Dr. Song is board certified in anatomic pathology, surgical pathology, and hematopathology. His specialty is the diagnosis of acute and chronic leukemia, lymphoma, and other benign or malignant hematopoietic disorders. His expertise includes evaluation and interpretation of peripheral blood smears, bone marrow biopsies, lymphoid and non-lymphoid tissues, flow cytometry, molecular pathology especially NextGen sequencing, and cytogenetics. Dr. Song’s research interest is personized medicine, the use of gene mutations and cytogenetic abnormalities for the diagnosis, and the prediction of prognosis and treatment responses in patients with hematopoietic disorders. Dr Song’s interest also includes identification of alternative indications for late stage compounds or drugs.
Education & Training
Anatomic Pathology & Clinical Pathology
Tianjin Medical University - Cardiology
University of Maryland at College Park -
The Institute for Genomic Research - Bioinformatics
Thomas Jefferson University Hospital - Hematopathology
Hahneman University Hospital, Drexel University - Pathology
Su J, Han J, Song J. A benchmark bone marrow aspirate smear dataset and a multi-scale cell detection model for the diagnosis of hematological disorders. Comput Med Imag Grap. 2021 Jun.90:101912. Pubmedid: 33892388.
Swoboda DM, Ali NA, Chan O, Padron E, Kuykendall AT, Song J, Hussaini M, Talati C, Sweet K, Lancet JE, Sallman DA, Komrokji RS. PTPN11 mutations are associated with poor outcomes across myeloid malignancies. Leukemia. 2021 Jan.35(1):286-288. Pubmedid: 33132383.
Gesiotto QJ, Swoboda DM, Shallis RM, Al Ali N, Padron E, Kuykendall AT, Song J, Talati C, Sweet K, Lancet JE, Zeidan AM, Komrokji RS, Sallman DA. Evaluating Predictors of Immune-Related Adverse Events and Response to Checkpoint Inhibitors in Myeloid Malignancies. Clin Lymphoma Myeloma Leuk. 2021 Jan. Pubmedid: 33583730.
Yun S, Geyer SM, Komrokji RS, Al Ali NH, Song J, Hussaini M, Sweet KL, Lancet JE, List AF, Padron E, Sallman DA. Prognostic significance of serial molecular annotation in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML). Leukemia. 2021 Apr.35(4):1145-1155. Pubmedid: 32728186. Pmcid: PMC7854836.
Song J, Liu K, Pinilla-Ibarz J, Zhang H. A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation. Leuk Res Rep. 2020 Sep.14:100222. Pubmedid: 33072512. Pmcid: PMC7549112.
Song J, Hussaini M. Adopting solutions for annotation and reporting of next generation sequencing in clinical practice. Pract Lab Med. 2020 Mar.19:e00154. Pubmedid: 32099889. Pmcid: PMC7031307.
Badar T, Szabo A, Sallman D, Komrokji R, Lancet J, Padron E, Song J, Hussaini MO. Interrogation of molecular profiles can help in differentiating between MDS and AML with MDS-related changes. Leuk Lymphoma. 2020 Jun.61(6):1418-1427. Pubmedid: 32013644.
Nguyen L, Zhang X, Roberts E, Yun S, McGraw K, Abraham I, Song J, Braswell D, Qin D, Sallman DA, Lancet JE, List AF, Moscinski LC, Padron E, Zhang L. Comparison of mutational profiles and clinical outcomes in patients with acute myeloid leukemia with mutated RUNX1 versus acute myeloid leukemia with myelodysplasia-related changes with mutated RUNX1. Leuk Lymphoma. 2020 Jun.61(6):1395-1405. Pubmedid: 32091281. Pmcid: PMC7269833.
Song J, Hussaini M, Qin D, Zhang X, Shao H, Zhang L, Gajzer D, Basra P, Moscinski L, Zhang H. Comparison of SF3B1/DNMT3A Comutations With DNMT3A or SF3B1 Mutation Alone in Myelodysplastic Syndrome and Clonal Cytopenia of Undetermined Significance. Am J Clin Pathol. 2020 Jun.154(1):48-56. Pubmedid: 32112088.
Zhang Y, Song J, Rutenberg D, Sokol L. Hepatic Infiltration with Malignant T-cells Manifesting as Impending Acute Liver Failure in Sezary Syndrome. Mediterr J Hematol Infect Dis. 2020 Jan.12(1):e2020007. Pubmedid: 31934317. Pmcid: PMC6951350.
Shao H, Wang W, Song J, Tang G, Zhang X, Tang Z, Srivastava J, Shah B, Medeiros LJ, Zhang L. Myeloid/lymphoid neoplasms with eosinophilia and FLT3 rearrangement. Leuk Res. 2020 Dec.99:106460. Pubmedid: 33166908.
Badaat I, Mirza S, Padron E, Sallman D, Komrokji R, Song J, Hussaini MO. Concurrent mutations in other epigenetic modulators portend better prognosis in BCOR-mutated myelodysplastic syndrome. J Clin Pathol. 2020 Apr.73(4):209-212. Pubmedid: 31771970.
Mirza AS, Horna P, Teer JK, Song J, Akabari R, Hussaini M, Sokol L. New Insights Into the Complex Mutational Landscape of Sézary Syndrome. Front Oncol. 2020 Apr.10:514. Pubmedid: 32373524. Pmcid: PMC7186303.
Hashmi H, Bachmeier C, Chavez JC, Song J, Hussaini M, Krivenko G, Nishihori T, Kotani H, Davila ML, Locke FL, Jain MD. Haemophagocytic lymphohistiocytosis has variable time to onset following CD19 chimeric antigen receptor T cell therapy. Brit J Haematol. 2019 Oct.187(2):e35-e38. Pubmedid: 31410842.
Song J, Moscinski L, Zhang H, Zhang X, Hussaini M. Does SF3B1/TET2 Double Mutation Portend Better or Worse Prognosis Than Isolated SF3B1 or TET2 Mutation?. Cancer Genomics Proteomics. 2019 Jan.16(1):91-98. Pubmedid: 30587503. Pmcid: PMC6348401.
McGraw KL, Nguyen J, Al Ali NH, Komrokji RS, Sallman D, Zhang X, Song J, Padron E, Lancet JE, Moscinski LC, List AF, Zhang L. Association of EZH2 protein expression by immunohistochemistry in myelodysplasia related neoplasms with mutation status, cytogenetics and clinical outcomes. Brit J Haematol. 2019 Feb.184(3):450-455. Pubmedid: 29359794. Pmcid: PMC7771337.
Hussaini MO, Mirza AS, Komrokji R, Lancet J, Padron E, Song J. Genetic Landscape of Acute Myeloid Leukemia Interrogated by Next-generation Sequencing: A Large Cancer Center Experience. Cancer Genomics Proteomics. 2018 Mar.15(2):121-126. Pubmedid: 29496691. Pmcid: PMC5892606.
Song J, Hussaini M, Zhang H, Shao H, Qin D, Zhang X, Ma Z, Hussnain Naqvi SM, Zhang L, Moscinski LC. Comparison of the Mutational Profiles of Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis. Am J Clin Pathol. 2017 May.147(5):444-452. Pubmedid: 28419183. Pmcid: PMC5402718.
Silva AS, Silva MC, Sudalagunta P, Distler AI, Jacobson T, Collins A, Nguyen T, Song J, Chen DT, Chen L, Cubitt CL, Baz R, Perez L, Rebatchouk D, Dalton W, Greene J, Gatenby RA, Gillies RJ, Sontag E, Meads MB, Shain K. An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma. Cancer Res. 2017 Jun.77(12):3336-3351. Pubmedid: 28400475. Pmcid: PMC7819642.
Zhang J, Kong G, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson K, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick E, Zhong X, Padron E, Zhang J. p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood. 2017 Jan.129(3):358-370. Pubmedid: 27815262. Pmcid: PMC5248933.
Su J, Liu S, Song J. A segmentation method based on HMRF for the aided diagnosis of acute myeloid leukemia. Comput Methods Programs Biomed. 2017 Dec.152:115-123. Pubmedid: 29054251.
Sallman DA, Komrokji R, Cluzeau T, Vaupel C, Al Ali NH, Lancet J, Hall J, List A, Padron E, Song J. ASXL1 frameshift mutations drive inferior outcomes in CMML without negative impact in MDS. Blood Cancer J. 2017 11.7(12):633. Pubmedid: 29176559. Pmcid: PMC5802523.
Su J, Xu X, He Y, Song J. Automatic Detection of Cervical Cancer Cells by a Two-Level Cascade Classification System. Anal Cell Pathol (Amst). 2016 Dec.2016:9535027. Pubmedid: 27298758. Pmcid: PMC4889791.
Nishihori T, Song J, Shain KH. Minimal Residual Disease Assessment in the Context of Multiple Myeloma Treatment. Curr Hematol Malig Rep. 2016 Apr.11(2):118-126. Pubmedid: 26898557. Pmcid: PMC4819726.
Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem. 2015 Nov.290(45):27014. Pubmedid: 26546693. Pmcid: PMC4646378.
Song J, Shao H. SNP Array in Hematopoietic Neoplasms: A Review. Microarrays (Basel). 2015 Dec.5(1). Pubmedid: 27600067. Pmcid: PMC5003446.
Gulati G, Song J, Florea AD, Gong J. Purpose and criteria for blood smear scan, blood smear examination, and blood smear review. Ann Lab Med. 2013 Jan.33(1):1-7. Pubmedid: 23301216. Pmcid: PMC3535191.
El-Sayed NM, Ghedin E, Song J, MacLeod A, Bringaud F, Larkin C, Wanless D, Peterson J, Hou L, Taylor S, Tweedie A, Biteau N, Khalak HG, Lin X, Mason T, Hannick L, Caler E, Blandin G, Bartholomeu D, Simpson AJ, Kaul S, Zhao H, Pai G, Van Aken S, Utterback T, Haas B, Koo HL, Umayam L, Suh B, Gerrard C, Leech V, Qi R, Zhou S, Schwartz D, Feldblyum T, Salzberg S, Tait A, Turner CM, Ullu E, White O, Melville S, Adams MD, Fraser CM, Donelson JE. The sequence and analysis of Trypanosoma brucei chromosome II. Nucleic Acids Res. 2003 Aug.31(16):4856-4863. Pubmedid: 12907728. Pmcid: PMC169936.
Song J, Melera PW. Further characterization of the sixth transmembrane domain of Pgp1 by site-directed mutagenesis. Cancer Chemother Pharmacol. 2001 Nov.48(5):339-346. Pubmedid: 11761450.
Song J, Melera PW. Transmembrane domain (TM) 9 represents a novel site in P-glycoprotein that affects drug resistance and cooperates with TM6 to mediate [125I]iodoarylazidoprazosin labeling. Mol Pharmacol. 2001 Aug.60(2):254-261. Pubmedid: 11455011.
Song J, Minetti CA, Blake MS, Colombini M. Meningococcal PorA/C1, a channel that combines high conductance and high selectivity. Biophys J. 1999 Feb.76(2):804-813. Pubmedid: 9929482. Pmcid: PMC1300082.
Song J, Midson C, Blachly-Dyson E, Forte M, Colombini M. The topology of VDAC as probed by biotin modification. J Biol Chem. 1998 Sep.273(38):24406-24413. Pubmedid: 9733730.
Song J, Minetti CA, Blake MS, Colombini M. Successful recovery of the normal electrophysiological properties of PorB (class 3) porin from Neisseria meningitidis after expression in Escherichia coli and renaturation. Biochim Biophys Acta. 1998 Mar.1370(2):289-298. Pubmedid: 9545584.
Song J, Midson C, Blachly-Dyson E, Forte M, Colombini M. The sensor regions of VDAC are translocated from within the membrane to the surface during the gating processes. Biophys J. 1998 Jun.74(6):2926-2944. Pubmedid: 9635747. Pmcid: PMC1299634.
Blachly-Dyson E, Song J, Wolfgang WJ, Colombini M, Forte M. Multicopy suppressors of phenotypes resulting from the absence of yeast VDAC encode a VDAC-like protein. Mol Cell Biol. 1997 Oct.17(10):5727-5738. Pubmedid: 9315631. Pmcid: PMC232421.
Song J, Colombini M. Indications of a common folding pattern for VDAC channels from all sources. J Bioenerg Biomembr. 1996 Apr.28(2):153-161. Pubmedid: 9132414.
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