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Patsy H. McDonald, PhD

Academic Rank: Associate Member

Overview


Discipline

    • Cancer Physiology
    • Chemical Biology and Molecular Medicine Program
    • Melanoma Research Center of Excellence

Education & Training

Fellowship:

  • University of Dundee, PhD - Molecular Genetics
  • Duke University, Fellow - GPCR Function/Regulation
  • Glasgow University, Fellow - Gene transfer/Gene Therapy
Publications

  • Levine PM, Balana AJ, Sturchler E, Koole C, Noda H, Zarzycka B, Daley EJ, Truong TT, Katritch V, Gardella TJ, Wootten D, Sexton PM, McDonald P, Pratt MR. O-GlcNAc engineering of GPCR peptide-agonists improves their stability and in vivo activity. J Am Chem Soc. 2019 Aug. Pubmedid: 31418572.
  • Bailey TL, Nieto A, McDonald PH. A Nonradioactive High-Throughput Screening-Compatible Cell-Based Assay to Identify Inhibitors of the Monocarboxylate Transporter Protein 1. Assay Drug Dev Technol. 2019 Aug;17(6):275-284. Pubmedid: 31532712.
  • Nieto A, Fernández-Vega V, Spicer TP, Sturchler E, Adhikari P, Kennedy N, Mandat S, Chase P, Scampavia L, Bannister T, Hodder P, McDonald PH. Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119. Assay Drug Dev Technol. 2018 Jul;16(5):278-288. Pubmedid: 30019946. Pmcid: PMC6065524.
  • Nieto Gutierrez A, McDonald PH. GPCRs: Emerging anti-cancer drug targets. Cell Signal. 2018 Jan;41:65-74. Pubmedid: 28931490.
  • Li X, Sturchler E, Kaczanowska K, Cameron M, Finn MG, Griffin P, McDonald P, Markou A. KK-92A, a novel GABA receptor positive allosteric modulator, attenuates nicotine self-administration and cue-induced nicotine seeking in rats. Psychopharmacology (Berl). 2017 May;234(9-10):1633-1644. Pubmedid: 28382542.
  • Sturchler E, Li X, de Lourdes Ladino M, Kaczanowska K, Cameron M, Griffin PR, Finn MG, Markou A, McDonald P. GABA receptor allosteric modulators exhibit pathway-dependent and species-selective activity. Pharmacol Res Perspect. 2017 Apr;5(2):e00288. Pubmedid: 28357120. Pmcid: PMC5368958.
  • Geng Y, Mosyak L, Kurinov I, Zuo H, Sturchler E, Cheng TC, Subramanyam P, Brown AP, Brennan SC, Mun HC, Bush M, Chen Y, Nguyen TX, Cao B, Chang DD, Quick M, Conigrave AD, Colecraft HM, McDonald P, Fan QR. Structural mechanism of ligand activation in human calcium-sensing receptor. Elife. 2016 Jul;5. Pubmedid: 27434672. Pmcid: PMC4977154.
  • Valero TR, Sturchler E, Jafferjee M, Rengo G, Magafa V, Cordopatis P, McDonald P, Koch WJ, Lymperopoulos A. Structure-activity relationship study of angiotensin II analogs in terms of β-arrestin-dependent signaling to aldosterone production. Pharmacol Res Perspect. 2016 Apr;4(2):e00226. Pubmedid: 27069636. Pmcid: PMC4804318.
  • Robinson JD, McDonald PH. The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism. Cell Signal. 2015 Jul;27(7):1449-1456. Pubmedid: 25857454. Pmcid: PMC5549559.
  • Dabul S, Bathgate-Siryk A, Valero TR, Jafferjee M, Sturchler E, McDonald P, Koch WJ, Lymperopoulos A. Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison. Sci Rep. 2015 Jan;5:8116. Pubmedid: 25631300. Pmcid: PMC4309955.
  • Zhang H, Sturchler E, Zhu J, Nieto A, Cistrone PA, Xie J, He L, Yea K, Jones T, Turn R, Di Stefano PS, Griffin PR, Dawson PE, McDonald PH, Lerner RA. Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects. Nat Commun. 2015 Dec;6:8918. Pubmedid: 26621478. Pmcid: PMC4686834.
  • Sturchler E, Chen W, Spicer T, Hodder P, McDonald P, Duckett D. Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology. Assay Drug Dev Technol. 2014 May;12(4):229-237. Pubmedid: 24831789. Pmcid: PMC4025566.
  • Lymperopoulos A, Sturchler E, Bathgate-Siryk A, Dabul S, Garcia D, Walklett K, Rengo G, McDonald P, Koch WJ. Different potencies of angiotensin receptor blockers at suppressing adrenal β-Arrestin1-dependent post-myocardial infarction hyperaldosteronism. J Am Coll Cardiol. 2014 Dec;64(25):2805-2806. Pubmedid: 25541135.
  • Di Fruscia P, He Y, Koenig M, Tabrizifard S, Nieto A, McDonald PH, Kamenecka TM. The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1). Bioorg Med Chem Lett. 2014 Aug;24(16):3974-3978. Pubmedid: 24997685. Pmcid: PMC4130903.
  • Robinson J, Smith A, Sturchler E, Tabrizifard S, Kamenecka T, McDonald P. Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3). Assay Drug Dev Technol. 2013 Oct;11(8):468-477. Pubmedid: 24116939. Pmcid: PMC3804082.
  • Begriche K, Girardet C, McDonald P, Butler AA. Melanocortin-3 receptors and metabolic homeostasis. Prog Mol Biol Transl Sci. 2013 Dec;114:109-146. Pubmedid: 23317784. Pmcid: PMC4064570.
  • Jiang R, Song X, Bali P, Smith A, Bayona CR, Lin L, Cameron MD, McDonald PH, Kenny PJ, Kamenecka TM. Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists. Bioorg Med Chem Lett. 2012 Jun;22(12):3890-3894. Pubmedid: 22617492. Pmcid: PMC3383661.
  • Begriche K, Marston OJ, Rossi J, Burke LK, McDonald P, Heisler LK, Butler AA. Melanocortin-3 receptors are involved in adaptation to restricted feeding. Genes Brain Behav. 2012 Apr;11(3):291-302. Pubmedid: 22353545. Pmcid: PMC3319531.
  • Sturchler E, Feurstein D, McDonald P, Duckett D. Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation. Biochemistry-Us. 2010 May;49(19):4094-4102. Pubmedid: 20364819.
  • Brothers SP, Saldanha SA, Spicer TP, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol Pharmacol. 2010 Jan;77(1):46-57. Pubmedid: 19837904. Pmcid: PMC2802430.
  • Bohn LM, McDonald PH. Seeking Ligand Bias: Assessing GPCR Coupling to Beta-Arrestins for Drug Discovery. Drug Discov Today Technol. 2010 Apr;7(1):e37-e42. Pubmedid: 21218149. Pmcid: PMC3014586.
  • Pachori AS, Smith A, McDonald P, Zhang L, Dzau VJ, Melo LG. Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway. J Mol Cell Cardiol. 2007 Nov;43(5):580-592. Pubmedid: 17920074. Pmcid: PMC2699998.
  • Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR. The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction. J Pharmacol Exp Ther. 2003 Jul;306(1):147-156. Pubmedid: 12665544.
  • McDonald PH, Lefkowitz RJ. Beta-Arrestins: new roles in regulating heptahelical receptors' functions. Cell Signal. 2001 Oct;13(10):683-689. Pubmedid: 11602178.
  • Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science. 2001 Nov;294(5545):1307-1313. Pubmedid: 11588219.
  • Kohout TA, Takaoka H, McDonald PH, Perry SJ, Mao L, Lefkowitz RJ, Rockman HA. Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. Circulation. 2001 Nov;104(20):2485-2491. Pubmedid: 11705829.
  • Miller WE, McDonald PH, Cai SF, Field ME, Davis RJ, Lefkowitz RJ. Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. J Biol Chem. 2001 Jul;276(30):27770-27777. Pubmedid: 11356842.
  • McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 2000 Nov;290(5496):1574-1577. Pubmedid: 11090355.
  • Alexander MY, Webster KA, McDonald PH, Prentice HM. Gene transfer and models of gene therapy for the myocardium. Clin Exp Pharmacol Physiol. 1999 Sep;26(9):661-668. Pubmedid: 10499153.
  • Maurice JP, Hata JA, Shah AS, White DC, McDonald PH, Dolber PC, Wilson KH, Lefkowitz RJ, Glower DD, Koch WJ. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. J Clin Invest. 1999 Jul;104(1):21-29. Pubmedid: 10393695. Pmcid: PMC408402.
  • Kypson A, Hendrickson S, Akhter S, Wilson K, McDonald P, Lilly R, Dolber P, Glower D, Lefkowitz R, Koch W. Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function. Gene Ther. 1999 Jul;6(7):1298-1304. Pubmedid: 10455439.
  • McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ. Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. J Biol Chem. 1999 Apr;274(16):10677-10680. Pubmedid: 10196135.
  • Peppel K, Boekhoff I, McDonald P, Breer H, Caron MG, Lefkowitz RJ. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J Biol Chem. 1997 Oct;272(41):25425-25428. Pubmedid: 9325250.
  • Akhter SA, Skaer CA, Kypson AP, McDonald PH, Peppel KC, Glower DD, Lefkowitz RJ, Koch WJ. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proc Natl Acad Sci U S A. 1997 Oct;94(22):12100-12105. Pubmedid: 9342369. Pmcid: PMC23716.
  • McDonald P, Hicks MN, Cobbe SM, Prentice H. Gene transfer in models of myocardial ischemia. Ann Ny Acad Sci. 1995 Mar;752:455-459. Pubmedid: 7755291.
  • Da Cruz e Silva EF, Hughes V, McDonald P, Stark MJ, Cohen PT. Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes. Biochim Biophys Acta. 1991 Jun;1089(2):269-272. Pubmedid: 1647215.