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Jason B. Klapman, MD, FASGE


Specialty: Gastroenterology
Program: Gastrointestinal Oncology

Call 1-888-MOFFITT
(1-888-663-3488)

or call 1-888-MOFFITT
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Overview

Dr. Jason Klapman is a gastroenterologist and Medical Director of Endoscopy in the Gastrointestinal Oncology Department at Moffitt Cancer Center.  He is an associate professor of oncology at the University of South Florida College of Medicine. Dr. Klapman received his medical degree from Finch University of Health Sciences/The Chicago Medical School.  He completed a residency in internal medicine at Rush University, Rush-Presbyterian-St. Luke’s Medical Center, where he was chief resident his last year. Dr. Klapman pursued additional training through a gastroenterology fellowship at the University of Chicago and an interventional endoscopy fellowship at the University of California at Irvine Medical Center. His clinical interests center around the diagnosis, staging and treatment of gastrointestinal malignancies with a focus on pancreatic cancer using advanced endoscopic procedures such as endoscopic ultrasound and ERCP. He is a nationally recognized gastroenterologist and researcher and has been invited faculty or course director for multiple educational and hands-on courses around the country focusing on education and training in gastroenterological procedures. Dr. Klapman performs clinical endoscopic research focusing on improving the diagnosis and treatment of a multitude of precancerous and cancerous gastrointestinal conditions. Dr. Klapman along with 4 of his colleagues from around the country have formed a research collaborative group called Mucin (mucingroup.com) whose purpose is to perform multicenter trials with this gastrointestinal endoscopy focus. This group has already generated multiple publications and research presentations at national meetings. Dr. Klapman’s research interests include early detection and screening of pancreatic cancer in high-risk individuals. He currently has an ongoing clinical trial enrolling patients at high-risk. He is also currently enrolling patients to compare two types of needles that place gold markers which are used to guide radiation in patients with pancreas cancer. Dr. Klapman is widely published, including peer-reviewed journals, book chapters and educational DVDs.  

Education & Training

Board Certification:

  • Gastroenterology

Fellowship:

  • University Chicago Hospital, Chicago, IL - Gastroenterology
  • University of California at Irvine Medical Center, Orange, CA - Interventional Endoscopy

Residency:

  • Rush Presbyterian St. Luke's Medical Center, Chicago, IL - Internal Medicine
  • Rush Presbyterian St. Luke's Medical Center, Chicago, IL - Internal Medicine

Medical School:

  • Finch University of Health Sciences/The Chicago Medical School - MD
Participating Trials

CLINICAL TRIAL 14882
Protocol for High-Risk Assessment, Screening, and Early Detection of Pancreatic Cancer at Moffitt Cancer Center
Condition: Gastrointestinal Tumor
Intervention:
Open

CLINICAL TRIAL 18941
Preoperative Extended Chemotherapy vs. Chemotherapy Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Head of the Pancreas
Condition: Gastrointestinal Tumor
Intervention: FOLFIRINOX; FOLFOX
Open

If you believe you are eligible for one of these trials or studies, please call
1-888-MOFFITT (1-888-663-3488).

Publications

  • Permuth JB, Chen DT, Yoder SJ, Li J, Smith AT, Choi JW, Kim J, Balagurunathan Y, Jiang K, Coppola D, Centeno BA, Klapman J, Hodul P, Karreth FA, Trevino JG, Merchant N, Magliocco A, Malafa MP, Gillies R. Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas. Sci Rep. 2017 Sep;7(1):10484. Pubmedid: 28874676. Pmcid: PMC5585319.
  • Bledsoe JR, Wallace ZS, Deshpande V, Richter JR, Klapman J, Cowan A, Stone JH, Ferry JA. Atypical IgG4+ Plasmacytic Proliferations and Lymphomas: Characterization of 11 Cases. Am J Clin Pathol. 2017 Sep;148(3):215-235. Pubmedid: 28821195.
  • Marshall C, Mounzer R, Hall M, Simon V, Centeno B, Dennis K, Dhillon J, Fan F, Khazai L, Klapman J, Komanduri S, Lin X, Lu D, Mehrotra S, Muthusamy VR, Nayar R, Paintal A, Rao J, Sams S, Shah J, Watson R, Rastogi A, Wani S. Suboptimal Interobserver Agreement Among Cytopathologists for Endoscopic Ultrasound Fine Needle Aspirates of Solid Pancreatic Lesions. Clin Gastroenterol H. 2017 Sep. Pubmedid: 28911946.
  • Oliver JA, Venkat P, Frakes JM, Klapman J, Harris C, Montilla-Soler J, Dhadham GC, Altazi BA, Zhang GG, Moros EG, Shridhar R, Hoffe SE, Latifi K. Fiducial markers coupled with 3D PET/CT offer more accurate radiation treatment delivery for locally advanced esophageal cancer. Endosc Int Open. 2017 Jun;5(6):E496-E504. Pubmedid: 28573183. Pmcid: PMC5451282.
  • Glazer ES, Rashid OM, Klapman JB, Harris CL, Hodul PJ, Pimiento JM, Malafa MP. Endoscopic ultrasonography complements computed tomography in predicting portal or superior mesenteric vein resection in patients with borderline resectable pancreatic carcinoma. Pancreatology. 2017 Jan;17(1):130-134. Pubmedid: 28043760.
  • Lee A, Aditi A, Bhat YM, Binmoeller KF, Hamerski C, Sendino O, Kane S, Cello JP, Day LW, Mohamadnejad M, Muthusamy VR, Watson R, Klapman JB, Komanduri S, Wani S, Shah JN. Endoscopic ultrasound-guided biliary access versus precut papillotomy in patients with failed biliary cannulation: a retrospective study. Endoscopy. 2017 Feb;49(2):146-153. Pubmedid: 28107764.
  • Gohil VB, Klapman JB. Endoscopic Palliation of Pancreatic Cancer. Curr Treat Options Gastroenterol. 2017 Aug. Pubmedid: 28795293.
  • Watson RR, Klapman J, Komanduri S, Shah JN, Wani S, Muthusamy R. Wide disparities in attitudes and practices regarding Type II sphincter of Oddi dysfunction: a survey of expert U.S. endoscopists. Endosc Int Open. 2016 Sep;4(9):E941-E946. Pubmedid: 27652298. Pmcid: PMC5025319.
  • Aadam AA, Wani S, Amick A, Shah JN, Bhat YM, Hamerski CM, Klapman JB, Muthusamy VR, Watson RR, Rademaker AW, Keswani RN, Keefer L, Das A, Komanduri S. A randomized controlled cross-over trial and cost analysis comparing endoscopic ultrasound fine needle aspiration and fine needle biopsy. Endosc Int Open. 2016 May;4(5):E497-E505. Pubmedid: 27227104. Pmcid: PMC4874800.
  • Korrapati P, Ciolino J, Wani S, Shah J, Watson R, Muthusamy VR, Klapman J, Komanduri S. The efficacy of peroral cholangioscopy for difficult bile duct stones and indeterminate strictures: a systematic review and meta-analysis. Endosc Int Open. 2016 Mar;4(3):E263-E275. Pubmedid: 27004242. Pmcid: PMC4798839.
  • Dhadham GC, Hoffe S, Harris CL, Klapman JB. Endoscopic ultrasound-guided fiducial marker placement for image-guided radiation therapy without fluoroscopy: safety and technical feasibility. Endosc Int Open. 2016 Mar;4(3):E378-E382. Pubmedid: 27004258. Pmcid: PMC4798935.
  • Kucera S, Barthel J, Klapman J, Shridhar R, Hoffe S, Harris C, Almhanna K, Meredith K. Small caliber covered self-expanding metal stents in the management of malignant dysphagia. J Gastrointest Oncol. 2016 Jun;7(3):411-419. Pubmedid: 27284474. Pmcid: PMC4880758.
  • Law R, Das A, Gregory D, Komanduri S, Muthusamy R, Rastogi A, Vargo J, Wallace MB, Raju GS, Mounzer R, Klapman J, Shah J, Watson R, Wilson R, Edmundowicz SA, Wani S. Endoscopic resection is cost-effective compared with laparoscopic resection in the management of complex colon polyps: an economic analysis. Gastrointest Endosc. 2016 Jun;83(6):1248-1257. Pubmedid: 26608129.
  • Mahipal A, Klapman J, Vignesh S, Yang CS, Neuger A, Chen DT, Malafa MP. Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites. Cancer Chemother Pharmacol. 2016 Jul;78(1):157-165. Pubmedid: 27278668. Pmcid: PMC4939900.
  • Jiang K, Neill K, Cowden D, Klapman J, Eschrich S, Pimiento J, Malafa MP, Coppola D. Expression of CAS/CSE1L, the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in Barrett's Esophagus. Appl Immunohistochem Mol Morphol. 2016 Dec. Pubmedid: 27941559. Pmcid: PMC5466515.
  • Kim S, Hamerski C, Ghassemi K, Shah J, Bhat Y, Klapman J, Komanduri S, Keswani RN, Bidari K, Wani S, Watson RR, Muthusamy VR. The Clinical Utility of Evaluating the Luminal Upper Gastrointestinal Tract During Linear Endoscopic Ultrasonography. J Clin Gastroenterol. 2016 Aug;50(7):538-544. Pubmedid: 26501879.
  • Provenzale D, Gupta S, Ahnen DJ, Bray T, Cannon JA, Cooper G, David DS, Early DS, Erwin D, Ford JM, Giardiello FM, Grady W, Halverson AL, Hamilton SR, Hampel H, Ismail MK, Klapman JB, Larson DW, Lazenby AJ, Lynch PM, Mayer RJ, Ness RM, Regenbogen SE, Samadder NJ, Shike M, Steinbach G, Weinberg D, Dwyer M, Darlow S. Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Ne. 2016 Aug;14(8):1010-1030. Pubmedid: 27496117.
  • Lin CL, Meredith K, Klapman J. Rate of Recurrent Luminal Esophageal Cancer in Asymptomatic Patients After Curative Treatment for Esophageal Cancer. J Clin Gastroenterol. 2015 Sep;49(8):e71-e75. Pubmedid: 25127115.
  • Strom TJ, Klapman JB, Springett GM, Meredith KL, Hoffe SE, Choi J, Hodul P, Malafa MP, Shridhar R. Comparative long-term outcomes of upfront resected pancreatic cancer after preoperative biliary drainage. Surg Endosc. 2015 Nov;29(11):3273-3281. Pubmedid: 25631110. Pmcid: PMC4918460.
  • Permuth-Wey J, Chen YA, Fisher K, McCarthy S, Qu X, Lloyd MC, Kasprzak A, Fournier M, Williams VL, Ghia KM, Yoder SJ, Hall L, Georgeades C, Olaoye F, Husain K, Springett GM, Chen DT, Yeatman T, Centeno BA, Klapman J, Coppola D, Malafa M. A genome-wide investigation of microRNA expression identifies biologically-meaningful microRNAs that distinguish between high-risk and low-risk intraductal papillary mucinous neoplasms of the pancreas. PLoS One. 2015 Jan;10(1):e0116869. Pubmedid: 25607660. Pmcid: PMC4301643.
  • Ge PS, Hamerski CM, Watson RR, Komanduri S, Cinnor BB, Bidari K, Klapman JB, Lin CL, Shah JN, Wani S, Donahue TR, Muthusamy VR. Plastic biliary stent patency in patients with locally advanced pancreatic adenocarcinoma receiving downstaging chemotherapy. Gastrointest Endosc. 2015 Feb;81(2):360-366. Pubmedid: 25442083.
  • Provenzale D, Jasperson K, Ahnen DJ, Aslanian H, Bray T, Cannon JA, David DS, Early DS, Erwin D, Ford JM, Giardiello FM, Gupta S, Halverson AL, Hamilton SR, Hampel H, Ismail MK, Klapman JB, Larson DW, Lazenby AJ, Lynch PM, Mayer RJ, Ness RM, Rao MS, Regenbogen SE, Shike M, Steinbach G, Weinberg D, Dwyer MA, Freedman-Cass DA, Darlow S. Colorectal Cancer Screening, Version 1.2015. J Natl Compr Canc Ne. 2015 Aug;13(8):959-968. Pubmedid: 26285241.
  • You Y, Shao H, Bui K, Bui M, Klapman J, Cui Q, Coppola D. Epstein-barr virus positive inflammatory pseudotumor of the liver: report of a challenging case and review of the literature. Ann Clin Lab Sci. 2014 Nov;44(4):489-498. Pubmedid: 25361938.
  • Fernandez DC, Hoffe SE, Barthel JS, Vignesh S, Klapman JB, Harris C, Almhanna K, Biagioli MC, Meredith KL, Feygelman V, Rao NG, Shridhar R. Stability of endoscopic ultrasound-guided fiducial marker placement for esophageal cancer target delineation and image-guided radiation therapy. Pract Radiat Oncol. 2014 Mar;3(1):32-39. Pubmedid: 24674261.
  • Brugge WR, De Witt J, Klapman JB, Ashfaq R, Shidham V, Chhieng D, Kwon R, Baloch Z, Zarka M, Staerkel G. Techniques for cytologic sampling of pancreatic and bile duct lesions: The Papanicolaou Society of Cytopathology Guidelines. Cytojournal. 2014 Jun;11(Suppl 1):2. Pubmedid: 25191516. Pmcid: PMC4153336.
  • Harris CL, Toloza EM, Klapman JB, Vignesh S, Rodriguez K, Kaszuba FJ. Minimally invasive mediastinal staging of non-small-cell lung cancer: emphasis on ultrasonography-guided fine-needle aspiration. Cancer Control. 2014 Jan;21(1):15-20. Pubmedid: 24357737.
  • Brugge W, Dewitt J, Klapman JB, Ashfaq R, Shidham V, Chhieng D, Kwon R, Baloch Z, Zarka M, Staerkel G. Techniques for cytologic sampling of pancreatic and bile duct lesions. Diagn Cytopathol. 2014 Apr;42(4):333-337. Pubmedid: 24554498.
  • Herman JM, Wild AT, Wang H, Tran PT, Chang KJ, Taylor GE, Donehower RC, Pawlik TM, Ziegler MA, Cai H, Savage DT, Canto MI, Klapman J, Reid T, Shah RJ, Hoffe SE, Rosemurgy A, Wolfgang CL, Laheru DA. Randomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final results. J Clin Oncol. 2013 Mar;31(7):886-894. Pubmedid: 23341531. Pmcid: PMC4820756.
  • Wong J, Weber J, A Centeno B, Vignesh S, Harris CL, Klapman JB, Hodul P. High-grade dysplasia and adenocarcinoma are frequent in side-branch intraductal papillary mucinous neoplasm measuring less than 3 cm on endoscopic ultrasound. J Gastrointest Surg. 2013 Jan;17(1):78-84. Pubmedid: 22948841.
  • Burt RW, Cannon JA, David DS, Early DS, Ford JM, Giardiello FM, Halverson AL, Hamilton SR, Hampel H, Ismail MK, Jasperson K, Klapman JB, Lazenby AJ, Lynch PM, Mayer RJ, Ness RM, Provenzale D, Rao MS, Shike M, Steinbach G, Terdiman JP, Weinberg D, Dwyer M, Freedman-Cass D. Colorectal cancer screening. J Natl Compr Canc Ne. 2013 Dec;11(12):1538-1575. Pubmedid: 24335688.
  • Kucera S, Centeno BA, Springett G, Malafa MP, Chen YA, Weber J, Klapman J. Cyst Fluid Carcinoembryonic Antigen Level Is not Predictive of Invasive Cancer in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas. JOP. 2012 Jul;13(4):409-413. Pubmedid: 22797397.
  • Lin JL, Barthel JS, Keshishian J, Eikman EA, Klapman JB. Negative predictive value of positron emission tomography/computed tomography in patients with a clinical suspicion of pancreatic cancer. Pancreas. 2011 Jul;40(5):653-656. Pubmedid: 21602734.
  • Patel M, Hoffe S, Malafa M, Hodul P, Klapman J, Centeno B, Kim J, Helm J, Valone T, Springett G. Neoadjuvant GTX chemotherapy and IMRT-based chemoradiation for borderline resectable pancreatic cancer. J Surg Oncol. 2011 Aug;104(2):155-161. Pubmedid: 21520097. Pmcid: PMC3347705.
  • Nair R, Barthel J, Centeno B, Choi J, Klapman J, Malafa M. Interdisciplinary management of an intraductal papillary mucinous neoplasm of the pancreas. Cancer Control. 2008 Oct;15(4):322-333. Pubmedid: 18813200.
  • Klapman J, Malafa M. Early detection of pancreatic cancer: why, who, and how to screen. Cancer Control. 2008 Oct;15(4):280-287. Pubmedid: 18813195.
  • Barthel JS, Kelley ST, Klapman JB. Management of persistent gastroesophageal anastomotic strictures with removable self-expandable polyester silicon-covered (Polyflex) stents: an alternative to serial dilation. Gastrointest Endosc. 2008 Mar;67(3):546-552. Pubmedid: 18294520.
  • Jensen EH, Klapman JB, Kelley ST. Angiolipoma of the esophagus: a rare clinical dilemma. Dis Esophagus. 2006 Jun;19(3):203-207. Pubmedid: 16723000.
  • Klapman JB, Chang KJ. Endoscopic ultrasound-guided fine-needle injection. Gastrointest Endosc Clin N Am. 2005 Jan;15(1):169-77, x. Pubmedid: 15555959.
  • Klapman JB, Chang KJ, Lee JG, Nguyen P. Negative predictive value of endoscopic ultrasound in a large series of patients with a clinical suspicion of pancreatic cancer. Am J Gastroenterol. 2005 Dec;100(12):2658-2661. Pubmedid: 16393216.
  • Klapman JB, Ene-Stroescu D, Becker MA, Hanauer SB. A lupus-like syndrome associated with infliximab therapy. Inflamm Bowel Dis. 2003 May;9(3):176-178. Pubmedid: 12792223.