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Evan Wuthrick, MD

Specialty: Radiation Oncology
Program: Radiation Oncology

Call 1-888-MOFFITT

or call 1-888-MOFFITT


Cancer Types Treated: Anal Cancer, Basal Cell Carcinoma, Colon Cancer, Esophageal Cancer, Liver Cancer, Merkel Cell Carcinoma, Pancreatic Cancer, Rectal Cancer, Stomach (Gastric) Cancer, Squamous Cell Carcinoma

Dr. Wuthrick specializes in radiation therapy for skin cancers such as melanoma, Merkel cell carcinoma, squamous cell carcinoma, and basal cell carcinoma. He is also clinically interested in gastrointestinal cancers, including esophagealstomach andliver cancers, and cancers of the pancreas, colon, rectum and anus. Dr. Wuthrick is interested in the combination of high dose per fraction radiation therapy and immunotherapy in melanoma and Merkel cell carcinoma. He is involved in numerous early phase clinical trials exploring the role of MAPK pathway inhibitors with radiation therapy. Dr. Wuthrick has a leadership role in the NCI-sponsored cooperative groups NRG, Alliance for Oncology, and SWOG, which conduct large practice-changing clinical trials in cutaneous and gastrointestinal cancers.

Education & Training

Board Certification:

  • Radiation Oncology


  • Washington University - Gynecologic Brachytherapy and Liquid Isotopes
  • St. Jude Children's Research Hospital - Pediatric Radiation Oncology
  • Thomas Jefferson University Hospital - Radiation Oncology

Medical School:

  • Jefferson Medical College - MD
Participating Trials

A Phase 2, Randomized, Multi-institutional Study of Nivolumab and Ipilimumab versus Nivolumab, Ipilimumab and Stereotactic Body Radiation Therapy for Metastatic Merkel Cell Carcinoma
Intervention: BMS-936558 (Nivolumab); Ipilimumab; Nivolumab; Yervoy (Ipilimumab)

If you believe you are eligible for one of these trials or studies, please call
1-888-MOFFITT (1-888-663-3488).


  • Ahn PH, Machtay M, Anne PR, Cognetti D, Keane WM, Wuthrick E, Dicker AP, Axelrod RS. Phase I Trial Using Induction Ciplatin, Docetaxel, 5-FU and Erlotinib Followed by Cisplatin, Bevacizumab and Erlotinib With Concurrent Radiotherapy for Advanced Head and Neck Cancer. Am J Clin Oncol. 2018 May;41(5):441-446. Pubmedid: 27391356.
  • Walston S, Salloum J, Grieco C, Wuthrick E, Diaz DA, Barney C, Manilchuk A, Schmidt C, Dillhoff M, Pawlik TM, Williams TM. Identifying Clinical Factors Which Predict for Early Failure Patterns Following Resection for Pancreatic Adenocarcinoma in Patients Who Received Adjuvant Chemotherapy Without Chemoradiation. Am J Clin Oncol. 2018 May. Pubmedid: 29727311.
  • Makary MS, Krishner LS, Wuthrick EJ, Bloomston MP, Dowell JD. Yttrium-90 microsphere selective internal radiation therapy for liver metastases following systemic chemotherapy and surgical resection for metastatic adrenocortical carcinoma. World J Clin Oncol. 2018 Feb;9(1):20-25. Pubmedid: 29468134. Pmcid: PMC5807889.
  • Nguyen P, Wuthrick E, Chablani P, Robinson A, Simmons L, Wu C, Arnold M, Harzman AE, Husain S, Schmidt C, Abdel-Misih S, Bekaii-Saab T, Chakravarti A, Williams TM. Does Delaying Surgical Resection After Neoadjuvant Chemoradiation Impact Clinical Outcomes in Locally Advanced Rectal Adenocarcinoma?: A Single-Institution Experience. Am J Clin Oncol. 2018 Feb;41(2):140-146. Pubmedid: 26535992. Pmcid: PMC4860166.
  • Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Engstrom PF, Garrido-Laguna I, Grem JL, Grothey A, Hochster HS, Hoffe S, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Murphy JD, Nurkin S, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Wuthrick E, Gregory KM, Freedman-Cass DA. NCCN Guidelines Insights: Colon Cancer, Version 2.2018. J Natl Compr Canc Ne. 2018 Apr;16(4):359-369. Pubmedid: 29632055.
  • Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. Cancer Res. 2017 Sep;77(18):5095-5106. Pubmedid: 28916678. Pmcid: PMC5678756.
  • Wald P, Liu XS, Pettit C, Dillhoff M, Manilchuk A, Schmidt C, Wuthrick E, Chen W, Williams TM. Prognostic value of microRNA expression levels in pancreatic adenocarcinoma: a review of the literature. Oncotarget. 2017 Sep;8(42):73345-73361. Pubmedid: 29069873. Pmcid: PMC5641216.
  • Williams NL, Wuthrick EJ, Kim H, Palmer JD, Garg S, Eldredge-Hindy H, Daskalakis C, Feeney KJ, Mastrangelo MJ, Kim LJ, Sato T, Kendra KL, Olencki T, Liebner DA, Farrell CJ, Evans JJ, Judy KD, Andrews DW, Dicker AP, Werner-Wasik M, Shi W. Phase 1 Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Patients With Brain Metastases. Int J Radiat Oncol Biol Phys. 2017 Sep;99(1):22-30. Pubmedid: 28816150.
  • Wright CL, Binzel K, Zhang J, Wuthrick EJ, Knopp MV. Clinical feasibility of 90Y digital PET/CT for imaging microsphere biodistribution following radioembolization. Eur J Nucl Med Mol Imaging. 2017 Jul;44(7):1194-1197. Pubmedid: 28405728.
  • Ahn DH, Wu C, Wei L, Williams TM, Wuthrick E, Abdel-Misih S, Harzman A, Husain S, Schmidt C, Goldberg RM, Bekaii-Saab T. The Efficacy of Adjuvant Chemotherapy in Patients With Stage II/III Resected Rectal Cancer Treated With Neoadjuvant Chemoradiation Therapy. Am J Clin Oncol. 2017 Dec;40(6):531-534. Pubmedid: 25723741. Pmcid: PMC4549218.
  • Chablani P, Nguyen P, Pan X, Robinson A, Walston S, Wu C, Frankel WL, Chen W, Bekaii-Saab T, Chakravarti A, Wuthrick E, Williams TM. Perineural Invasion Predicts for Distant Metastasis in Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiation and Surgery. Am J Clin Oncol. 2017 Dec;40(6):561-568. Pubmedid: 26703815. Pmcid: PMC5940000.
  • Wright CL, Zhang J, Binzel K, Wuthrick EJ, Knopp MV. 90Y Digital PET/CT Imaging Following Radioembolization. Clin Nucl Med. 2016 Dec;41(12):975-976. Pubmedid: 27749420.
  • Wuthrick EJ, Zhang Q, Machtay M, Rosenthal DI, Nguyen-Tan PF, Fortin A, Silverman CL, Raben A, Kim HE, Horwitz EM, Read NE, Harris J, Wu Q, Le QT, Gillison ML. Institutional clinical trial accrual volume and survival of patients with head and neck cancer. J Clin Oncol. 2015 Jan;33(2):156-164. Pubmedid: 25488965. Pmcid: PMC4279235.
  • Blazer M, Wu C, Goldberg RM, Phillips G, Schmidt C, Muscarella P, Wuthrick E, Williams TM, Reardon J, Ellison EC, Bloomston M, Bekaii-Saab T. Neoadjuvant modified (m) FOLFIRINOX for locally advanced unresectable (LAPC) and borderline resectable (BRPC) adenocarcinoma of the pancreas. Ann Surg Oncol. 2015 Apr;22(4):1153-1159. Pubmedid: 25358667. Pmcid: PMC4373613.
  • Wuthrick EJ, Curran WJ, Camphausen K, Lin A, Glass J, Evans J, Andrews DW, Axelrod R, Shi W, Werner-Wasik M, Haacke EM, Hillman GG, Dicker AP. A pilot study of hypofractionated stereotactic radiation therapy and sunitinib in previously irradiated patients with recurrent high-grade glioma. Int J Radiat Oncol Biol Phys. 2014 Oct;90(2):369-375. Pubmedid: 25104067.
  • Lawrence YR, Whiton MA, Symon Z, Wuthrick EJ, Doyle L, Harrison AS, Dicker AP. Quality assurance peer review chart rounds in 2011: a survey of academic institutions in the United States. Int J Radiat Oncol Biol Phys. 2012 Nov;84(3):590-595. Pubmedid: 22445006.
  • Evans J, Chen Q, Wuthrick E, Weldon M, Rong Y. SU-E-T-581: Planning Evaluation of Step-And-Shoot IMRT, RapidArc and Helical TomoTherapy for Hippocampal-Avoidance Whole Brain Radiotherapy (HA-WBRT). Med Phys. 2012 Jun;39(6Part19):3839. Pubmedid: 28517063.
  • Zaorsky NG, Malatesta TM, Den RB, Wuthrick E, Ahn PH, Werner-Wasik M, Shi W, Dicker AP, Anne PR, Bar-Ad V, Showalter TN. Assessing the value of an optional radiation oncology clinical rotation during the core clerkships in medical school. Int J Radiat Oncol Biol Phys. 2012 Jul;83(4):e465-e469. Pubmedid: 22704704.
  • Wuthrick EJ, Kamrava M, Curran WJ, Werner-Wasik M, Camphausen KA, Hyslop T, Axelrod R, Andrews DW, Glass J, Machtay M, Dicker AP. A phase 1b trial of the combination of the antiangiogenic agent sunitinib and radiation therapy for patients with primary and metastatic central nervous system malignancies. Cancer. 2011 Dec;117(24):5548-5559. Pubmedid: 21647871. Pmcid: PMC3170674.