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors. Bioorg Med Chem Lett. 2010 Apr;20(8):2489-2492. Pubmedid: 20304640. Pmcid: PMC2857964.
  • Rosca EV, Gillies RJ, Caplan MR. Glioblastoma targeting via integrins is concentration dependent. Biotechnol Bioeng. 2009 Oct;104(2):408-417. Pubmedid: 19575417. Pmcid: PMC2791716.
  • Silva AS, Yunes JA, Gillies RJ, Gatenby RA. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res. 2009 Mar;69(6):2677-2684. Pubmedid: 19276380. Pmcid: PMC3718046.
  • Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, Hashim AI, Morse DL, Raghunand N, Gatenby RA, Gillies RJ. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 2009 Mar;69(6):2260-2268. Pubmedid: 19276390. Pmcid: PMC2834485.
  • Fernandes SM, Sankaranarayanan R, Xu L, Josan J, Vagner J, Gillies R, Hruby VJ. Synthesis of bivalent MSH ligands and evaluation of their binding to hMC4R using MSH lanthaligand. Adv Exp Med Biol. 2009 Jun;611:433-434. Pubmedid: 19400253.
  • Josan JS, Morse DL, Xu L, Trissal M, Baggett B, Davis P, Vagner J, Gillies RJ, Hruby VJ. Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging. Org Lett. 2009 Jun;11(12):2479-2482. Pubmedid: 19445485. Pmcid: PMC2756606.
  • Gatenby RA, Silva AS, Gillies RJ, Frieden BR. Adaptive therapy. Cancer Res. 2009 Jun;69(11):4894-4903. Pubmedid: 19487300. Pmcid: PMC3728826.
  • De Leon-Rodriguez LM, Lubag AJ, Malloy CR, Martinez GV, Gillies RJ, Sherry AD. Responsive MRI agents for sensing metabolism in vivo. Acc Chem Res. 2009 Jul;42(7):948-957. Pubmedid: 19265438. Pmcid: PMC2713815.
  • Morse DL, Carroll D, Day S, Gray H, Sadarangani P, Murthi S, Job C, Baggett B, Raghunand N, Gillies RJ. Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway. Nmr Biomed. 2009 Jan;22(1):114-127. Pubmedid: 19016452. Pmcid: PMC4130559.
  • Lee HK, Smith MD, Smith BJ, Grussendorf J, Xu L, Gillies RJ, White HS, Bulaj G. Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain. Acs Chem Biol. 2009 Aug;4(8):659-671. Pubmedid: 19634861.
  • Xu L, Vagner J, Josan J, Lynch RM, Morse DL, Baggett B, Han H, Mash EA, Hruby VJ, Gillies RJ. Enhanced targeting with heterobivalent ligands. Mol Cancer Ther. 2009 Aug;8(8):2356-2365. Pubmedid: 19671749. Pmcid: PMC3662534.
  • Josan JS, Sankaranarayanan R, Handl HL, Fernandes S, Xu L, Vagner J, Gillies RJ, Hruby VJ. Heterobivalent ligands crosslink multiple cell-surface receptors--a step towards personal medicine. Adv Exp Med Biol. 2009 Apr;611:413-414. Pubmedid: 19400245.
  • Balagurunathan Y, Morse DL, Hostetter G, Shanmugam V, Stafford P, Shack S, Pearson J, Trissal M, Demeure MJ, Von Hoff DD, Hruby VJ, Gillies RJ, Han H. Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer. Mol Cancer Ther. 2008 Sep;7(9):3071-3080. Pubmedid: 18765825. Pmcid: PMC2567866.
  • Lope-Piedrafita S, Garcia-Martin ML, Galons JP, Gillies RJ, Trouard TP. Longitudinal diffusion tensor imaging in a rat brain glioma model. Nmr Biomed. 2008 Oct;21(8):799-808. Pubmedid: 18470959. Pmcid: PMC2857329.
  • Fang JS, Gillies RD, Gatenby RA. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol. 2008 Oct;18(5):330-337. Pubmedid: 18455429. Pmcid: PMC2953714.
  • Gillies R, Robey I, Gatenby R. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med. 2008 Jun;49 Suppl 2:24S-42S. Pubmedid: 18523064.
  • Borden MA, Zhang H, Gillies RJ, Dayton PA, Ferrara KW. A stimulus-responsive contrast agent for ultrasound molecular imaging. Biomaterials. 2008 Feb;29(5):597-606. Pubmedid: 17977595. Pmcid: PMC2266628.
  • Josan JS, Vagner J, Handl HL, Sankaranarayanan R, Gillies RJ, Hruby VJ. Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors. Int J Pept Res Ther. 2008 Dec;14(4):293-300. Pubmedid: 19714261. Pmcid: PMC2732021.
  • Jennings D, Raghunand N, Gillies R. Imaging hemodynamics. Cancer Metastasis Rev. 2008 Dec;27(4):589-613. Pubmedid: 18506397. Pmcid: PMC3990228.
  • Robey IF, Stephen RM, Brown KS, Baggett BK, Gatenby RA, Gillies RJ. Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia. 2008 Aug;10(8):745-756. Pubmedid: 18670636. Pmcid: PMC2481565.
  • Trouard TP, Harkins KD, Divijak JL, Gillies RJ, Galons JP. Ischemia-induced changes of intracellular water diffusion in rat glioma cell cultures. Magn Reson Med. 2008 Aug;60(2):258-264. Pubmedid: 18666112.
  • Moellering R, Black K, Krishnamurty C, Baggett B, Stafford P, Rain M, Gatenby R, Gillies R. Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastas. 2008 Aug;25(4):411-425. Pubmedid: 18301995.
  • Gatenby R, Gillies R. A microenvironmental model of carcinogenesis. Nat Rev Cancer. 2008 01;8(1):56-61. Pubmedid: 18059462.
  • Vagner J, Xu L, Handl HL, Josan JS, Morse DL, Mash EA, Gillies RJ, Hruby VJ. Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors. Angew Chem Int Ed Engl. 2008;47(9):1685-1688. Pubmedid: 18205159. Pmcid: PMC2716288.
  • Gatenby R, Smallbone K, Maini P, Rose F, Averill J, Nagle R, Worrall L, Gillies R. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Brit J Cancer. 2007 Sep;97(5):646-653. Pubmedid: 17687336. Pmcid: PMC2360372.
  • Handl HL, Sankaranarayanan R, Josan JS, Vagner J, Mash EA, Gillies RJ, Hruby VJ. Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R). Bioconjug Chem. 2007 Oct;18(4):1101-1109. Pubmedid: 17591746. Pmcid: PMC3538036.
  • Gatenby R, Gillies R. Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell B. 2007 Oct;39(7-8):1358-1366. Pubmedid: 17499003.
  • Morse D, Galons J, Payne C, Jennings D, Day S, Xia G, Gillies R. MRI-measured water mobility increases in response to chemotherapy via multiple cell-death mechanisms. Nmr Biomed. 2007 Oct;20(6):602-614. Pubmedid: 17265424.
  • Bowen ME, Monguchi Y, Sankaranarayanan R, Vagner J, Begay LJ, Xu L, Jagadish B, Hruby VJ, Gillies RJ, Mash EA. Design, synthesis, and validation of a branched flexible linker for bioactive peptides. J Org Chem. 2007 Mar;72(5):1675-1680. Pubmedid: 17279799. Pmcid: PMC3538035.
  • Stephen RM, Gillies RJ. Promise and progress for functional and molecular imaging of response to targeted therapies. Pharm Res. 2007 Jun;24(6):1172-1185. Pubmedid: 17385018.
  • Jagadish B, Sankaranarayanan R, Xu L, Richards R, Vagner J, Hruby VJ, Gillies RJ, Mash EA. Squalene-derived flexible linkers for bioactive peptides. Bioorg Med Chem Lett. 2007 Jun;17(12):3310-3313. Pubmedid: 17448660. Pmcid: PMC2033335.
  • Gillies R, Gatenby R. Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev. 2007 Jun;26(2):311-317. Pubmedid: 17404691.
  • Gillies R, Gatenby R. Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?. J Bioenerg Biomembr. 2007 Jun;39(3):251-257. Pubmedid: 17624581.
  • Smallbone K, Gatenby R, Gillies R, Maini P, Gavaghan D. Metabolic changes during carcinogenesis: potential impact on invasiveness. J Theor Biol. 2007 Feb;244(4):703-713. Pubmedid: 17055536.
  • Rosca EV, Stukel JM, Gillies RJ, Vagner J, Caplan MR. Specificity and mobility of biomacromolecular, multivalent constructs for cellular targeting. Biomacromolecules. 2007 Dec;8(12):3830-3835. Pubmedid: 18039007. Pmcid: PMC2542405.
  • Ackerstaff E, Artemov D, Gillies RJ, Bhujwalla ZM. Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism. Neoplasia. 2007 Dec;9(12):1138-1151. Pubmedid: 18084621. Pmcid: PMC2134910.
  • Borden M, Caskey C, Little E, Gillies R, Ferrara K. DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles. Langmuir. 2007 Aug;23(18):9401-9408. Pubmedid: 17665937.
  • Morse D, Raghunand N, Sadarangani P, Murthi S, Job C, Day S, Howison C, Gillies R. Response of choline metabolites to docetaxel therapy is quantified in vivo by localized (31)P MRS of human breast cancer xenografts and in vitro by high-resolution (31)P NMR spectroscopy of cell extracts. Magn Reson Med. 2007 Aug;58(2):270-280. Pubmedid: 17654590.
  • Tatum J, Kelloff G, Gillies R, Arbeit J, Brown J, Chao K, Chapman J, Eckelman W, Fyles A, Giaccia A, Hill R, Koch C, Krishna M, Krohn K, LewisJS, Mason R, Melillo G, Padhani A, Powis G, Rajendran J, Reba R, Robinson S, Sullivan D. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 2006 Oct;82(10):699-757. Pubmedid: 17118889.
  • Gatenby R, Gawlinski E, Gmitro A, Kaylor B, Gillies R. Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res. 2006 May;66(10):5216-5223. Pubmedid: 16707446.
  • Raghunand N, Jagadish B, Trouard TP, Galons JP, Gillies RJ, Mash EA. Redox-sensitive contrast agents for MRI based on reversible binding of thiols to serum albumin. Magn Reson Med. 2006 Jun;55(6):1272-1280. Pubmedid: 16700014. Pmcid: PMC1808246.
  • Garcia-Martin M, Martinez G, Raghunand N, Sherry A, Zhang S, Gillies R. High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity. Magn Reson Med. 2006 Feb;55(2):309-315. Pubmedid: 16402385.
  • Sloane B, Gillies R, Mohla S, Sogn J, Menkens A, Sullivan D. I2 imaging: cancer biology and the tumor microenvironment. Cancer Res. 2006 Dec;66(23):11097-11099. Pubmedid: 17114235.
  • Borden M, Martinez G, Ricker J, Tsvetkova N, Longo M, Gillies R, DaytonPA, Ferrara K. Lateral phase separation in lipid-coated microbubbles. Langmuir. 2006 Apr;22(9):4291-4297. Pubmedid: 16618177.
  • Martinez-Zaguilan R, Tompkins L, Gillies R, Lynch R. Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Methods Mol Biol. 2006;312:269-287. Pubmedid: 16422205.
  • Morse D, Gray H, Payne C, Gillies R. Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells. Mol Cancer Ther. 2005 Oct;4(10):1495-1504. Pubmedid: 16227398.
  • Jordan B, Black K, Robey I, Runquist M, Powis G, Gillies R. Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo. Nmr Biomed. 2005 Nov;18(7):430-439. Pubmedid: 16206237.
  • Jordan BF, Runquist M, Raghunand N, Baker A, Williams R, Kirkpatrick L, Powis G, Gillies RJ. Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478. Neoplasia. 2005 May;7(5):475-485. Pubmedid: 15967100. Pmcid: PMC1501160.
  • Handl H, Gillies R. Lanthanide-based luminescent assays for ligand-receptor interactions. Life Sci. 2005 Jun;77(4):361-371. Pubmedid: 15894006.
  • Galons J, Lope-Piedrafita S, Divijak J, Corum C, Gillies R, Trouard T. Uncovering of intracellular water in cultured cells. Magn Reson Med. 2005 Jul;54(1):79-86. Pubmedid: 15968680.
  • Morse D, Carroll D, Weberg L, Borgstrom M, Ranger-Moore J, Gillies R. Determining suitable internal standards for mRNA quantification of increasing cancer progression in human breast cells by real-time reverse transcriptase polymerase chain reaction. Anal Biochem. 2005 Jul;342(1):69-77. Pubmedid: 15958182.
  • Jordan BF, Runquist M, Raghunand N, Gillies RJ, Tate WR, Powis G, Baker AF. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin Cancer Res. 2005 Jan;11(2 Pt 1):529-536. Pubmedid: 15701837.
  • Handl H, Vagner J, Yamamura H, Hruby V, Gillies R. Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor. Anal Biochem. 2005 Aug;343(2):299-307. Pubmedid: 16004955.
  • Gillies RJ, Hoffman JM, Lam KS, Menkens AE, Piwnica-Worms DR, Sullivan DC, Weissleder R. Meeting report: high-throughput technologies for in vivo imaging agents. Mol Imaging. 2005 Apr;4(2):98-103. Pubmedid: 16105507.
  • Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ. Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia. 2005 Apr;7(4):324-330. Pubmedid: 15967109. Pmcid: PMC1501147.
  • Gillies RJ, Morse DL. In vivo magnetic resonance spectroscopy in cancer. Annu Rev Biomed Eng. 2005;7:287-326. Pubmedid: 16004573.
  • Martinez-Zaguilan R, Tompkins LS, Gillies RJ, Lynch RM. Simultaneous analysis of intracellular pH and Ca²+ from cell populations. Methods Mol Biol. 2005;312:269-287. Pubmedid: 21341106.
  • Baggett B, Roy R, Momen S, Morgan S, Tisi L, Morse D, Gillies RJ. Thermostability of firefly luciferases affects efficiency of detection by in vivo bioluminescence. Mol Imaging. 2004 Oct;3(4):324-332. Pubmedid: 15802049.
  • Theilmann RJ, Borders R, Trouard TP, Xia G, Outwater E, Ranger-Moore J, Gillies RJ, Stopeck A. Changes in water mobility measured by diffusion MRI predict response of metastatic breast cancer to chemotherapy. Neoplasia. 2004 Nov;6(6):831-837. Pubmedid: 15720810. Pmcid: PMC1531687.
  • Handl H, Vagner J, Yamamura H, Hruby V, Gillies R. Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions. Anal Biochem. 2004 Jul;330(2):242-250. Pubmedid: 15203329.
  • Vagner J, Handl H, Gillies R, Hruby V. Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorg Med Chem Lett. 2004 Jan;14(1):211-215. Pubmedid: 14684330.
  • Handl H, Vagner J, Han H, Mash E, Hruby V, Gillies R. Hitting multiple targets with multimeric ligands. Expert Opin Ther Targets. 2004 Dec;8(6):565-586. Pubmedid: 15584863.
  • Bascunan-Castillo E, Erickson R, Howison C, Hunter R, Heidenreich R, Hicks C, Trouard T, Gillies R. Tamoxifen and vitamin E treatments delay symptoms in the mouse model of Niemann-Pick C. J Appl Genet. 2004;45(4):461-467. Pubmedid: 15523158.
  • Guo J, Erickson R, Trouard T, Galons J, Gillies R. Magnetization transfer contrast imaging in Niemann pick type C mouse liver. J Magn Reson Imaging. 2003 Sep;18(3):321-327. Pubmedid: 12938127.
  • Raghunand N, Mahoney B, Gillies R. Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents. Biochem Pharmacol. 2003 Oct;66(7):1219-1229. Pubmedid: 14505801.
  • Mahoney B, Raghunand N, Baggett B, Gillies R. Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochem Pharmacol. 2003 Oct;66(7):1207-1218. Pubmedid: 14505800.
  • Gillies R. Noninvasive imaging of anticancer therapy. Mol Cancer Ther. 2003 Mar;2(3):333-334. Pubmedid: 12657728.
  • Raghunand N, Howison C, Sherry A, Zhang S, Gillies R. Renal and systemic pH imaging by contrast-enhanced MRI. Magn Reson Med. 2003 Feb;49(2):249-257. Pubmedid: 12541244.
  • Lukasik V, Gillies R. Animal anaesthesia for in vivo magnetic resonance. Nmr Biomed. 2003 Dec;16(8):459-467. Pubmedid: 14696002.
  • Gillies R, Hruby V. Expression-driven reverse engineering of targeted imaging and therapeutic agents. Expert Opin Ther Targets. 2003 Apr;7(2):137-139. Pubmedid: 12667092.
  • Gillies R, Freeman JE, Cancio LC, Brand D, Hopmeier M, Mansfield JR. Systemic effects of shock and resuscitation monitored by visible hyperspectral imaging. Diabetes Technol Ther. 2003;5(5):847-855. Pubmedid: 14633350.
  • Raghunand N, Gatenby R, Gillies R. Microenvironmenalamd cellular consequences of altered blood flow in tumours. Br J Radiol. 2003;76:S11-S22. Pubmedid: 15456710.
  • Gillies R, Raghunand N, Karczmar G, Bhujwalla Z. MRI of the tumor microenvironment. J Magn Reson Imaging. 2002 Oct;16(4):430-450. Pubmedid: 12353258.
  • Raghunand N, Zhang S, Sherry A, Gillies R. In vivo magnetic resonance imaging of tissue pH using a novel pH-sensitive contrast agent, GdDOTA-4AmP. Acad Radiol. 2002 Aug;9 Suppl 2:S481-S483. Pubmedid: 12188315.
  • Bhujwalla Z, Artemov D, Ballesteros P, Cerdan S, Gillies R, Solaiyappan M. Combined vascular and extracellular pH imaging of solid tumors. Nmr Biomed. 2002 Apr;15(2):114-119. Pubmedid: 11870907.
  • Gillies R. In vivo molecular imaging. J Cell Biochem Suppl. 2002;39:231-238. Pubmedid: 12552622.
  • Gillies R. Causes and consequences of hypoxia and acidity in tumors--Novartis Foundation symposium. Trends Mol Med. 2001 Feb;7(2):47-49. Pubmedid: 11330256.
  • Raghunand N, Gillies R. pH and chemotherapy. Novartis Found Symp. 2001;240:199-211. Pubmedid: 11727930.
  • Gillies R, Lynch R. Frontiers in the measurement of cell and tissue pH. Novartis Found Symp. 2001;240:7-22. Pubmedid: 11727938.
  • Bhujwalla Z, Artemov D, Aboagye E, Ackerstaff E, Gillies R, Natarajan K, Solaiyappan M. The physiological environment in cancer vascularization, invasion and metastasis. Novartis Found Symp. 2001;240:23-38. Pubmedid: 11727932.
  • Gillies R. The tumour microenvironment: causes and consequences of hypoxia and acidity. Novartis Found Symp. 2001;240:1-6. Pubmedid: 11727923.
  • Raghunand N, Gillies R. pH and drug resistance in tumors. Drug Resist Updat. 2000 Feb;3(1):39-47. Pubmedid: 11498364.
  • Raghunand N, Martinez-Zaguilan R, Wright S, Gillies R. pH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs. Biochem Pharmacol. 1999 May;57(9):1047-1058. Pubmedid: 10796075.
  • Bhujwalla Z, Aboagye E, Gillies R, Chacko V, Mendola C, Backer J. Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a 31P nuclear magnetic resonance study in vivo and in vitro. Magn Reson Med. 1999 May;41(5):897-903. Pubmedid: 10332871.
  • Martinez-Zaguilan R, Tompkins L, Gillies R, Lynch R. Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Methods Mol Biol. 1999 Jun;114:287-306. Pubmedid: 10081026.
  • Raghunand N, He X, van Sluis R, Mahoney B, Baggett B, Taylor C, Paine-Murrieta G, Roe D, Bhujwalla Z, Gillies R. Enhancement of chemotherapy by manipulation of tumour pH. Brit J Cancer. 1999 Jun;80(7):1005-1011. Pubmedid: 10362108. Pmcid: PMC2363059.
  • Galons J, Altbach M, Paine-Murrieta G, Taylor C, Gillies R. Early increases in breast tumor xenograft water mobility in response to paclitaxel therapy detected by non-invasive diffusion magnetic resonance imaging. Neoplasia. 1999 Jun;1(2):113-117. Pubmedid: 10933044. Pmcid: PMC1508128.
  • Raghunand N, Altbach MI, van Sluis R, Baggett B, Taylor CW, Bhujwalla ZM, Gillies RJ. Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy. Biochem Pharmacol. 1999 Feb;57(3):309-312. Pubmedid: 9890558.
  • Gillies R, Schornack P, Secomb T, Raghunand N. Causes and effects of heterogeneous perfusion in tumors. Neoplasia. 1999 Aug;1(3):197-207. Pubmedid: 10935474. Pmcid: PMC1508079.
  • van Sluis R, Bhujwalla Z, Raghunand N, Ballesteros P, Alvarez J, Cerd?!n S, Galons J, Gillies R. In vivo imaging of extracellular pH using 1H MRSI. Magn Reson Med. 1999 Apr;41(4):743-750. Pubmedid: 10332850.
  • Gillies R. Angiostatin's partners. Science. 1999 Apr;284(5413):434. Pubmedid: 10232986.
  • Bhujwalla Z, McCoy C, Glickson J, Gillies R, Stubbs M. Estimations of intra- and extracellular volume and pH by 31P magnetic resonance spectroscopy: effect of therapy on RIF-1 tumours. Br J Cancer. 1998 Sep;78(5):606-611. Pubmedid: 9744499 .
  • Bhujwalla ZM, McCoy CL, Glickson JD, Gillies RJ, Stubbs M. Estimations of intra- and extracellular volume and pH by 31P magnetic resonance spectroscopy: effect of therapy on RIF-1 tumours. Brit J Cancer. 1998 Sep;78(5):606-611. Pubmedid: 9744499. Pmcid: PMC2063062.
  • Martinez-Zaguilan R, Martinez G, Gomez A, Hendrix M, Gillies R. Distinct regulation of pHin and [Ca2+]in in human melanoma cells with different metastatic potential. J Cell Physiol. 1998 Jul;176(1):196-205. Pubmedid: 9618159 .
  • Martínez-Zaguilán R, Martinez GM, Gomez A, Hendrix MJ, Gillies RJ. Distinct regulation of pHin and [Ca2+]in in human melanoma cells with different metastatic potential. J Cell Physiol. 1998 Jul;176(1):196-205. Pubmedid: 9618159.
  • Xie X, Gillies R, Gerner E. Characterization of a diamine exporter in Chinese hamster ovary cells and identification of specific polyamine substrates. J Biol Chem. 1997 Aug;272(33):20484-20489. Pubmedid: 9252359 .
  • Xie X, Gillies RJ, Gerner EW. Characterization of a diamine exporter in Chinese hamster ovary cells and identification of specific polyamine substrates. J Biol Chem. 1997 Aug;272(33):20484-20489. Pubmedid: 9252359.
  • Aiken N, Gillies R. Phosphomonoester metabolism as a function of cell proliferative status and exogenous precursors. Anticancer Res. 1996 May;16(3B):1393-1397. Pubmedid: 8694507 .
  • Martínez-Zaguilán R, Seftor EA, Seftor RE, Chu YW, Gillies RJ, Hendrix MJ. Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastas. 1996 Mar;14(2):176-186. Pubmedid: 8605731.
  • Martinez-Zaguilan R, Seftor E, Seftor R, Chu Y, Gillies R, Hendrix M. Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastasis. 1996 Mar;14(2):176-186. Pubmedid: 8605731 .
  • Galons J, Job C, Gillies R. Increase of GPC levels in cultured mammalian cells during acidosis: A 31P MR spectroscopy study using a continuous bioreactor system. Magn Reson Med. 1995 Mar;33(3):422-426. Pubmedid: 7760711 .
  • Galons JP, Job C, Gillies RJ. Increase of GPC levels in cultured mammalian cells during acidosis. A 31P MR spectroscopy study using a continuous bioreactor system. Magn Reson Med. 1995 Mar;33(3):422-426. Pubmedid: 7760711.
  • Lien Y, Wang X, Gillies R, Martinez-Zaguilan R. Modulation of intracellular Ca2+ by glucose in MDCK cells: role of endoplasmic reticulum Ca(2+)-ATPase. Am J Physiol. 1995 Apr;268(4 Pt 2):F671-F679. Pubmedid: 7733324 .
  • Lien YH, Wang X, Gillies RJ, Martinez-Zaguilan R. Modulation of intracellular Ca2+ by glucose in MDCK cells: role of endoplasmic reticulum Ca(2+)-ATPase. Am J Physiol. 1995 Apr;268(4 Pt 2):F671-F679. Pubmedid: 7733324.
  • Gillies R, Barry J, Ross B. In vitro and in vivo 13C and 31P NMR analyses of phosphocholine metabolism in rat glioma cells. Magn Reson Med. 1994 Sep;32(3):310-318. Pubmedid: 7984063 .
  • Gillies RJ, Barry JA, Ross BD. In vitro and in vivo 13C and 31P NMR analyses of phosphocholine metabolism in rat glioma cells. Magn Reson Med. 1994 Sep;32(3):310-318. Pubmedid: 7984063.
  • Martinez G, Martinez-Zaguilan R, Gillies R. Effect of glucose on pHin and [Ca2+]in in NIH-3T3 cells transfected with the yeast P-type H(+)-ATPase. J Cell Physiol. 1994 Oct;161(1):129-141. Pubmedid: 7929598 .
  • Martínez GM, Martínez-Zaguilán R, Gillies RJ. Effect of glucose on pHin and [Ca2+]in in NIH-3T3 cells transfected with the yeast P-type H(+)-ATPase. J Cell Physiol. 1994 Oct;161(1):129-141. Pubmedid: 7929598.
  • Wysynski AM, Martínez-Zaguilán R, Alden C, Gandolfi AJ, Gillies RJ. Phenobarbital induces cytosolic acidification in an established liver epithelial cell line. Toxicol Lett. 1994 Nov;74(2):157-166. Pubmedid: 7940597.
  • Martinez-Zaguilan R, Wegner J, Gillies R, Hoyer P. Differential regulation of Ca2+ homeostasis in ovine large and small luteal cells. Endocrinology. 1994 Nov;135(5):2099-2108. Pubmedid: 7956933 .
  • Martínez-Zaguilán R, Wegner JA, Gillies RJ, Hoyer PB. Differential regulation of Ca2+ homeostasis in ovine large and small luteal cells. Endocrinology. 1994 Nov;135(5):2099-2108. Pubmedid: 7956933.
  • Wysynski A, Martinez-Zaguilan R, Alden C, Gandolfi A, Gillies R. Phenobarbital induces cytosolic acidification in an established liver epithelial cell line. Toxicol Lett. 1994 Nov;74(2):157-166. Pubmedid: 7940597 .
  • Gunn J, Martinez-Zaguilan R, Wald-Hopkins S, Woolridge D, Gillies R. NIH3T3 cells transfected with the yeast H(+)-ATPase have altered rates of protein turnover. Arch Biochem Biophys. 1994 Nov;314(2):268-275. Pubmedid: 7979364 .
  • Gunn JM, Martinez-Zaguilan R, Wald-Hopkins S, Woolridge D, Gillies RJ. NIH3T3 cells transfected with the yeast H(+)-ATPase have altered rates of protein turnover. Arch Biochem Biophys. 1994 Nov;314(2):268-275. Pubmedid: 7979364.
  • Martinez-Zaguilan R, Gillies R, Sanchez-Armass S. Regulation of pH in rat brain synaptosomes: Role of Cl-. J Neurophysiol. 1994 Jun;71(6):2249-2257. Pubmedid: 7931514 .
  • Peterson EP, Martinez GM, Martinez-Zaguilan R, Perona R, Gillies RJ. NIH 3T3 cells transfected with a yeast H(+)-ATPase have altered sensitivity to insulin, insulin growth factor-I, and platelet-derived growth factor-AA. J Cell Physiol. 1994 Jun;159(3):551-560. Pubmedid: 8188769.
  • Peterson E, Martinez G, Martinez-Zaguilan R, Perona R, Gillies R. NIH 3T3 cells transfected with a yeast H(+)-ATPase have altered sensitivity to insulin, insulin growth factor-I, and platelet-derived growth factor-AA. J Cell Physiol. 1994 Jun;159(3):551-560. Pubmedid: 8188769 .
  • Sanchez-Armass S, Martinez-Zaguilan R, Mart?-nez G, Gillies R. Regulation of pH in rat brain synaptosomes: Role of sodium, bicarbonate, and potassium. J Neurophysiol. 1994 Jun;71(6):2236-2248. Pubmedid: 7931513 .
  • Sánchez-Armass S, Martínez-Zaguilán R, Martínez GM, Gillies RJ. Regulation of pH in rat brain synaptosomes. I. Role of sodium, bicarbonate, and potassium. J Neurophysiol. 1994 Jun;71(6):2236-2248. Pubmedid: 7931513.
  • Gillies RJ, Liu Z, Bhujwalla Z. 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate. Am J Physiol. 1994 Jul;267(1 Pt 1):C195-C203. Pubmedid: 8048479.
  • Gillies R, Liu Z, Bhujwalla Z. 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate. Am J Physiol. 1994 Jul;267(1 Pt 1):C195-C203. Pubmedid: 8048479 .
  • Wegner JA, Martinez-Zaguilan R, Gillies RJ, Hoyer PB. Prostaglandin F2 alpha releases calcium from a thapsigargin-sensitive pool in ovine large luteal cells. Am J Physiol. 1994 Jan;266(1 Pt 1):E50-E56. Pubmedid: 8304445.
  • Wegner J, Martinez-Zaguilan R, Gillies R, Hoyer P. Prostaglandin F2 alpha releases calcium from a thapsigargin-sensitive pool in ovine large luteal cells. Am J Physiol. 1994 Jan;266(1 Pt 1):E50-E56. Pubmedid: 8304445 .
  • Lax D, Martinez-Zaguilan R, Gillies R. Furazolidone increases thapsigargin-sensitive Ca(2+)-ATPase in chick cardiac myocytes. Am J Physiol. 1994 Aug;267(2 Pt 2):H734-H741. Pubmedid: 8067429 .
  • Lax D, Martínez-Zaguilán R, Gillies RJ. Furazolidone increases thapsigargin-sensitive Ca(2+)-ATPase in chick cardiac myocytes. Am J Physiol. 1994 Aug;267(2 Pt 2):H734-H741. Pubmedid: 8067429.
  • Martinez-Zaguilan R, Lynch R, Martinez G, Gillies R. Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells. Am J Physiol. 1993 Oct;265(4 Pt 1):C1015-C1029. Pubmedid: 8238296 .
  • Martinez-Zaguilan R, Lynch RM, Martinez GM, Gillies RJ. Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells. Am J Physiol. 1993 Oct;265(4 Pt 1):C1015-C1029. Pubmedid: 8238296.
  • Barry J, McGovern K, Lien Y, Ashmore B, Gillies R. Dimethyl methylphosphonate (DMMP): a 31P nuclear magnetic resonance spectroscopic probe of intracellular volume in mammalian cell cultures. Biochemistry. 1993 May;32(17):4665-4670. Pubmedid: 8485143 .
  • Barry JA, McGovern KA, Lien YH, Ashmore B, Gillies RJ. Dimethyl methylphosphonate (DMMP): a 31P nuclear magnetic resonance spectroscopic probe of intracellular volume in mammalian cell cultures. Biochemistry. 1993 May;32(17):4665-4670. Pubmedid: 8485143.
  • Gillies R, Galons J, McGovern K, Scherer P, Lien Y, Job C, Ratcliff R, Chapa F, Cerdan S, Dale B. Design and application of NMR-compatible bioreactor circuits for extended perfusion of high-density mammalian cell cultures. Nmr Biomed. 1993 Jan;6(1):95-104. Pubmedid: 8457432 .
  • Gillies RJ, Galons JP, McGovern KA, Scherer PG, Lien YH, Job C, Ratcliff R, Chapa F, Cerdan S, Dale BE. Design and application of NMR-compatible bioreactor circuits for extended perfusion of high-density mammalian cell cultures. Nmr Biomed. 1993;6(1):95-104. Pubmedid: 8457432.
  • Lien Y, Zhou H, Job C, Barry J, Gillies R. In vivo 31P NMR study of early cellular responses to hyperosmotic shock in cultured glioma cells. Biochimie. 1992 Sep;74(9-10):931-939. Pubmedid: 1467347 .
  • Martinez-Zaguilan R, Gillies R. A plasma membrane V-type H(+)-ATPase may contribute to elevated intracellular pH(pHin) in some human tumor cells. Ann N Y Acad Sci. 1992 Nov;671:478-480. Pubmedid: 1288345 .
  • Gillies R. Nuclear magnetic resonance and its applications to physiological problems. Annu Rev Physiol. 1992;54:733-748. Pubmedid: 1562189 .
  • Lien YH, Zhou HZ, Job C, Barry JA, Gillies RJ. In vivo 31P NMR study of early cellular responses to hyperosmotic shock in cultured glioma cells. Biochimie. 1992;74(9-10):931-939. Pubmedid: 1467347.
  • Gillies RJ, Scherer PG, Raghunand N, Okerlund LS, Martinez-Zaguilan R, Hesterberg L, Dale BE. Iteration of hybridoma growth and productivity in hollow fiber bioreactors using 31P NMR. Magn Reson Med. 1991 Mar;18(1):181-192. Pubmedid: 2062229.
  • Gillies R, Scherer P, Raghunand N, Okerlund L, Martinez-Zaguilan R, Hesterberg L, Dale B. Iteration of hybridoma growth and productivity in hollow fiber bioreactors using 31P NMR. Magn Reson Med. 1991 Mar;18(1):181-192. Pubmedid: 2062229 .
  • Dale B, Gillies R. Nuclear magnetic resonance spectroscopy of dense cell populations for metabolic studies and bioreactor engineering: a synergistic partnership. Biotechnology. 1991 Jul;17:107-118. Pubmedid: 2049536 .
  • Gillies R, Martinez-Zaguilan R. Regulation of intracellular pH in BALB/c 3T3 cells: Bicarbonate raises pH via NaHCO3/HCl exchange and attenuates the activation of Na+/H+ exchange by serum. J Biol Chem. 1991 Jan;266(3):1551-1556. Pubmedid: 1846359 .
  • Gillies RJ, Martinez-Zaguilan R. Regulation of intracellular pH in BALB/c 3T3 cells. Bicarbonate raises pH via NaHCO3/HCl exchange and attenuates the activation of Na+/H+ exchange by serum. J Biol Chem. 1991 Jan;266(3):1551-1556. Pubmedid: 1846359.
  • Wegner J, Martinez-Zaguilan R, Gillies R, Hoyer P. Prostaglandin F2 alpha-induced calcium transient in ovine large luteal cells: Modulation of the transient and resting cytosolic free calcium alters progesterone secretion. Endocrinology. 1991 Feb;128(2):929-936. Pubmedid: 1899223 .
  • Martínez-Zaguilán R, Martínez GM, Lattanzio F, Gillies RJ. Simultaneous measurement of intracellular pH and Ca2+ using the fluorescence of SNARF-1 and fura-2. Am J Physiol. 1991 Feb;260(2 Pt 1):C297-C307. Pubmedid: 1996613.
  • Wegner JA, Martinez-Zaguilan R, Gillies RJ, Hoyer PB. Prostaglandin F2 alpha-induced calcium transient in ovine large luteal cells: II. Modulation of the transient and resting cytosolic free calcium alters progesterone secretion. Endocrinology. 1991 Feb;128(2):929-936. Pubmedid: 1899223.
  • Martinez-Zaguilan R, Martinez G, Lattanzio F, Gillies R. Simultaneous measurement of intracellular pH and Ca2+ using the fluorescence of SNARF-1 and fura-2. Am J Physiol. 1991 Feb;260(2 Pt 1):C297-C307. Pubmedid: 1996613 .
  • Gillies RJ, Martinez-Zaguilan R, Martinez GM, Serrano R, Perona R. Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7414-7418. Pubmedid: 2170979. Pmcid: PMC54757.
  • Gillies R, Martinez-Zaguilan R, Martinez G, Serrano R, Perona R. Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7414-7418. Pubmedid: 2170979 .
  • Wegner J, Martinez-Zaguilan R, Wise M, Gillies R, Hoyer P. Prostaglandin F2 alpha-induced calcium transient in ovine large luteal cells: Alterations in cytosolic-free calcium levels and calcium flux. Endocrinology. 1990 Dec;127(6):3029-3037. Pubmedid: 2249641 .
  • Wegner JA, Martinez-Zaguilan R, Wise ME, Gillies RJ, Hoyer PB. Prostaglandin F2 alpha-induced calcium transient in ovine large luteal cells: I. Alterations in cytosolic-free calcium levels and calcium flux. Endocrinology. 1990 Dec;127(6):3029-3037. Pubmedid: 2249641.
  • Gillies R, Martinez R, Sneider J, Hoyer P. Sphingosine inhibits phorbol 12-myristate 13-acetate-, but not serum-induced, activation of Na+/H+ exchange in mammalian cells. J Cell Physiol. 1989 Apr;139(1):125-130. Pubmedid: 2540207 .
  • Martinez R, Gillies R. Dimethylsulfoxide modifies the sensitivity of BALB/c-3T3 cells to the activation of Na+/H+ exchange by phorbol esters. J Cell Physiol. 1989 Apr;139(1):131-135. Pubmedid: 2540208 .
  • Gillies RJ, Martinez R, Sneider JM, Hoyer PB. Sphingosine inhibits phorbol 12-myristate 13-acetate-, but not serum-induced, activation of Na+/H+ exchange in mammalian cells. J Cell Physiol. 1989 Apr;139(1):125-130. Pubmedid: 2540207.
  • Martinez R, Gillies RJ. Dimethylsulfoxide modifies the sensitivity of BALB/c-3T3 cells to the activation of Na+/H+ exchange by phorbol esters. J Cell Physiol. 1989 Apr;139(1):131-135. Pubmedid: 2540208.
  • Lucas C, Gillies R, Olson J, Giuliano K, Martinez R, Sneider J. Intracellular acidification inhibits the proliferative response in BALB/c-3T3 cells. J Cell Physiol. 1988 Jul;136(1):161-167. Pubmedid: 3397393 .
  • Lucas CA, Gillies RJ, Olson JE, Giuliano KA, Martinez R, Sneider JM. Intracellular acidification inhibits the proliferative response in BALB/c-3T3 cells. J Cell Physiol. 1988 Jul;136(1):161-167. Pubmedid: 3397393.
  • Martinez R, Gillies R, Giuliano K. Effect of serum on the intracellular pH of BALB/c-3T3 cells: serum deprivation causes changes in sensitivity of cells to serum. J Cell Physiol. 1988 Jul;136(1):154-160. Pubmedid: 2840441 .
  • Nelson T, Gillies R, Powell D, Schrader M, Manchester D, Pretorius D. High resolution proton NMR spectroscopy of human amniotic fluid. Prenat Diagn. 1987 Jun;7(5):363-372. Pubmedid: 3615362 .
  • Gillies R, Cook J, Fox M, Giuliano K. Flow cytometric analysis of intracellular pH in 3T3 cells. Am J Physiol. 1987 Jul;253(1 Pt 1):C121-C125. Pubmedid: 3605325 .
  • Giuliano K, Gillies R. Determination of intracellular pH of BALB/c-3T3 cells using the fluorescence of pyranine. Anal Biochem. 1987 Dec;167(2):362-371. Pubmedid: 2831755 .
  • Giuliano KA, Gillies RJ. Determination of intracellular pH of BALB/c-3T3 cells using the fluorescence of pyranine. Anal Biochem. 1987 Dec;167(2):362-371. Pubmedid: 2831755.
  • DeFronzo M, Gillies RJ. Characterization of methylphosphonate as a 31P NMR pH indicator. J Biol Chem. 1987 Aug;262(23):11032-11037. Pubmedid: 3611105.
  • DeFronzo M, Gillies R. Characterization of methylphosphonate as a 31P NMR pH indicator. J Biol Chem. 1987 Aug;262(23):11032-11037. Pubmedid: 3611105 .
  • Gillies RJ, Didier N, Denton M. Determination of cell number in monolayer cultures. Anal Biochem. 1986 Nov;159(1):109-113. Pubmedid: 3812988.
  • Gillies R, Didier N, Denton M. Determination of cell number in monolayer cultures. Anal Biochem. 1986 Nov;159(1):109-113. Pubmedid: 3812988 .
  • Findly R, Gillies R, Shulman R. In vivo phosphorus-31 nuclear magnetic resonance reveals lowered ATP during heat shock of Tetrahymena. Science. 1983 Mar;219(4589):1223-1225. Pubmedid: 6828852 .
  • Findly RC, Gillies RJ, Shulman RG. In vivo phosphorus-31 nuclear magnetic resonance reveals lowered ATP during heat shock of Tetrahymena. Science. 1983 Mar;219(4589):1223-1225. Pubmedid: 6828852.
  • Gillies R, Benoit A. NMR analysis of a cell division cycle mutant of Saccharomyces cerevisiae. Biochim Biophys Acta. 1983 Jun;762(3):466-470. Pubmedid: 6303444 .
  • Gillies RJ, Benoit AG. NMR analysis of a cell division cycle mutant of Saccharomyces cerevisiae. Biochim Biophys Acta. 1983 Jun;762(3):466-470. Pubmedid: 6303444.
  • Gillies RJ, Ogino T, Shulman RG, Ward DC. 31P nuclear magnetic resonance evidence for the regulation of intracellular pH by Ehrlich ascites tumor cells. J Cell Biol. 1982 Oct;95(1):24-28. Pubmedid: 7142288. Pmcid: PMC2112363.
  • Gillies R, Ogino T, Shulman R, Ward D. 31P nuclear magnetic resonance evidence for the regulation of intracellular pH by Ehrlich ascites tumor cells. J Cell Biol. 1982 Oct;95(1):24-28. Pubmedid: 7142288 .
  • Alger J, Sillerud L, Behar K, Gillies R, Shulman R, Gordon R, Shae D, Hanley P. In vivo carbon-13 nuclear magnetic resonance studies of mammals. Science. 1981 Nov;214(4521):660-662. Pubmedid: 7292005 .
  • Alger JR, Sillerud LO, Behar KL, Gillies RJ, Shulman RG, Gordon RE, Shae D, Hanley PE. In vivo carbon-13 nuclear magnetic resonance studies of mammals. Science. 1981 Nov;214(4521):660-662. Pubmedid: 7292005.
  • Gillies R. Intracellular pH and proliferation in yeast, Tetrahymena and sea urchin eggs. Kroc Found Ser. 1981 Jul;15:341-359. Pubmedid: 7042923 .
  • Gillies R, Alger J, den Hollander J, Shulman R. Intracellular pH measured by NMR: methods and results. Kroc Found Ser. 1981 Jul;15:79-104. Pubmedid: 7042927 .
  • Gillies R, Rosenberg M, Deamer D. Carbon dioxide efflux accompanies release of fertilization acid from sea urchin eggs. J Cell Physiol. 1981 Aug;108(2):115-122. Pubmedid: 6790553 .
  • Gillies RJ, Rosenberg MP, Deamer DW. Carbon dioxide efflux accompanies release of fertilization acid from sea urchin eggs. J Cell Physiol. 1981 Aug;108(2):115-122. Pubmedid: 6790553.
  • Gillies RJ, Ugurbil K, den Hollander JA, Shulman RG. 31P NMR studies of intracellular pH and phosphate metabolism during cell division cycle of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2125-2129. Pubmedid: 7017724. Pmcid: PMC319296.
  • Gillies R, Ugurbil K, den Hollander J, Shulman R. 31P NMR studies of intracellular pH and phosphate metabolism during cell division cycle of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2125-2129. Pubmedid: 7017724 .
  • Gillies R, Deamer D. Endogenously produced CO2 induces stationary phase in Tetrahymena cultures. J Cell Physiol. 1980 Nov;105(2):221-225. Pubmedid: 6780574 .
  • Gillies RJ, Deamer DW. Endogenously produced CO2 induces stationary phase in Tetrahymena cultures. J Cell Physiol. 1980 Nov;105(2):221-225. Pubmedid: 6780574.
  • Gillies R, Deamer D. Intracellular pH changes during the cell cycle in Tetrahymena. J Cell Physiol. 1979 Jul;100(1):23-31. Pubmedid: 38259.
  • Noble E, Gillies R, Vigran R, Mandel P. The modification of the ethanol withdrawal syndrome in rats by di-n-propylacetate. Psychopharmacologia. 1976 Mar;46(2):127-131. Pubmedid: 781711.
  • Raghunand N, Mahoney B, van Sluis R, Baggett B, Gillies R. Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone. Neoplasia. 3(3):227-235. Pubmedid: 11494116. Pmcid: PMC1505597.
  • Pilatus U, Ackerstaff E, Artemov D, Mori N, Gillies R, Bhujwalla Z. Imaging prostate cancer invasion with multi-nuclear magnetic resonance methods: the Metabolic Boyden Chamber. Neoplasia. 2(3):273-279. Pubmedid: 10935513. Pmcid: PMC1507569.
  • Evelhoch JL, Gillies RJ, Karczmar GS, Koutcher JA, Maxwell RJ, Nalcioglu O, Raghunand N, Ronen SM, Ross BD, Swartz HM. Applications of magnetic resonance in model systems: cancer therapeutics. Neoplasia. 2(1-2):152-165. Pubmedid: 10933074. Pmcid: PMC1531871.
  • Gillies RJ, Gatenby RA. Metabolism and its sequelae in cancer evolution and therapy. Cancer J. 21(2):88-96. Pubmedid: 25815848. Pmcid: PMC4446699.
  • Black KC, Kirkpatrick ND, Troutman TS, Xu L, Vagner J, Gillies RJ, Barton JK, Utzinger U, Romanowski M. Gold nanorods targeted to delta opioid receptor: plasmon-resonant contrast and photothermal agents. Mol Imaging. 7(1):50-57. Pubmedid: 18384724.
  • Aiken NR, Gillies RJ. Phosphomonoester metabolism as a function of cell proliferative status and exogenous precursors. Anticancer Res. 16(3B):1393-1397. Pubmedid: 8694507.
  • Gillies R, Raghunand N, Garcia-Martin M, Gatenby R. pH imaging. A review of pH measurement methods and applications in cancers. Ieee Eng Med Biol Mag. 23(5):57-64. Pubmedid: 15565800.
  • Gillies R, Bhujwalla Z, Evelhoch J, Garwood M, Neeman M, Robinson S, SotakCH, Van Der Sanden B. Applications of magnetic resonance in model systems: tumor biology and physiology. Neoplasia. 2(1-2):139-151. Pubmedid: 10933073. Pmcid: PMC1531870.
  • Jennings D, Hatton B, Guo J, Galons J, Trouard T, Raghunand N, Marshall J, Gillies R. Early response of prostate carcinoma xenografts to docetaxel chemotherapy monitored with diffusion MRI. Neoplasia. 4(3):255-262. Pubmedid: 11988845. Pmcid: PMC1531699.
  • Schornack PA, Gillies RJ. Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. Neoplasia. 5(2):135-145. Pubmedid: 12659686. Pmcid: PMC1502399.
  • Vagner J, Handl HL, Monguchi Y, Jana U, Begay LJ, Mash EA, Hruby VJ, Gillies RJ. Rigid linkers for bioactive peptides. Bioconjug Chem. 17(6):1545-1550. Pubmedid: 17105235. Pmcid: PMC2743982.