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Vladimir Feygelman, PhD

 
Program: Radiation Oncology

Overview

Dr. Feygelman earned his PhD in Physical Chemistry in the former Soviet Union and was active in the field of Photochemistry. He is currently an Associate Member of the Department of Radiation Oncology. He is an experienced board-certified clinical physicist, with research interests centered on radiation dosimetry and quality assurance of complex dynamic treatments. This includes evaluation and improvement of dosimetry systems, particularly diode arrays, clinical comparisons, applications to different dose modulation techniques, and 4D dosimetry. Over the span of his career, Dr. Feygelman has over 60 peer-reviewed publications.  


Education & Training

Fellowship:

  • University of Florida - Medical Physics
Participating Trials

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Publications

  • Latifi K, Lotey R, Feygelman V. On the MLC leaves alignment in the direction orthogonal to movement. J Appl Clin Med Phys. 2021 Jun.22(6):268-273. Pubmedid: 34056837. Pmcid: PMC8200498.
  • Hernandez V, Saez J, Angerud A, Cayez R, Khamphan C, Nguyen D, Vieillevigne L, Feygelman V. Dosimetric leaf gap and leaf trailing effect in a double-stacked multileaf collimator. Med Phys. 2021 Jul.48(7):3413-3424. Pubmedid: 33932237.
  • Saini A, Tichacek C, Johansson W, Redler G, Zhang G, Moros EG, Qayyum M, Feygelman V. Unlocking a closed system: dosimetric commissioning of a ring gantry linear accelerator in a multivendor environment. J Appl Clin Med Phys. 2021 Feb.22(2):21-34. Pubmedid: 33452738. Pmcid: PMC7882119.
  • Yuan Z, Frazer M, Rishi A, Latifi K, Tomaszewski MR, Moros EG, Feygelman V, Felder S, Sanchez J, Dessureault S, Imanirad I, Kim RD, Harrison LB, Hoffe SE, Zhang GG, Frakes JM. Pretreatment CT and PET radiomics predicting rectal cancer patients in response to neoadjuvant chemoradiotherapy. Rep Pract Oncol Radiother. 2021 Feb.26(1):29-34. Pubmedid: 33948299. Pmcid: PMC8086711.
  • Sim AJ, Palm RF, DeLozier KB, Feygelman V, Latifi K, Redler G, Washington IR, Wuthrick EJ, Rosenberg SA. MR-guided stereotactic body radiation therapy for intracardiac and pericardial metastases. Clin Transl Radiat Oncol. 2020 Nov.25:102-106. Pubmedid: 33204858. Pmcid: PMC7653008.
  • Kry SF, Feygelman V, Balter P, Knöös T, Ma CC, Snyder M, Tonner B, Vassiliev ON. AAPM Task Group 329: Reference dose specification for dose calculations: Dose-to-water or dose-to-muscle?. Med Phys. 2020 Mar.47(3):e52-e64. Pubmedid: 31883390.
  • Yuan Z, Frazer M, Zhang GG, Latifi K, Moros EG, Feygelman V, Felder S, Sanchez J, Dessureault S, Imanirad I, Kim RD, Harrison LB, Hoffe SE, Frakes JM. CT-based radiomic features to predict pathological response in rectal cancer: A retrospective cohort study. J Med Imaging Radiat Oncol. 2020 Jun.64(3):444-449. Pubmedid: 32386109.
  • Rozenfeld AB, Biasi G, Petasecca M, Lerch MLF, Villani G, Feygelman V. Semiconductor dosimetry in modern external-beam radiation therapy. Phys Med Biol. 2020 Aug.65(16):16TR01. Pubmedid: 32604077.
  • Ahmed S, Zhang G, Moros EG, Feygelman V. Comprehensive evaluation of the high-resolution diode array for SRS dosimetry. J Appl Clin Med Phys. 2019 Sep.20(10):13-23. Pubmedid: 31478343. Pmcid: PMC6806480.
  • Latifi K, Moros EG, Zhang G, Harrison L, Feygelman V. A Method to Determine the Coincidence of MRI-Guided Linac Radiation and Magnetic Isocenters. Technol Cancer Res Treat. 2019 Jan.18. Pubmedid: 31537173. Pmcid: PMC6755638.
  • Ahmed S, Kapatoes J, Zhang G, Moros EG, Feygelman V. A hybrid volumetric dose verification method for single-isocenter multiple-target cranial SRS. J Appl Clin Med Phys. 2018 Sep.19(5):651-658. Pubmedid: 30112817. Pmcid: PMC6123151.
  • Nichols D, Boyle TA, Noyes D, Latifi K, Feygelman V, Jackson I, Vujaskovic Z, Antonia S, Perez BA. Evaluation of combined anti-PD-1 immunotherapy and radiation therapy in a preclinical mouse model of pneumonitis and fibrosis. J Thorac Dis. 2018 Nov.10(11):6254-6260. Pubmedid: 30622798. Pmcid: PMC6297393.
  • Latifi K, Caudell J, Zhang G, Hunt D, Moros EG, Feygelman V. Practical quantification of image registration accuracy following the AAPM TG-132 report framework. J Appl Clin Med Phys. 2018 Jul.19(4):125-133. Pubmedid: 29882231. Pmcid: PMC6036411.
  • Abuodeh Y, Naghavi AO, Echevarria M, DeMarco M, Tonner B, Feygelman V, Stevens CW, Perez BA, Dilling TJ. Quantitatively Excessive Normal Tissue Toxicity and Poor Target Coverage in Postoperative Lung Cancer Radiotherapy Meta-analysis. Clin Lung Cancer. 2018 Jan.19(1):e123-e130. Pubmedid: 29107487.
  • Zhang GG, Latifi K, Feygelman V, Chou KT, Huang TC, Dilling TJ, Perez BA, Moros EG. Ventilation Series Similarity: A Study for Ventilation Calculation Using Deformable Image Registration and 4DCT to Avoid Motion Artifacts. Contrast Media Mol Imaging. 2017 Sep.2017:9730380. Pubmedid: 29097945. Pmcid: PMC5623778.
  • Oliver JA, Budzevich M, Hunt D, Moros EG, Latifi K, Dilling TJ, Feygelman V, Zhang G. Sensitivity of Image Features to Noise in Conventional and Respiratory-Gated PET/CT Images of Lung Cancer: Uncorrelated Noise Effects. Technol Cancer Res Treat. 2017 Oct.16(5):595-608. Pubmedid: 27502957. Pmcid: PMC5665151.
  • Ahmed S, Nelms B, Gintz D, Caudell J, Zhang G, Moros EG, Feygelman V. A method for a priori estimation of best feasible DVH for organs-at-risk: Validation for head and neck VMAT planning. Med Phys. 2017 Oct.44(10):5486-5497. Pubmedid: 28777469.
  • Ahmed S, Hunt D, Kapatoes J, Hayward R, Zhang G, Moros EG, Feygelman V. Validation of a GPU-Based 3D dose calculator for modulated beams. J Appl Clin Med Phys. 2017 May.18(3):73-82. Pubmedid: 28371377. Pmcid: PMC5689856.
  • Zhang DG, Feygelman V, Moros EG, Latifi K, Hoffe S, Frakes J, Zhang GG. Superficial and peripheral dose in compensator-based FFF beam IMRT. J Appl Clin Med Phys. 2017 Jan.18(1):151-156. Pubmedid: 28291940. Pmcid: PMC5689887.
  • Feygelman V, Lohr F, Orton CG. The future of MRI in radiation therapy belongs to integrated MRI-linac systems, not the standalone MRI-Sim. Med Phys. 2017 03.44(3):791-794. Pubmedid: 28063171.
  • Abuodeh YA, Naghavi AO, DeMarco M, Tonner B, Feygelman V, Stevens CW, Perez BA, Dilling TJ. Quantitatively Excessive Normal Tissue Toxicity and Poor Target Coverage in the PORT Meta-Analysis (MA): A Dosimetric Study. Int J Radiat Oncol Biol Phys. 2016 Oct.96(2S):E442. Pubmedid: 27674703.
  • Ahmed S, Nelms B, Kozelka J, Zhang G, Moros E, Feygelman V. Validation of an improved helical diode array and dose reconstruction software using TG-244 datasets and stringent dose comparison criteria. J Appl Clin Med Phys. 2016 Nov.17(6):163-178. Pubmedid: 27929491. Pmcid: PMC5690493.
  • Ahmed S, Nelms B, Kozelka J, Zhang G, Moros E, Feygelman V. Validation of an improved helical diode array and dose reconstruction software using TG-244 datasets and stringent dose comparison criteria. J Appl Clin Med Phys. 2016 Nov.17(6):163-178. Pubmedid: 28297274.
  • Gintz D, Latifi K, Caudell J, Nelms B, Zhang G, Moros E, Feygelman V. Initial evaluation of automated treatment planning software. J Appl Clin Med Phys. 2016 May.17(3):331-346. Pubmedid: 27167292. Pmcid: PMC5690942.
  • Gintz D, Latifi K, Caudell J, Nelms B, Zhang G, Moros E, Feygelman V. Initial evaluation of automated treatment planning software. J Appl Clin Med Phys. 2016 May.17(3):331-346. Pubmedid: 28297346.
  • Zhang GG, Latifi K, Du K, Reinhardt JM, Christensen GE, Ding K, Feygelman V, Moros EG. Evaluation of the ΔV 4D CT ventilation calculation method using in vivo xenon CT ventilation data and comparison to other methods. J Appl Clin Med Phys. 2016 Mar.17(2):550-560. Pubmedid: 27074479. Pmcid: PMC5874808.
  • Zhang GG, Latifi K, Du K, Reinhardt JM, Christensen GE, Ding K, Feygelman V, Moros EG. Evaluation of the ΔV 4D CT ventilation calculation method using in vivo xenon CT ventilation data and comparison to other methods. J Appl Clin Med Phys. 2016 Mar.17(2):550-560. Pubmedid: 28297411.
  • Smilowitz JB, Das IJ, Feygelman V, Fraass BA, Geurts M, Kry SF, Marshall IR, Mihailidis DN, Ouhib Z, Ritter T, Snyder MG, Fairobent L, Staff A. AAPM Medical Physics Practice Guideline 5.a.: Commissioning and QA of Treatment Planning Dose Calculations - Megavoltage Photon and Electron Beams. J Appl Clin Med Phys. 2016 Jan.17(1):6166. Pubmedid: 26894369.
  • Smilowitz JB, Das IJ, Feygelman V, Fraass BA, Kry SF, Marshall IR, Mihailidis DN, Ouhib Z, Ritter T, Snyder MG, Fairobent L. AAPM Medical Physics Practice Guideline 5.a.: Commissioning and QA of Treatment Planning Dose Calculations - Megavoltage Photon and Electron Beams. J Appl Clin Med Phys. 2015 Sep.16(5):14–34. Pubmedid: 26699330. Pmcid: PMC5690154.
  • Feygelman V, Tonner B, Stambaugh C, Hunt D, Zhang G, Moros E, Nelms BE. Technical Note: Motion-perturbation method applied to dosimetry of dynamic MLC target tracking--A proof-of-concept. Med Phys. 2015 Nov.42(11):6147-6151. Pubmedid: 26520707.
  • Stambaugh C, Nelms B, Wolf T, Mueller R, Geurts M, Opp D, Moros E, Zhang G, Feygelman V. Measurement-guided volumetric dose reconstruction for helical tomotherapy. J Appl Clin Med Phys. 2015 Mar.16(2):5298. Pubmedid: 26103199. Pmcid: PMC5690083.
  • Nelms B, Stambaugh C, Hunt D, Tonner B, Zhang G, Feygelman V. Methods, software and datasets to verify DVH calculations against analytical values: Twenty years late(r). Med Phys. 2015 Aug.42(8):4435-4448. Pubmedid: 26233174.
  • Zhang DG, Feygelman V, Moros EG, Latifi K, Zhang GG. Monte Carlo study of radiation dose enhancement by gadolinium in megavoltage and high dose rate radiotherapy. PLoS One. 2014 Oct.9(10):e109389. Pubmedid: 25275550. Pmcid: PMC4183586.
  • Feygelman V, Stambaugh C, Opp D, Zhang G, Moros EG, Nelms BE. Cross-validation of two commercial methods for volumetric high-resolution dose reconstruction on a phantom for non-coplanar VMAT beams. Radiother Oncol. 2014 Mar.110(3):558-561. Pubmedid: 24440044.
  • Stambaugh C, Opp D, Wasserman S, Zhang G, Feygelman V. Evaluation of semiempirical VMAT dose reconstruction on a patient dataset based on biplanar diode array measurements. J Appl Clin Med Phys. 2014 Mar.15(2):4705. Pubmedid: 24710459. Pmcid: PMC5875491.
  • Fernandez DC, Hoffe SE, Barthel JS, Vignesh S, Klapman JB, Harris C, Almhanna K, Biagioli MC, Meredith KL, Feygelman V, Rao NG, Shridhar R. Stability of endoscopic ultrasound-guided fiducial marker placement for esophageal cancer target delineation and image-guided radiation therapy. Pract Radiat Oncol. 2014 Mar.3(1):32-39. Pubmedid: 24674261.
  • Stambaugh C, Opp D, Wassrman S, Zhang G, Feygelman V. Evaluation of semiempirical VMAT dose reconstruction on a patient dataset based on biplanar diode array measurements. J Appl Clin Med Phys. 2014 Mar.15(2):169-180. Pubmedid: 28296076.
  • Javedan K, Feygelman V, Zhang RR, Moros EG, Correa CR, Trotti A, Li W, Zhang GG. Monte Carlo comparison of superficial dose between flattening filter free and flattened beams. Phys Med. 2014 Jun.30(4):503-508. Pubmedid: 24662096.
  • Nelms BE, Opp D, Zhang G, Moros E, Feygelman V. Motion as perturbation. II. Development of the method for dosimetric analysis of motion effects with fixed-gantry IMRT. Med Phys. 2014 Jun.41(6):061704. Pubmedid: 24877799.
  • Stambaugh C, Nelms BE, Dilling T, Stevens C, Latifi K, Zhang G, Moros E, Feygelman V. Experimentally studied dynamic dose interplay does not meaningfully affect target dose in VMAT SBRT lung treatments. Med Phys. 2013 Sep.40(9):091710. Pubmedid: 24007143.
  • Latifi K, Huang TC, Feygelman V, Budzevich MM, Moros EG, Dilling TJ, Stevens CW, van Elmpt W, Dekker A, Zhang GG. Effects of quantum noise in 4D-CT on deformable image registration and derived ventilation data. Phys Med Biol. 2013 Nov.58(21):7661-7672. Pubmedid: 24113375.
  • Nelms BE, Chan MF, Jarry G, Lemire M, Lowden J, Hampton C, Feygelman V. Evaluating IMRT and VMAT dose accuracy: practical examples of failure to detect systematic errors when applying a commonly used metric and action levels. Med Phys. 2013 Nov.40(11):111722. Pubmedid: 24320430. Pmcid: PMC8353583.
  • Robinson J, Opp D, Zhang G, Feygelman V. Evaluation of inhomogeneity correction factors for 6 MV flattening filter-free beams with brass compensators. J Appl Clin Med Phys. 2013 May.14(3):3990. Pubmedid: 23652238. Pmcid: PMC5714406.
  • Opp D, Nelms BE, Zhang G, Stevens C, Feygelman V. Validation of measurement-guided 3D VMAT dose reconstruction on a heterogeneous anthropomorphic phantom. J Appl Clin Med Phys. 2013 Jul.14(4):4154. Pubmedid: 23835381. Pmcid: PMC5714524.
  • Zhang RR, Feygelman V, Harris ER, Rao N, Moros EG, Zhang GG. Is wax equivalent to tissue in electron conformal therapy planning? A Monte Carlo study of material approximation introduced dose difference. J Appl Clin Med Phys. 2013 Jan.14(1):3991. Pubmedid: 23318384. Pmcid: PMC5713917.
  • Feygelman V, Stambaugh C, Zhang G, Hunt D, Opp D, Wolf TK, Nelms BE. Motion as a perturbation: measurement-guided dose estimates to moving patient voxels during modulated arc deliveries. Med Phys. 2013 Feb.40(2):021708. Pubmedid: 23387731.
  • Latifi K, Feygelman V, Moros EG, Dilling TJ, Stevens CW, Zhang GG. Normalization of ventilation data from 4D-CT to facilitate comparison between datasets acquired at different times. PLoS One. 2013.8(12):e84083. Pubmedid: 24358330. Pmcid: PMC3866128.
  • Javedan K, Zhang GG, Hoffe S, Feygelman V, Forster K. Comparing dose in the build-up region between compensator- and MLC-based IMRT. J Appl Clin Med Phys. 2012 Sep.13(5):3748. Pubmedid: 22955641. Pmcid: PMC5718229.
  • Nelms BE, Opp D, Robinson J, Wolf TK, Zhang G, Moros E, Feygelman V. VMAT QA: measurement-guided 4D dose reconstruction on a patient. Med Phys. 2012 Jul.39(7):4228-4238. Pubmedid: 22830756.
  • Nelms BE, Opp D, Robinson J, Wolf TK, Zhang G, Moros E, Feygelman V. VMAT QA: Measurement-guided 4D dose reconstruction on a patient. Med Phys. 2012 Jul.39(7Part1):4228-4238. Pubmedid: 28516597.
  • Robinson J, Opp D, Zhang G, Cashon K, Kozelka J, Hunt D, Walker L, Hoffe S, Shridhar R, Feygelman V. Evaluating dosimetric accuracy of flattening filter free compensator-based IMRT: measurements with diode arrays. Med Phys. 2012 Jan.39(1):342-352. Pubmedid: 22225304.
  • Kozelka J, Robinson J, Nelms B, Zhang G, Savitskij D, Feygelman V. Optimizing the accuracy of a helical diode array dosimeter: a comprehensive calibration methodology coupled with a novel virtual inclinometer. Med Phys. 2011 Sep.38(9):5021-5032. Pubmedid: 21978046.
  • Zhang GG, Ku L, Dilling TJ, Stevens CW, Zhang RR, Li W, Feygelman V. Volumetric modulated arc planning for lung stereotactic body radiotherapy using conventional and unflattened photon beams: a dosimetric comparison with 3D technique. Radiat Oncol. 2011 Nov.6:152. Pubmedid: 22070866. Pmcid: PMC3354344.
  • Feygelman V, Opp D, Javedan K, Saini AJ, Zhang G. Evaluation of a 3D diode array dosimeter for helical tomotherapy delivery QA. Med Dosim. 2011 Mar.35(4):324-329. Pubmedid: 20097061.
  • Opp D, Forster K, Feygelman V. Commissioning compensator-based IMRT on the Pinnacle treatment planning system. J Appl Clin Med Phys. 2011 Mar.12(2):3396. Pubmedid: 21587187. Pmcid: PMC5718674.
  • Zhang G, Feygelman V, Stevens C, Li W, Leuthold S, Springett G, Hoffe S. Re-planning for compensator-based IMRT with original compensators. Med Dosim. 2011 Jun.36(1):102-108. Pubmedid: 20207532.
  • Feygelman V, Zhang G, Stevens C, Nelms BE. Evaluation of a new VMAT QA device, or the "X" and "O" array geometries. J Appl Clin Med Phys. 2011 Jan.12(2):3346. Pubmedid: 21587178. Pmcid: PMC5718675.
  • Zhang G, Feygelman V, Huang TC, Stevens C, Li W, Dilling T. Motion-weighted target volume and dose-volume histogram: a practical approximation of four-dimensional planning and evaluation. Radiother Oncol. 2011 Apr.99(1):67-72. Pubmedid: 21397967.
  • Zhang GG, Ku L, Michael Yu HH, Sarangkasiri S, Zhang RR, Li W, Feygelman V. Dosimetric analysis of modulated and hybrid arcs in stereotactic radiosurgery. J Radiosurg SBRT. 2011.1(3):177-182. Pubmedid: 29296315. Pmcid: PMC5725314.
  • Zhang G, Huang TC, Feygelman V, Stevens C, Forster K. Generation of composite dose and biological effective dose (BED) over multiple treatment modalities and multistage planning using deformable image registration. Med Dosim. 2010 Sep.35(2):143-150. Pubmedid: 19931027.
  • Faygelman V, Hunt D, Walker L, Mueller R, Demarco ML, Dilling T, Stevens C, Zhang G. Validation of Pinnacle treatment planning system for use with Novalis delivery unit. J Appl Clin Med Phys. 2010 Jun.11(3):3240. Pubmedid: 20717094. Pmcid: PMC5720441.
  • Feygelman V, Zhang GG, Stevens CW. Initial dosimetric evaluation of SmartArc - a novel VMAT treatment planning module implemented in a multi-vendor delivery chain. J Appl Clin Med Phys. 2010 Jan.11(1):3169. Pubmedid: 20160702. Pmcid: PMC5719766.
  • Feygelman V, Forster K, Opp D, Nilsson G. Evaluation of a biplanar diode array dosimeter for quality assurance of step-and-shoot IMRT. J Appl Clin Med Phys. 2009 Sep.10(4):64-78. Pubmedid: 19918238. Pmcid: PMC5720580.
  • Feygelman V, Walker L, Chinnaiyan P, Forster K. Simulation of intrafraction motion and overall geometrical accuracy of a frameless intracranial radiosurgery process. J Appl Clin Med Phys. 2008 Oct.9(4):68-86. Pubmedid: 19020489. Pmcid: PMC5722363.
  • Feygelman V, Pow-Sang JM, Friedland JL, Sanders RM. Needle imaging during ultrasound-guided permanent prostate implants. Tech Urol. 1999 Sep.5(3):143-145. Pubmedid: 10527257.
  • Feygelman V, Pow-Sang J, Friedland J, Sanders R. Needle imaging during ultrasound-guided permanent prostate implants. Tech Urol. 1999.3:143-145.
  • Friedland J, Feygelman V, Haller E, Bradley L, Sanders R, Noriega B. Problems with rigid seed strand lodging during prostate implantation: a proposed mechanism and solution. Med Dosim. 1997 Jun.22(1):17-21. Pubmedid: 9136103 .
  • Feygelman V, Noriega B, Sanders R, Friedland J. A simple method for verifying activity of iodine-125 seeds in rigid absorbable suture. Med Dosim. 1996 Win.21(4):261-262. Pubmedid: 8985933 .
  • Feygelman V, Friedland J, Sanders R, Noriega B, Pow-Sang J. Improvement in dosimetry of ultrasound-guided prostate implants with the use of multiple stabilization needles. Med Dosim. 1996 Dec.21(2):109-112. Pubmedid: 8807612 .
  • Feygelman V, Friedland JL, Sanders RM, Noriega BK, Pow-Sang JM. Improvement in dosimetry of ultrasound-guided prostate implants with the use of multiple stabilization needles. Med Dosim. 1996.21(2):109-112. Pubmedid: 8807612.
  • Feygelman V, Noriega B, Sanders R, Friedland J. A spreadsheet technique for dosimetry of transperineal prostate implants. Med Phys. 1995 Jan.22(1):97-100. Pubmedid: 7715574 .
  • Feygelman V, Mandelzweig Y, Baral E. Matching electron beams without secondary collimation for treatment of extensive recurrent chest-wall carcinoma. Med Dosim. 1994 Jul.19(1):23-27. Pubmedid: 8003203 .
  • Mandelzweig Y, Feygelman V. Evaluation of electron-beam uniformity during commissioning of a linear accelerator. Med Phys. 1993 Jul.20(4):1233-1236. Pubmedid: 8413034 .
  • Feygelman V, Huda W, Peters K. Effective dose equivalents to patients undergoing cerebral angiography. Ajnr Am J Neuroradiol. 1992 May.13(3):845-849. Pubmedid: 1590181 .

Grants

Title: Objective Evaluation of Machine Learning Potential for Automated Segmentation and Generation of Head and Neck Plans with Proven Reduced Toxicity
Sponsor: Varian Medical Systems, Inc.
PI: Feygelman, V., CO-PI: Caudell, J., CO-PI: Latifi, K., CO-PI: Moros, E.

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