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Thomas Jonathan Dilling, MD


Specialty: Radiation Oncology
Program: Radiation Oncology

Call 1-888-MOFFITT
(1-888-663-3488)

or call 1-888-MOFFITT
(1-888-663-3488)

Overview

Dr. Dilling's primary clinical focus is the radiotherapeutic treatment of thoracic malignancies. He is interested in the application of new technologies to the treatment of lung cancer, with the ongoing goal to improve treatment efficacy while minimizing untoward side effects. In particular, Dr. Dilling is interested in the use of stereotactic radiotherapy for the treatment of early-stage lung cancers, and is also interested in tumoral genetic mutations which might confer greater (or reduced) radiation sensitivity.

Education & Training

Board Certification:

  • Radiation Oncology

Fellowship:

  • University of Pennsylvania - Radiation Oncology

Residency:

  • University of Pennsylvania - Radiation Oncology

Medical School:

  • University of Pennsylvania - MD
Participating Trials

CLINICAL TRIAL 18428
A Randomized Phase II Study of Individualized Combined Modality Therapy for Stage III Non-Small Cell Lung Cancer (NSCLC)
Condition: Thoracic
Intervention: Crizotinib; Erlotinib; Paraplatin (carboplatin); Tarceva (Erlotinib); Taxol (paclitaxel); Xalkori (Crizotinib); carboplatin; cisplatin; etoposide; paclitaxel
Open

CLINICAL TRIAL 16480
Radiomics: A Prospective Study of Outcome in Lung Cancer
Condition: Thoracic
Intervention:
Open

CLINICAL TRIAL 18914
Consolidative Ipilimumab and Nivolumab with Thoracic Radiotherapy after Platinum Based Chemotherapy for Patients with Extensive-Stage Small Cell Lung Cancer
Condition: Thoracic
Intervention: BMS-936558 (Nivolumab); Ipilimumab; Nivolumab; Yervoy (Ipilimumab)
Open

If you believe you are eligible for one of these trials or studies, please call
1-888-MOFFITT (1-888-663-3488).

Publications

  • Li Q, Kim J, Balagurunathan Y, Qi J, Liu Y, Latifi K, Moros EG, Schabath MB, Ye Z, Gillies RJ, Dilling TJ. CT imaging features associated with recurrence in non-small cell lung cancer patients after stereotactic body radiotherapy. Radiat Oncol. 2017 Sep;12(1):158. Pubmedid: 28946909. Pmcid: PMC5613447.
  • Yuan Z, Fromm A, Ahmed KA, Grass GD, Yang GQ, Oliver DE, Dilling TJ, Antonia SJ, Perez BA. Radiotherapy Rescue of a Nivolumab-Refractory Immune Response in a Patient with PD-L1-Negative Metastatic Squamous Cell Carcinoma of the Lung. J Thorac Oncol. 2017 Sep;12(9):e135-e136. Pubmedid: 28502722.
  • Zhang GG, Latifi K, Feygelman V, Chou KT, Huang TC, Dilling TJ, Perez BA, Moros EG. Ventilation Series Similarity: A Study for Ventilation Calculation Using Deformable Image Registration and 4DCT to Avoid Motion Artifacts. Contrast Media Mol Imaging. 2017 Sep;2017:9730380. Pubmedid: 29097945. Pmcid: PMC5623778.
  • Oliver JA, Budzevich M, Hunt D, Moros EG, Latifi K, Dilling TJ, Feygelman V, Zhang G. Sensitivity of Image Features to Noise in Conventional and Respiratory-Gated PET/CT Images of Lung Cancer: Uncorrelated Noise Effects. Technol Cancer Res Treat. 2017 Oct;16(5):595-608. Pubmedid: 27502957. Pmcid: PMC5665151.
  • Ahmed KA, Grass GD, Creelan B, Gray J, Kim S, Dilling TJ, Antonia SJ, Perez BA. Tolerability and Safety of Thoracic Radiation and Immune Checkpoint Inhibitors Among Patients with Lung Cancer. Int J Radiat Oncol Biol Phys. 2017 May;98(1):224. Pubmedid: 28586976.
  • Ahmed KA, Kim S, Arrington J, Naghavi AO, Dilling TJ, Creelan BC, Antonia SJ, Caudell JJ, Harrison LB, Sahebjam S, Gray JE, Etame AB, Johnstone PA, Yu M, Perez BA. Outcomes targeting the PD-1/PD-L1 axis in conjunction with stereotactic radiation for patients with non-small cell lung cancer brain metastases. J Neurooncol. 2017 Jun;133(2):331-338. Pubmedid: 28466250.
  • Abuodeh Y, Naghavi AO, Echevarria M, DeMarco M, Tonner B, Feygelman V, Stevens CW, Perez BA, Dilling TJ. Quantitatively Excessive Normal Tissue Toxicity and Poor Target Coverage in Postoperative Lung Cancer Radiotherapy Meta-analysis. Clin Lung Cancer. 2017 Jul. Pubmedid: 29107487.
  • Verma V, Simone CB, Allen PK, Gajjar SR, Shah C, Zhen W, Harkenrider MM, Hallemeier CL, Jabbour SK, Matthiesen CL, Braunstein SE, Lee P, Dilling TJ, Allen BG, Nichols EM, Attia A, Zeng J, Biswas T, Paximadis P, Wang F, Walker JM, Stahl JM, Daly ME, Decker RH, Hales RK, Willers H, Videtic GM, Mehta MP, Lin SH. Multi-Institutional Experience of Stereotactic Ablative Radiation Therapy for Stage I Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2017 Feb;97(2):362-371. Pubmedid: 28011047.
  • Li Q, Kim J, Balagurunathan Y, Liu Y, Latifi K, Stringfield O, Garcia A, Moros EG, Dilling TJ, Schabath MB, Ye Z, Gillies RJ. Imaging features from pretreatment CT scans are associated with clinical outcomes in nonsmall-cell lung cancer patients treated with stereotactic body radiotherapy. Med Phys. 2017 Aug;44(8):4341-4349. Pubmedid: 28464316. Pmcid: PMC5553698.
  • Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman J, Chirieac LR, D'Amico TA, DeCamp MM, Dilling TJ, Dobelbower M, Doebele RC, Govindan R, Gubens MA, Hennon M, Horn L, Komaki R, Lackner RP, Lanuti M, Leal TA, Leisch LJ, Lilenbaum R, Lin J, Loo BW, Martins R, Otterson GA, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M. Non-Small Cell Lung Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Ne. 2017 Apr;15(4):504-535. Pubmedid: 28404761.
  • Grass GD, Naghavi AO, Frakes JM, Perez BA, Dilling TJ. Treatment of Stage III Non-Small Cell Lung Cancer Patients With Concurrent Chemotherapy and Radiation (70 Gy): Equivalent or Superior to 60 or 74 Gy of RTOG 0617?. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E428-E429. Pubmedid: 27674664.
  • Ahmed KA, Berglund AE, Welsh EA, Naghavi AO, Perez BA, Dilling TJ, Eschrich SA, Torres-Roca JF. Differences in the Radiosensitivity Index (RSI) Between Lung Metastases Based Upon Primary Histology. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):S68. Pubmedid: 27675988.
  • Ahmed KA, Creelan BC, Kim S, Dilling TJ, Perez BA. Safety and Tolerability of Extracranial Radiation Therapy and Immune Checkpoint Inhibitors Among Patients With Metastatic Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):S201. Pubmedid: 27675781.
  • Abuodeh YA, Naghavi AO, DeMarco M, Tonner B, Feygelman V, Stevens CW, Perez BA, Dilling TJ. Quantitatively Excessive Normal Tissue Toxicity and Poor Target Coverage in the PORT Meta-Analysis (MA): A Dosimetric Study. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E442. Pubmedid: 27674703.
  • Meyer JE, Dilling TJ, Amdur RJ, Strasser JF, Tendulkar R, Lee WR, Jani AB, Elshaikh M, Poppe MM, Takita C, Currey A, Cheng SK, Jagsi R, Kuo JV, Chen AM, Dragun AE, Bradley K, Beriwal S, Smith RP, Chen RC, Rosenzweig K, Kim S, Mehta K. In regard to Wu and Vapiwala et al. Int J Radiat Oncol Biol Phys. 2016 Mar;94(4):858-859. Pubmedid: 26972659.
  • Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Dilling TJ, Dobelbower MC, Govindan R, Hennon M, Horn L, Jahan TM, Komaki R, Lackner RP, Lanuti M, Lilenbaum R, Lin J, Loo BW, Martins R, Otterson GA, Patel JD, Pisters KM, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Sharma N, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M. NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 4.2016. J Natl Compr Canc Ne. 2016 Mar;14(3):255-264. Pubmedid: 26957612.
  • Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Dilling T, Dobelbower M, Govindan R, Hennon M, Horn L, Jahan TM, Komaki R, Lackner RP, Lanuti M, Lilenbaum R, Lin J, Loo BW, Martins R, Otterson GA, Patel JD, Pisters KM, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Sharma N, Swanson SJ, Stevenson J, Tauer K, Yang SC, Gregory K, Hughes M. NCCN Guidelines Insights: Malignant Pleural Mesothelioma, Version 3.2016. J Natl Compr Canc Ne. 2016 Jul;14(7):825-836. Pubmedid: 27407123.
  • Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Dilling TJ, Dobelbower MC, Govindan R, Grannis FW, Horn L, Jahan TM, Komaki R, Krug LM, Lackner RP, Lanuti M, Lilenbaum R, Lin J, Loo BW, Martins R, Otterson GA, Patel JD, Pisters KM, Reckamp K, Riely GJ, Rohren E, Schild SE, Shapiro TA, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M. Non-small cell lung cancer, version 6.2015. J Natl Compr Canc Ne. 2015 May;13(5):515-524. Pubmedid: 25964637.
  • D'Ambrosio DJ, Bayouth J, Chetty IJ, Buyyounouski MK, Price RA, Correa CR, Dilling TJ, Franklin GE, Xia P, Harris EE, Konski A. Continuous localization technologies for radiotherapy delivery: Report of the American Society for Radiation Oncology Emerging Technology Committee. Pract Radiat Oncol. 2015 Mar;2(2):145-150. Pubmedid: 24175000. Pmcid: PMC3808750.
  • Ahmed KA, Fulp WJ, Berglund AE, Hoffe SE, Dilling TJ, Eschrich SA, Shridhar R, Torres-Roca JF. Differences Between Colon Cancer Primaries and Metastases Using a Molecular Assay for Tumor Radiation Sensitivity Suggest Implications for Potential Oligometastatic SBRT Patient Selection. Int J Radiat Oncol Biol Phys. 2015 Jul;92(4):837-842. Pubmedid: 25838188. Pmcid: PMC4481172.
  • Oliver JA, Budzevich M, Zhang GG, Dilling TJ, Latifi K, Moros EG. Variability of Image Features Computed from Conventional and Respiratory-Gated PET/CT Images of Lung Cancer. Transl Oncol. 2015 Dec;8(6):524-534. Pubmedid: 26692535. Pmcid: PMC4700295.
  • Dilling TJ, Extermann M, Kim J, Thompson LM, Yue B, Stevens CW, Antonia S, Gray J, Williams C, Haura E, Pinder-Schenck M, Tanvetyanon T, Kim S, Chiappori A. Phase 2 study of concurrent cetuximab plus definitive thoracic radiation therapy followed by consolidation docetaxel plus cetuximab in poor prognosis or elderly patients with locally advanced non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2014 Nov;90(4):828-833. Pubmedid: 25216856.
  • Figura N, Latifi K, Dilling TJ, Kuykendall CC, Eikman EA, Moros EG, Zhang GG, Leuthold S, Mehra C, Hoffe SE. Dosimetric Implications of Treating 4D PET/CT-Defined Maximum Inhale Versus Exhale Target Volumes in Esophageal Cancer. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S34-S35. Pubmedid: 24674556.
  • Latifi K, Dilling TJ, Hoffe SE, Stevens CW, Moros EG, Zhang GG. Evaluating Effects of Radiation Therapy Treatment on 4DCT-Calculated Lung Ventilation. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S6-S7. Pubmedid: 24674563.
  • Saeed N, Latifi K, Hoffe SE, Cruz A, Opp DW, Moros EG, Zhang GG, Budzevich MM, Shridhar R, Dilling TJ. Optimizing Options for Re-irradiation With Deformable Image Registration of Prior Plans. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S16-S17. Pubmedid: 24674497.
  • Zhang GG, Latifi K, Huang T, Feygelman V, Stevens CW, Dilling TJ, Moros EG, Elmpt Wv, Dekker A. Effects of Noise in 4D CT on Deformable Image Registration and Derived Ventilation Data. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S7-S8. Pubmedid: 24674566.
  • Budzevich MM, Kuykendall CC, Latifi K, Oliver J, Dilling TJ, Hoffe SE, Eikman EA, Montilla-Soler JI, Zhang GG, Moros EG. A Method to Determine the Optimal Number of Bins in 4D PET. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S25. Pubmedid: 24674527.
  • Kuykendall CC, Budzevich MM, Latifi K, Moros EG, Hoffe SE, Dilling TJ, Zhang GG, Montilla-Soler JL, Eikman EA. 4D PET/CT: Radiology Imaging to Radiation Therapy. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S28. Pubmedid: 24674534.
  • Oliver JA, Budzevich M, Zhang G, Moros EG, Latifi K, Kuykendall C, Hoffe S, Montilla-Soler J, Eikman E, Dilling T. Positron emission tomography texture analysis of necrosis in primary adenocarcinomas of the lung. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S29-S30. Pubmedid: 24674537.
  • Ahmed KA, Correa CR, Dilling TJ, Rao NG, Shridhar R, Trotti AM, Wilder RB, Caudell JJ. Altered fractionation schedules in radiation treatment: a review. Semin Oncol. 2014 Dec;41(6):730-750. Pubmedid: 25499633.
  • Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Dilling TJ, Govindan R, Grannis FW, Horn L, Jahan TM, Komaki R, Kris MG, Krug LM, Lackner RP, Lanuti M, Lilenbaum R, Lin J, Loo BW, Martins R, Otterson GA, Patel JD, Pisters KM, Reckamp K, Riely GJ, Rohren E, Schild S, Shapiro TA, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M. Non-small cell lung cancer, version 1.2015. J Natl Compr Canc Ne. 2014 Dec;12(12):1738-1761. Pubmedid: 25505215.
  • Latifi K, Oliver J, Baker R, Dilling TJ, Stevens CW, Kim J, Yue B, Demarco M, Zhang GG, Moros EG, Feygelman V. Study of 201 non-small cell lung cancer patients given stereotactic ablative radiation therapy shows local control dependence on dose calculation algorithm. Int J Radiat Oncol Biol Phys. 2014 Apr;88(5):1108-1113. Pubmedid: 24529716.
  • Stambaugh C, Nelms BE, Dilling T, Stevens C, Latifi K, Zhang G, Moros E, Feygelman V. Experimentally studied dynamic dose interplay does not meaningfully affect target dose in VMAT SBRT lung treatments. Med Phys. 2013 Sep;40(9):091710. Pubmedid: 24007143.
  • Latifi K, Huang TC, Feygelman V, Budzevich MM, Moros EG, Dilling TJ, Stevens CW, van Elmpt W, Dekker A, Zhang GG. Effects of quantum noise in 4D-CT on deformable image registration and derived ventilation data. Phys Med Biol. 2013 Nov;58(21):7661-7672. Pubmedid: 24113375.
  • Ramnath N, Dilling TJ, Harris LJ, Kim AW, Michaud GC, Balekian AA, Diekemper R, Detterbeck FC, Arenberg DA. Treatment of stage III non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013 May;143(5 Suppl):e314S-e340S. Pubmedid: 23649445.
  • Latifi K, Forster KM, Hoffe SE, Dilling TJ, Dekker A, Van Elmpt W, Zhang GG. Dependence of ventilation image derived from 4D CT on deformable image registration and ventilation algorithms. J Appl Clin Med Phys. 2013 Jul;14(4):4247. Pubmedid: 23835389.
  • Baker R, Han G, Sarangkasiri S, DeMarco M, Turke C, Stevens CW, Dilling TJ. Clinical and dosimetric predictors of radiation pneumonitis in a large series of patients treated with stereotactic body radiation therapy to the lung. Int J Radiat Oncol Biol Phys. 2013 Jan;85(1):190-195. Pubmedid: 22929858.
  • Latifi K, Feygelman V, Moros EG, Dilling TJ, Stevens CW, Zhang GG. Normalization of ventilation data from 4D-CT to facilitate comparison between datasets acquired at different times. PLoS One. 2013 Dec;8(12):e84083. Pubmedid: 24358330. Pmcid: PMC3866128.
  • Zhang GG, Ku L, Dilling TJ, Stevens CW, Zhang RR, Li W, Feygelman V. Volumetric modulated arc planning for lung stereotactic body radiotherapy using conventional and unflattened photon beams: a dosimetric comparison with 3D technique. Radiat Oncol. 2012 Mar;6:152. Pubmedid: 22070866. Pmcid: PMC3354344.
  • Ahmed I, Demarco M, Stevens CW, Fulp WJ, Dilling TJ. Analysis of incidental radiation dose to uninvolved mediastinal/supraclavicular lymph nodes in patients with limited-stage small cell lung cancer treated without elective nodal irradiation. Med Dosim. 2012 Apr;36(4):440-447. Pubmedid: 21397488.
  • Dilling TJ, Bae K, Paulus R, Watkins-Bruner D, Garden AS, Forastiere A, Kian Ang K, Movsas B. Impact of gender, partner status, and race on locoregional failure and overall survival in head and neck cancer patients in three radiation therapy oncology group trials. Int J Radiat Oncol Biol Phys. 2011 Nov;81(3):e101-e109. Pubmedid: 21549515. Pmcid: PMC3170693.
  • Bepler G, Dilling TJ, Wagner H, Hazelton T, Williams C, Chen DT, Greenberg H, Walsh F, Simon G, Tanvetyanon T, Chiappori A, Haura E, Stevens C. Phase II trial of induction gemcitabine and carboplatin followed by conformal thoracic radiation to 74 Gy with weekly paclitaxel and carboplatin in unresectable stage III non-small cell lung cancer. J Thorac Oncol. 2011 Mar;6(3):553-558. Pubmedid: 21289520. Pmcid: PMC3839293.
  • Zhang G, Huang TC, Dilling T, Stevens C, Forster K. Comments on 'Ventilation from four-dimensional computed tomography: density versus Jacobian methods'. Phys Med Biol. 2011 Jun;56(11):3445-3446. Pubmedid: 21572233.
  • Zhang G, Feygelman V, Huang TC, Stevens C, Li W, Dilling T. Motion-weighted target volume and dose-volume histogram: a practical approximation of four-dimensional planning and evaluation. Radiother Oncol. 2011 Apr;99(1):67-72. Pubmedid: 21397967.
  • Buyyounouski MK, Balter P, Lewis B, D'Ambrosio DJ, Dilling TJ, Miller RC, Schefter T, Tomé W, Harris EE, Price RA, Konski AA, Wallner PE. Stereotactic body radiotherapy for early-stage non-small-cell lung cancer: report of the ASTRO Emerging Technology Committee. Int J Radiat Oncol Biol Phys. 2010 Sep;78(1):3-10. Pubmedid: 20643514.
  • Huang TC, Liang JA, Dilling T, Wu TH, Zhang G. Four-dimensional dosimetry validation and study in lung radiotherapy using deformable image registration and Monte Carlo techniques. Radiat Oncol. 2010 May;5:45. Pubmedid: 20509955. Pmcid: PMC2890615.
  • Faygelman V, Hunt D, Walker L, Mueller R, Demarco ML, Dilling T, Stevens C, Zhang G. Validation of Pinnacle treatment planning system for use with Novalis delivery unit. J Appl Clin Med Phys. 2010 Jun;11(3):3240. Pubmedid: 20717094.
  • Barthel JS, Kucera ST, Lin JL, Hoffe SE, Strosberg JR, Ahmed I, Dilling TJ, Stevens CW. Does Barrett's esophagus respond to chemoradiation therapy for adenocarcinoma of the esophagus?. Gastrointest Endosc. 2010 Feb;71(2):235-240. Pubmedid: 20003971.
  • Evans SM, Jenkins KW, Jenkins WT, Dilling T, Judy KD, Schrlau A, Judkins A, Hahn SM, Koch CJ. Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors. Radiat Res. 2008 Dec;170(6):677-690. Pubmedid: 19138031. Pmcid: PMC2629387.
  • Dilling TJ, Hoffe SE. Stereotactic body radiation therapy: transcending the conventional to improve outcomes. Cancer Control. 2008 Apr;15(2):104-111. Pubmedid: 18376377.
  • Zhang G, Dilling T, Stevens C, Forster K. Functional lung imaging in thoracic cancer radiotherapy. Cancer Control. 2008 Apr;15(2):112-119. Pubmedid: 18376378.
  • Emrich JG, Hand CM, Dilling TJ, Class R, Bender H, Brady LW. Biodistribution of 125I-MAb 425 in a human glioma xenograft model: effect of chloroquine. Hybridoma. 1997 Feb;16(1):93-100. Pubmedid: 9085135.