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Elizabeth Hyjek, MD, PhD

 
Specialty: Pathology
Program: Pathology

Overview

  Dr. Hyjek earned her MD and PhD from the Medical University of Lodz in Poland. She completed an Anatomic/Clinical Pathology residency and a Hematopathology fellowship at New York-Presbyterian/Weill Cornell Medical Center. She was most recently an Associate Professor of Pathology and a Hematopathology attending at the University of Chicago. Dr. Hyjek has a clinical interest in myeloid neoplasms, acute leukemias and lymphoproliferative disorders, with particular interest in myeloproliferative and myelodysplastic/myeloproliferative neoplasms. She is also interested in flow cytometry for diagnosis of acute leukemias and monitoring of minimal residual disease, and immunohistochemistry for diagnosis of hematopoietic neoplasms, lymphomas and solid tumors. Dr. Hyjek has a research interest in pathobiology of myeloid and lymphoid neoplasms and investigating the relationship between cancer cells (hematopoietic neoplasms and solid tumors) and microenvironment using various approaches, including morphology, flow cytometry, immunohistochemistry, and molecular techniques. She has an additional research interest in the development/validation of flow cytometry protocols for immunophenotyping and monitoring of minimal residual disease in acute leukemias and immunohistochemistry for identification/development of new biomarkers.    


Education & Training

Fellowship:

  • Temple University School of Medicine - Molecular Biology and Immunology

Residency:

  • Weill Medical College of Cornell - Clinical Pathology

Medical School:

  • Medical University of Lodz - MD
Participating Trials

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.

Publications

  • Gupta M, Jafari K, Rajab A, Wei C, Mazur J, Tierens A, Hyjek E, Musani R, Porwit A. Radar plots facilitate differential diagnosis of acute promyelocytic leukemia and NPM1+ acute myeloid leukemia by flow cytometry. Cytometry B Clin Cytom. 2021 Jul.100(4):409-420. Pubmedid: 33301193. Pmcid: PMC8359362.
  • Carll T, Patel A, Derman B, Hyjek E, Lager A, Wanjari P, Segal J, Odenike O, Fidai S, Arber D. Diagnosis and treatment of mixed phenotype (T-myeloid/lymphoid) acute leukemia with novel ETV6-FGFR2 rearrangement. Blood Adv. 2020 Oct.4(19):4924-4928. Pubmedid: 33049052. Pmcid: PMC7556145.
  • Medina MV, D Agostino A, Ma Q, Eroles P, Cavallin L, Chiozzini C, Sapochnik D, Cymeryng C, Hyjek E, Cesarman E, Naipauer J, Mesri EA, Coso OA. KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi's sarcoma. PLoS Pathog. 2020 Oct.16(10):e1009006. Pubmedid: 33057440. Pmcid: PMC7591070.
  • Böttinger P, Schreiber K, Hyjek E, Krausz T, Spiotto MT, Steiner M, Idel C, Booras H, Beck-Engeser G, Riederer J, Willimsky G, Wolf SP, Karrison T, Jensen E, Weichselbaum RR, Nakamura Y, Yew PY, Lambert PF, Kurita T, Kiyotani K, Leisegang M, Schreiber H. Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens. Carcinogenesis. 2020 Nov.41(11):1605-1615. Pubmedid: 32221533. Pmcid: PMC7896110.
  • Limbach AL, Lingen MW, McElherne J, Mashek H, Fitzpatrick C, Hyjek E, Mostofi R, Cipriani NA. The Utility of MDM2 and CDK4 Immunohistochemistry and MDM2 FISH in Craniofacial Osteosarcoma. Head Neck Pathol. 2020 Dec.14(4):889-898. Pubmedid: 32026294. Pmcid: PMC7669933.
  • Zhou Y, Unno K, Hyjek E, Liu H, Zimmerman T, Karmakar S, Putt KS, Shen J, Low PS, Wickrema A. Expression of functional folate receptors in multiple myeloma. Leuk Lymphoma. 2018 Dec.59(12):2982-2989. Pubmedid: 29616859.
  • Li Z, Huang H, Chen P, He M, Li Y, Arnovitz S, Jiang X, He C, Hyjek E, Zhang J, Zhang Z, Elkahloun A, Cao D, Shen C, Wunderlich M, Wang Y, Neilly MB, Jin J, Wei M, Lu J, Valk PJM, Delwel R, Lowenberg B, Le Beau MM, Vardiman J, Mulloy JC, Zeleznik-Le NJ, Liu PP, Zhang J, Chen J. Publisher Correction: miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun. 2018 Apr.9:16192. Pubmedid: 29633759. Pmcid: PMC5898456.
  • Badros A, Hyjek E, Ma N, Lesokhin A, Dogan A, Rapoport AP, Kocoglu M, Lederer E, Philip S, Milliron T, Dell C, Goloubeva O, Singh Z. Pembrolizumab, pomalidomide, and low-dose dexamethasone for relapsed/refractory multiple myeloma. Blood. 2017 Sep.130(10):1189-1197. Pubmedid: 28461396.
  • Godfrey J, Bishop MR, Syed S, Hyjek E, Kline J. PD-1 blockade induces remissions in relapsed classical Hodgkin lymphoma following allogeneic hematopoietic stem cell transplantation. J Immunother Cancer. 2017 Feb.5:11. Pubmedid: 28239465. Pmcid: PMC5319147.
  • Choy B, Hyjek E, Montag AG, Pytel P, Haydon R, Luu HH, Zhen CJ, Long BC, Kadri S, Segal JP, Furtado LV, Cipriani NA. High prevalence of MiTF staining in undifferentiated pleomorphic sarcoma: caution in the use of melanocytic markers in sarcoma. Histopathology. 2017 Apr.70(5):734-745. Pubmedid: 27926791.
  • Apperley ST, Hyjek EM, Musani R, Thenganatt J. Intrathoracic Rosai Dorfman Disease with Focal Aggregates of IgG4-bearing Plasma Cells. Case Report and Literature Review. Ann Am Thorac Soc. 2016 May.13(5):666-670. Pubmedid: 26820713.
  • Deotare U, Yee KW, Le LW, Porwit A, Tierens A, Musani R, Barth D, Torlakovic E, Schimmer A, Schuh AC, Seftel M, Minden MD, Gupta V, Hyjek E. Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: 10-Color flow cytometry diagnosis and HyperCVAD therapy. Am J Hematol. 2016 Mar.91(3):283-286. Pubmedid: 26619305.
  • Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Weichselbaum RR, Schreiber H. Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc Natl Acad Sci U S A. 2016 Jul.113(27):7551-7556. Pubmedid: 27317748. Pmcid: PMC4941507.
  • McGregor SM, Dunning R, Hyjek E, Vigneswaran W, Husain AN, Krausz T. BAP1 facilitates diagnostic objectivity, classification, and prognostication in malignant pleural mesothelioma. Hum Pathol. 2015 Nov.46(11):1670-1678. Pubmedid: 26376834.
  • Torlakovic EE, Nielsen S, Francis G, Garratt J, Gilks B, Goldsmith JD, Hornick JL, Hyjek E, Ibrahim M, Miller K, Petcu E, Swanson PE, Zhou X, Taylor CR, Vyberg M. Standardization of positive controls in diagnostic immunohistochemistry: recommendations from the International Ad Hoc Expert Committee. Appl Immunohistochem Mol Morphol. 2015 Jan.23(1):1-18. Pubmedid: 25474126.
  • Zhao L, David MZ, Hyjek E, Chang A, Meehan SM. M2 macrophage infiltrates in the early stages of ANCA-associated pauci-immune necrotizing GN. Clin J Am Soc Nephrol. 2015 Jan.10(1):54-62. Pubmedid: 25516918. Pmcid: PMC4284408.
  • Alikhan M, Koshy A, Hyjek E, Stenson K, Cohen RN, Yeo KT. Discrepant serum and urine β-hCG results due to production of β-hCG by a cribriform-morular variant of thyroid papillary carcinoma. Clin Chim Acta. 2015 Jan.438:181-185. Pubmedid: 25181612.
  • Schwock J, Hyjek EM, Torlakovic EE, Geddie WR. Enteropathy-associated intestinal T-cell lymphoma in cavitating mesenteric lymph node syndrome: fine-needle aspiration contributes to the diagnosis. Diagn Cytopathol. 2015 Feb.43(2):125-130. Pubmedid: 24610808.
  • Torlakovic EE, Brynes RK, Hyjek E, Lee SH, Kreipe H, Kremer M, McKenna R, Sadahira Y, Tzankov A, Reis M, Porwit A. ICSH guidelines for the standardization of bone marrow immunohistochemistry. Int J Lab Hematol. 2015 Aug.37(4):431-449. Pubmedid: 25977137.
  • Alikhan MB, Tretiakova M, Khan G, Hyjek E, Antic T. Cytopathologic diagnosis of Kaposi sarcoma in unusual clinical settings. J Am Soc Cytopathol. 2014 Sep.3(5):244-249. Pubmedid: 31051677.
  • Baron BW, Anastasi J, Hyjek EM, Baron JM. Expression of PIM1 protein in chronic lymphocytic leukemia/small lymphocytic lymphoma. Leuk Lymphoma. 2014 Nov.55(11):2658-2659. Pubmedid: 24547709.
  • McGregor S, Shah A, Raca G, Mirza MK, Smith SM, Anastasi J, Vardiman JW, Hyjek E, Gurbuxani S. PLZF staining identifies peripheral T-cell lymphomas derived from innate-like T-cells with TRAV1-2-TRAJ33 TCR-α rearrangement. Blood. 2014 Apr.123(17):2742-2743. Pubmedid: 24764561.
  • Torlakovic EE, Francis G, Garratt J, Gilks B, Hyjek E, Ibrahim M, Miller R, Nielsen S, Petcu EB, Swanson PE, Taylor CR, Vyberg M. Standardization of negative controls in diagnostic immunohistochemistry: recommendations from the international ad hoc expert panel. Appl Immunohistochem Mol Morphol. 2014 Apr.22(4):241-252. Pubmedid: 24714041. Pmcid: PMC4206554.
  • Gao L, Yue MM, Davis J, Hyjek E, Schuger L. In pulmonary lymphangioleiomyomatosis expression of progesterone receptor is frequently higher than that of estrogen receptor. Virchows Arch. 2014 Apr.464(4):495-503. Pubmedid: 24570392.
  • Gao L, Antic T, Hyjek E, Gong C, Mueller J, Waxman I, DeMay RM, Reeves W. Immunohistochemical analysis of E-cadherin and zeste homolog 2 expression in endoscopic ultrasound-guided fine-needle aspiration of pancreatic adenocarcinoma. Cancer Cytopathol. 2013 Nov.121(11):644-652. Pubmedid: 23674382.
  • Zhang X, Hyjek E, Vardiman J. A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease. Am J Clin Pathol. 2013 May.139(5):622-632. Pubmedid: 23596114.
  • Badri KR, Gao L, Hyjek E, Schuger N, Schuger L, Qin W, Chekaluk Y, Kwiatkowski DJ, Zhe X. Exonic mutations of TSC2/TSC1 are common but not seen in all sporadic pulmonary lymphangioleiomyomatosis. Am J Respir Crit Care Med. 2013 Mar.187(6):663-665. Pubmedid: 23504366. Pmcid: PMC3733437.
  • Boyerinas B, Zafrir M, Yesilkanal AE, Price TT, Hyjek EM, Sipkins DA. Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy. Blood. 2013 Jun.121(24):4821-4831. Pubmedid: 23589674. Pmcid: PMC3682335.
  • Yoon JW, Gallant M, Lamm ML, Iannaccone S, Vieux KF, Proytcheva M, Hyjek E, Iannaccone P, Walterhouse D. Noncanonical regulation of the Hedgehog mediator GLI1 by c-MYC in Burkitt lymphoma. Mol Cancer Res. 2013 Jun.11(6):604-615. Pubmedid: 23525267.
  • Hasina R, Mollberg N, Kawada I, Mutreja K, Kanade G, Yala S, Surati M, Liu R, Li X, Zhou Y, Ferguson BD, Nallasura V, Cohen KS, Hyjek E, Mueller J, Kanteti R, El Hashani E, Kane D, Shimada Y, Lingen MW, Husain AN, Posner MC, Waxman I, Villaflor VM, Ferguson MK, Varticovski L, Vokes EE, Gill P, Salgia R. Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers. Cancer Res. 2013 Jan.73(1):184-194. Pubmedid: 23100466.
  • Roberts MJ, Chadburn A, Ma S, Hyjek E, Peterson LC. Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia. Am J Clin Pathol. 2013 Feb.139(2):210-219. Pubmedid: 23355206.
  • Morales La Madrid A, Ouyang K, Raca G, Jamali M, Hyjek E, McNeer JL, Anastasi J. A case of pediatric γ/δ T-cell malignancy with t(8;14)(q24;q11)/MYC-TCR successfully treated with pulse type chemotherapy followed by stem cell transplant. Leuk Lymphoma. 2013 Feb.54(2):403-405. Pubmedid: 22800289.
  • Davis JM, Hyjek E, Husain AN, Shen L, Jones J, Schuger LA. Lymphatic endothelial differentiation in pulmonary lymphangioleiomyomatosis cells. J Histochem Cytochem. 2013 Aug.61(8):580-590. Pubmedid: 23609227. Pmcid: PMC3724387.
  • Zhang X, Hyjek E, Soltani K, Petronic-Rosic V, Shea CR. Immunohistochemistry for immunoglobulin G4 on paraffin sections for the diagnosis of pemphigus. Arch Pathol Lab Med. 2012 Nov.136(11):1402-1407. Pubmedid: 23106586.
  • Larson SM, Campbell NP, Huo D, Artz A, Zhang Y, Gajria D, Green M, Weiner H, Daugherty C, Odenike O, Godley LA, Hyjek E, Gurbuxani S, Thirman M, Sipkins D, Van Besien K, Larson RA, Stock W. High dose cytarabine and mitoxantrone: an effective induction regimen for high-risk acute myeloid leukemia (AML). Leuk Lymphoma. 2012 Mar.53(3):445-450. Pubmedid: 21913806.
  • Li Z, Huang H, Chen P, He M, Li Y, Arnovitz S, Jiang X, He C, Hyjek E, Zhang J, Zhang Z, Elkahloun A, Cao D, Shen C, Wunderlich M, Wang Y, Neilly MB, Jin J, Wei M, Lu J, Valk PJM, Delwel R, Lowenberg B, Le Beau MM, Vardiman J, Mulloy JC, Zeleznik-Le NJ, Liu PP, Zhang J, Chen J. miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun. 2012 Feb.3:688. Pubmedid: 22353710. Pmcid: PMC3514459.
  • Carbone M, Ferris LK, Baumann F, Napolitano A, Lum CA, Flores EG, Gaudino G, Powers A, Bryant-Greenwood P, Krausz T, Hyjek E, Tate R, Friedberg J, Weigel T, Pass HI, Yang H. BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. J Transl Med. 2012 Aug.10:179. Pubmedid: 22935333. Pmcid: PMC3493315.
  • Baron BW, Anastasi J, Hyjek EM, Bies J, Reddy PL, Dong J, Joseph L, Thirman MJ, Wroblewski K, Wolff L, Baron JM. PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas. Proc Natl Acad Sci U S A. 2012 Apr.109(15):5735-5739. Pubmedid: 22451912. Pmcid: PMC3326467.
  • Liu RB, Engels B, Arina A, Schreiber K, Hyjek E, Schietinger A, Binder DC, Butz E, Krausz T, Rowley DA, Jabri B, Schreiber H. Densely granulated murine NK cells eradicate large solid tumors. Cancer Res. 2012 Apr.72(8):1964-1974. Pubmedid: 22374983. Pmcid: PMC3680344.
  • Hyjek E, Vardiman JW. Myelodysplastic/myeloproliferative neoplasms. Semin Diagn Pathol. 2011 Nov.28(4):283-297. Pubmedid: 22195406.
  • Torlakovic EE, Hyjek E, Butany J. Bone marrow disorders: recent advances, part I. Introduction. Semin Diagn Pathol. 2011 Nov.28(4):257. Pubmedid: 22195403.
  • Sweis RF, Propes MJ, Hyjek E. Actinomyces-induced inflammatory pseudotumor of the lymph node mimicking scrofula. Ann Intern Med. 2011 Jul.155(1):66-67. Pubmedid: 21727298.
  • Chiu A, Czader M, Cheng L, Hasserjian RP, Wang M, Bhagavathi S, Hyjek EM, Al-Ahmadie H, Knowles DM, Orazi A. Clonal X-chromosome inactivation suggests that splenic cord capillary hemangioma is a true neoplasm and not a subtype of splenic hamartoma. Mod Pathol. 2011 Jan.24(1):108-116. Pubmedid: 20852592.
  • Vardiman J, Hyjek E. World health organization classification, evaluation, and genetics of the myeloproliferative neoplasm variants. Hematology Am Soc Hematol Educ Program. 2011 Dec.2011:250-256. Pubmedid: 22160042.
  • Antic T, Hyjek EM, Taxy JB. The vanishing testis: a histomorphologic and clinical assessment. Am J Clin Pathol. 2011 Dec.136(6):872-880. Pubmedid: 22095372.
  • Gwin K, Cipriani N, Zhang X, Schmidt R, Hyjek E. Bilateral breast involvement by disseminated extranodal Rosai-Dorfman disease. Breast J. 2011 Aug.17(3):309-311. Pubmedid: 21450017.
  • Bhatta S, Kut V, Petronic-Rosic V, Hyjek E, Larson RA. Therapy-related myeloid sarcoma with an NPM1 mutation. Leuk Lymphoma. 2010 Nov.51(11):2130-2131. Pubmedid: 20858094.
  • Yan BC, Gong C, Song J, Krausz T, Tretiakova M, Hyjek E, Al-Ahmadie H, Alves V, Xiao SY, Anders RA, Hart JA. Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms. Am J Surg Pathol. 2010 Aug.34(8):1147-1154. Pubmedid: 20661013. Pmcid: PMC3160135.
  • Baron BW, Hyjek E, Gladstone B, Thirman MJ, Baron JM. PDCD2, a protein whose expression is repressed by BCL6, induces apoptosis in human cells by activation of the caspase cascade. Blood Cells Mol Dis. 2010 Aug.45(2):169-175. Pubmedid: 20605493.
  • Chadburn A, Chiu A, Lee JY, Chen X, Hyjek E, Banham AH, Noy A, Kaplan LD, Sparano JA, Bhatia K, Cesarman E. Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034. J Clin Oncol. 2009 Oct.27(30):5039-5048. Pubmedid: 19752343. Pmcid: PMC2799056.
  • Chiu A, Frizzera G, Mathew S, Hyjek EM, Chadburn A, Tam W, Knowles DM, Orazi A. Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma. Mod Pathol. 2009 Nov.22(11):1507-1517. Pubmedid: 19633642.
  • Di Bartolo DL, Hyjek E, Keller S, Guasparri I, Deng H, Sun R, Chadburn A, Knowles DM, Cesarman E. Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma. J Virol. 2009 May.83(9):4308-4315. Pubmedid: 19224997. Pmcid: PMC2668464.
  • Wagner PL, Hyjek E, Vazquez MF, Meherally D, Liu YF, Chadwick PA, Rengifo T, Sica GL, Port JL, Lee PC, Paul S, Altorki NK, Saqi A. CXCL12 and CXCR4 in adenocarcinoma of the lung: association with metastasis and survival. J Thorac Cardiovasc Surg. 2009 Mar.137(3):615-621. Pubmedid: 19258077.
  • Torlakovic EE, Naresh K, Kremer M, van der Walt J, Hyjek E, Porwit A. Call for a European programme in external quality assurance for bone marrow immunohistochemistry; report of a European Bone Marrow Working Group pilot study. J Clin Pathol. 2009 Jun.62(6):547-551. Pubmedid: 19474355.
  • Gurbuxani S, Gurbaxani S, Anastasi J, Hyjek E. Diffuse large B-cell lymphoma--more than a diffuse collection of large B cells: an entity in search of a meaningful classification. Arch Pathol Lab Med. 2009 Jul.133(7):1121-1134. Pubmedid: 19642739.
  • Chadburn A, Hyjek EM, Tam W, Liu Y, Rengifo T, Cesarman E, Knowles DM. Immunophenotypic analysis of the Kaposi sarcoma herpesvirus (KSHV; HHV-8)-infected B cells in HIV+ multicentric Castleman disease (MCD). Histopathology. 2008 Nov.53(5):513-524. Pubmedid: 18983461.
  • Czuchlewski DR, Csernus B, Bubman D, Hyjek E, Martin P, Chadburn A, Knowles DM, Cesarman E. Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome. Am J Clin Pathol. 2008 Dec.130(6):957-962. Pubmedid: 19019774. Pmcid: PMC3614404.
  • Sica G, Vazquez MF, Altorki N, Port J, Lee PC, Liu Y, Hyjek E, Saqi A. PAX-5 expression in pulmonary neuroendocrine neoplasms: its usefulness in surgical and fine-needle aspiration biopsy specimens. Am J Clin Pathol. 2008 Apr.129(4):556-562. Pubmedid: 18343782.
  • Iaconis L, Hyjek E, Ellenson LH, Pirog EC. p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: correlation with human papillomavirus detection. Arch Pathol Lab Med. 2007 Sep.131(9):1343-1349. Pubmedid: 17824788.
  • Shin SJ, Chen B, Hyjek E, Vazquez M. Immunocytochemistry and fluorescence in situ hybridization in HER-2/neu status in cell block preparations. Acta Cytol. 2007 Jul.51(4):552-557. Pubmedid: 17718120.
  • Chiu A, Xu W, He B, Dillon SR, Gross JA, Sievers E, Qiao X, Santini P, Hyjek E, Lee JW, Cesarman E, Chadburn A, Knowles DM, Cerutti A. Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood. 2007 Jan.109(2):729-739. Pubmedid: 16960154. Pmcid: PMC1785096.
  • Shamonki JM, Salmon JE, Hyjek E, Baergen RN. Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies. Am J Obstet Gynecol. 2007 Feb.196(2):167.e1-167.e5. Pubmedid: 17306667. Pmcid: PMC2248299.
  • Yang C, Jo SH, Csernus B, Hyjek E, Liu Y, Chadburn A, Wang YL. Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. Am J Pathol. 2007 Feb.170(2):722-732. Pubmedid: 17255338. Pmcid: PMC1851856.
  • Chung SM, Kao J, Hyjek E, Chen YT. p53 in esophageal adenocarcinoma: a critical reassessment of mutation frequency and identification of 72Arg as the dominant allele. Int J Oncol. 2007 Dec.31(6):1351-1355. Pubmedid: 17982662.
  • Ruan J, Hyjek E, Kermani P, Christos PJ, Hooper AT, Coleman M, Hempstead B, Leonard JP, Chadburn A, Rafii S. Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma. Clin Cancer Res. 2006 Oct.12(19):5622-5631. Pubmedid: 17020964.
  • Shin SJ, Hyjek E, Early E, Knowles DM. Intratumoral heterogeneity of her-2/neu in invasive mammary carcinomas using fluorescence in-situ hybridization and tissue microarray. Int J Surg Pathol. 2006 Oct.14(4):279-284. Pubmedid: 17041191.
  • Shamonki MI, Kligman I, Shamonki JM, Schattman GL, Hyjek E, Spandorfer SD, Zaninovic N, Rosenwaks Z. Immunohistochemical expression of endometrial L-selectin ligand is higher in donor egg recipients with embryonic implantation. Fertil Steril. 2006 Nov.86(5):1365-1375. Pubmedid: 16989829.
  • Scognamiglio T, Hyjek E, Kao J, Chen YT. Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma. Am J Clin Pathol. 2006 Nov.126(5):700-708. Pubmedid: 17050067.
  • Rohan S, Tu JJ, Kao J, Mukherjee P, Campagne F, Zhou XK, Hyjek E, Alonso MA, Chen YT. Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Clin Cancer Res. 2006 Dec.12(23):6937-6945. Pubmedid: 17145811.
  • Keller SA, Hernandez-Hopkins D, Vider J, Ponomarev V, Hyjek E, Schattner EJ, Cesarman E. NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo. Blood. 2006 Apr.107(8):3295-3302. Pubmedid: 16380446. Pmcid: PMC1432097.
  • Jaggi JS, Seshan SV, McDevitt MR, Sgouros G, Hyjek E, Scheinberg DA. Mitigation of radiation nephropathy after internal alpha-particle irradiation of kidneys. Int J Radiat Oncol Biol Phys. 2006 Apr.64(5):1503-1512. Pubmedid: 16503385.
  • Rush D, Hyjek E, Baergen RN, Ellenson LH, Pirog EC. Detection of microinvasion in vulvar and cervical intraepithelial neoplasia using double immunostaining for cytokeratin and basement membrane components. Arch Pathol Lab Med. 2005 Jun.129(6):747-753. Pubmedid: 15913422.
  • Chadburn A, Hyjek E, Mathew S, Cesarman E, Said J, Knowles DM. KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma. Am J Surg Pathol. 2004 Nov.28(11):1401-1416. Pubmedid: 15489644.
  • Chevallier N, Corcoran CM, Lennon C, Hyjek E, Chadburn A, Bardwell VJ, Licht JD, Melnick A. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein. Blood. 2004 Feb.103(4):1454-1463. Pubmedid: 14551142.
  • Wadler S, Yu B, Tan JY, Kaleya R, Rozenblit A, Makower D, Edelman M, Lane M, Hyjek E, Horwitz M. Persistent replication of the modified chimeric adenovirus ONYX-015 in both tumor and stromal cells from a patient with gall bladder carcinoma implants. Clin Cancer Res. 2003 Jan.9(1):33-43. Pubmedid: 12538449.
  • Hyjek E, Chadburn A, Liu YF, Cesarman E, Knowles DM. BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood. 2001 Jan.97(1):270-276. Pubmedid: 11133771.
  • Dias S, Hattori K, Zhu Z, Heissig B, Choy M, Lane W, Wu Y, Chadburn A, Hyjek E, Gill M, Hicklin DJ, Witte L, Moore MA, Rafii S. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J Clin Invest. 2000 Aug.106(4):511-521. Pubmedid: 10953026. Pmcid: PMC380247.
  • Prasad ML, Hyjek E, Giri DD, Ying L, O'Leary JJ, Hoda SA. Double immunolabeling with cytokeratin and smooth-muscle actin in confirming early invasive carcinoma of breast. Am J Surg Pathol. 1999 Feb.23(2):176-181. Pubmedid: 9989844.
  • Flore O, Rafii S, Ely S, O'Leary JJ, Hyjek EM, Cesarman E. Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature. 1998 Aug.394(6693):588-592. Pubmedid: 9707121.
  • Wasik TJ, Jagodzinski PP, Hyjek EM, Wustner J, Trinchieri G, Lischner HW, Kozbor D. Diminished HIV-specific CTL activity is associated with lower type 1 and enhanced type 2 responses to HIV-specific peptides during perinatal HIV infection. J Immunol. 1997 Jun.158(12):6029-6036. Pubmedid: 9190958.
  • Hyjek EM, Bartkowiak J, Drozdz R, Wasik TJ, Jasinski M, Kaneko Y, Lischner HW, Kozbor D. Evidence for B cell-mediated activation of V delta 1+ T lymphocytes during progression of HIV infection. J Immunol. 1997 Jan.158(1):464-474. Pubmedid: 8977224.
  • Horenstein MG, Nador RG, Chadburn A, Hyjek EM, Inghirami G, Knowles DM, Cesarman E. Epstein-Barr virus latent gene expression in primary effusion lymphomas containing Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. Blood. 1997 Aug.90(3):1186-1191. Pubmedid: 9242551.
  • Lasota J, Hyjek E, Koo CH, Blonski J, Miettinen M. Cytokeratin-positive large-cell lymphomas of B-cell lineage. A study of five phenotypically unusual cases verified by polymerase chain reaction. Am J Surg Pathol. 1996 Mar.20(3):346-354. Pubmedid: 8772789.
  • Hyjek E, Lischner HW, Hyslop T, Bartkowiak J, Kubin M, Trinchieri G, Kozbor D. Cytokine patterns during progression to AIDS in children with perinatal HIV infection. J Immunol. 1995 Oct.155(8):4060-4071. Pubmedid: 7561117.
  • Jagodzinski PP, Wiaderkiewicz R, Kurzawski G, Kloczewiak M, Nakashima H, Hyjek E, Yamamoto N, Uryu T, Kaneko Y, Posner MR. Mechanism of the inhibitory effect of curdlan sulfate on HIV-1 infection in vitro. Virology. 1994 Aug.202(2):735-745. Pubmedid: 7913276.
  • Loh EY, Wang M, Bartkowiak J, Wiaderkiewicz R, Hyjek E, Wang Z, Kozbor D. Gene transfer studies of T cell receptor-gamma delta recognition. Specificity for staphylococcal enterotoxin A is conveyed by V gamma 9 alone. J Immunol. 1994 Apr.152(7):3324-3332. Pubmedid: 8144918.
  • Kozbor D, Hyjek E, Wiaderkiewicz R, Kurzawski G, Lischner HW. Analysis of gamma delta+ T cells in peripheral blood of children with perinatal human immunodeficiency virus (HIV) infection. J Clin Immunol. 1993 May.13(3):193-203. Pubmedid: 8391544.
  • Kozbor D, Hyjek E, Wiaderkiewicz R, Wang Z, Wang M, Loh E. Competitor mRNA fragments for quantitation of cytokine specific transcripts in cell lysates. Mol Immunol. 1993 Jan.30(1):1-7. Pubmedid: 7678056.
  • Kończalik P, Hyjek E. [Intermediate lymphocytic lymphoma]. Wiad Lek. 1992 Feb.45(3-4):111-115. Pubmedid: 1413789.
  • Smolewski P, Hyjek E. [Etiopathogenesis of Hodgkin's disease in the light of current studies]. Postepy Hig Med Dosw. 1989 Dec.43(2-4):275-290. Pubmedid: 2702355.
  • Hyjek E, Isaacson PG. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto's thyroiditis. Hum Pathol. 1988 Nov.19(11):1315-1326. Pubmedid: 3141260.
  • Hyjek E, Smith WJ, Isaacson PG. Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol. 1988 Jul.19(7):766-776. Pubmedid: 3136072.
  • Addis BJ, Hyjek E, Isaacson PG. Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology. 1988 Jul.13(1):1-17. Pubmedid: 3209184.
  • Płuzańska A, Małecka E, Krykowski E, Olszańska-Skorek T, Stempczyńska J, Polkowska E, Hyjek E. [Modified CHOP-Bleo protocol in the treatment of malignant non-Hodgkin's lymphoma of low cell differentiation]. Pol Arch Med Wewn. 1988 Dec.80(6):323-330. Pubmedid: 2481844.
  • Giryn I, Hyjek E, Mirecka B, Woźniak L. [Usefulness of routine electron-microscopic studies in the diagnosis of malignant lymphoma]. Patol Pol. 1983 Apr.34(2):165-172. Pubmedid: 6197690.
  • Płuzańska A, Krykowski E, Robak T, Oliskiewicz W, Polkowska E, Dowgier I, Hyjek E. [Results of treating lymphomas with high degree of malignancy using COPP, CHOP-Bleo and MEV protocols]. Pol Tyg Lek. 1982 Sep.37(36):1049-1053. Pubmedid: 6189105.
  • Płuzańska A, Kowalczyński M, Polkowska E, Stempczyńska J, Hyjek E. [Results of treatment of the lymphoblastic and immunoblastic malignant lymphomas using the CHOP-bleo protocol (cyclophosphamide, doxorubicin, vincristine, bleomycin and prednisolone)]. Pol Arch Med Wewn. 1982 Jul.68(1-2):55-64. Pubmedid: 6186997.
  • Hyjek E, Kelényi G. Pseudolymphomas of the stomach: a lesion characterized by progressively transformed germinal centres. Histopathology. 1982 Jan.6(1):61-68. Pubmedid: 7056512.
  • Polkowska-Kulesza E, Hyjek E, Woźniak L, Płułzańska A, Krykowski E, Mazurowa A. Observations on angioimmunoblastic lymphadenopathy. Acta Med Pol. 1981 Oct.22(1):81-95. Pubmedid: 7270250.
  • Polkowska-Kulesza E, Krykowski E, Woźniak L, Hyjek E, Czarnecki B. [Angioimmunoblastic lymphadenopathy as a paraneoplastic syndrome in stomach cancer]. Patol Pol. 1980 Oct.31(4):591-595. Pubmedid: 7243354.
  • Mioduszewska O, Woźniak L, Hyjek E, Krykowski E, Musiatowicz B, Ostrowski L, Polkowska-Kulesza K, Porwit-Ksiazek A, Sochacka B, Szadowska A, Walewski J. [Preliminary analysis of the Polish lymphoma register: usefulness of the Kiel classification for clinical characteristics and evaluation of therapeutic results]. Nowotwory. 1980 Apr.30(2):109-117. Pubmedid: 7413444.
  • Karasek M, Marek K, Hyjek E. The ultrastructure of rat pineal organ after administration of human chorionic gonadotropin. Acta Med Pol. 1979 Dec.20(1):27-28. Pubmedid: 495202.
  • Woźniak L, Krykowski E, Miller T, Polkowska-Kulesza E, Szadowska A, Hyjek E. [Correlation between pathomorphological and clinical features in the group of malignant lymphomas]. Patol Pol. 1978 Oct.29(4):475-485. Pubmedid: 754150.

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