The new clinic will focus on cellular immunotherapies such as chimeric antigen receptor T-cell therapy (CAR T), which reengineers a patient’s own immune cells to fight cancer. For this treatment, the patient’s T cells are removed and modified with additional receptors to help identify, attack and ultimately destroy the cancer cells. The re-engineered T cells are then infused back into the patient’s body in a single treatment, enabling the body’s immune system to better combat the disease.
The state-of-the-art ICE-T unit will give patients and their caregivers a better treatment experience, according to Chrystal Pompos, MSN, RN, MBA, the patient care manager of ICE-T.
“The combined inpatient and outpatient unit will provide our patients with the best continuity because their therapy will be in the same general area with the same team members throughout their continuum of care,” explained Pompos.
Previously, this treatment occurred in Moffitt’s infusion center. Now cellular therapy patients can receive their chemotherapy in the outpatient area of the new ICE-T unit, and when it is time for therapy they will be admitted to the inpatient side of the clinic for treatment and recovery.
“The same physicians, APPs, nurses, techs and secretaries will see them from beginning to end,” she said. “This will allow us to develop stronger relationships with our patients and caregivers, which in turn will allow us to better anticipate their needs, communicate better as a team and deliver the best evidence-based care and best outcomes for our patients.”
The Moffitt Immune Cell Therapy (ICE-T) clinic has 12 inpatient beds and eight treatment bays for outpatient visits. The cancer center hired additional staff to man the new unit alongside veteran members of Moffitt’s Blood and Marrow Transplantation program, where CAR T therapy began with the first clinical trials in 2015.
Cellular immunotherapy can be used to treat several different types of cancer– One specific therapy, CAR T, has proved to be successful in treating blood cancers, such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma. However, clinical trials are underway to expand its use to other blood malignancies, such as multiple myeloma.
“This therapy has been a game-changer for patients with large B cell lymphoma who have failed two or more lines of therapy,” said Dr. Frederick Locke, vice chair of the Blood and Marrow Transplant and Cellular Immunotherapy Department and co-leader of the Immunology Program at Moffitt.
Moffitt was the first to provide commercially available Yescarta after FDA approval in October of 2017. When the FDA expanded use of Novartis’ KymriahTM to this patient population on April 30, 2018, Moffitt became the first Florida center to offer both CAR T choices to patients. In 2019 alone, nearly 100 patients have been treated with CAR T at Moffitt.
To refer a patient to a specialist in our Immunology Program, complete our online form or contact a physician liaison for assistance or support. As part of our efforts to shorten referral times as much as possible, online referrals are typically responded to within 24 - 48 hours.