Jinming Song, MD, PhD

Cancer Focus:
Hodgkin Lymphoma, Leukemia, Multiple Myeloma-Plasma Cell Disorders, Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes (MDS), Non-Hodgkin Lymphoma

Dr. Song is board certified in anatomic pathology, surgical pathology, and hematopathology. His specialty is the diagnosis of acute and chronic leukemia, lymphoma, and other benign or malignant hematopoietic disorders. His expertise includes evaluation and interpretation of peripheral blood smears, bone marrow biopsies, lymphoid and non-lymphoid tissues, flow cytometry, molecular pathology especially NextGen sequencing, and cytogenetics. Dr. Song’s research interest is personized medicine, the use of gene mutations and cytogenetic abnormalities for the diagnosis, and the prediction of prognosis and treatment responses in patients with hematopoietic disorders. Dr Song’s interest also includes identification of alternative indications for late stage compounds or drugs. 

Education & Training

Fellowship:

• Tianjin Medical University - Cardiology
• University of Maryland at College Park -
• The Institute for Genomic Research - Bioinformatics
• Thomas Jefferson University Hospital - Hematopathology

Residency:

• Hahneman University Hospital, Drexel University - Pathology

Medical School:

• Beijing Medical University - MD

• Meads MB, Zhao X, Noyes DR, Sudalagunta P, Achille A, Zhang C, Renatino Canevarolo R, Silva M, Magaletti D, DeAvila D, Toska S, Oates A, Lastorino D, Idiaquez DW, Song J, Sansil S, Yoder SJ, Grajales-Cruz AF, Blue BJ, Freeman CL, Kim J, Alsina M, Brayer J, Siqueira Silva A, Song X, Shain KH, Baz RC. Target antigen and plasma cell phenotype are critical factors for sensitivity to response-adapted daratumumab therapy. Blood. 2025 Sep. Pubmedid: 40983035.
• Karapetyan L, Kuriakose J, Perez MC, Ali JR, Hall MS, Beatty MS, Otteni CD, Xu J, Kalos D, Moran-Segura C, Vieira E, Adams K, Rodriguez-Alfonso L, DiMaggio EC, Bailey H, Pinilla-Ibarz J, Locke FL, Mullinax JE, Chen PL, Song J, Messina JL, Johnson DB, Morgan DS, Eroglu Z, Khushalani NI, Sondak VK, Sarnaik AA, Tsai K, Mulé JJ, Pilon-Thomas S. Case Report: Durable response to tumor-infiltrating lymphocyte therapy in a patient with metastatic melanoma and chronic lymphocytic leukemia/small lymphocytic lymphoma. Front Immunol. 2025 Nov.16:1718443. Pubmedid: 41333460. Pmcid: PMC12665918.
• Wang L, Li J, Arbitman L, Zhang H, Shao H, Martin M, Moscinski L, Song J. Current Advances in the Diagnosis and Treatment of Major Myeloproliferative Neoplasms. Cancers (Basel). 2025 May.17(11). Pubmedid: 40507313. Pmcid: PMC12153907.
• Henning JE, Nishihori T, Freeman C, Lazarides A, Song J, Kuruvilla D, Feuerlein S, Costello JR. Whole-body MRI for a patient with progressive multiple myeloma. BJR Case Rep. 2025 May.11(3):uaaf028. Pubmedid: 40386466. Pmcid: PMC12085220.
• Cockey SG, Zhang H, Hussaini M, Zhang L, Moscinski L, Yang E, Li J, Wang L, Song J. Molecular landscape and clinical outcome of SRSF2/TET2 Co-mutated myeloid neoplasms. Leuk Lymphoma. 2025 Mar.66(3):469-478. Pubmedid: 39611281.
• Shao R, Wang L, Zhang H, Martin M, Moscinski L, Li A, Li J, Song J. Comparison of the clinicopathological features in myeloproliferative or myelodysplastic neoplasms with SF3B1/JAK2, SF3B1/CALR, or SF3B1/MPL co-mutations. Leuk Lymphoma. 2025 Dec.66(13):2518-2527. Pubmedid: 41074577.
• Chen T, Hughes J, Gregory A, Conroy J, Loughran P, Song J, Chen W, Billiar T. Single-cell transcriptomic analysis identified resistant MDSCs and a stress-tolerant gene co-expression network as common MDSC features across multiple disease settings. Front Immunol. 2025 Apr.16:1565211. Pubmedid: 40264770. Pmcid: PMC12011849.
• Gravenmier C, Song J, Shao H. Implicit Flow Cytometric Diagnosis of Classic Hodgkin Lymphoma Using CD3+CD4+CD26- T-Cells. J Clin Lab Anal. 2024 Sep.38(17-18):e25096. Pubmedid: 39235202. Pmcid: PMC11484709.
• Wang J, Zhang W, Xu X, Buglioni A, Li P, Chen X, Liu Y, Xu M, Herrick JL, Horna P, Zhang X, Song J, Jevremovic D, He R, Shi M, Yuan J. Clinicopathologic features and outcomes of acute leukemia harboring PICALM::MLLT10 fusion. Hum Pathol. 2024 Sep.151:105626. Pubmedid: 38971327.
• Fortuna GG, Banerjee R, Savid-Frontera C, Song J, Morán-Segura CM, Nguyen JV, Lekakis L, Fernandez-Pol S, Samraj AN, Naresh KN, Vazquez-Martinez M, Baz RC, Spiegel JY, Mikkilineni L, Gubatan JM, Sidana S, de Menezes Silva Corraes A, Kalariya NM, Patel KK, Shim KG, Fonseca R, Ferreri C, Voorhees PM, Richard S, Valdes CR, Sireesha Asoori, Wolf JL, Cowan AJ, Sborov DW, Locke FL, Lin Y, Wang Y, Hansen DK. Immune effector cell-associated enterocolitis following chimeric antigen receptor T-cell therapy in multiple myeloma. Blood Cancer J. 2024 Oct.14(1):180. Pubmedid: 39414769. Pmcid: PMC11484697.
• Chan O, Al Ali NH, Tashkandi H, Ellis A, Ball S, Grenet J, Hana C, Deutsch Y, Zhang L, Hussaini MO, Song J, Yun S, Talati C, Kuykendall AT, Padron E, Walker AR, Roboz GJ, Desai P, Sallman DA, Sweet KL, Komrokji RS, Lancet JE. Mutations highly specific for secondary AML are associated with poor outcomes in ELN favorable risk NPM1-mutated AML. Blood Adv. 2024 Mar.8(5):1075-1083. Pubmedid: 38170740. Pmcid: PMC10907389.
• Dong N, Zhang H, Song J, Mammadova J, Shah B, Saeed H, Gaballa S, Grajales-Cruz A, Isenalumhe L, Bello C, Sokol L, Pinilla J, Chavez J. B-cell maturation antigen expression and clinical features of plasmablastic lymphoma. EJHaem. 2024 Feb.5(1):285-289. Pubmedid: 38406544. Pmcid: PMC10887266.
• Su J, Liu Y, Zhang J, Han J, Song J. CDC-NET: a cell detection and confirmation network of bone marrow aspirate images for the aided diagnosis of AML. Med Biol Eng Comput. 2024 Feb.62(2):575-589. Pubmedid: 37953336.
• Su J, Wang Y, Zhang J, Niu S, Han J, Xing L, Song J. ROI-BMC-DNNet: An efficient automatic analysis model of whole-slide scanned bone marrow aspirate images for the diagnosis of hematological disorders. Biomed Signal Process Control. 2023 Sep.86(Part B).
• Li JY, Ryder CB, Zhang H, Cockey SG, Hyjek E, Moscinski LC, Sagatys E, Song J. Review and Updates on Systemic Mastocytosis and Related Entities. Cancers (Basel). 2023 Nov.15(23). Pubmedid: 38067330.
• Song J, Moscinski L, Yang E, Shao H, Hussaini M, Zhang H. Co-mutation of ASXL1 and SF3B1 Predicts Poorer Overall Survival Than Isolated ASXL1 or SF3B1 Mutations. In Vivo. 2023 May.37(3):985-993. Pubmedid: 37103105. Pmcid: PMC10188047.
• Zhang L, Shah B, Zhang Y, Tashkandi H, Xiao W, Fernandez-Pol S, Vergara-Lluri M, Hussaini M, Song J, Lancet J, Moscinski L, Yun S, Lu CM, Medeiros LJ, Tang G. Clinicopathologic characteristics, genetic features, and treatment options for acute lymphoblastic leukemia with JAK2 rearrangement-A 10-case study and literature review. Hum Pathol. 2023 Jun.136:1-15. Pubmedid: 36958463.
• Song J, Moscinski L, Zhang L, Zhang H. Case report: Co-existing chronic myeloid leukemia and chronic myelomonocytic leukemia-A clinically important but challenging scenario. Leuk Res Rep. 2023 Jun.20:100378. Pubmedid: 37415731. Pmcid: PMC10319893.
• Nakanishi S, Li J, Berglund AE, Kim Y, Zhang Y, Zhang L, Yang C, Song J, Mirmira RG, Cleveland JL. The Polyamine-Hypusine Circuit Controls an Oncogenic Translational Program Essential for Malignant Conversion in MYC-Driven Lymphoma. Blood Cancer Discov. 2023 Jul.4(4):294-317. Pubmedid: 37070973. Pmcid: PMC10320645.
• Song J, Zhang H, Dong N, Zhang X, Hussaini M, Jain A, Moscinski L, Shain K, Baz R, Alsina M, Nishihori T, Zhang L. The Application of NextGen Sequencing in the Diagnosis of Myeloid Neoplasms in Myeloma Patients With Cytopenia. Clin Lymphoma Myeloma Leuk. 2022 Jun.22(6):e414-e426. Pubmedid: 34998786.
• Swoboda DM, Kanagal-Shamanna R, Brunner AM, Cluzeau T, Chan O, Al Ali N, Montalban-Bravo G, Gesiotto QJ, Gavralidis A, Hunter AM, Lee JH, Kuykendall AT, Talati C, Sweet KL, Lancet JE, Padron E, Hussaini M, Song J, Garcia-Manero G, Komrokji RS, Sallman DA. Marrow ring sideroblasts are highly predictive for TP53 mutation in MDS with excess blasts. Leukemia. 2022 Apr.36(4):1189-1192. Pubmedid: 34975158.
• Gesiotto QJ, Swoboda DM, Shallis RM, Al Ali N, Padron E, Kuykendall AT, Song J, Talati C, Sweet K, Lancet JE, Zeidan AM, Komrokji RS, Sallman DA. Evaluating Predictors of Immune-Related Adverse Events and Response to Checkpoint Inhibitors in Myeloid Malignancies. Clin Lymphoma Myeloma Leuk. 2021 Jun.21(6):421-424.e2. Pubmedid: 33583730.
• Su J, Han J, Song J. A benchmark bone marrow aspirate smear dataset and a multi-scale cell detection model for the diagnosis of hematological disorders. Comput Med Imag Grap. 2021 Jun.90:101912. Pubmedid: 33892388.
• Swoboda DM, Ali NA, Chan O, Padron E, Kuykendall AT, Song J, Hussaini M, Talati C, Sweet K, Lancet JE, Sallman DA, Komrokji RS. PTPN11 mutations are associated with poor outcomes across myeloid malignancies. Leukemia. 2021 Jan.35(1):286-288. Pubmedid: 33132383.
• Lee K, Evans MG, Yang L, Ng S, Snowden C, Khodadoust MS, Brown RA, Trum NA, Querfeld C, Doan LT, Song J, Zhang H, Gru A, Wood GS, Wada DA, Shanmugam V, Haun PL, Aster JC, Duncan LM, Guitart J, Weinstock DM, Nardi V, Choi J. Primary cytotoxic T-cell lymphomas harbor recurrent targetable alterations in the JAK-STAT pathway. Blood. 2021 Dec.138(23):2435-2440. Pubmedid: 34432866. Pmcid: PMC8662071.
• Yun S, Geyer SM, Komrokji RS, Al Ali NH, Song J, Hussaini M, Sweet KL, Lancet JE, List AF, Padron E, Sallman DA. Prognostic significance of serial molecular annotation in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML). Leukemia. 2021 Apr.35(4):1145-1155. Pubmedid: 32728186. Pmcid: PMC7854836.
• Song J, Liu K, Pinilla-Ibarz J, Zhang H. A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation. Leuk Res Rep. 2020 Sep.14:100222. Pubmedid: 33072512. Pmcid: PMC7549112.
• Song J, Hussaini M. Adopting solutions for annotation and reporting of next generation sequencing in clinical practice. Pract Lab Med. 2020 Mar.19:e00154. Pubmedid: 32099889. Pmcid: PMC7031307.
• Nguyen L, Zhang X, Roberts E, Yun S, McGraw K, Abraham I, Song J, Braswell D, Qin D, Sallman DA, Lancet JE, List AF, Moscinski LC, Padron E, Zhang L. Comparison of mutational profiles and clinical outcomes in patients with acute myeloid leukemia with mutated RUNX1 versus acute myeloid leukemia with myelodysplasia-related changes with mutated RUNX1. Leuk Lymphoma. 2020 Jun.61(6):1395-1405. Pubmedid: 32091281. Pmcid: PMC7269833.
• Song J, Hussaini M, Qin D, Zhang X, Shao H, Zhang L, Gajzer D, Basra P, Moscinski L, Zhang H. Comparison of SF3B1/DNMT3A Comutations With DNMT3A or SF3B1 Mutation Alone in Myelodysplastic Syndrome and Clonal Cytopenia of Undetermined Significance. Am J Clin Pathol. 2020 Jun.154(1):48-56. Pubmedid: 32112088.
• Badar T, Szabo A, Sallman D, Komrokji R, Lancet J, Padron E, Song J, Hussaini MO. Interrogation of molecular profiles can help in differentiating between MDS and AML with MDS-related changes. Leuk Lymphoma. 2020 Jun.61(6):1418-1427. Pubmedid: 32013644.
• Zhang Y, Song J, Rutenberg D, Sokol L. Hepatic Infiltration with Malignant T-cells Manifesting as Impending Acute Liver Failure in Sezary Syndrome. Mediterr J Hematol Infect Dis. 2020 Jan.12(1):e2020007. Pubmedid: 31934317. Pmcid: PMC6951350.
• Shao H, Wang W, Song J, Tang G, Zhang X, Tang Z, Srivastava J, Shah B, Medeiros LJ, Zhang L. Myeloid/lymphoid neoplasms with eosinophilia and FLT3 rearrangement. Leuk Res. 2020 Dec.99:106460. Pubmedid: 33166908.
• Mirza AS, Horna P, Teer JK, Song J, Akabari R, Hussaini M, Sokol L. New Insights Into the Complex Mutational Landscape of Sézary Syndrome. Front Oncol. 2020 Apr.10:514. Pubmedid: 32373524. Pmcid: PMC7186303.
• Badaat I, Mirza S, Padron E, Sallman D, Komrokji R, Song J, Hussaini MO. Concurrent mutations in other epigenetic modulators portend better prognosis in BCOR-mutated myelodysplastic syndrome. J Clin Pathol. 2020 Apr.73(4):209-212. Pubmedid: 31771970.
• Hashmi H, Bachmeier C, Chavez JC, Song J, Hussaini M, Krivenko G, Nishihori T, Kotani H, Davila ML, Locke FL, Jain MD. Haemophagocytic lymphohistiocytosis has variable time to onset following CD19 chimeric antigen receptor T cell therapy. Brit J Haematol. 2019 Oct.187(2):e35-e38. Pubmedid: 31410842.
• Song J, Moscinski L, Zhang H, Zhang X, Hussaini M. Does SF3B1/TET2 Double Mutation Portend Better or Worse Prognosis Than Isolated SF3B1 or TET2 Mutation?. Cancer Genomics Proteomics. 2019 Jan.16(1):91-98. Pubmedid: 30587503. Pmcid: PMC6348401.
• McGraw KL, Nguyen J, Al Ali NH, Komrokji RS, Sallman D, Zhang X, Song J, Padron E, Lancet JE, Moscinski LC, List AF, Zhang L. Association of EZH2 protein expression by immunohistochemistry in myelodysplasia related neoplasms with mutation status, cytogenetics and clinical outcomes. Brit J Haematol. 2019 Feb.184(3):450-455. Pubmedid: 29359794. Pmcid: PMC7771337.
• Hussaini MO, Mirza AS, Komrokji R, Lancet J, Padron E, Song J. Genetic Landscape of Acute Myeloid Leukemia Interrogated by Next-generation Sequencing: A Large Cancer Center Experience. Cancer Genomics Proteomics. 2018 Mar.15(2):121-126. Pubmedid: 29496691. Pmcid: PMC5892606.
• Song J, Hussaini M, Zhang H, Shao H, Qin D, Zhang X, Ma Z, Hussnain Naqvi SM, Zhang L, Moscinski LC. Comparison of the Mutational Profiles of Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis. Am J Clin Pathol. 2017 May.147(5):444-452. Pubmedid: 28419183. Pmcid: PMC5402718.
• Silva AS, Silva MC, Sudalagunta P, Distler AI, Jacobson T, Collins A, Nguyen T, Song J, Chen DT, Chen L, Cubitt CL, Baz R, Perez L, Rebatchouk D, Dalton W, Greene J, Gatenby RA, Gillies RJ, Sontag E, Meads MB, Shain K. An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma. Cancer Res. 2017 Jun.77(12):3336-3351. Pubmedid: 28400475. Pmcid: PMC7819642.
• Zhang J, Kong G, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson K, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick E, Zhong X, Padron E, Zhang J. p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood. 2017 Jan.129(3):358-370. Pubmedid: 27815262. Pmcid: PMC5248933.
• Su J, Liu S, Song J. A segmentation method based on HMRF for the aided diagnosis of acute myeloid leukemia. Comput Methods Programs Biomed. 2017 Dec.152:115-123. Pubmedid: 29054251.
• Sallman DA, Komrokji R, Cluzeau T, Vaupel C, Al Ali NH, Lancet J, Hall J, List A, Padron E, Song J. ASXL1 frameshift mutations drive inferior outcomes in CMML without negative impact in MDS. Blood Cancer J. 2017 11.7(12):633. Pubmedid: 29176559. Pmcid: PMC5802523.
• Su J, Xu X, He Y, Song J. Automatic Detection of Cervical Cancer Cells by a Two-Level Cascade Classification System. Anal Cell Pathol (Amst). 2016 Dec.2016:9535027. Pubmedid: 27298758. Pmcid: PMC4889791.
• Nishihori T, Song J, Shain KH. Minimal Residual Disease Assessment in the Context of Multiple Myeloma Treatment. Curr Hematol Malig Rep. 2016 Apr.11(2):118-126. Pubmedid: 26898557. Pmcid: PMC4819726.
• Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem. 2015 Nov.290(45):27014. Pubmedid: 26546693. Pmcid: PMC4646378.
• Song J, Shao H. SNP Array in Hematopoietic Neoplasms: A Review. Microarrays (Basel). 2015 Dec.5(1). Pubmedid: 27600067. Pmcid: PMC5003446.
• Gulati G, Song J, Florea AD, Gong J. Purpose and criteria for blood smear scan, blood smear examination, and blood smear review. Ann Lab Med. 2013 Jan.33(1):1-7. Pubmedid: 23301216. Pmcid: PMC3535191.
• El-Sayed NM, Ghedin E, Song J, MacLeod A, Bringaud F, Larkin C, Wanless D, Peterson J, Hou L, Taylor S, Tweedie A, Biteau N, Khalak HG, Lin X, Mason T, Hannick L, Caler E, Blandin G, Bartholomeu D, Simpson AJ, Kaul S, Zhao H, Pai G, Van Aken S, Utterback T, Haas B, Koo HL, Umayam L, Suh B, Gerrard C, Leech V, Qi R, Zhou S, Schwartz D, Feldblyum T, Salzberg S, Tait A, Turner CM, Ullu E, White O, Melville S, Adams MD, Fraser CM, Donelson JE. The sequence and analysis of Trypanosoma brucei chromosome II. Nucleic Acids Res. 2003 Aug.31(16):4856-4863. Pubmedid: 12907728. Pmcid: PMC169936.
• Song J, Melera PW. Further characterization of the sixth transmembrane domain of Pgp1 by site-directed mutagenesis. Cancer Chemother Pharmacol. 2001 Nov.48(5):339-346. Pubmedid: 11761450.
• Song J, Melera PW. Transmembrane domain (TM) 9 represents a novel site in P-glycoprotein that affects drug resistance and cooperates with TM6 to mediate [125I]iodoarylazidoprazosin labeling. Mol Pharmacol. 2001 Aug.60(2):254-261. Pubmedid: 11455011.
• Song J, Minetti CA, Blake MS, Colombini M. Meningococcal PorA/C1, a channel that combines high conductance and high selectivity. Biophys J. 1999 Feb.76(2):804-813. Pubmedid: 9929482. Pmcid: PMC1300082.
• Song J, Midson C, Blachly-Dyson E, Forte M, Colombini M. The topology of VDAC as probed by biotin modification. J Biol Chem. 1998 Sep.273(38):24406-24413. Pubmedid: 9733730.
• Song J, Minetti CA, Blake MS, Colombini M. Successful recovery of the normal electrophysiological properties of PorB (class 3) porin from Neisseria meningitidis after expression in Escherichia coli and renaturation. Biochim Biophys Acta. 1998 Mar.1370(2):289-298. Pubmedid: 9545584.
• Song J, Midson C, Blachly-Dyson E, Forte M, Colombini M. The sensor regions of VDAC are translocated from within the membrane to the surface during the gating processes. Biophys J. 1998 Jun.74(6):2926-2944. Pubmedid: 9635747. Pmcid: PMC1299634.
• Blachly-Dyson E, Song J, Wolfgang WJ, Colombini M, Forte M. Multicopy suppressors of phenotypes resulting from the absence of yeast VDAC encode a VDAC-like protein. Mol Cell Biol. 1997 Oct.17(10):5727-5738. Pubmedid: 9315631. Pmcid: PMC232421.
• Song J, Colombini M. Indications of a common folding pattern for VDAC channels from all sources. J Bioenerg Biomembr. 1996 Apr.28(2):153-161. Pubmedid: 9132414.