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Gregory Y. Lauwers, MD


Specialty: Pathology
Program: Anatomic Pathology

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Overview

Dr. Gregory Lauwers is a Senior Member in Anatomic Pathology at Moffitt Cancer Center. Dr. Lauwers received his MD from the University of Paris, France. He completed a Surgical Pathology Residency at Lenox Hill Hospital, New York, NY and a Fellowship in Oncologic Pathology at Memorial Sloan-Kettering Cancer Center, where he also served as Chief Fellow. Following his Fellowship, Dr. Lauwers was in the Division of Anatomic Pathology, Department of Pathology at the University of Florida. From 2000 to 2016, Dr. Lauwers was in the Department of Pathology at Harvard Medical School and also served as Director, Gastrointestinal Pathology Service and Vice Chair, Department of Pathology at Massachusetts General Hospital. He most recently has been a Professor in the Department of Pathology at the University of California San Francisco. He is currently adjunct Professor of Pathology at Pusan National University, School of Medicine, Pusan, Korea and Clinical Professor at the School of Pathology and Laboratory Medicine, at the University of Western Australia, in Perth. Dr. Lauwers has published over 350 peer-reviewed articles, editorials, reviews, and book chapters, and is coauthor of several textbooks, including the 5th edition of Morson and Dawson's Gastrointestinal Pathology and Advances in Surgical Pathology: Gastric Cancer. Dr. Lauwers serves on the editorial boards of several journals, he is Deputy Editor-in-Chief of the Archives of Pathology and Laboratory Medicine, and he contributed to the WHO Classification of Tumours of the Digestive System (2010). Dr. Lauwers’ areas of clinical focus include luminal malignancies of the gut (particularly esophageal and gastric adenocarcinoma) and hepatocellular carcinoma. He is particularly interested in refining the pathologic assessment of new diagnostic and therapeutic modalities, closely collaborating with gastroenterologists, surgeons, oncologists and radiation oncologists. His research focuses predominantly on pre-neoplastic lesions and early cancers of the gut and particularly Barrett's esophagus-related neoplasms and gastric cancer. More specifically his interests are: 1) to refine diagnostic criteria and to bridge the traditional morphologic classifications with the novel molecular taxonomy in order to improve prognostication and enhance targeted therapies; and 2) to evaluate the diagnostic capabilities of new imaging modalities (optical coherent tomography, confocal laser endomicroscopy) in the screening and surveillance of patients. He is focused on support of the GI pathology service; further developing outreach, applying the latest advances in molecular diagnostics to clinical diagnostics, and participating in translational research. 

Education & Training

Fellowship:

  • Memorial Sloan-Kettering Cancer Center - Oncologic Pathology

Residency:

  • Lenox Hill Hospital - Surgical Pathology

Medical School:

  • University of Paris VII, France - MD
Participating Trials

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Publications

  • Kwon CH, Kim YK, Lee S, Kim A, Park HJ, Choi Y, Won YJ, Park DY, Lauwers GY. Gastric Poorly Cohesive Carcinoma: A correlative study of mutational signatures and prognostic significance based on histopathologic subtypes. Histopathology. 2017 Sep. Pubmedid: 28873240.
  • Umetsu SE, Brown I, Langner C, Lauwers GY. Autoimmune enteropathies. Virchows Arch. 2017 Oct. Pubmedid: 29022145.
  • Chen JH, Pezhouh MK, Lauwers GY, Masia R. Histopathologic Features of Colitis Due to Immunotherapy With Anti-PD-1 Antibodies. Am J Surg Pathol. 2017 May;41(5):643-654. Pubmedid: 28296676.
  • Zhu B, Wei L, Rotile N, Day H, Rietz T, Farrar CT, Lauwers GY, Tanabe KK, Rosen B, Fuchs BC, Caravan P. Combined magnetic resonance elastography and collagen molecular magnetic resonance imaging accurately stage liver fibrosis in a rat model. Hepatology. 2017 Mar;65(3):1015-1025. Pubmedid: 28039886. Pmcid: PMC5319882.
  • Shih AR, Lauwers GY, Mattia A, Schaefer EA, Misdraji J. Vascular Injury Characterizes Doxycycline-induced Upper Gastrointestinal Tract Mucosal Injury. Am J Surg Pathol. 2017 Mar;41(3):374-381. Pubmedid: 28009607.
  • Adar T, Rodgers LH, Shannon KM, Yoshida M, Ma T, Mattia A, Lauwers GY, Iafrate AJ, Chung DC. A tailored approach to BRAF and MLH1 methylation testing in a universal screening program for Lynch syndrome. Mod Pathol. 2017 Mar;30(3):440-447. Pubmedid: 28059100.
  • Hoda RS, Sanyal S, Abraham JL, Everett JM, Hundemer GL, Yee E, Lauwers GY, Tolkoff-Rubin N, Misdraji J. Lanthanum deposition from oral lanthanum carbonate in the upper gastrointestinal tract. Histopathology. 2017 Jun;70(7):1072-1078. Pubmedid: 28134986. Pmcid: PMC5450641.
  • Chen HH, Waghorn PA, Wei L, Tapias LF, Schu Hle DT, Rotile NJ, Jones CM, Looby RJ, Zhao G, Elliott JM, Probst CK, Mino-Kenudson M, Lauwers GY, Tager AM, Tanabe KK, Lanuti M, Fuchs BC, Caravan P. Molecular imaging of oxidized collagen quantifies pulmonary and hepatic fibrogenesis. JCI Insight. 2017 Jun;2(11). Pubmedid: 28570270. Pmcid: PMC5453697.
  • Slavik T, Lauwers GY. Navigating the jungles of tropical infectious gastrointestinal pathology: a pattern-based approach to the endoscopic biopsy. Virchows Arch. 2017 Jun. Pubmedid: 28589386.
  • Younes M, Brown K, Lauwers GY, Ergun G, Meriano F, Schmulen AC, Barroso A, Ertan A. p53 protein accumulation predicts malignant progression in Barrett's metaplasia: a prospective study of 275 patients. Histopathology. 2017 Jul;71(1):27-33. Pubmedid: 28226185. Pmcid: PMC5466464.
  • Davis J, Petterson M, Newell J, Lauwers GY, Royce T, Demeure MJ. Micrometastatic Gastric Glomus Tumor Confirmed by Next-Generation Sequencing. Histopathology. 2017 Jul. Pubmedid: 28675515.
  • Mosli MH, Feagan BG, Zou G, Sandborn WJ, D'Haens G, Khanna R, Shackelton LM, Walker CW, Nelson S, Vandervoort MK, Frisbie V, Samaan MA, Jairath V, Driman DK, Geboes K, Valasek MA, Pai RK, Lauwers GY, Riddell R, Stitt LW, Levesque BG. Development and validation of a histological index for UC. Gut. 2017 Jan;66(1):50-58. Pubmedid: 26475633.
  • Kojima M, Shimazaki H, Iwaya K, Nakamura T, Kawachi H, Ichikawa K, Sekine S, Ishiguro S, Shimoda T, Kushima R, Yao T, Fujimori T, Hase K, Watanabe T, Sugihara K, Lauwers GY, Ochiai A. Intramucosal colorectal carcinoma with invasion of the lamina propria: a study by the Japanese Society for Cancer of the Colon and Rectum. Hum Pathol. 2017 Aug;66:230-237. Pubmedid: 28711649.
  • Schoellhammer CM, Lauwers GY, Goettel JA, Oberli MA, Cleveland C, Park JY, Minahan D, Chen Y, Anderson DG, Jaklenec A, Snapper SB, Langer R, Traverso G. Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice. Gastroenterology. 2017 Apr;152(5):1151-1160. Pubmedid: 28088460. Pmcid: PMC5368009.
  • Arnason T, Borger DR, Corless C, Hagen C, Iafrate AJ, Makhlouf H, Misdraji J, Sapp H, Tsui WM, Wanless IR, Zuluaga Toro T, Lauwers GY. Biliary Adenofibroma of Liver: Morphology, Tumor Genetics, and Outcomes in 6 Cases. Am J Surg Pathol. 2017 Apr;41(4):499-505. Pubmedid: 28266931.
  • Singh P, Lauwers GY, Garber JJ. Outcomes of Seropositive Patients With Marsh 1 Histology in Clinical Practice. J Clin Gastroenterol. 2016 Sep;50(8):619-623. Pubmedid: 27003856. Pmcid: PMC4980207.
  • Kim A, Ahn SJ, Park do Y, Lee BE, Song GA, Kim GH, Lauwers GY. Gastric crypt dysplasia: a distinct subtype of gastric dysplasia with characteristic endoscopic features and immunophenotypic and biological anomalies. Histopathology. 2016 May;68(6):843-849. Pubmedid: 26336971.
  • Colussi D, Salari B, Stewart KO, Lauwers GY, Richter JR, Chan AT, Ricciardiello L, Khalili H. Clinical characteristics and patterns and predictors of response to therapy in collagenous and lymphocytic colitis. Scand J Gastroenterol. 2016 May;50(11):1382-1388. Pubmedid: 25997458. Pmcid: PMC4834840.
  • Chan K, Brown IS, Kyle T, Lauwers GY, Kumarasinghe MP. Chief cell-predominant gastric polyps: a series of 12 cases with literature review. Histopathology. 2016 May;68(6):825-833. Pubmedid: 26335020.
  • Ahmad R, Setia N, Schmidt BH, Hong TS, Wo JY, Kwak EL, Rattner DW, Lauwers GY, Mullen JT. Predictors of Lymph Node Metastasis in Western Early Gastric Cancer. J Gastrointest Surg. 2016 Mar;20(3):531-538. Pubmedid: 26385006.
  • Cottreau J, Gruchy S, Kamionek M, Lauwers GY, Arnason T. Prevalence of oesophageal epidermoid metaplasia in 1048 consecutive patients and 58 patients with squamous neoplasms. Histopathology. 2016 Jun;68(7):988-995. Pubmedid: 26426946.
  • Gallivan C, Brown I, Setia N, Rosty C, Lauwers GY. Diffuse collagenosis of the gastrointestinal tract - A clinicopathological study of 10 cases. Pathology. 2016 Feb;48 Suppl 1:S125. Pubmedid: 27772846.
  • Nakagawa S, Wei L, Song WM, Higashi T, Ghoshal S, Kim RS, Bian CB, Yamada S, Sun X, Venkatesh A, Goossens N, Bain G, Lauwers GY, Koh AP, El-Abtah M, Ahmad NB, Hoshida H, Erstad DJ, Gunasekaran G, Lee Y, Yu ML, Chuang WL, Dai CY, Kobayashi M, Kumada H, Beppu T, Baba H, Mahajan M, Nair VD, Lanuti M, Villanueva A, Sangiovanni A, Iavarone M, Colombo M, Llovet JM, Subramanian A, Tager AM, Friedman SL, Baumert TF, Schwarz ME, Chung RT, Tanabe KK, Zhang B, Fuchs BC, Hoshida Y. Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition. Cancer Cell. 2016 Dec;30(6):879-890. Pubmedid: 27960085. Pmcid: PMC5161110.
  • Robles AI, Traverso G, Zhang M, Roberts NJ, Khan MA, Joseph C, Lauwers GY, Selaru FM, Popoli M, Pittman ME, Ke X, Hruban RH, Meltzer SJ, Kinzler KW, Vogelstein B, Harris CC, Papadopoulos N. Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers. Gastroenterology. 2016 Apr;150(4):931-943. Pubmedid: 26764183. Pmcid: PMC5270616.
  • DePeralta DK, Wei L, Ghoshal S, Schmidt B, Lauwers GY, Lanuti M, Chung RT, Tanabe KK, Fuchs BC. Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis. Cancer. 2016 Apr;122(8):1216-1227. Pubmedid: 26914713. Pmcid: PMC4828262.
  • Ushiku T, Ishikawa S, Kakiuchi M, Tanaka A, Katoh H, Aburatani H, Lauwers GY, Fukayama M. RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases. Gastric Cancer. 2016 Apr;19(2):403-411. Pubmedid: 25823974. Pmcid: PMC4824805.
  • Lennerz JK, van der Sloot KW, Le LP, Batten JM, Han JY, Fan KC, Siegel CA, Srivastava A, Park do Y, Chen JH, Sands BE, Korzenik JR, Odze RD, Dias-Santagata D, Borger DR, Khalili H, Iafrate AJ, Lauwers GY. Colorectal cancer in Crohn's colitis is comparable to sporadic colorectal cancer. Int J Colorectal Dis. 2016 05;31(5):973-982. Pubmedid: 27026089.
  • Farrar CT, DePeralta DK, Day H, Rietz TA, Wei L, Lauwers GY, Keil B, Subramaniam A, Sinskey AJ, Tanabe KK, Fuchs BC, Caravan P. 3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model. J Hepatol. 2015 Sep;63(3):689-696. Pubmedid: 26022693. Pmcid: PMC4543390.
  • Khor TS, Lauwers GY, Odze RD, Srivastava A. "Mass-forming" variant of ischemic colitis is a distinct entity with predilection for the proximal colon. Am J Surg Pathol. 2015 Sep;39(9):1275-1281. Pubmedid: 26034865.
  • Schoellhammer CM, Schroeder A, Maa R, Lauwers GY, Swiston A, Zervas M, Barman R, DiCiccio AM, Brugge WR, Anderson DG, Blankschtein D, Langer R, Traverso G. Ultrasound-mediated gastrointestinal drug delivery. Sci Transl Med. 2015 Oct;7(310):310ra168. Pubmedid: 26491078. Pmcid: PMC4825174.
  • Traverso G, Schoellhammer CM, Schroeder A, Maa R, Lauwers GY, Polat BE, Anderson DG, Blankschtein D, Langer R. Microneedles for drug delivery via the gastrointestinal tract. J Pharm Sci. 2015 Feb;104(2):362-367. Pubmedid: 25250829. Pmcid: PMC4349565.
  • Setia N, Clark JW, Duda DG, Hong TS, Kwak EL, Mullen JT, Lauwers GY. Familial Gastric Cancers. Oncologist. 2015 Dec;20(12):1365-1377. Pubmedid: 26424758. Pmcid: PMC4679084.
  • Senger S, Sapone A, Fiorentino MR, Mazzarella G, Lauwers GY, Fasano A. Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation. PLoS One. 2015 Dec;10(12):e0144634. Pubmedid: 26649570. Pmcid: PMC4674131.
  • Johncilla M, Misdraji J, Pratt DS, Agoston AT, Lauwers GY, Srivastava A, Doyle LA. Ipilimumab-associated Hepatitis: Clinicopathologic Characterization in a Series of 11 Cases. Am J Surg Pathol. 2015 Aug;39(8):1075-1084. Pubmedid: 26034866.
  • Reiberger T, Chen Y, Ramjiawan RR, Hato T, Fan C, Samuel R, Roberge S, Huang P, Lauwers GY, Zhu AX, Bardeesy N, Jain RK, Duda DG. An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. Nat Protoc. 2015 Aug;10(8):1264-1274. Pubmedid: 26203823. Pmcid: PMC4800979.
  • Arnason T, Brown IS, Goldsmith JD, Anderson W, O'Brien BH, Wilson C, Winter H, Lauwers GY. Collagenous gastritis: a morphologic and immunohistochemical study of 40 patients. Mod Pathol. 2015 Apr;28(4):533-544. Pubmedid: 25234289.
  • Masia R, Peyton S, Lauwers GY, Brown I. Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases. Am J Surg Pathol. 2014 Oct;38(10):1319-1329. Pubmedid: 25188868. Pmcid: PMC4162848.
  • Kumarasinghe MP, Brown I, Raftopoulos S, Bourke MJ, Charlton A, de Boer WB, Eckstein R, Epari K, Gill AJ, Lam AK, Price T, Streutker C, Lauwers GY. Standardised reporting protocol for endoscopic resection for Barrett oesophagus associated neoplasia: expert consensus recommendations. Pathology. 2014 Oct;46(6):473-480. Pubmedid: 25158823.
  • Chetty R, Bateman AC, Torlakovic E, Wang LM, Gill P, Al-Badri A, Arends M, Biddlestone L, Burroughs S, Carey F, Cowlishaw D, Crowther S, Da Costa P, Dada MA, d'Adhemar C, Dasgupta K, de Cates C, Deshpande V, Feakins RM, Foria B, Foria V, Fuller C, Green B, Greenson JK, Griffiths P, Hafezi-Bakhtiari S, Henry J, Jaynes E, Jeffers MD, Kaye P, Landers R, Lauwers GY, Loughrey M, Mapstone N, Novelli M, Odze R, Poller D, Rowsell C, Sanders S, Sarsfield P, Schofield JB, Sheahan K, Shepherd N, Sherif A, Sington J, Walsh S, Williams N, Wong N. A pathologist's survey on the reporting of sessile serrated adenomas/polyps. J Clin Pathol. 2014 May;67(5):426-430. Pubmedid: 24399034.
  • Lee SE, Kang SY, Cho J, Lee B, Chang DK, Woo H, Kim JW, Park HY, Do IG, Kim YE, Kushima R, Lauwers GY, Park CK, Kim KM. Pyloric gland adenoma in Lynch syndrome. Am J Surg Pathol. 2014 Jun;38(6):784-792. Pubmedid: 24518125. Pmcid: PMC4014525.
  • Suter MJ, Gora MJ, Lauwers GY, Arnason T, Sauk J, Gallagher KA, Kava L, Tan KM, Soomro AR, Gallagher TP, Gardecki JA, Bouma BE, Rosenberg M, Nishioka NS, Tearney GJ. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study. Gastrointest Endosc. 2014 Jun;79(6):886-896. Pubmedid: 24462171.
  • Lee SM, Yang S, Joo M, Kim KM, Park CK, Ahn S, Min BH, Lee JH, Kim S, Rhee JC, Kim JJ, Lauwers GY. Poorly differentiated component in gastric pinch biopsies predicts submucosal invasion. Diagn Pathol. 2014 Feb;9:34. Pubmedid: 24555807. Pmcid: PMC3938134.
  • Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC. Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. Gastroenterology. 2014 Feb;146(2):520-529. Pubmedid: 24512911. Pmcid: PMC3978775.
  • Chen Y, Huang Y, Reiberger T, Duyverman AM, Huang P, Samuel R, Hiddingh L, Roberge S, Koppel C, Lauwers GY, Zhu AX, Jain RK, Duda DG. Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. Hepatology. 2014 Apr;59(4):1435-1447. Pubmedid: 24242874. Pmcid: PMC3966948.
  • Sylla P, Bordeianou LG, Berger D, Han KS, Lauwers GY, Sahani DV, Sbeih MA, Lacy AM, Rattner DW. A pilot study of natural orifice transanal endoscopic total mesorectal excision with laparoscopic assistance for rectal cancer. Surg Endosc. 2013 Sep;27(9):3396-3405. Pubmedid: 23572214.
  • Lennerz JK, Lauwers GY. Amelanotic adenoma. Int J Surg Pathol. 2013 Oct;21(5):504-505. Pubmedid: 23855023.
  • Fuchs BC, Wang H, Yang Y, Wei L, Polasek M, Schühle DT, Lauwers GY, Parkar A, Sinskey AJ, Tanabe KK, Caravan P. Molecular MRI of collagen to diagnose and stage liver fibrosis. J Hepatol. 2013 Nov;59(5):992-998. Pubmedid: 23838178. Pmcid: PMC3805694.
  • Ushiku T, Moran CJ, Lauwers GY. Focally enhanced gastritis in newly diagnosed pediatric inflammatory bowel disease. Am J Surg Pathol. 2013 Dec;37(12):1882-1888. Pubmedid: 24121177. Pmcid: PMC4333144.
  • Sauk J, Coron E, Kava L, Suter M, Gora M, Gallagher K, Rosenberg M, Ananthakrishnan A, Nishioka N, Lauwers G, Woods K, Brugge W, Forcione D, Bouma BE, Tearney G. Interobserver agreement for the detection of Barrett's esophagus with optical frequency domain imaging. Digest Dis Sci. 2013 Aug;58(8):2261-2265. Pubmedid: 23508980. Pmcid: PMC3732518.
  • Shindoh J, Andreou A, Aloia TA, Zimmitti G, Lauwers GY, Laurent A, Nagorney DM, Belghiti J, Cherqui D, Poon RT, Kokudo N, Vauthey JN. Microvascular invasion does not predict long-term survival in hepatocellular carcinoma up to 2 cm: reappraisal of the staging system for solitary tumors. Ann Surg Oncol. 2013 Apr;20(4):1223-1229. Pubmedid: 23179993. Pmcid: PMC3856190.
  • Polasek M, Fuchs BC, Uppal R, Schühle DT, Alford JK, Loving GS, Yamada S, Wei L, Lauwers GY, Guimaraes AR, Tanabe KK, Caravan P. Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models. J Hepatol. 2012 Sep;57(3):549-555. Pubmedid: 22634342. Pmcid: PMC3423553.
  • Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo JA, Thayer SP, Lauwers GY, Deshpande V, Mino-Kenudson M, Fernández-del Castillo C, Lillemoe KD, Warshaw AL. Pancreatic ductal adenocarcinoma: long-term survival does not equal cure. Surgery. 2012 Sep;152(3 Suppl 1):S43-S49. Pubmedid: 22763261. Pmcid: PMC3806092.
  • Khor TS, Alfaro EE, Ooi EM, Li Y, Srivastava A, Fujita H, Park Y, Kumarasinghe MP, Lauwers GY. Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus?. Am J Surg Pathol. 2012 Mar;36(3):331-342. Pubmedid: 22261707.
  • Konstantinidis IT, Bajpai S, Kambadakone AR, Tanabe KK, Berger DL, Zheng H, Sahani DV, Lauwers GY, Fernandez-del Castillo C, Warshaw AL, Ferrone CR. Gallbladder lesions identified on ultrasound. Lessons from the last 10 years. J Gastrointest Surg. 2012 Mar;16(3):549-553. Pubmedid: 22108768.
  • Sharma P, Meining AR, Coron E, Lightdale CJ, Wolfsen HC, Bansal A, Bajbouj M, Galmiche JP, Abrams JA, Rastogi A, Gupta N, Michalek JE, Lauwers GY, Wallace MB. Real-time increased detection of neoplastic tissue in Barrett's esophagus with probe-based confocal laser endomicroscopy: final results of an international multicenter, prospective, randomized, controlled trial. Gastrointest Endosc. 2011 Sep;74(3):465-472. Pubmedid: 21741642. Pmcid: PMC3629729.
  • Puppa G, Risio M, Sheahan K, Vieth M, Zlobec I, Lugli A, Pecori S, Wang LM, Langner C, Mitomi H, Nakamura T, Watanabe M, Ueno H, Chasle J, Senore C, Conley SA, Herlin P, Lauwers GY. Standardization of whole slide image morphologic assessment with definition of a new application: Digital slide dynamic morphometry. J Pathol Inform. 2011 Oct;2:48. Pubmedid: 22200031. Pmcid: PMC3237062.
  • Yoo H, Kang D, Katz AJ, Lauwers GY, Nishioka NS, Yagi Y, Tanpowpong P, Namati J, Bouma BE, Tearney GJ. Reflectance confocal microscopy for the diagnosis of eosinophilic esophagitis: a pilot study conducted on biopsy specimens. Gastrointest Endosc. 2011 Nov;74(5):992-1000. Pubmedid: 21944314. Pmcid: PMC3425354.
  • Masciari S, Dewanwala A, Stoffel EM, Lauwers GY, Zheng H, Achatz MI, Riegert-Johnson D, Foretova L, Silva EM, Digianni L, Verselis SJ, Schneider K, Li FP, Fraumeni J, Garber JE, Syngal S. Gastric cancer in individuals with Li-Fraumeni syndrome. Genet Med. 2011 Jul;13(7):651-657. Pubmedid: 21552135. Pmcid: PMC3595598.
  • Kelly PJ, Lauwers GY. Clinical guidelines: Consensus for the management of patients with gastric polyps. Nat Rev Gastroenterol Hepatol. 2011 Jan;8(1):7-8. Pubmedid: 21119611.
  • Deshpande V, Nduaguba A, Zimmerman SM, Kehoe SM, Macconaill LE, Lauwers GY, Ferrone C, Bardeesy N, Zhu AX, Hezel AF. Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma. BMC Cancer. 2011 Feb;11:60. Pubmedid: 21303542. Pmcid: PMC3045359.
  • Yachimski P, Mino-Kenudson M, Sherwood ME, Puricelli WP, Nishioka NS, Lauwers GY. Cyclooxygenase-2 expression in esophageal epithelium before and after photodynamic therapy for Barrett's esophagus with high-grade dysplasia or intramucosal carcinoma. Virchows Arch. 2011 Dec;459(6):581-586. Pubmedid: 22081106.
  • Lennerz JK, Kwak EL, Ackerman A, Michael M, Fox SB, Bergethon K, Lauwers GY, Christensen JG, Wilner KD, Haber DA, Salgia R, Bang YJ, Clark JW, Solomon BJ, Iafrate AJ. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol. 2011 Dec;29(36):4803-4810. Pubmedid: 22042947. Pmcid: PMC3255989.
  • Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol. 2010 Sep;177(3):1514-1533. Pubmedid: 20709804. Pmcid: PMC2928982.
  • Farris AB, Lauwers GY, Deshpande V. Autoimmune pancreatitis-related diabetes: quantitative analysis of endocrine islet cells and inflammatory infiltrate. Virchows Arch. 2010 Sep;457(3):329-336. Pubmedid: 20632032.
  • Duda DG, Willett CG, Ancukiewicz M, di Tomaso E, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK. Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer. Oncologist. 2010 Oct;15(6):577-583. Pubmedid: 20484123. Pmcid: PMC3061828.
  • Maduekwe UN, Lauwers GY, Fernandez-Del-Castillo C, Berger DL, Ferguson CM, Rattner DW, Yoon SS. New metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinoma. Ann Surg Oncol. 2010 May;17(5):1267-1277. Pubmedid: 20099040. Pmcid: PMC3785005.
  • Rubbia-Brandt L, Lauwers GY, Wang H, Majno PE, Tanabe K, Zhu AX, Brezault C, Soubrane O, Abdalla EK, Vauthey JN, Mentha G, Terris B. Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis. Histopathology. 2010 Mar;56(4):430-439. Pubmedid: 20459550.
  • Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Alsina J, Fernández-Del Castillo C, Warshaw AL, Thayer SP. Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia. Gastroenterology. 2010 Mar;138(3):1166-1177. Pubmedid: 20026066. Pmcid: PMC3806111.
  • Brown IS, Whiteman DC, Lauwers GY. Foveolar type dysplasia in Barrett esophagus. Mod Pathol. 2010 Jun;23(6):834-843. Pubmedid: 20228780.
  • Fujii T, Fuchs BC, Yamada S, Lauwers GY, Kulu Y, Goodwin JM, Lanuti M, Tanabe KK. Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor. BMC Gastroenterol. 2010 Jul;10:79. Pubmedid: 20618941. Pmcid: PMC2912240.
  • Park DY, Srivastava A, Kim GH, Mino-Kenudson M, Deshpande V, Zukerberg LR, Song GA, Lauwers GY. CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance. Mod Pathol. 2010 Jan;23(1):54-61. Pubmedid: 19820687.
  • Kang D, Suter MJ, Boudoux C, Yoo H, Yachimski PS, Puricelli WP, Nishioka NS, Mino-Kenudson M, Lauwers GY, Bouma BE, Tearney GJ. Comprehensive imaging of gastroesophageal biopsy samples by spectrally encoded confocal microscopy. Gastrointest Endosc. 2010 Jan;71(1):35-43. Pubmedid: 19922916. Pmcid: PMC3135336.
  • Konstantinidis IT, Deshpande V, Zheng H, Wargo JA, Fernandez-del Castillo C, Thayer SP, Androutsopoulos V, Lauwers GY, Warshaw AL, Ferrone CR. Does the mechanism of lymph node invasion affect survival in patients with pancreatic ductal adenocarcinoma?. J Gastrointest Surg. 2010 Feb;14(2):261-267. Pubmedid: 19937477. Pmcid: PMC3135335.
  • Suter MJ, Jillella PA, Vakoc BJ, Halpern EF, Mino-Kenudson M, Lauwers GY, Bouma BE, Nishioka NS, Tearney GJ. Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine. Gastrointest Endosc. 2010 Feb;71(2):346-353. Pubmedid: 19879573. Pmcid: PMC2857407.
  • Crippa S, Fernández-Del Castillo C, Salvia R, Finkelstein D, Bassi C, Domínguez I, Muzikansky A, Thayer SP, Falconi M, Mino-Kenudson M, Capelli P, Lauwers GY, Partelli S, Pederzoli P, Warshaw AL. Mucin-producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics. Clin Gastroenterol H. 2010 Feb;8(2):213-219. Pubmedid: 19835989. Pmcid: PMC3135334.
  • Lisovsky M, Ogawa F, Dresser K, Woda B, Lauwers GY. Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta. Virchows Arch. 2010 Dec;457(6):635-642. Pubmedid: 20941506.
  • Willett CG, Duda DG, Ancukiewicz M, Shah M, Czito BG, Bentley R, Poleski M, Fujita H, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Chung DC, Clark JW, Jain RK. A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer. Oncologist. 2010 Dec;15(8):845-851. Pubmedid: 20667969. Pmcid: PMC3078712.
  • Kang DK, Suter MJ, Boudoux C, Yachimski PS, Puricelli WP, Nishioka NS, Mino-Kenudson M, Lauwers GY, Bouma BE, Tearney GJ. Co-registered spectrally encoded confocal microscopy and optical frequency domain imaging system. J Microsc. 2010 Aug;239(2):87-91. Pubmedid: 20629914. Pmcid: PMC3135377.
  • Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res. 2009 Oct;69(20):7905-7910. Pubmedid: 19826039. Pmcid: PMC2859041.
  • Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009 Nov;16(5):425-438. Pubmedid: 19878874. Pmcid: PMC3023165.
  • Cleary JM, Tanabe KT, Lauwers GY, Zhu AX. Hepatic toxicities associated with the use of preoperative systemic therapy in patients with metastatic colorectal adenocarcinoma to the liver. Oncologist. 2009 Nov;14(11):1095-1105. Pubmedid: 19880627.
  • Jordan KW, Nordenstam J, Lauwers GY, Rothenberger DA, Alavi K, Garwood M, Cheng LL. Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum. 2009 Mar;52(3):520-525. Pubmedid: 19333056. Pmcid: PMC2720561.
  • Fritz S, Fernandez-del Castillo C, Mino-Kenudson M, Crippa S, Deshpande V, Lauwers GY, Warshaw AL, Thayer SP, Iafrate AJ. Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma. Ann Surg. 2009 Mar;249(3):440-447. Pubmedid: 19247032. Pmcid: PMC3957431.
  • Kwak EL, Hong TS, Berger DL, Forcione DG, Uppot RN, Lauwers GY. Case records of the Massachusetts General Hospital. Case 19-2009. A 63-year-old woman with carcinoma of the gastroesophageal junction. N Engl J Med. 2009 Jun;360(25):2656-2664. Pubmedid: 19535805.
  • Carmack SW, Genta RM, Graham DY, Lauwers GY. Management of gastric polyps: a pathology-based guide for gastroenterologists. Nat Rev Gastroenterol Hepatol. 2009 Jun;6(6):331-341. Pubmedid: 19421245.
  • Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol. 2009 Jun;27(18):3020-3026. Pubmedid: 19470921. Pmcid: PMC2702234.
  • Ryan JL, Morgan DR, Dominguez RL, Thorne LB, Elmore SH, Mino-Kenudson M, Lauwers GY, Booker JK, Gulley ML. High levels of Epstein-Barr virus DNA in latently infected gastric adenocarcinoma. Lab Invest. 2009 Jan;89(1):80-90. Pubmedid: 19002111. Pmcid: PMC2612099.
  • Wilbur DC, Madi K, Colvin RB, Duncan LM, Faquin WC, Ferry JA, Frosch MP, Houser SL, Kradin RL, Lauwers GY, Louis DN, Mark EJ, Mino-Kenudson M, Misdraji J, Nielsen GP, Pitman MB, Rosenberg AE, Smith RN, Sohani AR, Stone JR, Tambouret RH, Wu CL, Young RH, Zembowicz A, Klietmann W. Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations. Arch Pathol Lab Med. 2009 Dec;133(12):1949-1953. Pubmedid: 19961250. Pmcid: PMC3694269.
  • Hornig M, Briese T, Buie T, Bauman ML, Lauwers G, Siemetzki U, Hummel K, Rota PA, Bellini WJ, O'Leary JJ, Sheils O, Alden E, Pickering L, Lipkin WI. Lack of association between measles virus vaccine and autism with enteropathy: a case-control study. PLoS One. 2008 Sep;3(9):e3140. Pubmedid: 18769550. Pmcid: PMC2526159.
  • Suter MJ, Vakoc BJ, Yachimski PS, Shishkov M, Lauwers GY, Mino-Kenudson M, Bouma BE, Nishioka NS, Tearney GJ. Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging. Gastrointest Endosc. 2008 Oct;68(4):745-753. Pubmedid: 18926183. Pmcid: PMC2715833.
  • Sabo E, Meitner PA, Tavares R, Corless CL, Lauwers GY, Moss SF, Resnick MB. Expression analysis of Barrett's esophagus-associated high-grade dysplasia in laser capture microdissected archival tissue. Clin Cancer Res. 2008 Oct;14(20):6440-6448. Pubmedid: 18927283. Pmcid: PMC2701739.
  • Weylandt KH, Nadolny A, Kahlke L, Köhnke T, Schmöcker C, Wang J, Lauwers GY, Glickman JN, Kang JX. Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis. Biochim Biophys Acta. 2008 Nov;1782(11):634-641. Pubmedid: 18832028. Pmcid: PMC2614880.
  • Tanabe KK, Lemoine A, Finkelstein DM, Kawasaki H, Fujii T, Chung RT, Lauwers GY, Kulu Y, Muzikansky A, Kuruppu D, Lanuti M, Goodwin JM, Azoulay D, Fuchs BC. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. Jama. 2008 Jan;299(1):53-60. Pubmedid: 18167406.
  • Harris EI, Lewin DN, Wang HL, Lauwers GY, Srivastava A, Shyr Y, Shakhtour B, Revetta F, Washington MK. Lymphovascular invasion in colorectal cancer: an interobserver variability study. Am J Surg Pathol. 2008 Dec;32(12):1816-1821. Pubmedid: 18779725. Pmcid: PMC2605104.
  • Oble DA, Mino-Kenudson M, Goldsmith J, Hodi FS, Seliem RM, Dranoff G, Mihm M, Hasserjian R, Lauwers GY. Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis. Am J Surg Pathol. 2008 Aug;32(8):1130-1137. Pubmedid: 18545145.
  • Belsley NA, Pitman MB, Lauwers GY, Brugge WR, Deshpande V. Serous cystadenoma of the pancreas: limitations and pitfalls of endoscopic ultrasound-guided fine-needle aspiration biopsy. Cancer. 2008 Apr;114(2):102-110. Pubmedid: 18260088.
  • Crippa S, Salvia R, Warshaw AL, Domínguez I, Bassi C, Falconi M, Thayer SP, Zamboni G, Lauwers GY, Mino-Kenudson M, Capelli P, Pederzoli P, Castillo CF. Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg. 2008 Apr;247(4):571-579. Pubmedid: 18362619. Pmcid: PMC3806104.
  • Shields HM, Shaffer K, O'farrell RP, Travers R, Hayward JN, Becker LS, Lauwers GY. Gastrointestinal manifestations of dermatologic disorders. Clin Gastroenterol H. 2007 Sep;5(9):1010-1017. Pubmedid: 17825768.
  • Koreishi A, Lauwers GY, Misdraji J. Pneumatosis intestinalis: a challenging biopsy diagnosis. Am J Surg Pathol. 2007 Oct;31(10):1469-1475. Pubmedid: 17895747.
  • Park DY, Sakamoto H, Kirley SD, Ogino S, Kawasaki T, Kwon E, Mino-Kenudson M, Lauwers GY, Chung DC, Rueda BR, Zukerberg LR. The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer. Am J Pathol. 2007 Nov;171(5):1509-1519. Pubmedid: 17982127. Pmcid: PMC2043512.
  • Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol. 2007 May;4(5):316-321. Pubmedid: 17464339. Pmcid: PMC2686127.
  • Kaurah P, MacMillan A, Boyd N, Senz J, De Luca A, Chun N, Suriano G, Zaor S, Van Manen L, Gilpin C, Nikkel S, Connolly-Wilson M, Weissman S, Rubinstein WS, Sebold C, Greenstein R, Stroop J, Yim D, Panzini B, McKinnon W, Greenblatt M, Wirtzfeld D, Fontaine D, Coit D, Yoon S, Chung D, Lauwers G, Pizzuti A, Vaccaro C, Redal MA, Oliveira C, Tischkowitz M, Olschwang S, Gallinger S, Lynch H, Green J, Ford J, Pharoah P, Fernandez B, Huntsman D. Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. Jama. 2007 Jun;297(21):2360-2372. Pubmedid: 17545690.
  • Rodriguez JR, Salvia R, Crippa S, Warshaw AL, Bassi C, Falconi M, Thayer SP, Lauwers GY, Capelli P, Mino-Kenudson M, Razo O, McGrath D, Pederzoli P, Fernández-Del Castillo C. Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection. Gastroenterology. 2007 Jul;133(1):72-79. Pubmedid: 17631133. Pmcid: PMC3807096.
  • Evans JA, Bouma BE, Bressner J, Shishkov M, Lauwers GY, Mino-Kenudson M, Nishioka NS, Tearney GJ. Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography. Gastrointest Endosc. 2007 Jan;65(1):50-56. Pubmedid: 17137858. Pmcid: PMC2719434.
  • Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Castillo CF, Warshaw AL, Thayer SP. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology. 2007 Dec;133(6):1999-2009. Pubmedid: 18054571. Pmcid: PMC2254582.
  • Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernández-Del Castillo C. Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. Arch Surg. 2007 Apr;142(4):347-354. Pubmedid: 17438169. Pmcid: PMC3979851.
  • Bartlett DL, Berlin J, Lauwers GY, Messersmith WA, Petrelli NJ, Venook AP. Chemotherapy and regional therapy of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol. 2006 Oct;13(10):1284-1292. Pubmedid: 16955384.
  • Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Gene Dev. 2006 Nov;20(22):3130-3146. Pubmedid: 17114584. Pmcid: PMC1635148.
  • Kwak EL, Jankowski J, Thayer SP, Lauwers GY, Brannigan BW, Harris PL, Okimoto RA, Haserlat SM, Driscoll DR, Ferry D, Muir B, Settleman J, Fuchs CS, Kulke MH, Ryan DP, Clark JW, Sgroi DC, Haber DA, Bell DW. Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res. 2006 Jul;12(14 Pt 1):4283-4287. Pubmedid: 16857803. Pmcid: PMC3807136.
  • Evans JA, Poneros JM, Bouma BE, Bressner J, Halpern EF, Shishkov M, Lauwers GY, Mino-Kenudson M, Nishioka NS, Tearney GJ. Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus. Clin Gastroenterol H. 2006 Jan;4(1):38-43. Pubmedid: 16431303. Pmcid: PMC2703582.
  • Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep;8(3):185-195. Pubmedid: 16169464.
  • Deshpande V, Mino-Kenudson M, Brugge W, Lauwers GY. Autoimmune pancreatitis: more than just a pancreatic disease? A contemporary review of its pathology. Arch Pathol Lab Med. 2005 Sep;129(9):1148-1154. Pubmedid: 16119989.
  • Robert ME, Washington MK, Lee JR, Goldenring JR, Bronner MP, Goldblum JR, Greenson JK, Haber MM, Hart JA, Lamps LW, Lauwers GY, Lewin D, Lazenby AJ, Montgomery E, Crawford JM. Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus. Am J Clin Pathol. 2005 Oct;124(4):519-527. Pubmedid: 16146818.
  • Deshpande V, Mino-Kenudson M, Brugge WR, Pitman MB, Fernandez-del Castillo C, Warshaw AL, Lauwers GY. Endoscopic ultrasound guided fine needle aspiration biopsy of autoimmune pancreatitis: diagnostic criteria and pitfalls. Am J Surg Pathol. 2005 Nov;29(11):1464-1471. Pubmedid: 16224213.
  • Gan SI, Thompson CC, Lauwers GY, Bounds BC, Brugge WR. Ethanol lavage of pancreatic cystic lesions: initial pilot study. Gastrointest Endosc. 2005 May;61(6):746-752. Pubmedid: 15855986.
  • Tanabe KK, Blaszkowsky LS, Chung RT, Blake MA, Lauwers GY. Case records of the Massachusetts General Hospital. Case 23-2005. A 57-year-old man with a mass in the liver. N Engl J Med. 2005 Jul;353(4):401-410. Pubmedid: 16049213.
  • Ogino S, Kawasaki T, Brahmandam M, Yan L, Cantor M, Namgyal C, Mino-Kenudson M, Lauwers GY, Loda M, Fuchs CS. Sensitive sequencing method for KRAS mutation detection by Pyrosequencing. J Mol Diagn. 2005 Aug;7(3):413-421. Pubmedid: 16049314. Pmcid: PMC1867544.
  • Chan HH, Nishioka NS, Mino M, Lauwers GY, Puricelli WP, Collier KN, Brugge WR. EUS-guided photodynamic therapy of the pancreas: a pilot study. Gastrointest Endosc. 2004 Jan;59(1):95-99. Pubmedid: 14722560.
  • Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004 Feb;10(2):145-147. Pubmedid: 14745444. Pmcid: PMC2693485.
  • Misdraji J, Burgart LJ, Lauwers GY. Defective mismatch repair in the pathogenesis of low-grade appendiceal mucinous neoplasms and adenocarcinomas. Mod Pathol. 2004 Dec;17(12):1447-1454. Pubmedid: 15354187.
  • Nielsen CM, Williams J, van den Brink GR, Lauwers GY, Roberts DJ. Hh pathway expression in human gut tissues and in inflammatory gut diseases. Lab Invest. 2004 Dec;84(12):1631-1642. Pubmedid: 15502857.
  • Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernández-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003 Oct;425(6960):851-856. Pubmedid: 14520413. Pmcid: PMC3688051.
  • Esnaola NF, Mirza N, Lauwers GY, Ikai I, Regimbeau JM, Belghiti J, Yamaoka Y, Curley SA, Ellis LM, Nagorney DM, Vauthey JN. Comparison of clinicopathologic characteristics and outcomes after resection in patients with hepatocellular carcinoma treated in the United States, France, and Japan. Ann Surg. 2003 Nov;238(5):711-719. Pubmedid: 14578734. Pmcid: PMC1356150.
  • Kelsey PB, Chen S, Lauwers GY. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-2003. A 79-year-old man with coronary artery disease, peripheral vascular disease, end-stage renal disease, and abdominal pain and distention. N Engl J Med. 2003 Nov;349(22):2147-2155. Pubmedid: 14645643.
  • Fernández-del Castillo CF, Sahani DV, Lauwers GY. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 27-2003. A 36-year-old man with recurrent epigastric pain and elevated amylase levels. N Engl J Med. 2003 Aug;349(9):893-901. Pubmedid: 12944576.
  • Brand S, Wang TD, Schomacker KT, Poneros JM, Lauwers GY, Compton CC, Pedrosa MC, Nishioka NS. Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence. Gastrointest Endosc. 2002 Oct;56(4):479-487. Pubmedid: 12297761.
  • Ashley SW, Lauwers GY. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-2002. A 69-year-old man with painful cutaneous nodules, elevated lipase levels, and abnormal results on abdominal scanning. N Engl J Med. 2002 Nov;347(22):1783-1791. Pubmedid: 12456855.
  • Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Reed A, Hemming A, Howard R, Van Der Werf W, Lauwers G, Liu C, Crawford JM, Davis GL, Nelson DR. Combination of interferon alfa-2b and ribavirin in liver transplant recipients with histological recurrent hepatitis C. Liver Transpl. 2002 Nov;8(11):1000-1006. Pubmedid: 12424712.
  • Wayne JD, Lauwers GY, Ikai I, Doherty DA, Belghiti J, Yamaoka Y, Regimbeau JM, Nagorney DM, Do KA, Ellis LM, Curley SA, Pollock RE, Vauthey JN. Preoperative predictors of survival after resection of small hepatocellular carcinomas. Ann Surg. 2002 May;235(5):722-730. Pubmedid: 11981219. Pmcid: PMC1422499.
  • Vauthey JN, Lauwers GY, Esnaola NF, Do KA, Belghiti J, Mirza N, Curley SA, Ellis LM, Regimbeau JM, Rashid A, Cleary KR, Nagorney DM. Simplified staging for hepatocellular carcinoma. J Clin Oncol. 2002 Mar;20(6):1527-1536. Pubmedid: 11896101.
  • Poneros JM, Tearney GJ, Shiskov M, Kelsey PB, Lauwers GY, Nishioka NS, Bouma BE. Optical coherence tomography of the biliary tree during ERCP. Gastrointest Endosc. 2002 Jan;55(1):84-88. Pubmedid: 11756925.
  • Campbell-Thompson M, Lauwers GY, Reyher KK, Cromwell J, Shiverick KT. 17β-Estradiol Modulates Gastroduodenal Preneoplastic Alterations in Rats Exposed to the Carcinogen N-Methyl-N'-Nitro-Nitrosoguanidine1. Endocrinology. 1999 Oct;140(10):4886-4894. Pubmedid: 28200763.
  • Lauwers GY, Riddell RH. Gastric epithelial dysplasia. Gut. 1999 Nov;45(5):784-790. Pubmedid: 10517922. Pmcid: PMC1727726.
  • Chaoui A, Mergo PJ, Lauwers GY. Unusual appearance of focal nodular hyperplasia with fatty change. Ajr Am J Roentgenol. 1998 Nov;171(5):1433-1434. Pubmedid: 9798902.
  • Lauwers GY, Grant LD, Donnelly WH, Meloni AM, Foss RM, Sanberg AA, Langham MR. Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. Am J Surg Pathol. 1997 Oct;21(10):1248-1254. Pubmedid: 9331300.
  • Solorzano CC, Ksontini R, Pruitt JH, Hess PJ, Edwards PD, Kaibara A, Abouhamze A, Auffenberg T, Galardy RE, Vauthey JN, Copeland EM, Edwards CK, Lauwers GY, Clare-Salzler M, MacKay SL, Moldawer LL, Lazarus DD. Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor. J Immunol. 1997 Jan;158(1):414-419. Pubmedid: 8977217.
  • Lauwers GY, Prendergast NC, Wahl SJ, Bagchi S. Invagination of vermiform appendix. Digest Dis Sci. 1993 Mar;38(3):565-568. Pubmedid: 8444089.