Hailing Zhang, MD

Cancer Focus:
Cutaneous Lymphoma (CTCL), Hodgkin Lymphoma, Leukemia, Multiple Myeloma-Plasma Cell Disorders, Myelodysplastic Syndromes (MDS), Non-Hodgkin Lymphoma

Hailing Zhang, MD is an Assistant Member in Moffitt’s Department of Hematopathology and Laboratory Medicine and Assistant Professor of Oncologic Sciences at USF. Dr. Hailing Zhang received her Bachelor of Medicine degree from the Medical College of TongJi University in Shanghai, China in 1994 (1989-1994) and completed a renal pathology fellowship in Shanghai Medical University. In 1996, she came to the United States and attended graduate school at the University of Arkansas for Medical Sciences (UAMS) where she received her MS degree in pathology in 1999. She subsequently spent 7 years working (UAMS and Tufts University School of Medicine) as a research associate. She completed her pathology residency training in New Jersey Medical School (UMDNJ-Newark) between 2006 and 2010 and hematopathology fellowship training in Montefiore Medical Center (MMC) in New York. Upon finishing training, she joined Chilton Hospital in New Jersey and served as a staff pathologist before coming to Moffitt Cancer Center in 2012. Dr. Zhang is a dedicated clinician educator whose clinical and research interests include morphologic evaluation, immunophenotyping and molecular diagnosis of hematolymphoid malignancies. As PI or co-investigator on several university or hospital funded projects, she reviews the morphology, immunophenotype, and molecular classification, and develops budgets, compliance oversight and effective measures of analysis. As faculty she is also dedicated to teaching medical students, residents, fellows and international scholars. In addition, she serves as medical director of Specimen Processing, Chair of the Laboratory Safety Committee and Chair of the Committee for Laboratory Diagnostics. Her clinical interests focus on clinical diagnostic hematopathology, including leukemia, lymphoma, clinical flow cytometry and molecular genetics.

Education & Training

Fellowship:

• Shanghai Medical University - Renal Pathology
• Albert Einstein College of Medicine Montefiore Medical Center - Hematopathology

Residency:

• UMDNJ-New Jersey Medical School -

Medical School:

• TongHi University Medical School - MD

• Wang L, Li J, Arbitman L, Zhang H, Shao H, Martin M, Moscinski L, Song J. Current Advances in the Diagnosis and Treatment of Major Myeloproliferative Neoplasms. Cancers (Basel). 2025 May.17(11). Pubmedid: 40507313. Pmcid: PMC12153907.
• Cockey SG, Zhang H, Hussaini M, Zhang L, Moscinski L, Yang E, Li J, Wang L, Song J. Molecular landscape and clinical outcome of SRSF2/TET2 Co-mutated myeloid neoplasms. Leuk Lymphoma. 2025 Mar.66(3):469-478. Pubmedid: 39611281.
• Hammami MB, Qasim A, Shah A, Zhang H, Haver MK, Sokol L. Cutaneous manifestations of large granular lymphocytic leukemia: A case report and systematic review. Leuk Res. 2025 Jul.154:107720. Pubmedid: 40466343.
• Shao R, Wang L, Zhang H, Martin M, Moscinski L, Li A, Li J, Song J. Comparison of the clinicopathological features in myeloproliferative or myelodysplastic neoplasms with SF3B1/JAK2, SF3B1/CALR, or SF3B1/MPL co-mutations. Leuk Lymphoma. 2025 Dec.66(13):2518-2527. Pubmedid: 41074577.
• Hassan F, Zhang H, Idiaquez DW, Pakasticali N, Hyjek E, Hussaini M. KRAS may facilitate transformation of chronic lymphocytic leukemia to histiocytic sarcoma with indeterminate dendritic cell features. Am J Clin Pathol. 2025 Aug.164(2):157-162. Pubmedid: 40418704.
• Song A, Li JY, Cockey SG, Shao R, Zhang H. EBV-Positive Pleomorphic Variant Transformation of CD5-Negative Mantle Cell Lymphoma: A Rare Case Report and Literature Review. Case Rep Hematol. 2024 June.2024:3267739. Pubmedid: 38938449. Pmcid: PMC11208810.
• Dong N, Zhang H, Song J, Mammadova J, Shah B, Saeed H, Gaballa S, Grajales-Cruz A, Isenalumhe L, Bello C, Sokol L, Pinilla J, Chavez J. B-cell maturation antigen expression and clinical features of plasmablastic lymphoma. EJHaem. 2024 Feb.5(1):285-289. Pubmedid: 38406544. Pmcid: PMC10887266.
• Li JY, Ryder CB, Zhang H, Cockey SG, Hyjek E, Moscinski LC, Sagatys E, Song J. Review and Updates on Systemic Mastocytosis and Related Entities. Cancers (Basel). 2023 Nov.15(23). Pubmedid: 38067330.
• Song J, Moscinski L, Yang E, Shao H, Hussaini M, Zhang H. Co-mutation of ASXL1 and SF3B1 Predicts Poorer Overall Survival Than Isolated ASXL1 or SF3B1 Mutations. In Vivo. 2023 May.37(3):985-993. Pubmedid: 37103105. Pmcid: PMC10188047.
• Song J, Moscinski L, Zhang L, Zhang H. Case report: Co-existing chronic myeloid leukemia and chronic myelomonocytic leukemia-A clinically important but challenging scenario. Leuk Res Rep. 2023 Jun.20:100378. Pubmedid: 37415731. Pmcid: PMC10319893.
• Singh AM, Zhang H, Sokol L. Severe Thrombocytopenia in a Patient With a History of Olfactory Neuroblastoma. Cureus. 2023 Jan.15(1):e33297. Pubmedid: 36741647. Pmcid: PMC9894644.
• Song J, Zhang H, Dong N, Zhang X, Hussaini M, Jain A, Moscinski L, Shain K, Baz R, Alsina M, Nishihori T, Zhang L. The Application of NextGen Sequencing in the Diagnosis of Myeloid Neoplasms in Myeloma Patients With Cytopenia. Clin Lymphoma Myeloma Leuk. 2022 Jun.22(6):e414-e426. Pubmedid: 34998786.
• Hunter AM, Newman H, DeZern AE, Steensma DP, Niyongere S, Roboz GJ, Mo Q, Chan O, Gerds A, Sallman DA, Dominguez-Viqueira W, Letson C, Balasis ME, Ball M, Kruer T, Zhang H, Lancet JE, List AF, Sekeres MA, Komrokji RS, Padron E. Integrated Human and Murine Clinical Study Establishes Clinical Efficacy of Ruxolitinib in Chronic Myelomonocytic Leukemia. Clin Cancer Res. 2021 Nov.27(22):6095-6105. Pubmedid: 34253584. Pmcid: PMC8595542.
• Bui KM, Zhang H, Boac BM, Chatwal MS, Dhillon J. Pathology of Seminoma Coinciding With Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia. Cureus. 2021 Jul.13(7):e16509. Pubmedid: 34430123. Pmcid: PMC8374996.
• Gibbs JD, Ma S, Kim A, Seminario-Vidal L, Sokol L, Zhang H, Zhang X, Sagatys E, Chen PL, Messina JL. Utility of flow cytometry and gene rearrangement analysis in tissue and blood of patients with suspected cutaneous T‑cell lymphoma. Oncol Rep. 2021 Jan.45(1):349-358. Pubmedid: 33416132.
• Lee K, Evans MG, Yang L, Ng S, Snowden C, Khodadoust MS, Brown RA, Trum NA, Querfeld C, Doan LT, Song J, Zhang H, Gru A, Wood GS, Wada DA, Shanmugam V, Haun PL, Aster JC, Duncan LM, Guitart J, Weinstock DM, Nardi V, Choi J. Primary cytotoxic T-cell lymphomas harbor recurrent targetable alterations in the JAK-STAT pathway. Blood. 2021 Dec.138(23):2435-2440. Pubmedid: 34432866. Pmcid: PMC8662071.
• Song J, Liu K, Pinilla-Ibarz J, Zhang H. A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation. Leuk Res Rep. 2020 Sep.14:100222. Pubmedid: 33072512. Pmcid: PMC7549112.
• Song J, Hussaini M, Qin D, Zhang X, Shao H, Zhang L, Gajzer D, Basra P, Moscinski L, Zhang H. Comparison of SF3B1/DNMT3A Comutations With DNMT3A or SF3B1 Mutation Alone in Myelodysplastic Syndrome and Clonal Cytopenia of Undetermined Significance. Am J Clin Pathol. 2020 Jun.154(1):48-56. Pubmedid: 32112088.
• Song J, Moscinski L, Zhang H, Zhang X, Hussaini M. Does SF3B1/TET2 Double Mutation Portend Better or Worse Prognosis Than Isolated SF3B1 or TET2 Mutation?. Cancer Genomics Proteomics. 2019 Jan.16(1):91-98. Pubmedid: 30587503. Pmcid: PMC6348401.
• Afiat TP, Zhang X, Zhang H, Ayala E, Zhang L, Sokol L. Sezary syndrome manifesting as posttransplant lymphoproliferative disorder. Leuk Res Rep. 2018 May.9:72-75. Pubmedid: 29761072. Pmcid: PMC5948470.
• Song J, Hussaini M, Zhang H, Shao H, Qin D, Zhang X, Ma Z, Hussnain Naqvi SM, Zhang L, Moscinski LC. Comparison of the Mutational Profiles of Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis. Am J Clin Pathol. 2017 May.147(5):444-452. Pubmedid: 28419183. Pmcid: PMC5402718.
• Yoshimi A, Balasis ME, Vedder A, Feldman K, Ma Y, Zhang H, Lee SC, Letson C, Niyongere S, Lu SX, Ball M, Taylor J, Zhang Q, Zhao Y, Youssef S, Chung YR, Zhang XJ, Durham BH, Yang W, List AF, Loh ML, Klimek V, Berger MF, Stieglitz E, Padron E, Abdel-Wahab O. Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML. Blood. 2017 Jul.130(4):397-407. Pubmedid: 28576879. Pmcid: PMC5533204.
• Dalia S, Brayer J, Horna P, Zhang H, Pinilla-Ibarz J. Transformation to Hodgkin lymphoma in chronic lymphocytic leukemia coexisting with Epstein-Barr viremia. Leuk Lymphoma. 2014 Nov.55(11):2660-2662. Pubmedid: 24528217.
• Zhang H, Gupta G, Yang XY, Rosenbluth R, Bhattacharyya PK. A unique case of merkel cell carcinoma and chronic lymphocytic leukaemia presenting in a single cutaneous lesion (collision tumour). BMJ Case Rep. 2011 Nov.2009. Pubmedid: 21686502. Pmcid: PMC3027557.
• Maitta RW, Wolgast LR, Wang Q, Zhang H, Bhattacharyya P, Gong JZ, Sunkara J, Albanese JM, Pizzolo JG, Cannizzaro LA, Ramesh KH, Ratech H. Alpha- and beta-synucleins are new diagnostic tools for acute erythroid leukemia and acute megakaryoblastic leukemia. Am J Hematol. 2011 Feb.86(2):230-234. Pubmedid: 21264917.
• Zhang H, Maitta RW, Bhattacharyya PK, Florea AD, Sen F, Wang Q, Ratech H. γ-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. Am J Surg Pathol. 2011 Dec.35(12):1857-1865. Pubmedid: 21959308.
• Zhang H, Yang XY, Hong T, Feldman T, Bhattacharyya PK. Kaposi sarcoma-associated herpesvirus (human herpesvirus type 8)-associated extracavitary lymphoma: Report of a case in an HIV-positive patient with simultaneous kaposi sarcoma and a review of the literature. Acta Haematol. 2010 Jun.123(4):237-241. Pubmedid: 20484888.
• Bose C, Zhang H, Udupa KB, Chowdhury P. Activation of p-ERK1/2 by nicotine in pancreatic tumor cell line AR42J: effects on proliferation and secretion. Am J Physiol Gastrointest Liver Physiol. 2005 Nov.289(5):G926-G934. Pubmedid: 16051920.
• Zhang H, Jia Y, Cooper JJ, Hale T, Zhang Z, Elbein SC. Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels. J Clin Endocrinol Metab. 2004 Feb.89(2):748-755. Pubmedid: 14764791.
• Elbein SC, Zheng H, Jia Y, Chu W, Cooper JJ, Hale T, Zhang Z. Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy. Mol Genet Metab. 2004 Aug.82(4):321-328. Pubmedid: 15308130.
• Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, Elbein SC. Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance. Diabetes. 2004 Aug.53(8):2132-2136. Pubmedid: 15277397.