Jose <span>R.</span> Conejo-Garcia
Researcher

Jose R. Conejo-Garcia

Overview

Discipline

    • Immunology
    • Gynecologic Oncology
    • Immunology

Education & Training

    • University of Zaragoza, MD
    • Hospital Universitario De Guadalajara, Resident - Clinical Chemistry
    • University of Alcala, PhD
    • University of Bern, Fellow
    • IPF Pharmaceuticals, Fellow
    • University of Pennsylvania, Fellow
Research

The goal of Dr. Conejo-Garcia’s research program is to identify and target mechanisms governing the balance between immunosuppression and protective immunity in the tumor microenvironment, with an emphasis on the role of cancer-driven pathological myelopoiesis. By combining clinical information and specimens with mechanistic studies in mouse models, Dr. Conejo-Garcia’s research program has contributed to elucidate most of the mechanisms driving protective immunity against ovarian cancer that have been unveiled in recent years, as demonstrated by dozens of recent articles that total thousands of citations. This research traces its roots to his postdoctoral work, when Dr. Coukos’ laboratory unveiled the role of spontaneous T-cell responses in ovarian cancer patients. Current priorities in the lab include the characterization of novel mechanisms of immune checkpoint inhibition in the tumor microenvironment, the role of commensal microorganisms in the orchestration of tumor-promoting vs. anti-tumor inflammatory responses; the identification of novel tumor antigens different from point mutations; and the dissection of novel epigenetic mechanisms driving anti-tumor immune responses. Dr. Conejo-Garcia’s laboratory keeps looking forward to moving basic discoveries to clinical testing for the benefit of Moffitt’s patients.

Publications

  • Svoronos N, Perales-Puchalt A, Allegrezza MJ, Rutkowski MR, Payne KK, Tesone AJ, Nguyen JM, Curiel TJ, Cadungog MG, Singhal S, Eruslanov EB, Zhang P, Tchou J, Zhang R, Conejo-Garcia JR. Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells. Cancer Discov. 2017 Jan;7(1):72-85. Pubmedid: 27694385. Pmcid: PMC5222699.
  • Conejo-Garcia JR, Payne KK, Svoronos N. Estrogens drive myeloid-derived suppressor cell accumulation. Oncoscience. 2017 Jan;4(1-2):5-6. Pubmedid: 28484727. Pmcid: PMC5361641.
  • Perales-Puchalt A, Svoronos N, Rutkowski MR, Allegrezza MJ, Tesone AJ, Payne KK, Wickramasinghe J, Nguyen JM, O'Brien SW, Gumireddy K, Huang Q, Cadungog MG, Connolly DC, Tchou J, Curiel TJ, Conejo-Garcia JR. Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target. Clin Cancer Res. 2017 Jan;23(2):441-453. Pubmedid: 27435394. Pmcid: PMC5241180.
  • Allegrezza MJ, Conejo-Garcia JR. Targeted Therapy and Immunosuppression in the Tumor Microenvironment. Trends Cancer. 2017 Jan;3(1):19-27. Pubmedid: 28718424.
  • Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher Iii FJ, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, Christianson DW, Zhang R. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat Cell Biol. 2017 Aug;19(8):962-973. Pubmedid: 28737768. Pmcid: PMC5541905.
  • Gupta HB, Clark CA, Yuan B, Sareddy G, Pandeswara S, Padron AS, Hurez V, Conejo-Garcia J, Vadlamudi R, Li R, Curiel TJ. Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer. Signal Transduct Target Ther. 2017 Aug;1. Pubmedid: 28798885. Pmcid: PMC5547561.
  • Zhu H, Bengsch F, Svoronos N, Rutkowski MR, Bitler BG, Allegrezza MJ, Yokoyama Y, Kossenkov AV, Bradner JE, Conejo-Garcia JR, Zhang R. BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression. Cell Rep. 2016 Sep;16(11):2829-2837. Pubmedid: 27626654. Pmcid: PMC5177024.
  • Sheen MR, Marotti JD, Allegrezza MJ, Rutkowski M, Conejo-Garcia JR, Fiering S. Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer. Oncogenesis. 2016 Oct;5(10):e267. Pubmedid: 27797363. Pmcid: PMC5141269.
  • Goldman AR, Bitler BG, Schug Z, Conejo-Garcia JR, Zhang R, Speicher DW. The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. Mol Cell Proteomics. 2016 Nov;15(11):3348-3360. Pubmedid: 27654507. Pmcid: PMC5098034.
  • Yokoyama Y, Zhu H, Lee JH, Kossenkov AV, Wu SY, Wickramasinghe JM, Yin X, Palozola KC, Gardini A, Showe LC, Zaret KS, Liu Q, Speicher D, Conejo-Garcia JR, Bradner JE, Zhang Z, Sood AK, Ordog T, Bitler BG, Zhang R. BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer. Cancer Res. 2016 Nov;76(21):6320-6330. Pubmedid: 27803105. Pmcid: PMC5117661.
  • Allegrezza MJ, Rutkowski MR, Stephen TL, Svoronos N, Perales-Puchalt A, Nguyen JM, Payne KK, Singhal S, Eruslanov EB, Tchou J, Conejo-Garcia JR. Trametinib Drives T-cell-Dependent Control of KRAS-Mutated Tumors by Inhibiting Pathological Myelopoiesis. Cancer Res. 2016 Nov;76(21):6253-6265. Pubmedid: 27803104. Pmcid: PMC5094194.
  • Allegrezza MJ, Rutkowski MR, Stephen TL, Svoronos N, Tesone AJ, Perales-Puchalt A, Nguyen JM, Sarmin F, Sheen MR, Jeng EK, Tchou J, Wong HC, Fiering SN, Conejo-Garcia JR. IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors. Cancer Res. 2016 May;76(9):2561-2572. Pubmedid: 26980764. Pmcid: PMC4873368.
  • Mari ER, Rasouli J, Ciric B, Moore JN, Conejo-Garcia JR, Rajasagi N, Zhang GX, Rabinovich GA, Rostami A. Galectin-1 is essential for the induction of MOG35-55 -based intravenous tolerance in experimental autoimmune encephalomyelitis. Eur J Immunol. 2016 Jul;46(7):1783-1796. Pubmedid: 27151444. Pmcid: PMC4984530.
  • Tesone AJ, Rutkowski MR, Brencicova E, Svoronos N, Perales-Puchalt A, Stephen TL, Allegrezza MJ, Payne KK, Nguyen JM, Wickramasinghe J, Tchou J, Borowsky ME, Rabinovich GA, Kossenkov AV, Conejo-Garcia JR. Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells. Cell Rep. 2016 Feb;14(7):1774-1786. Pubmedid: 26876172. Pmcid: PMC4767618.
  • Clark CA, Gupta H, Sareddy GR, Pandeswara S, Lao S, Yuan B, Drerup JM, Padron A, Conejo-Garcia JR, Murthy K, Liu Y, Turk MJ, Thedieck K, Hurez V, Li R, Vadlamudi RK, Curiel TJ. Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma. Cancer Res. 2016 Dec;76(23):6964-6974. Pubmedid: 27671674. Pmcid: PMC5228566.
  • Rabinovich GA, Conejo-García JR. Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways. J Mol Biol. 2016 Aug;428(16):3266-3281. Pubmedid: 27038510.
  • Conejo-Garcia JR, Rutkowski MR, Cubillos-Ruiz JR. State-of-the-art of regulatory dendritic cells in cancer. Pharmacol Ther. 2016 Aug;164:97-104. Pubmedid: 27118338. Pmcid: PMC4942379.
  • Rutkowski MR, Svoronos N, Perales-Puchalt A, Conejo-Garcia JR. The Tumor Macroenvironment: Cancer-Promoting Networks Beyond Tumor Beds. Adv Cancer Res. 2016 Apr;128:235-262. Pubmedid: 26216635. Pmcid: PMC4668932.
  • Singhal S, Bhojnagarwala PS, O'Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB. Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer. Cancer Cell. 2016 07;30(1):120-135. Pubmedid: 27374224. Pmcid: PMC4945447.
  • Sheen MR, Warner SL, Fields JL, Conejo-Garcia JR, Fiering S. Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects. Open Life Sci. 2015 Oct;10(1):461-478. Pubmedid: 27482546. Pmcid: PMC4966669.
  • Wang Z, Deng Z, Dahmane N, Tsai K, Wang P, Williams DR, Kossenkov AV, Showe LC, Zhang R, Huang Q, Conejo-Garcia JR, Lieberman PM. Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes. Proc Natl Acad Sci U S A. 2015 Nov;112(46):E6293-E6300. Pubmedid: 26578789. Pmcid: PMC4655533.
  • Rutkowski MR, Conejo-Garcia JR. Size does not matter: commensal microorganisms forge tumor-promoting inflammation and anti-tumor immunity. Oncoscience. 2015 Mar;2(3):239-246. Pubmedid: 25897427. Pmcid: PMC4394129.
  • Bitler BG, Aird KM, Garipov A, Li H, Amatangelo M, Kossenkov AV, Schultz DC, Liu Q, Shih IeM, Conejo-Garcia JR, Speicher DW, Zhang R. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med. 2015 Mar;21(3):231-238. Pubmedid: 25686104. Pmcid: PMC4352133.
  • Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH. ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. Cell. 2015 Jun;161(7):1527-1538. Pubmedid: 26073941. Pmcid: PMC4580135.
  • Rutkowski MR, Stephen TL, Svoronos N, Allegrezza MJ, Tesone AJ, Perales-Puchalt A, Brencicova E, Escovar-Fadul X, Nguyen JM, Cadungog MG, Zhang R, Salatino M, Tchou J, Rabinovich GA, Conejo-Garcia JR. Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation. Cancer Cell. 2015 Jan;27(1):27-40. Pubmedid: 25533336. Pmcid: PMC4293269.
  • Conejo-Garcia JR, Rutkowski MR. Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies. Immunity. 2015 Dec;43(6):1037-1039. Pubmedid: 26682980.
  • Villarreal DO, Svoronos N, Wise MC, Shedlock DJ, Morrow MP, Conejo-Garcia JR, Weiner DB. Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model. Vaccine. 2015 Aug;33(35):4313-4320. Pubmedid: 25887087. Pmcid: PMC4546882.
  • Rutkowski MR, Conejo-Garcia JR. TLR5 signaling, commensal microbiota and systemic tumor promoting inflammation: the three parcae of malignant progression. Oncoimmunology. 2015 Aug;4(8):e1021542. Pubmedid: 26405577. Pmcid: PMC4570098.
  • Stephen TL, Rutkowski MR, Allegrezza MJ, Perales-Puchalt A, Tesone AJ, Svoronos N, Nguyen JM, Sarmin F, Borowsky ME, Tchou J, Conejo-Garcia JR. Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression. Immunity. 2014 Sep;41(3):427-439. Pubmedid: 25238097. Pmcid: PMC4174366.
  • Li YR, Xian RR, Ziober A, Conejo-Garcia J, Perales-Puchalt A, June CH, Zhang PJ, Tchou J. Mesothelin expression is associated with poor outcomes in breast cancer. Breast Cancer Res Treat. 2014 Oct;147(3):675-684. Pubmedid: 25193277. Pmcid: PMC4261925.
  • Rutkowski MR, Allegrezza MJ, Svoronos N, Tesone AJ, Stephen TL, Perales-Puchalt A, Nguyen J, Zhang PJ, Fiering SN, Tchou J, Conejo-Garcia JR. Initiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer. J Vis Exp. 2014 Mar;(85). Pubmedid: 24748051. Pmcid: PMC4027029.
  • Eruslanov EB, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, Conejo-Garcia JR, Feldman M, Albelda SM, Singhal S. Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J Clin Invest. 2014 Dec;124(12):5466-5480. Pubmedid: 25384214. Pmcid: PMC4348966.
  • Toraya-Brown S, Sheen MR, Zhang P, Chen L, Baird JR, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S. Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors. Nanomedicine. 2014 Aug;10(6):1273-1285. Pubmedid: 24566274. Pmcid: PMC4119841.
  • Tchou J, Zhang PJ, Bi Y, Satija C, Marjumdar R, Stephen TL, Lo A, Chen H, Mies C, June CH, Conejo-Garcia J, Puré E. Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer. Hum Pathol. 2013 Nov;44(11):2549-2557. Pubmedid: 24074532. Pmcid: PMC4283499.
  • Amatangelo MD, Garipov A, Li H, Conejo-Garcia JR, Speicher DW, Zhang R. Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition. Cell Cycle. 2013 Jul;12(13):2113-2119. Pubmedid: 23759589. Pmcid: PMC3737313.
  • Baird JR, Fox BA, Sanders KL, Lizotte PH, Cubillos-Ruiz JR, Scarlett UK, Rutkowski MR, Conejo-Garcia JR, Fiering S, Bzik DJ. Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Cancer Res. 2013 Jul;73(13):3842-3851. Pubmedid: 23704211. Pmcid: PMC3702636.
  • Rutkowski MR, Stephen TL, Conejo-Garcia JR. Anti-tumor immunity: myeloid leukocytes control the immune landscape. Cell Immunol. 2013 Jan;278(1-2):21-26. Pubmedid: 23121972. Pmcid: PMC3490130.
  • Toraya-Brown S, Sheen MR, Baird JR, Barry S, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S. Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy. Integr Biol (Camb). 2013 Jan;5(1):159-171. Pubmedid: 22935885. Pmcid: PMC3524361.
  • Tesone AJ, Svoronos N, Allegrezza MJ, Conejo-Garcia JR. Pathological mobilization and activities of dendritic cells in tumor-bearing hosts: challenges and opportunities for immunotherapy of cancer. Front Immunol. 2013 Dec;4:435. Pubmedid: 24339824. Pmcid: PMC3857526.
  • Cubillos-Ruiz JR, Rutkowski MR, Tchou J, Conejo-Garcia JR. Reprogramming immune responses via microRNA modulation. Microrna Diagn Ther. 2013 Apr;1(1). Pubmedid: 25285232. Pmcid: PMC4183223.
  • Deng Z, Wang Z, Xiang C, Molczan A, Baubet V, Conejo-Garcia J, Xu X, Lieberman PM, Dahmane N. Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. J Cell Sci. 2012 Sep;125(Pt 18):4383-4394. Pubmedid: 22641694. Pmcid: PMC3516443.
  • Cubillos-Ruiz JR, Sempere LF, Conejo-Garcia JR. Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles. Oncoimmunology. 2012 Sep;1(6):968-970. Pubmedid: 23162774. Pmcid: PMC3489762.
  • Tchou J, Conejo-Garcia J. Targeting the tumor stroma as a novel treatment strategy for breast cancer: shifting from the neoplastic cell-centric to a stroma-centric paradigm. Adv Pharmacol. 2012 Sep;65:45-61. Pubmedid: 22959023.
  • Hampton TH, Ballok AE, Bomberger JM, Rutkowski MR, Barnaby R, Coutermarsh B, Conejo-Garcia JR, O'Toole GA, Stanton BA. Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells?. Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(6):L509-L518. Pubmedid: 22821996. Pmcid: PMC3468482.
  • Scarlett UK, Conejo-Garcia JR. Modulating the tumor immune microenvironment as an ovarian cancer treatment strategy. Expert Rev Obstet Gynecol. 2012 Sep;7(5):413-419. Pubmedid: 24039628. Pmcid: PMC3772732.
  • Scarlett UK, Rutkowski MR, Rauwerdink AM, Fields J, Escovar-Fadul X, Baird J, Cubillos-Ruiz JR, Jacobs AC, Gonzalez JL, Weaver J, Fiering S, Conejo-Garcia JR. Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. J Exp Med. 2012 Mar;209(3):495-506. Pubmedid: 22351930. Pmcid: PMC3302234.
  • Tchou J, Wang LC, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vondeheide RH, Albelda SM, June CH, Zhang PJ. Mesothelin, a novel immunotherapy target for triple negative breast cancer. Breast Cancer Res Treat. 2012 Jun;133(2):799-804. Pubmedid: 22418702. Pmcid: PMC4964602.
  • Wasiuk A, Dalton DK, Schpero WL, Stan RV, Conejo-Garcia JR, Noelle RJ. Mast cells impair the development of protective anti-tumor immunity. Cancer Immunol Immun. 2012 Dec;61(12):2273-2282. Pubmedid: 22684520. Pmcid: PMC3808181.
  • Cubillos-Ruiz JR, Baird JR, Tesone AJ, Rutkowski MR, Scarlett UK, Camposeco-Jacobs AL, Anadon-Arnillas J, Harwood NM, Korc M, Fiering SN, Sempere LF, Conejo-Garcia JR. Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer. Cancer Res. 2012 Apr;72(7):1683-1693. Pubmedid: 22307839. Pmcid: PMC3319850.
  • Cubillos-Ruiz JR, Conejo-Garcia JR. It never rains but it pours: potential role of butyrophilins in inhibiting anti-tumor immune responses. Cell Cycle. 2011 Feb;10(3):368-369. Pubmedid: 21270530. Pmcid: PMC3115012.
  • Cubillos-Ruiz JR, Martinez D, Scarlett UK, Rutkowski MR, Nesbeth YC, Camposeco-Jacobs AL, Conejo-Garcia JR. CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells. Oncotarget. 2010 Sep;1(5):329-338. Pubmedid: 21113407. Pmcid: PMC2992324.
  • Nesbeth YC, Martinez DG, Toraya S, Scarlett UK, Cubillos-Ruiz JR, Rutkowski MR, Conejo-Garcia JR. CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. J Immunol. 2010 May;184(10):5654-5662. Pubmedid: 20400704. Pmcid: PMC2874073.
  • Robinson RT, Khader SA, Martino CA, Fountain JJ, Teixeira-Coelho M, Pearl JE, Smiley ST, Winslow GM, Woodland DL, Walter MJ, Conejo-Garcia JR, Gubler U, Cooper AM. Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration. J Exp Med. 2010 Mar;207(3):591-605. Pubmedid: 20212068. Pmcid: PMC2839154.
  • Cubillos-Ruiz JR, Rutkowski M, Conejo-Garcia JR. Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes. Cell Cycle. 2010 Jan;9(2):260-268. Pubmedid: 20023378. Pmcid: PMC3056209.
  • Sempere LF, Preis M, Yezefski T, Ouyang H, Suriawinata AA, Silahtaroglu A, Conejo-Garcia JR, Kauppinen S, Wells W, Korc M. Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors. Clin Cancer Res. 2010 Aug;16(16):4246-4255. Pubmedid: 20682703. Pmcid: PMC3229296.
  • Scarlett UK, Cubillos-Ruiz JR, Nesbeth YC, Martinez DG, Engle X, Gewirtz AT, Ahonen CL, Conejo-Garcia JR. In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer Res. 2009 Sep;69(18):7329-7337. Pubmedid: 19738057. Pmcid: PMC2754806.
  • Cubillos-Ruiz JR, Fiering S, Conejo-Garcia JR. Nanomolecular targeting of dendritic cells for ovarian cancer therapy. Future Oncol. 2009 Oct;5(8):1189-1192. Pubmedid: 19852731. Pmcid: PMC3056055.
  • Pulaski HL, Spahlinger G, Silva IA, McLean K, Kueck AS, Reynolds RK, Coukos G, Conejo-Garcia JR, Buckanovich RJ. Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer. J Transl Med. 2009 Jun;7:49. Pubmedid: 19545375. Pmcid: PMC2704183.
  • Basu S, Eriksson M, Pioli PA, Conejo-Garcia J, Mselle TF, Yamamoto S, Wira CR, Sentman CL. Human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPs. Am J Reprod Immunol. 2009 Jan;61(1):52-61. Pubmedid: 19086992. Pmcid: PMC2902174.
  • Nesbeth Y, Scarlett U, Cubillos-Ruiz J, Martinez D, Engle X, Turk MJ, Conejo-Garcia JR. CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion. Cancer Res. 2009 Aug;69(15):6331-6338. Pubmedid: 19602595. Pmcid: PMC2755640.
  • Cubillos-Ruiz JR, Engle X, Scarlett UK, Martinez D, Barber A, Elgueta R, Wang L, Nesbeth Y, Durant Y, Gewirtz AT, Sentman CL, Kedl R, Conejo-Garcia JR. Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest. 2009 Aug;119(8):2231-2244. Pubmedid: 19620771. Pmcid: PMC2719935.
  • Huarte E, Cubillos-Ruiz JR, Nesbeth YC, Scarlett UK, Martinez DG, Buckanovich RJ, Benencia F, Stan RV, Keler T, Sarobe P, Sentman CL, Conejo-Garcia JR. Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity. Cancer Res. 2008 Sep;68(18):7684-7691. Pubmedid: 18768667. Pmcid: PMC2742361.
  • Basu S, Pioli PA, Conejo-Garcia J, Wira CR, Sentman CL. Estradiol regulates MICA expression in human endometrial cells. Clin Immunol. 2008 Nov;129(2):325-332. Pubmedid: 18728002. Pmcid: PMC2596062.
  • Balint K, Conejo-Garcia JR, Buckanovich R, Coukos G. Role of vascular leukocytes in ovarian cancer neovascularization. Adv Exp Med Biol. 2008 Jun;622:273-280. Pubmedid: 18546635.
  • Huarte E, Cubillos-Ruiz JR, Nesbeth YC, Scarlett UK, Martinez DG, Engle XA, Rigby WF, Pioli PA, Guyre PM, Conejo-Garcia JR. PILAR is a novel modulator of human T-cell expansion. Blood. 2008 Aug;112(4):1259-1268. Pubmedid: 18550855. Pmcid: PMC2515140.
  • Coukos G, Conejo-Garcia JR, Buckanovich R, Benencia F. Vascular leukocytes: a population with angiogenic and immunossuppressive properties highly represented in ovarian cancer. Adv Exp Med Biol. 2007 Feb;590:185-193. Pubmedid: 17191386.
  • Coukos G, Benencia F, Buckanovich RJ, Conejo-Garcia JR. The role of dendritic cell precursors in tumour vasculogenesis. Brit J Cancer. 2005 Apr;92(7):1182-1187. Pubmedid: 15785750. Pmcid: PMC2361965.
  • Bauer F, Schweimer K, Klüver E, Conejo-Garcia JR, Forssmann WG, Rösch P, Adermann K, Sticht H. Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. Protein Sci. 2001 Dec;10(12):2470-2479. Pubmedid: 11714914. Pmcid: PMC2374044.