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Dennis O. Adeegbe, PhD

Academic Rank: Assistant Member

Overview

Research in Dr. Adeegbe’s lab is in the area of immune regulation and immunotherapy in the context of cancer. The lab focuses on understanding the dynamics and functions of various immune cells that are present in solid cancers such as Lung Cancer and Melanoma with emphasis on immune-suppressive T cells and how they can be targeted for therapeutic outcomes.


Discipline

    • Immunology
    • Thoracic Oncology
    • Immunology

Education & Training

Fellowship:

  • Dana-Farber Cancer Institute, Harvard Medical School, Fellow - Immuno-Oncology
  • University of Miami School of Medicine, PhD - Microbiology and Immunology
  • WPI Immunology Frontier Research Center, Osaka University, Fellow - Immunology
Publications

  • Miao D, Margolis CA, Vokes NI, Liu D, Taylor-Weiner A, Wankowicz SM, Adeegbe D, Keliher D, Schilling B, Tracy A, Manos M, Chau NG, Hanna GJ, Polak P, Rodig SJ, Signoretti S, Sholl LM, Engelman JA, Getz G, Jänne PA, Haddad RI, Choueiri TK, Barbie DA, Haq R, Awad MM, Schadendorf D, Hodi FS, Bellmunt J, Wong KK, Hammerman P, Van Allen EM. Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors. Nat Genetics. 2018 Sep;50(9):1271-1281. Pubmedid: 30150660. Pmcid: PMC6119118.
  • Li S, Liu S, Deng J, Akbay EA, Hai J, Ambrogio C, Zhang L, Zhou F, Jenkins RW, Adeegbe DO, Gao P, Wang X, Paweletz CP, Herter-Sprie GS, Chen T, Gutierrez Quiceno L, Zhang Y, Merlino AA, Quinn MM, Zeng Y, Yu X, Liu Y, Fan L, Aguirre AJ, Barbie DA, Yi X, Wong KK. Assessing Therapeutic Efficacy of MEK Inhibition in a KRAS-Driven Mouse Model of Lung Cancer. Clin Cancer Res. 2018 Oct;24(19):4854-4864. Pubmedid: 29945997.
  • Adeegbe DO, Liu S, Hattersley M, Bowden M, Zhou CW, Li S, Vlahos R, Grondine M, Dolgalev I, Ivanova E, Quinn MM, Gao P, Hammerman PS, Bradner JE, Diehl JA, Rustgi AK, Bass AJ, Tsirigos A, Freeman GJ, Chen H, Wong KK. BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in -Mutant Non-Small Cell Lung Cancer. Cancer Immunol Res. 2018 Oct;6(10):1234-1245. Pubmedid: 30087114. Pmcid: PMC6170698.
  • Wang W, Marinis JM, Beal AM, Savadkar S, Wu Y, Khan M, Taunk PS, Wu N, Su W, Wu J, Ahsan A, Kurz E, Chen T, Yaboh I, Li F, Gutierrez J, Diskin B, Hundeyin M, Reilly M, Lich JD, Harris PA, Mahajan MK, Thorpe JH, Nassau P, Mosley JE, Leinwand J, Kochen Rossi JA, Mishra A, Aykut B, Glacken M, Ochi A, Verma N, Kim JI, Vasudevaraja V, Adeegbe D, Almonte C, Bagdatlioglu E, Cohen DJ, Wong KK, Bertin J, Miller G. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 2018 Nov;34(5):757-774.e7. Pubmedid: 30423296.
  • Liu Y, Li Y, Liu S, Adeegbe DO, Christensen CL, Quinn MM, Dries R, Han S, Buczkowski K, Wang X, Chen T, Gao P, Zhang H, Li F, Hammerman PS, Bradner JE, Quayle SN, Wong KK. NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model. Cancer Res. 2018 Jul;78(13):3709-3717. Pubmedid: 29760044.
  • Smart AC, Margolis CA, Pimentel H, He MX, Miao D, Adeegbe D, Fugmann T, Wong KK, Van Allen EM. Intron retention is a source of neoepitopes in cancer. Nat Biotechnol. 2018 Dec;36(11):1056-1058. Pubmedid: 30114007. Pmcid: PMC6226333.
  • Bouillez A, Rajabi H, Jin C, Samur M, Tagde A, Alam M, Hiraki M, Maeda T, Hu X, Adeegbe D, Kharbanda S, Wong KK, Kufe D. MUC1-C integrates PD-L1 induction with repression of immune effectors in non-small-cell lung cancer. Oncogene. 2017 Jul;36(28):4037-4046. Pubmedid: 28288138. Pmcid: PMC5509481.
  • Adeegbe DO, Liu Y, Lizotte PH, Kamihara Y, Aref AR, Almonte C, Dries R, Li Y, Liu S, Wang X, Warner-Hatten T, Castrillon J, Yuan GC, Poudel-Neupane N, Zhang H, Guerriero JL, Han S, Awad MM, Barbie DA, Ritz J, Jones SS, Hammerman PS, Bradner J, Quayle SN, Wong KK. Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer. Cancer Discov. 2017 08;7(8):852-867. Pubmedid: 28408401. Pmcid: PMC5540748.
  • Yu A, Dee MJ, Adeegbe D, Dwyer CJ, Altman NH, Malek TR. The Lower Limit of Regulatory CD4 Foxp3 TCRβ Repertoire Diversity Required To Control Autoimmunity. J Immunol. 2017 04;198(8):3127-3135. Pubmedid: 28264971. Pmcid: PMC5381961.
  • George S, Miao D, Demetri GD, Adeegbe D, Rodig SJ, Shukla S, Lipschitz M, Amin-Mansour A, Raut CP, Carter SL, Hammerman P, Freeman GJ, Wu CJ, Ott PA, Wong KK, Van Allen EM. Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma. Immunity. 2017 02;46(2):197-204. Pubmedid: 28228279. Pmcid: PMC5408320.
  • Bouillez A, Adeegbe D, Jin C, Hu X, Tagde A, Alam M, Rajabi H, Wong KK, Kufe D. MUC1-C promotes the suppressive immune microenvironment in non-small cell lung cancer. Oncoimmunology. 2017;6(9):e1338998. Pubmedid: 28932637. Pmcid: PMC5599083.
  • Adeegbe DO, Nishikawa H. Regulatory T cells in cancer; can they be controlled?. Immunotherapy. 2016 Jun;7(8):843-846. Pubmedid: 26316166.
  • Maeda Y, Nishikawa H, Sugiyama D, Ha D, Hamaguchi M, Saito T, Nishioka M, Wing JB, Adeegbe D, Katayama I, Sakaguchi S. Detection of self-reactive CD8⁺ T cells with an anergic phenotype in healthy individuals. Science. 2014 Dec;346(6216):1536-1540. Pubmedid: 25525252.
  • Adeegbe DO, Nishikawa H. Natural and induced T regulatory cells in cancer. Front Immunol. 2013;4:190. Pubmedid: 23874336. Pmcid: PMC3708155.
  • Adeegbe D, Serafini P, Bronte V, Zoso A, Ricordi C, Inverardi L. In vivo induction of myeloid suppressor cells and CD4(+)Foxp3(+) T regulatory cells prolongs skin allograft survival in mice. Cell Transplant. 2011 Dec;20(6):941-954. Pubmedid: 21054938.
  • Adeegbe D, Levy RB, Malek TR. Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance. Blood. 2010 Mar;115(10):1932-1940. Pubmedid: 20040758. Pmcid: PMC2837323.
  • Adeegbe D, Matsutani T, Yang J, Altman NH, Malek TR. CD4(+) CD25(+) Foxp3(+) T regulatory cells with limited TCR diversity in control of autoimmunity. J Immunol. 2010 Jan;184(1):56-66. Pubmedid: 19949075. Pmcid: PMC2949410.
  • Malek TR, Yu A, Zhu L, Matsutani T, Adeegbe D, Bayer AL. IL-2 family of cytokines in T regulatory cell development and homeostasis. J Clin Immunol. 2008 Nov;28(6):635-639. Pubmedid: 18726679.
  • Adeegbe D, Bayer AL, Levy RB, Malek TR. Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance. J Immunol. 2006 Jun;176(12):7149-7153. Pubmedid: 16751356.
  • Jin H, Gong D, Adeegbe D, Bayer AL, Rolle C, Yu A, Malek TR. Quantitative assessment concerning the contribution of IL-2Rbeta for superantigen-mediated T cell responses in vivo. Int Immunol. 2006 Apr;18(4):565-572. Pubmedid: 16540525.
  • Bayer AL, Yu A, Adeegbe D, Malek TR. Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. J Exp Med. 2005 Mar;201(5):769-777. Pubmedid: 15753210. Pmcid: PMC2212835.