Odion Binitie, MD

Cancer Focus:
Osteosarcoma, Sarcoma

Dr. Binitie earned his MD degree from the University of South Florida College of Medicine. He completed an Orthopedic Surgery Residency at the University of South Florida. In 2012, he completed a Pediatric Orthopedic Fellowship at Children’s Hospital of Philadelphia and then a Musculoskeletal Oncology Fellowship at the University of South Florida at Moffitt Cancer Center. Dr. Binitie’s clinical interests include bone and soft tissue sarcomas, limb preserving surgeries and sarcomas in all patients, with a focus in pediatric and young adults. His research interests include limb preservation after oncologic resection, expandable pediatric limb reconstruction, and adolescent and young adult sarcomas. 

Education & Training

Fellowship:

• Children's Hospital of Philadelphia - Pediatric Orthopedics
• Moffitt Cancer Center - Muscoskeletal Oncology

Residency:

• University of South Florida - Orthopedic Surgery

Medical School:

• University of South Florida - MD

• West W, Moore A, Gerhardt C, Webb P, Binitie O, Lazarides A, Letson D, Joyce D. Dual plating in the metastatic distal humerus: Benefits may outweigh the risks. J Orthop. 2024 May.51:103-108. Pubmedid: 38361983. Pmcid: PMC10864758.
• Belzarena AC, Binitie O, Letson GD, Joyce DM. Unplanned Sarcoma Excisions: Understanding How They Happen. J Am Acad Orthop Surg Glob Res Rev. 2024 Jan.8(1). Pubmedid: 38252542. Pmcid: PMC10805420.
• Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA. Children's Oncology Group's 2023 blueprint for research: Bone tumors. Pediatr Blood Cancer. 2023 Sep.70 Suppl 6(Suppl 6):e30583. Pubmedid: 37501549. Pmcid: PMC10499366.
• Cash T, Krailo MD, Buxton AB, Pawel BR, Healey JH, Binitie O, Marcus KJ, Grier HE, Grohar PJ, Reed DR, Weiss AR, Gorlick R, Janeway KA, DuBois SG, Womer RB. Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031. J Clin Oncol. 2023 Oct.41(30):4724-4728. Pubmedid: 37651654. Pmcid: PMC10602538.
• Totadri S, Bansal D, Donaldson SS, Binitie O, Teot L, Gupta AA, Oberoi S. Common queries in managing rhabdomyosarcoma in low- and middle-income countries: An Indo-North American collaboration. Pediatr Blood Cancer. 2023 Nov.70(11):e30616. Pubmedid: 37574816.
• Crimì A, Joyce DM, Binitie O, Ruggieri P, Letson GD. The history of resection prosthesis. Int Orthop. 2023 Mar.47(3):873-883. Pubmedid: 36651984.
• Morris CD, Tunn PU, Rodeberg DA, Terwisscha van Scheltinga S, Binitie O, Godzinski J, Dall'Igna P, Million L, Hawkins DS, Koscielniak E, Bisogno G, Rogers TN. Surgical management of extremity rhabdomyosarcoma: A consensus opinion from the Children's Oncology Group, the European Pediatric Soft-Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe. Pediatr Blood Cancer. 2023 Mar.70(3):e28608. Pubmedid: 32776456.
• Palm RF, Liveringhouse CL, Gonzalez RJ, Bui MM, Binitie O, Yang GQ, Naghavi AO. Effect of Favorable Pathologic Response After Neoadjuvant Radiation Therapy Alone in Soft-tissue Sarcoma. Adv Radiat Oncol. 2023 Jan.8(1):101086. Pubmedid: 36483058. Pmcid: PMC9723307.
• Huynh THN, Kuruvilla DR, Nester MD, Zervoudakis G, Letson GD, Joyce DM, Binitie OT, Lazarides AL. Limb Amputations in Cancer: Modern Perspectives, Outcomes, and Alternatives. Curr Oncol Rep. 2023 Dec.25(12):1457-1465. Pubmedid: 37999825.
• Wright J, Qamar F, McLaughlin M, Jodeh DS, Amankwah E, Mosha M, Halsey J, Binitie O, Metts J, Goldenberg N, Rottgers SA. The Incidence of Thromboembolic Events During Hospitalizations Following Surgical Resection of Lower Extremity Sarcomas in Children: Utilizing the Pediatric Health Information System Database. J Pediatr Orthop. 2023 Apr.43(4):268-272. Pubmedid: 36693390.
• Kayton ML, Weiss AR, Xue W, Binitie O, Hayes Dixon A, Randall RL, Sorger JI, Hawkins DS, Spunt SL, Wang D, Million L, Terezakis S, Choy E, Okuno SH, Venkatramani R, Chen YL, Scharschmidt TJ. Neoadjuvant pazopanib in nonrhabdomyosarcoma soft tissue sarcomas (ARST1321): A report of major wound complications from the Children's Oncology Group and NRG Oncology. J Surg Oncol. 2023 Apr.127(5):871-881. Pubmedid: 36779385. Pmcid: PMC10121189.
• Crimì A, Binitie OT, Crimì F, Letson GD, Joyce DM. Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?. J Clin Med. 2022 Nov.11(23). Pubmedid: 36498687. Pmcid: PMC9740033.
• Evans TJ, Wang X, Binitie O. Orthopaedic Manifestations of Neurofibromatosis Type I. J Am Acad Orthop Surg. 2022 Dec.30(23):e1495-e1503. Pubmedid: 36400059.
• Alexander JH, Binitie OT, Letson GD, Joyce DM. Osteosarcoma: An Evolving Understanding of a Complex Disease. J Am Acad Orthop Surg. 2021 Oct.29(20):e993-e1004. Pubmedid: 34623342.
• Broman KK, Joyce D, Binitie O, Letson GD, Gonzalez RJ, Choi J, Mullinax JE. Intraoperative Localization Using an Implanted Radar Reflector Facilitates Resection of Non-Palpable Trunk and Extremity Sarcoma. Ann Surg Oncol. 2021 Jun.28(6):3366-3374. Pubmedid: 33073344.
• Belzarena AC, Binitie O, Letson D, Joyce DM. Intramedullary rod failure in metastatic breast cancer: Do triple negative cancer patients have more revision surgery?. J Bone Oncol. 2021 Jun.28:100358. Pubmedid: 33898214. Pmcid: PMC8056433.
• Thacker MM, Binitie OT, Lindberg AW, Arkader A. Pediatric Tumor Management: Current and Controversial. Instr Course Lect. 2021 Jan.70:453-464. Pubmedid: 33438927.
• Lautz TB, Chi YY, Li M, Wolden SL, Casey DL, Routh JC, Granberg CF, Binite O, Rudzinski ER, Hawkins DS, Venkatramani R, Rodeberg DA. Benefit of delayed primary excision in rhabdomyosarcoma: A report from the Children's Oncology Group. Cancer. 2021 Jan.127(2):275-283. Pubmedid: 33079399. Pmcid: PMC7790947.
• Arkader A, Williams A, Binitie O, Thacker MM, Farfalli GL. Pediatric Chondroblastoma and the Need for Lung Staging at Presentation. J Pediatr Orthop. 2020 Oct.40(9):e894-e897. Pubmedid: 32658156.
• Piakong P, Kiatisevi P, Yau R, Trovarelli G, Lam YL, Joyce D, Ruggieri P, Temple HT, Letson D, Binitie O. What Is the 10-year Survivorship of Cemented Distal Femoral Endoprostheses for Tumor Reconstructions and What Radiographic Features Are Associated with Survival?. Clin Orthop Relat Res. 2020 Nov.478(11):2573-2581. Pubmedid: 32469487. Pmcid: PMC7594923.
• Aye JM, Chi YY, Tian J, Rudzinski ER, Binitie OT, Dasgupta R, Wolden SL, Hawkins DS, Gupta AA. Do children and adolescents with completely resected alveolar rhabdomyosarcoma require adjuvant radiation? A report from the Children's Oncology Group. Pediatr Blood Cancer. 2020 May.67(5):e28243. Pubmedid: 32124549. Pmcid: PMC7325864.
• Rizk VT, Naghavi AO, Brohl AS, Joyce DM, Binitie O, Kim Y, Hanna JP, Swank J, Gonzalez RJ, Reed DR, Druta M. Chemotherapy improves distant control in localized high-grade soft tissue sarcoma of the extremity/trunk. Clin Sarcoma Res. 2020 Jul.10:11. Pubmedid: 32670544. Pmcid: PMC7350709.
• Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D. Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial. Lancet Oncol. 2020 Aug.21(8):1110-1122. Pubmedid: 32702309. Pmcid: PMC7745646.
• Reed DR, Naghavi A, Binitie O. Sarcoma as a Model for Adolescent and Young Adult Care. J Oncol Pract. 2019 May.15(5):239-247. Pubmedid: 31075215.
• Caracciolo JT, Henderson-Jackson E, Binitie O. Synovial sarcoma of bone: Sarcoma typically of soft tissues presenting as a primary bone tumor. Radiol Case Rep. 2019 Feb.14(2):204-207. Pubmedid: 30425775. Pmcid: PMC6231113.
• Binitie O. CORR Insights®: Tenosynovial Giant Cell Tumors in Children: A Similar Entity Compared With Adults. Clin Orthop Relat Res. 2018 Sep.476(9):1813-1814. Pubmedid: 29470238. Pmcid: PMC6259785.
• Boddu S, Walko CM, Bienasz S, Bui MM, Henderson-Jackson E, Naghavi AO, Mullinax JE, Joyce DM, Binitie O, Letson GD, Gonzalez RJ, Reed DR, Druta M, Brohl AS. Clinical Utility of Genomic Profiling in the Treatment of Advanced Sarcomas: A Single-Center Experience. JCO Precis Oncol. 2018 Nov.2:1-8. Pubmedid: 35135155.
• Borinstein SC, Steppan D, Hayashi M, Loeb DM, Isakoff MS, Binitie O, Brohl AS, Bridge JA, Stavas M, Shinohara ET, Meyer WH, Reed DR, Wagner LM. Consensus and controversies regarding the treatment of rhabdomyosarcoma. Pediatr Blood Cancer. 2018 Feb.65(2). Pubmedid: 28905489.
• Peters K, Caracciolo JT, Henderson-Jackson E, Binitie O. Myopericytoma/myopericytomatosis of the lower extremity in two young patients: a recently designated rare soft tissue neoplasm. Radiol Case Rep. 2018 Feb.13(1):275-280. Pubmedid: 29552265. Pmcid: PMC5851063.
• Fontenot PB, Jesurajan J, Bui M, Reed D, Binitie O. Recurrent Aneurysmal Bone Cyst of the Distal Fibula Treated with Denosumab and Curettage. Case Rep Oncol Med. 2018 Dec.2018:1574343. Pubmedid: 30631617. Pmcid: PMC6304848.
• Christopher Z, Binitie O, Henderson-Jackson E, Perno J, Makanji RJ. Langerhans cell histiocytosis of bone in an adult: A case report. Radiol Case Rep. 2018 Apr.13(2):310-314. Pubmedid: 29904462. Pmcid: PMC5999879.
• Reed DR, Hayashi M, Wagner L, Binitie O, Steppan DA, Brohl AS, Shinohara ET, Bridge JA, Loeb DM, Borinstein SC, Isakoff MS. Treatment pathway of bone sarcoma in children, adolescents, and young adults. Cancer. 2017 Jun.123(12):2206-2218. Pubmedid: 28323337. Pmcid: PMC5485018.
• Naghavi AO, Gonzalez RJ, Scott JG, Mullinax JE, Abuodeh YA, Kim Y, Binitie O, Ahmed KA, Bui MM, Saini AS, Zager JS, Biagioli MC, Letson D, Harrison LB, Fernandez DC. Implications of staged reconstruction and adjuvant brachytherapy in the treatment of recurrent soft tissue sarcoma. Brachytherapy. 2017 Jul.15(4):495-503. Pubmedid: 27180128. Pmcid: PMC7771533.
• Kadhim M, Binitie O, O'Toole P, Grigoriou E, De Mattos CB, Dormans JP. Surgical resection of osteoid osteoma and osteoblastoma of the spine. J Pediatr Orthop B. 2017 Jul.26(4):362-369. Pubmedid: 27832013.
• Durfee RA, Sabo SA, Letson GD, Binitie O, Cheong D. Percutaneous Acetabuloplasty for Metastatic Lesions to the Pelvis. Orthopedics. 2017 Jan.40(1):e170-e175. Pubmedid: 27783835.
• Reed DR, Oshrine B, Pratt C, Fridgen O, Elstner C, Wilson L, Soliman H, Lee MC, McLeod HL, Shah B, Donovan KA, Pabbathi S, Turney M, Binitie O, Healy C, Nieder M, Shaw PH, Galligan A, Letson GD, Stern M, Quinn GP, Davies S. Sink or Collaborate: How the Immersive Model Has Helped Address Typical Adolescent and Young Adult Barriers at a Single Institution and Kept the Adolescent and Young Adult Program Afloat. J Adolesc Young Adult Oncol. 2017 Dec.6(4):503-511. Pubmedid: 28777007. Pmcid: PMC5725631.
• Hoggard TM, Henderson-Jackson E, Bui MM, Caracciolo J, Teer JK, Yoder S, Binitie O, Gonzalez RJ, Brohl AS, Reed DR. Myoepithelial carcinoma with RB1 mutation: remarkable chemosensitivity to carcinoma of unknown origin therapy. BMC Cancer. 2017 Apr.17(1):250. Pubmedid: 28390395. Pmcid: PMC5385017.
• Bertrand TE, Cruz A, Binitie O, Cheong D, Letson GD. Do Surgical Margins Affect Local Recurrence and Survival in Extremity, Nonmetastatic, High-grade Osteosarcoma?. Clin Orthop Relat Res. 2016 Mar.474(3):677-683. Pubmedid: 26013153. Pmcid: PMC4746163.
• Groundland JS, Binitie O. Reconstruction After Tumor Resection in the Growing Child. Orthop Clin N Am. 2016 Jan.47(1):265-281. Pubmedid: 26614940.
• Doepker MP, Hanna KH, Thompson ZJ, Binitie OT, Letson DG, Gonzalez RJ. Recurrence and survival analysis of resected soft tissue sarcomas of pelvic retroperitoneal structures. J Surg Oncol. 2016 Jan.113(1):103-107. Pubmedid: 26744131.
• Groundland JS, Ambler SB, Houskamp LD, Orriola JJ, Binitie OT, Letson GD. Surgical and Functional Outcomes After Limb-Preservation Surgery for Tumor in Pediatric Patients: A Systematic Review. JBJS Rev. 2016 Feb.4(2). Pubmedid: 27490132.
• Henderson ER, Gao J, Groundland J, Binitie O, Letson GD. Expandable Total Humeral Replacement in a Child with Osteosarcoma. Case Rep Orthop. 2015 Jun.2015:690159. Pubmedid: 26090254. Pmcid: PMC4452195.
• Xu H, Niu X, Li Y, Binitie OT, Letson GD, Cheong D. What are the results using the modified trapdoor procedure to treat chondroblastoma of the femoral head?. Clin Orthop Relat Res. 2014 Nov.472(11):3462-3467. Pubmedid: 25115583. Pmcid: PMC4182374.
• Haddox CL, Han G, Anijar L, Binitie O, Letson GD, Bui MM, Reed DR. Osteosarcoma in pediatric patients and young adults: a single institution retrospective review of presentation, therapy, and outcome. Sarcoma. 2014 Jun.2014:402509. Pubmedid: 24976784. Pmcid: PMC4021746.
• Binitie O, Tejiram S, Conway S, Cheong D, Temple HT, Letson GD. Adult soft tissue sarcoma local recurrence after adjuvant treatment without resection of core needle biopsy tract. Clin Orthop Relat Res. 2013 Mar.471(3):891-898. Pubmedid: 22968531. Pmcid: PMC3563812.
• DeMattos C., Binitie O., Dormans J. . Pathological fractures in children. Bone Joint Res. 2012 Oct.1(10):272-280. Pubmedid: 23610658. Pmcid: PMC3626256.
• Binitie O, Flynn J. . Vertical Expandable Prosthetic Titanium Rib in Early-Onset Scoliosis. Semin Spine Surg. 2012 May.24(4):209-258.
• Henderson ER, Pepper AM, Marulanda G, Binitie OT, Cheong D, Letson GD. Outcome of lower-limb preservation with an expandable endoprosthesis after bone tumor resection in children. J Bone Joint Surg Am. 2012 Mar.94(6):537-547. Pubmedid: 22438003.
• Papanastassiou ID, Setzer M, Eleraky M, Baaj AA, Nam T, Binitie O, Katsares K, Cheong D, Vrionis FD. Minimally invasive sacroiliac fixation in oncologic patients with sacral insufficiency fractures using a fluoroscopy-based navigation system. J Spinal Disord Tech. 2011 Apr.24(2):76-82. Pubmedid: 20634734.
• Rosemurgy A, Binitie O, Araoutakis D, Thometz D, Giarelli N, Bloomston M, Goldin S, Albrink M. Reoperative fundoplications are effective treatment for dysphagia and recurrent gastroesophageal reflux. Am Surg. 2004 Dec.70(12):1061-1067. Pubmedid: 15663045.
• Bloomston M, Binitie O, Fraiji E, Murr M, Zervos E, Goldin S, Kudryk B, Zwiebel B, Black T, Rosemurgy A. Transcatheter arterial chemoembolization with or without radiofrequency ablation in the management of patients with advanced hepatic malignancy. Am Surg. 2002 Sep.68(9):827-831. Pubmedid: 12356160.

Title: COG NCTN Network Group Operations Center
Sponsor: Nat Institutes of Health
PI: Binitie, O.