Small Intestine Cancer Clinical Trials

Small intestine cancer clinical trials offer participants access to a wide variety of exciting new treatment options, such as innovative surgical techniques, novel radiation therapy delivery methods and more targeted chemotherapy drugs. The main purpose of these studies is to evaluate the effectiveness of a brand-new treatment as compared to the current standard of care. If the results of a clinical trial establish that a new treatment is more effective than the currently available treatments, or equally effective with fewer side effects, the new treatment may become the new standard of care. Every treatment goes through a similar process prior to being made widely available for use in all clinical settings.

Moffitt Cancer Center has a robust portfolio of small intestine cancer clinical trials. At any given time, one or more new therapies are under study, such as:

  • Biological therapy – Substances created by the body or in a laboratory are used to enhance, target or restore the body’s immune system to provide a natural defense against cancer.
  • Radiation therapy with radiosensitizers – Certain drugs, which have been found to make cancer cells more receptive to radiation therapy, are administered in conjunction with radiation therapy to potentially destroy more cancer.
  • Chemotherapy – Drugs injected into a vein or taken by mouth can destroy cancer cells or prevent them from growing, and researchers are continually testing new medications and drug combinations to improve effectiveness and reduce side effects.
  • Surgical approaches – Surgery, which is the most commonly recommended form of treatment for small intestine cancer, may be more effective when performed with certain techniques to help remove (resect) an affected portion of the small intestine or create a path for food to bypass a cancerous obstruction.

As a National Cancer Institute-designated Comprehensive Cancer Center, Moffitt has established an outstanding reputation for excellence in cancer research. As we continue to expand the knowledge base about all forms of cancer, we use clinical trials as a way to translate breakthrough laboratory discoveries into accessible treatment options for current and future cancer patients, improving their survival rate and quality of life.

If you've been diagnosed with small intestine cancer and are interested in clinical trials, our clinical trial navigators can answer your questions. Call call 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form online.


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Open Clinical Trials:

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A Randomized Phase 3 Study of the Efficacy and Safety of Glufosfamide Compared with Fluorouracil (5-FU) in Patients with Metastatic Pancreatic Adenocarcinoma Previously Treated with Gemcitabine

Disease Site: Colon, Liver, Lung, Other Endocrine System, Pancreas, Small Intestine, Stomach

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Phase 1b/3 z=Global, Randomized, Controlled, Open-Label Trial Comparing Treatment with RYZ101 to Standard of Care (SoC) Therapy in Subjects with Inoperable, Advanced, Somatostatin Receptor Expressing (SSTR+), Well-Differentiated Gastro-Enteropancreatic Neuroendocrine Tumors (GEP-NETs) that have Progressed Following Prior 177Lulabelled Somatostatin Analogue (177Lu-SSA) Therapy (ACTION-1).

Disease Site: Esophagus, Other Digestive Organ, Pancreas, Small Intestine, Stomach

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A Phase 2 Open Label Study to Evaluate the Safety and Effectiveness of 212Pb-DOTAMTATE in PRRT Naïve Subjects with Somatostatin Receptor Expressing Neuroendocrine Tumors

Disease Site: Any Site, Liver, Lung, Other Digestive Organ, Other Endocrine System, Pancreas, Rectum, Small Intestine, Stomach

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(Peak) A Phase 3 Randomized, Open-label, Multicenter Clinical Study of GT9486+Sunitinib vs Sunitinib in Subjects with Locally Advanced, Unresectable, or Metastatic Gastrointestinal Stromal Tumors

Disease Site: Other Digestive Organ, Small Intestine, Stomach

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Tele-Resistance Training During Chemotherapy For Advanced Upper Gastrointestinal Cancer

Disease Site: Esophagus, Small Intestine, Stomach

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