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Bela Kis, MD, PhD


Specialty: Interventional Radiology
Program: Diagnostic Imaging and Interventional Radiology

Call 1-888-MOFFITT
(1-888-663-3488)

or call 1-888-MOFFITT
(1-888-663-3488)

Overview

Image-guided tumor therapy including transcatheter chemo- and radioembolization, minimally invasive percutaneous tumor ablation (Nanoknift, cryo- and radiofrequency ablation), image guided biopsies, image-guided urinary and biliary interventions, arterial and venous stenting, uterine fibroid embolization, pelvic congestion syndrome and vericose veins, vertbroplasty and kyphoplasty.

Education & Training

Board Certification:

  • Radiology

Fellowship:

  • Brigham and Women's Hospital - Interventional Radiology
  • Wake Forest University Baptist Medical Center - Physiology and Pharmacology
  • University of Occupational and Environmental Health, Japan - Physiology

Residency:

  • Brigham and Women's Hospital -

Medical School:

  • University of Szeged - MD
Participating Trials

CLINICAL TRIAL 18395
Phase 1/2 Study Of Intratumoral G100 With Or Without Pembrolizumab In Patients With Follicular Non-Hodgkin's Lymphoma
Condition: Malignant Hematology
Intervention: G100; Pembrolizumab (Keytruda)
Open

CLINICAL TRIAL 18094
A Phase 2 Study of Transarterial Chemoperfusion Treatment with Cisplatin, Methotrexate and Gemcitabine in Patients with Unresectable Pleural Mesothelioma
Condition: Thoracic
Intervention: Gemzar (gemcitabine); cisplatin; gemcitabine; methotrexate
Open

CLINICAL TRIAL 18396
A Phase III Clinical Trial Evaluating TheraSphere® in Patients with Metastatic Colorectal Carcinoma of the Liver who have Failed First Line Chemotherapy
Condition: Gastrointestinal Tumor
Intervention: FOLFIRI; FOLFOX
Open

If you believe you are eligible for one of these trials or studies, please call
1-888-MOFFITT (1-888-663-3488).

Publications

  • Nanjappa S, Pla-Fernandez CA, Apuri S, Loftus L, Kis B. Liver-Directed Embolization for the Long-Term Control of Hypercalcemia of Malignancy in Metastatic Breast Cancer. Cancer Control. 2017 Jan;24(1):57-59. Pubmedid: 28178714.
  • Kis B, Shah J, Choi J, El-Haddad G, Sweeney J, Biebel B, Mellon E, Frakes JM, Hoffe SE, Fishman MN, Shridhar R. Transarterial Yttrium-90 Radioembolization Treatment of Patients with Liver-Dominant Metastatic Renal Cell Carcinoma. J Vasc Interv Radiol. 2017 Feb;28(2):254-259. Pubmedid: 27955832.
  • Hill ED, Nanjappa S, Kis B. Klebsiella pneumoniae Hepatic Abscess and Bacteremia Despite Prophylactic Antibiotics Posttransarterial Bland Embolization. Infect Dis Clin Prac. 2016 Sep;24(5):e24-e26.
  • Mohammadi H, Abuodeh YA, Jin W, Frakes JM, Friedman M, Biebel B, Choi J, El-Haddad GE, Kis B, Sweeney J, Kim R, Pimiento JM, Malafa MP, Anaya D, Hoffe SE. Using the ALBI Grade as a Prognostic Marker for Radioembolization of Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E194-E195.
  • Abuodeh Y, Naghavi AO, Ahmed KA, Venkat PS, Kim Y, Kis B, Choi J, Biebel B, Sweeney J, Anaya DA, Kim R, Malafa M, Frakes JM, Hoffe SE, El-Haddad G. Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization. World J Gastroenterol. 2016 Dec;22(47):10406-10414. Pubmedid: 28058021. Pmcid: PMC5175253.
  • Abbott AM, Kim R, Hoffe SE, Arslan B, Biebel B, Choi J, El-Haddad G, Kis B, Sweeney J, Meredith KL, Almhanna K, Strosberg J, Shibata D, Fulp WJ, Shridhar R. Outcomes of Therasphere Radioembolization for Colorectal Metastases. Clin Colorectal Cancer. 2015 Sep;14(3):146-153. Pubmedid: 25795047.
  • Kis B, Pamarthi V, Fan CM, Rabkin D, Baum RA. Safety and utility of transjugular liver biopsy in hematopoietic stem cell transplant recipients. J Vasc Interv Radiol. 2013 Jan;24(1):85-89. Pubmedid: 23200125.
  • Varban OA, Ardestani A, Azagury DE, Kis B, Brooks DC, Tavakkoli A. Contemporary management of adult intussusception: who needs a resection?. World J Surg. 2013 Aug;37(8):1872-1877. Pubmedid: 23571865.
  • Kis B, O'Regan KN, Agoston A, Javery O, Jagannathan J, Ramaiya NH. Imaging of desmoplastic small round cell tumour in adults. Br J Radiol. 2012 Feb;85(1010):187-192. Pubmedid: 22128126.
  • Javery O, Krajewski K, O'Regan K, Kis B, Giardino A, Jagannathan J, Ramaiya NH. A to Z of extraskeletal Ewing sarcoma family of tumors in adults: imaging features of primary disease, metastatic patterns, and treatment responses. Ajr Am J Roentgenol. 2011 Dec;197(6):W1015-W1022. Pubmedid: 22109315.
  • Domoki F, Kis B, Gáspár T, Snipes JA, Bari F, Busija DW. Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. Neurochem Int. 2010 Feb;56(3):404-409. Pubmedid: 19931334. Pmcid: PMC2824032.
  • Domoki F, Kis B, Gáspár T, Snipes JA, Parks JS, Bari F, Busija DW. Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. Am J Physiol Cell Physiol. 2009 Jan;296(1):C97-105. Pubmedid: 18971391. Pmcid: PMC2636993.
  • Domoki F, Kis B, Gáspár T, Bari F, Busija DW. Cerebromicrovascular endothelial cells are resistant to L-glutamate. Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1099-R1108. Pubmedid: 18667711. Pmcid: PMC2576095.
  • Gáspár T, Katakam P, Snipes JA, Kis B, Domoki F, Bari F, Busija DW. Delayed neuronal preconditioning by NS1619 is independent of calcium activated potassium channels. J Neurochem. 2008 May;105(4):1115-1128. Pubmedid: 18182041. Pmcid: PMC2814534.
  • Gáspár T, Snipes JA, Busija AR, Kis B, Domoki F, Bari F, Busija DW. ROS-independent preconditioning in neurons via activation of mitoK(ATP) channels by BMS-191095. J Cereb Blood Flow Metab. 2008 Jun;28(6):1090-1103. Pubmedid: 18212794.
  • Lenzsér G, Kis B, Snipes JA, Gáspár T, Sándor P, Komjáti K, Szabó C, Busija DW. Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. J Cereb Blood Flow Metab. 2007 Jul;27(7):1318-1326. Pubmedid: 17213862.
  • Hortobágyi L, Kis B, Hrabák A, Horváth B, Huszty G, Schweer H, Benyó B, Sándor P, Busija DW, Benyó Z. Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. Brain Res. 2007 Feb;1131(1):129-137. Pubmedid: 17161389. Pmcid: PMC1820619.
  • Mayanagi K, Gáspár T, Katakam PV, Kis B, Busija DW. The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2007 Feb;27(2):348-355. Pubmedid: 16736040.
  • Gáspár T, Kis B, Snipes JA, Lenzsér G, Mayanagi K, Bari F, Busija DW. Neuronal preconditioning with the antianginal drug, bepridil. J Neurochem. 2007 Aug;102(3):595-608. Pubmedid: 17394552.
  • Chen L, Kis B, Hashimoto H, Busija DW, Takei Y, Yamashita H, Ueta Y. Adrenomedullin 2 protects rat cerebral endothelial cells from oxidative damage in vitro. Brain Res. 2006 May;1086(1):42-49. Pubmedid: 16616051.
  • Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Neuroscience. 2006 Jun;140(2):723-730. Pubmedid: 16567054.
  • Gáspár T, Kis B, Snipes JA, Lenzsér G, Mayanagi K, Bari F, Busija DW. Transient glucose and amino acid deprivation induces delayed preconditioning in cultured rat cortical neurons. J Neurochem. 2006 Jul;98(2):555-565. Pubmedid: 16805846.
  • Kis B, Snipes JA, Gaspar T, Lenzser G, Tulbert CD, Busija DW. Cloning of cyclooxygenase-1b (putative COX-3) in mouse. Inflamm Res. 2006 Jul;55(7):274-278. Pubmedid: 16955389.
  • Kis B, Chen L, Ueta Y, Busija DW. Autocrine peptide mediators of cerebral endothelial cells and their role in the regulation of blood-brain barrier. Peptides. 2006 Jan;27(1):211-222. Pubmedid: 16137789.
  • Kobayashi H, Yokoo H, Yanagita T, Satoh S, Kis B, Deli M, Niwa M, Wada A. Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells. Brain Res. 2006 Dec;1123(1):12-19. Pubmedid: 17074307.
  • Kis B, Isse T, Snipes JA, Chen L, Yamashita H, Ueta Y, Busija DW. Effects of LPS stimulation on the expression of prostaglandin carriers in the cells of the blood-brain and blood-cerebrospinal fluid barriers. J Appl Physiol Respir Environ Exerc Physiol. 2006 Apr;100(4):1392-1399. Pubmedid: 16322371.
  • Kis B, Snipes JA, Busija DW. Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties. J Pharmacol Exp Ther. 2005 Oct;315(1):1-7. Pubmedid: 15879007.
  • Horiguchi T, Kis B, Rajapakse N, Shimizu K, Busija DW. Cortical spreading depression (CSD)-induced tolerance to transient focal cerebral ischemia in halothane anesthetized rats is affected by anesthetic level but not ATP-sensitive potassium channels. Brain Res. 2005 Nov;1062(1-2):127-133. Pubmedid: 16256083.
  • Snipes JA, Kis B, Shelness GS, Hewett JA, Busija DW. Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat. J Pharmacol Exp Ther. 2005 May;313(2):668-676. Pubmedid: 15650114.
  • Horiguchi T, Snipes JA, Kis B, Shimizu K, Busija DW. The role of nitric oxide in the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Brain Res. 2005 Mar;1039(1-2):84-89. Pubmedid: 15781049.
  • Domoki F, Kis B, Nagy K, Farkas E, Busija DW, Bari F. Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H368-H373. Pubmedid: 15734886.
  • Lenzsér G, Kis B, Bari F, Busija DW. Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. Brain Res. 2005 Jul;1051(1-2):72-80. Pubmedid: 16004973.
  • Busija DW, Katakam P, Rajapakse NC, Kis B, Grover G, Domoki F, Bari F. Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria. Brain Res Bull. 2005 Jul;66(2):85-90. Pubmedid: 15982523.
  • Chen L, Kis B, Busija DW, Yamashita H, Ueta Y. Adrenomedullin protects rat cerebral endothelial cells from oxidant damage in vitro. Regul Pept. 2005 Aug;130(1-2):27-34. Pubmedid: 15913808.
  • Kis B, Snipes JA, Simandle SA, Busija DW. Acetaminophen-sensitive prostaglandin production in rat cerebral endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2005 Apr;288(4):R897-R902. Pubmedid: 15618346.
  • Busija DW, Lacza Z, Rajapakse N, Shimizu K, Kis B, Bari F, Domoki F, Horiguchi T. Targeting mitochondrial ATP-sensitive potassium channels--a novel approach to neuroprotection. Brain Res Brain Res Rev. 2004 Nov;46(3):282-294. Pubmedid: 15571770.
  • Nagy K, Kis B, Rajapakse NC, Bari F, Busija DW. Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation. J Neurosci Res. 2004 Jun;76(5):697-704. Pubmedid: 15139028.
  • Kis B, Snipes A, Bari F, Busija DW. Regional distribution of cyclooxygenase-3 mRNA in the rat central nervous system. Brain Res Mol Brain Res. 2004 Jul;126(1):78-80. Pubmedid: 15207919.
  • Kis B, Nagy K, Snipes JA, Rajapakse NC, Horiguchi T, Grover GJ, Busija DW. The mitochondrial K(ATP) channel opener BMS-191095 induces neuronal preconditioning. Neuroreport. 2004 Feb;15(2):345-349. Pubmedid: 15076766.
  • Erdös B, Snipes JA, Kis B, Miller AW, Busija DW. Vasoconstrictor mechanisms in the cerebral circulation are unaffected by insulin resistance. Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1456-R1461. Pubmedid: 15331381.
  • Chen L, Hashida S, Kitamura K, Eto T, Kangawa K, Serino R, Kis B, Yamashita H, Ueta Y. Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide. Peptides. 2004 Apr;25(4):609-614. Pubmedid: 15165716.
  • Kis B, Rajapakse NC, Snipes JA, Nagy K, Horiguchi T, Busija DW. Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons. J Neurochem. 2003 Nov;87(4):969-980. Pubmedid: 14622127.
  • Kis B, Snipes JA, Isse T, Nagy K, Busija DW. Putative cyclooxygenase-3 expression in rat brain cells. J Cereb Blood Flow Metab. 2003 Nov;23(11):1287-1292. Pubmedid: 14600435.
  • Rajapakse N, Kis B, Horiguchi T, Snipes J, Busija D. Diazoxide pretreatment induces delayed preconditioning in astrocytes against oxygen glucose deprivation and hydrogen peroxide-induced toxicity. J Neurosci Res. 2003 Jul;73(2):206-214. Pubmedid: 12836163.
  • Kis B, Abrahám CS, Deli MA, Kobayashi H, Niwa M, Yamashita H, Busija DW, Ueta Y. Adrenomedullin, an autocrine mediator of blood-brain barrier function. Hypertens Res. 2003 Feb;26 Suppl:S61-S70. Pubmedid: 12630813.
  • Lacza Z, Snipes JA, Kis B, Szabó C, Grover G, Busija DW. Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain. Brain Res. 2003 Dec;994(1):27-36. Pubmedid: 14642445.
  • Horiguchi T, Kis B, Rajapakse N, Shimizu K, Busija DW. Opening of mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats. Stroke. 2003 Apr;34(4):1015-1020. Pubmedid: 12649508.
  • Kis B, Snipes JA, Deli MA, Abrahám CS, Yamashita H, Ueta Y, Busija DW. Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins. Acta Neurochir Suppl. 2003;86:565-568. Pubmedid: 14753507.
  • Béla K, Csongor AS, Deli MA, Ueta Y. Adrenomedullin and migraine. Headache. 2002 Nov;42(10):1064-1065. Pubmedid: 12453043.
  • Rajapakse N, Shimizu K, Kis B, Snipes J, Lacza Z, Busija D. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Neurosci Lett. 2002 Jul;327(3):208-212. Pubmedid: 12113913.
  • Lacza Z, Puskar M, Kis B, Perciaccante JV, Miller AW, Busija DW. Hydrogen peroxide acts as an EDHF in the piglet pial vasculature in response to bradykinin. Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H406-H411. Pubmedid: 12063315.
  • Kis B, Kaiya H, Nishi R, Deli MA, Abrahám CS, Yanagita T, Isse T, Gotoh S, Kobayashi H, Wada A, Niwa M, Kangawa K, Greenwood J, Yamashita H, Ueta Y. Cerebral endothelial cells are a major source of adrenomedullin. J Neuroendocrinol. 2002 Apr;14(4):283-293. Pubmedid: 11963825.
  • Kis B, Abrahám CS, Deli MA, Kobayashi H, Wada A, Niwa M, Yamashita H, Ueta Y. Adrenomedullin in the cerebral circulation. Peptides. 2001 Nov;22(11):1825-1834. Pubmedid: 11754969.
  • Kis B, Deli MA, Kobayashi H, Abrahám CS, Yanagita T, Kaiya H, Isse T, Nishi R, Gotoh S, Kangawa K, Wada A, Greenwood J, Niwa M, Yamashita H, Ueta Y. Adrenomedullin regulates blood-brain barrier functions in vitro. Neuroreport. 2001 Dec;12(18):4139-4142. Pubmedid: 11742253.
  • Kis B, Mezei Z, Forgács P, Gecse A, Telegdy G, Bari F. Prostanoid synthesis in the cerebral blood vessels of asphyxiated piglets. Acta Physiol Hung. 2001;88(2):87-100. Pubmedid: 11999809.
  • Mezei Z, Kis B, Gecse A, Tajti J, Boda B, Telegdy G, Vécsei L. Platelet arachidonate cascade of migraineurs in the interictal phase. Platelets. 2000 Jun;11(4):222-225. Pubmedid: 10938901.
  • Szupera Z, Mezei Z, Kis B, Gecse A, Vécsei L, Telegdy G. The effects of valproate on the arachidonic acid metabolism of rat brain microvessels and of platelets. Eur J Pharmacol. 2000 Jan;387(2):205-210. Pubmedid: 10650161.
  • Kis B, Gáspár T, Mezei Z, Gecse A, Telegdy G. Pituitary adenylate cyclase-activating polypeptide inhibits the cyclooxygenase pathway of rat cerebral microvessels. Acta Physiol Scand. 1999 Sep;167(1):43-47. Pubmedid: 10519976.
  • Kis B, Mezei Z, Dancsó G, Pataricza J, Gecse A, Papp JG, Telegdy G. Effects of pituitary adenylate cyclase-activating polypeptide on the cyclooxygenase pathway of rat platelets and on platelet aggregation. Prostaglandins Other Lipid Mediat. 1999 Oct;58(2-4):103-112. Pubmedid: 10560613.
  • Kis B, Szupera Z, Mezei Z, Gecse A, Telegdy G, Vécsei L. Valproate treatment and platelet function: the role of arachidonate metabolites. Epilepsia. 1999 Mar;40(3):307-310. Pubmedid: 10080510.
  • Kis B, Szabó CA, Pataricza J, Krizbai IA, Mezei Z, Gecse A, Telegdy G, Papp JG, Deli MA. Vasoactive substances produced by cultured rat brain endothelial cells. Eur J Pharmacol. 1999 Feb;368(1):35-42. Pubmedid: 10096767.
  • Gecse A, Kis B, Mezei Z, Telegdy G. Effects of inflammatory neuropeptides on the arachidonate cascade of platelets. Int Arch Allergy Immunol. 1999 Feb;118(2-4):166-170. Pubmedid: 10224368.
  • Kis B, Mezei Z, Gecse A, Telegdy G. The effect of substance P on the arachidonate cascade of rat platelets. Acta Physiol Hung. 1997 None;85(2):89-97. Pubmedid: 9706302.
  • Mezei Z, Kis B, Gecse A, Telegdy G, Abrahám G, Sonkodi S. Platelet eicosanoids and the effect of captopril in blood pressure regulation. Eur J Pharmacol. 1997 Dec;340(1):67-73. Pubmedid: 9527508.
  • Gecse A, Kis B, Mezei Z, Telegdy G. The effect of bradykinin and substance P on the arachidonate cascade of platelets. Immunopharmacology. 1996 Jun;33(1-3):167-170. Pubmedid: 8856141.
  • Kis B, Mills M, Hoffe SE. Hepatic radioembolization from transradial access: initial experience and comparison to transfemoral access. Diagn Interv Radiol. 22(5):444-449. Pubmedid: 27353460. Pmcid: PMC5019848.
  • Csányi G, Kis B, Gecse A, Telegdy G, Szupera Z, Vécsei L, Szente M, Leprán I, Mezei Z. Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. Pharmacol Rep. 60(3):345-352. Pubmedid: 18622059.