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Luis Pena, MD, FACG, AGAF

Specialty: Gastroenterology
Program: Gastrointestinal Oncology

Call 1-888-MOFFITT

Call 1-888-MOFFITT

Locations: Moffitt Cancer Center

Dr. Peña’s clinical and research interests’ include the treatment for Barrett’s esophagus and early esophageal cancer using endoscopic mucosal resection (EMR) and mucosal ablation including radiofrequency ablation and cryoablation; endoscopic retrograde cholangiopancreatography (ERCP) for biliary and pancreatic disorders including cancer, esophageal stenting and wireless capsule endoscopy for small bowel evaluation. Additional research interests include endoscopic outcomes and capsule endoscopy.

Education & Training

Board Certification:

  • Gastroenterology
  • Internal Medicine


  • University of Kentucky - Gastroenterology


  • University of Kentucky - Internal Medicine

Medical School:

  • Francisco Marrouquin University(MD, - MD)
Participating Trials

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.


  • Song E, Segarra D, Latifi K, Leuthold S, Belinc D, Pena L, Malafa M, Frakes JM, Hoffe SE. Recognition of Tumor Invasion of a Pancreatic Head Biliary Stent During Stereotactic Body Radiation Therapy. Pract Radiat Oncol. 2019 May.9(3):132-135. Pubmedid: 30708132.
  • Setia N, Lauwers GY, Peña LR. Unearthing the significance of buried intestinal metaplasia. Gastrointest Endosc. 2018 01;87(1):75-76. Pubmedid: 29241864.
  • Saligram S, Lim D, Pena L, Friedman M, Harris C, Klapman J. Safety and feasibility of esophageal self- expandable metal stent placement without the aid of fluoroscopy. Dis Esophagus. 2017 Aug.30(8):1-6. Pubmedid: 28575246.
  • Davis-Yadley AH, Neill KG, Malafa MP, Pena LR. Advances in the Endoscopic Diagnosis of Barrett Esophagus. Cancer Control. 2016 Jan;23(1):67-77. Pubmedid: 27009460.
  • Sundar Alagusundaramoorthy S, Vilchez V, Zanni A, Sourianarayanane A, Maynard E, Shah M, Daily MF, Pena LR, Gedaly R. Role of transplantation in the treatment of benign solid tumors of the liver: a review of the United Network of Organ Sharing data set. JAMA Surg. 2015 Apr;150(4):337-342. Pubmedid: 25714928.
  • Peña LR, Horn TL, Cross CB. Acute pancreatitis secondary to hemobilia after percutaneous liver biopsy. Therap Adv Gastroenterol. 2009 May;2(3):165-168. Pubmedid: 21180542. Pmcid: PMC3002516.
  • Horn TL, Reynolds J, de Villiers W, Peña LR. Hepatitis C virus and inflammatory bowel disease. Digest Dis Sci. 2009 Jun;54(6):1171-1177. Pubmedid: 18975088.
  • Pena LR, Cox T, Koch AG, Bosch A. Study comparing oesophageal capsule endoscopy versus EGD in the detection of varices. Dig Liver Dis. 2008 Mar;40(3):216-223. Pubmedid: 18082473.
  • Knopp TC, Mardini HE, Peña LR. Wireless capsule endoscopy indication as a predictor of study quality. Digest Dis Sci. 2008 Jul;53(7):1898-1901. Pubmedid: 18034326.
  • Peña LR, Mardini H, Nickl N. An instrument to predict endoscopy tolerance: a prospective randomized study. Digest Dis Sci. 2007 Oct;52(10):2888-2891. Pubmedid: 17394063.
  • Sifford M, Koch A, Lee E, Peña LR. Abnormal liver tests as an initial presentation of celiac disease. Digest Dis Sci. 2007 Nov;52(11):3016-3018. Pubmedid: 17530403.
  • Bosch A, Peña LR. The sphincter of oddi. Digest Dis Sci. 2007 May;52(5):1211-1218. Pubmedid: 17356921.
  • Peña LR, Mardini HE, Nickl NJ. Development of an instrument to assess and predict satisfaction and poor tolerance among patients undergoing endoscopic procedures. Digest Dis Sci. 2005 Oct;50(10):1860-1871. Pubmedid: 16187188.
  • Horn TL, Peña LR. Subcapsular hepatic hematoma after ERCP: case report and review. Gastrointest Endosc. 2004 Apr;59(4):594-596. Pubmedid: 15044910.
  • Peña LR, Nand S, De Maria N, Van Thiel DH. Hepatitis C virus infection and lymphoproliferative disorders. Digest Dis Sci. 2000 Sep;45(9):1854-1860. Pubmedid: 11052331.
  • Pena LR, Hill DB, McClain CJ. Treatment with glutathione precursor decreases cytokine activity. JPEN J Parenter Enteral Nutr. 1999 Jan;23(1):1-6. Pubmedid: 9888410.
  • Marsano LS, Peña LR. The interaction of alcoholic liver disease and hepatitis C. Hepatogastroenterology. 1998 Mar;45(20):331-339. Pubmedid: 9638402.
  • Shiani A, Narayanan S, Pena L, Friedman M. The Role of Diagnosis and Treatment of Underlying Liver Disease for the Prognosis of Primary Liver Cancer. Cancer Control. 24(3):1073274817729240. Pubmedid: 28975833. Pmcid: PMC5937237.
  • Lopez C, Abuel-Haija M, Pena L, Coppola D. Novel Germline Mutation Associated with Cowden Syndrome and Osteosarcoma. Cancer Genomics Proteomics. 15(2):115-120. Pubmedid: 29496690. Pmcid: PMC5892603.