Page Menu

Brain Tumor Clinical Trials

clinical trial

Brain tumor clinical trials play a vital role in facilitating breakthroughs in care and improving outcomes for patients now and into the future. Individuals who participate in a clinical trial - a controlled research study into a new treatment or methodology - help provide key answers to physicians and scientists regarding the effectiveness of emerging cancer therapies and how they compare to established brain tumor treatments.

Brain tumor clinical trials at Moffitt

Moffitt Cancer Center is making great strides in the fight against brain tumors through our trailblazing clinical trials and research initiatives. Here, patients in our Neuro-Oncology Program have unique opportunities to receive promising new brain tumor therapies before those options are made widely available. We are actively exploring innovations in the prevention, diagnosis and treatment of brain tumors, including:

  • Screening and diagnostic strategies
  • Targeted therapies
  • Chemotherapy combinations and delivery methods
  • Immunotherapies
  • Vaccine therapies
  • Radiation therapies
  • Treatment options for benign (noncancerous) brain tumors
  • Surgical treatments and robotic-assisted techniques

The types of tumors that we have clinical trials for include:

  • Gliomas
  • Brain metastasis
  • Leptomeningeal disease
  • Spinal tumors

Why choose Moffitt?

Moffitt is a nationally recognized leader in clinical trials and research, maintaining one of the largest clinical trial outcome databases in the United States. We have also been awarded multiple grants from the National Cancer Institute, as well as their prestigious Comprehensive Cancer Center designation that speaks to our ambitious approach to cancer research. Moffitt is currently the only Florida-based cancer center to hold this distinction.

Another distinguishing factor of Moffitt is our collaborative approach to brain tumor treatment. The multispecialty team in our brain tumor program works hand in hand to develop individualized treatment plans for patients, which may include clinical trials. Furthermore, our brain tumor specialists focus exclusively on brain cancers and routinely address uncommon and complex cases. This unparalleled expertise, combined with our dedication to research, allows us to help our patients achieve more positive outcomes and better quality of life.

How do I take part in a brain tumor clinical trial?

Your first step toward participating in a brain tumor clinical trial is to speak with a physician about the studies currently available and whether one may be right for you. Clinical trials aren’t appropriate for every patient. Our team prioritizes patient education and will ensure you receive the information you need to make confident decisions about your care.

For further information about brain tumor clinical trials at Moffitt, submit a clinical trial inquiry form online or call 1-813-745-6100 or 1-800-679-0775 (toll-free). Our clinical navigators can discuss your options and answer any questions you may have.

Medically Reviewed by Dr. Michael Vogelbaum, Program Leader, Department of Neuro-Oncology.

 

calledFromCancerPage=True - substr=
testProtocol=

Open Clinical Trials:

Showing of 50

CLINICAL TRIAL 18752

ACTION Trial- Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas (Phase I)

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 18778

A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 19327

A Phase 2 Trial of Pembrolizumab Plus Bevacizumab in Patients with Metastatic Melanoma or Non-small Cell Lung Cancer with Untreated Brain Metastases

Disease Site: Non small cell lung cancer, Brain and Nervous System, Lung, Melanoma, skin

View Trial Details

CLINICAL TRIAL 19648

Phase IB Study of Avelumab with Radiotherapy in Patients with Leptomeningeal Disease

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 19970

A Pilot Trial of Intratumorally-Administered Topotecan using Convection-Enhanced Delivery (CED) in Patients with Suspected Recurrent/Progressive WHO Grade III or IV (High Grade) Glioma Undergoing Stereotactic Biopsy (IND 117,240)

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 20145

A Pilot Study of Intratumorally and Intraparenchymally Administered OS2966 using Convection-enhanced Delivery in Patients with Recurrent/Progressive High-grade Glioma Undergoing a Clinically-indicated Surgical Resection

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 20347

A Phase 2 Basket Trial of Glutaminase Inhibitor (BeGIN) CB-839 HCl in Patients with NF1 Aberrations, NF1 Mutant Malignant Peripheral Nerve Sheath Tumors (MPNST), KEAP1/NRF2 and LKB1 Aberrant Tumors

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 20637

Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 20899

Phase I/II Study of Stereotactic Radiation and Abemaciclib in the Management of Hormone Receptor Positive HER2 Negative Breast Cancer Brain Metastases

Disease Site: Brain and Nervous System, Breast

View Trial Details

CLINICAL TRIAL 20956

A Two-Part, Phase 1a/B, Open-Label, Multicenter Trial Evaluating Pharmacokinetics, Safety and Efficacy Of PF-07284890 (ARRY-461) In Participants With BRAF V600-Mutant Solid Tumors With And Without Brain Involvement

Disease Site: Any Site, Brain and Nervous System, Larynx, Lip, Oral Cavity and Pharynx, Lung, Melanoma, skin, Other Skin

View Trial Details

CLINICAL TRIAL 20964

A Phase 2 Basket Study of Tucatinib in Combination with Trastuzumab in Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Disease Site: Brain and Nervous System, Breast, Ill-Defined Sites, Lung, Other Digestive Organ, Urinary Bladder

View Trial Details

CLINICAL TRIAL 21070

A Multi-indication, Single-treatment Arm, Open-label Phase 2 Study of Regorafenib and Nivolumab in Combination in Patients with Recurrent or Metastatic Solid Tumors

Disease Site: Brain and Nervous System, Esophagus, Liver, Other Hematopoietic, Pancreas

View Trial Details

CLINICAL TRIAL 21084

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1PI

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 19731

Electronic Social Network Assessment Program (eSNAP) + Caregiver Navigator Intervention for Neuro-Oncology Couples

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 50388

Targeting the Hemangiopericytoma NAB2-STAT6 Gene Fusion

Disease Site: Brain and Nervous System

View Trial Details

CLINICAL TRIAL 50399

Mechanisms of Functional Heterogeneity of Tumor Associated Macrophages in Glioblastoma

Disease Site: Brain and Nervous System

View Trial Details