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Brain Tumor Clinical Trials

clinical trial

Brain tumor clinical trials play a vital role in facilitating breakthroughs in care and improving outcomes for patients now and into the future. Individuals who participate in a clinical trial - a controlled research study into a new treatment or methodology - help provide key answers to physicians and scientists regarding the effectiveness of emerging cancer therapies and how they compare to established brain tumor treatments.

Brain tumor clinical trials at Moffitt

Moffitt Cancer Center is making great strides in the fight against brain tumors through our trailblazing clinical trials and research initiatives. Here, patients in our Neuro-Oncology Program have unique opportunities to receive promising new brain tumor therapies before those options are made widely available. We are actively exploring innovations in the prevention, diagnosis and treatment of brain tumors, including:

  • Screening and diagnostic strategies
  • Targeted therapies
  • Chemotherapy combinations and delivery methods
  • Immunotherapies
  • Vaccine therapies
  • Radiation therapies
  • Treatment options for benign (noncancerous) brain tumors
  • Surgical treatments and robotic-assisted techniques

The types of tumors that we have clinical trials for include:

  • Gliomas
  • Brain metastasis
  • Leptomeningeal disease
  • Spinal tumors

Why choose Moffitt?

Moffitt is a nationally recognized leader in clinical trials and research, maintaining one of the largest clinical trial outcome databases in the United States. We have also been awarded multiple grants from the National Cancer Institute, as well as their prestigious Comprehensive Cancer Center designation that speaks to our ambitious approach to cancer research. Moffitt is currently the only Florida-based cancer center to hold this distinction.

Another distinguishing factor of Moffitt is our collaborative approach to brain tumor treatment. The multispecialty team in our brain tumor program works hand in hand to develop individualized treatment plans for patients, which may include clinical trials. Furthermore, our brain tumor specialists focus exclusively on brain cancers and routinely address uncommon and complex cases. This unparalleled expertise, combined with our dedication to research, allows us to help our patients achieve more positive outcomes and better quality of life.

How do I take part in a brain tumor clinical trial?

Your first step toward participating in a brain tumor clinical trial is to speak with a physician about the studies currently available and whether one may be right for you. Clinical trials aren’t appropriate for every patient. Our team prioritizes patient education and will ensure you receive the information you need to make confident decisions about your care.

For further information about brain tumor clinical trials at Moffitt, submit a clinical trial inquiry form online or call 1-813-745-6100 or 1-800-679-0775 (toll-free). Our clinical navigators can discuss your options and answer any questions you may have.

Medically Reviewed by Dr. Michael Vogelbaum, Program Leader, Department of Neuro-Oncology.


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Open Clinical Trials:

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ACTION Trial- Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas (Phase I)

Disease Site: Brain and Nervous System, Gliomas

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A Pilot Trial of Intratumorally-Administered Topotecan using Convection-Enhanced Delivery (CED) in Patients with Suspected Recurrent/Progressive WHO Grade III or IV (High Grade) Glioma Undergoing Stereotactic Biopsy (IND 117,240)

Disease Site: Brain and Nervous System

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Phase I/II Study of Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in the Management of HER2+ Breast Leptomeningeal Disease

Disease Site: Brain and Nervous System, Breast, Leptomeningeal (LMD)

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Phase I/II Study of Stereotactic Radiation and Abemaciclib in the Management of Hormone Receptor Positive HER2 Negative Breast Cancer Brain Metastases

Disease Site: Brain and Nervous System, Breast

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A Phase 2 Basket Study of Tucatinib in Combination with Trastuzumab in Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Disease Site: Brain and Nervous System, Breast, Ill-Defined Sites, Lung, Other Digestive Organ, Urinary Bladder, Brain metastasis, Leptomeningeal (LMD)

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A Pivotal Randomized, Open-Label Study Of OPTUNE(R)(TTFIELDS, 200KHZ) Concomitant With Radiation Therapy And Temozolomide For The Treatment Of Newly Diagnosed Glioblastoma

Disease Site: Brain and Nervous System, Gliomas

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Electronic Social Network Assessment Program (eSNAP) + Caregiver Navigator Intervention for Neuro-Oncology Couples

Disease Site: Brain and Nervous System, Brain metastasis, Gliomas, Leptomeningeal (LMD), Meningiomas

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A Pilot Study of Advanced Multi-parametric MRI to Evaluate De Novo Glioblastoma Tumors Prior to Surgical Resection

Disease Site: Brain and Nervous System, Gliomas

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