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Skin Cancer Clinical Trials

Skin cancer clinical trials are used to compare emerging, innovative treatments to the current standard of care. These trials offer a number of benefits, such as:

  • The ability to access new, promising drugs long before they are available in other settings
  • The ability to explore additional therapies when other treatments do not provide adequate benefits (as is often the case with late-stage cancers)
  • The ability to contribute to new developments that will eventually benefit thousands of patients who have been diagnosed with skin cancer

At Moffitt Cancer Center, our skin cancer clinical trials have tested some of the most promising developments in treatment to date. For instance, we’ve tested several forms of immunotherapy, intralesional therapy and molecular targeted therapy. Additionally, we’re one of the only centers in the country that has the protocol to test T-cell therapies, which boost the body’s natural ability to fight cancer using its own immune system.

When you participate in a clinical trial at Moffitt, you can expect to have your progress monitored by a team of oncologists who specialize in skin cancer. This way, we can ensure that you’re receiving an ideal dose of the treatment and that any side effects are kept to a minimum.

Depending on the protocol of your specific trial, you may also be able to receive additional treatments here at Moffitt Cancer Center. We’ll make sure that you’re receiving the treatments that are most appropriate for your specific diagnosis, and you’ll be able to access all of your treatments in one convenient location.

For more information about the skin cancer clinical trials offered at Moffitt,  call 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form. No referral is required; our clinical trial navigators will help you determine whether you might benefit from a clinical trial, and will explain to you all of the requirements involved.

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Open Clinical Trials:

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CLINICAL TRIAL 19441

Pilot Study of Adaptive BRAF-MEK Inhibitor Therapy for Advanced BRAF Mutant Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 19495

A Multicenter, Randomized, Double Blinded, Placebo Controlled, Phase 3 trial of Adjuvant Avelumab (anti PDL1 antibody) in Merkel Cell Carcinoma Patients with Clinically Detected Lymph Node Metastases

Disease Site: Merkel cell carcinoma, Other Skin

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CLINICAL TRIAL 19868

First in Human Phase I Study of 225Actinium-DOTA-Ahx-MC1RL (225Ac-MTI-201) in Metastatic Melanoma

Disease Site: Eye and Orbit, Melanoma, skin

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CLINICAL TRIAL 20068

A Randomized, Placebo-Controlled, Double-Blind Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

Disease Site: Other Skin, Skin, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20162

Phase 1 Trial of Intralesional Immunotherapy with IFx-Hu2.0 Vaccine in Patients with Advanced Merkel Cell Carcinoma or Cutaneous Squamous Cell Carcinoma

Disease Site: Melanoma, skin, Merkel cell carcinoma, Other Skin, Skin, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20270

A Phase 2, Multicenter Study of Autologous Tumor Infiltrating Lymphocytes (LN-144 or LN-145) in Patients with Solid Tumors (IOV-COM-202)

Disease Site: Lung, Melanoma, skin, Non small cell lung cancer

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CLINICAL TRIAL 20313

Neoadjuvant Immunotherapy with Intratumoral Tavokinogene Telseplasmid (Tavo) plus Electroporation in Combination with Intravenous Nivolumab in Patients with Operable Locally- Regionally Advanced Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 20490

Keystroke: A Randomized Phase II Study of Pembrolizumab (Keytruda) Plus Stereotactic Re-irradiation versus SBRT Alone For Locoregionally Recurrent or Second Primary Head and Neck Carcinoma

Disease Site: Other Skin

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CLINICAL TRIAL 20494

A Phase II Study of High Dose Bolus IL2 in Combination with Low Dose Ipilimumab Followed Sequentially by Nivolumab in Patients with Inoperable Stage III or Stage IV Melanoma Who Have Failed Prior Anti-PD1 Immunotherapy

Disease Site: Melanoma, skin

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CLINICAL TRIAL 20641

A Randomized Pilot Trial of Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib and Binimetinib in Advanced Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 20731

Phase 2 Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma

Disease Site: Other Skin, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20773

Neoadjuvant Lenvatinib Plus Pembrolizumab in Resectable Merkel Cell Carcinoma

Disease Site: Other Skin, Merkel cell carcinoma

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CLINICAL TRIAL 20794

Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma: Safety and Biomarker Analysis

Disease Site: Other Skin, Merkel cell carcinoma

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CLINICAL TRIAL 20854

Exercise to Boost Response to Checkpoint Blockade Immunotherapy

Disease Site: Melanoma, skin, Other Skin

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CLINICAL TRIAL 20904

A Randomized Phase 2 Trial of Encorafenib + Binimetinib + Nivolumab vs Ipilimumab + Nivolumab in Braf-V600 Mutant Melanoma with Brain Metastases

Disease Site: Melanoma, skin

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CLINICAL TRIAL 20955

A Phase II Study of Binimetinib plus Belinostat for Subjects with Metastatic Uveal Melanoma

Disease Site: Other Skin

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CLINICAL TRIAL 21023

Open Label, Multicenter Phase II Study of the C5A- Antibody IFX-1 Alone or IFX-1 + Pembrolizumab in Patients with PD-1- or PD-L1-Resistant/Refractory Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma (CSCC)

Disease Site: Other Skin

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CLINICAL TRIAL 21080

A Phase 1, Open-Label, Dose-Escalation, and Dose-Expansion Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of SRK-181 Administered Alone or in Combination with a Checkpoint Inhibitor in Patients with Locally Advanced or Metastatic Solid Tumors (DRAGON)

Disease Site: Any Site, Lung, Melanoma, skin, Urinary Bladder

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CLINICAL TRIAL 21112

Phase 2 Study of Axitinib + Ipilimumab in Advanced Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21180

A First-in-Human, Two-Part, Open-Label, Clinical Study to Assess the Safety, Tolerability and Activity of Intravenous Doses of ICT01 as Monotherapy and in Combination with an Immune Checkpoint Inhibitor, in Patients with Advanced-Stage, Relapsed/Refractory Cancer (EVICTION Study)

Disease Site: Any Site, Breast, Colon, Larynx, Leukemia, other, Lip, Oral Cavity and Pharynx, Lung, Melanoma, skin, Ovary, Prostate, Stomach, Urinary Bladder

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CLINICAL TRIAL 21239

Randomized Phase II/III Study of Nivolumab plus Ipilimumab plus Sargramostim versus Nivolumab plus Ipilimumab in Patients with Unresectable Stage III or Stage IV Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21273

A Randomized, Pilot Study to Evaluate the Molecular and Cellular Response to Treatment with Nivolumab with either Adjuvant Ipilimumab or Relatlimab in Adult Patients with Surgically Resectable Melanoma Brain Metastases

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21344

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients with Melanoma (Morpheus-Melanoma)

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21553

A Multicenter, Randomized, Double-Blind Phase 3 Study of HBI-8000 Combined with Nivolumab versus Placebo with Nivolumab in Patients with Unresectable or Metastatic Melanoma Not Previously Treated with PD-1 or PD-L1 Inhibitors

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21573

An Open-Label Expanded Access Study of the Melphalan/Hepatic Delivery System (HDS) in Patients with Hepatic Dominant Ocular Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21707

A Proof of Concept Study of TBio-4101 (an autologous selected and expanded tumor infiltrating lymphocyte [TIL] therapy) using Short-Term Cultured, Selected Autologous TIL Following a Lymphodepleting Chemotherapy Regimen and Followed by IL-2 for Patients with Relapsed or Refractory Melanoma (Phase 1)

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21731

A Phase II Trial of Olaparib in Combination with Pembrolizumab for Advanced Uveal Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21997

Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma

Disease Site: Other Skin

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CLINICAL TRIAL 20256

CemiplimAb Survivorship Epidemiology (CASE) Study

Disease Site: Squamous Cell Carcinoma (SCC), Other Skin

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CLINICAL TRIAL 19950

Linking the Skin and Gut Microbiome to Immunosuppression in Skin Cancer

Disease Site: Other Skin

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CLINICAL TRIAL 21125

MElanoma Research Lymph Node Prediction Implementation National_001 (MERLIN_001)

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21942

Characterization of Lymphoid Aggregates in Desmoplastic Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 50401

Creation of Cell Lines and Corresponding DNA and RNA Analysis from Acral Lentiginous Malignant Melanoma

Disease Site: Melanoma, skin

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