Bladder Cancer Clinical Trials & Research

Clinical trials offer bladder cancer patients the opportunity to be among the first to benefit from breakthrough treatment options, before they become widely available. Sometimes, it is mistakenly believed that participating in a clinical trial means that the patient will become a "guinea pig," either testing a drug or procedure that has never before been used or unknowingly receiving a placebo, but this could not be further from the truth. In reality, cancer treatments that are in the clinical trial phase have already undergone extensive testing for safety, and in the rare instances that placebos are used in clinical trials, participants are made fully aware of this possibility and are never denied access to other treatments they may need. Furthermore, clinical trial participants can choose to withdraw from the program at any time.

Are You a Candidate for a Bladder Cancer Clinical Trial?

The purpose of clinical trials, for bladder cancer or any other type of cancer, is to compare innovative new therapies with standard treatments (standard treatments that are considered the most advanced options currently available). Any patient can be considered for participation in a clinical trial, but they must meet the inclusion criteria for the particular study. These criteria may include factors such as:

  • The type of cancer
  • The patient’s gender
  • The patient’s age
  • Past treatments
  • The staging, or extent, of the cancer

For the most groundbreaking treatments and clinical trials, bladder cancer patients should look to high-volume cancer facilities, like Moffitt Cancer Center, that have a specialty program concentrated on urologic cancers. Moffitt boasts a robust clinical trials program and is home to a vast research team that’s comprised of a wide range of professionals, including physician-scientists, research data specialists and oncologists who specialize solely in the treatment of bladder cancer. For our extensive research efforts, Moffitt has been designated a National Cancer Institute Comprehensive Care Center – the only one based in Florida.

If you’d like to learn about specific bladder cancer clinical trials available at Moffitt, call 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form.

 

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Open Clinical Trials:

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CLINICAL TRIAL 18680

A study of Intravesical Bacillus Calmette-Guerin (BCG) in Combination with ALT-803 in Patients with Non-Muscle Invasive Bladder Cancer

Disease Site: Urinary Bladder

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CLINICAL TRIAL 19873

A Phase II Open Label Single Arm Study of Adjuvant Nivolumab following Chemo-Radiation in localized Muscle-Invasive Bladder Cancer (NEXT)

Disease Site: Urinary Bladder

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CLINICAL TRIAL 19988

A Phase II Open Label, Study of IMMU-132 in Metastatic Urothelial Cancer After Failure of Platinum-Based Regimen or Anti-PD-1/ PD-L1 Based Immunotherapy

Disease Site: Urothelial Cancer, Urinary Bladder

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CLINICAL TRIAL 20050

QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination with ALT-803 in Patients with BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer

Disease Site: Urinary Bladder

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CLINICAL TRIAL 20353

S1806, Phase III Randomized Trial of Concurrent Chemoradiotherapy with or without Atezolizumab in Localized Muscle Invasive Bladder Cancer

Disease Site: Urinary Bladder

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CLINICAL TRIAL 20534

A Phase 1b Dose-Escalation Study of Cabozantinib (XL184) Administered Alone or in Combination with Atezolizumab to Subjects with Locally Advanced or Metastatic Solid Tumors

Disease Site: Other Urinary, Prostate, Urinary Bladder

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CLINICAL TRIAL 20575

A Phase 1 Study of CG0070 Combined with Nivolumab in Cisplatin Ineligible Patients with Muscle Invasive Bladder Cancer (MIBC)

Disease Site: Urinary Bladder

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CLINICAL TRIAL 20711

A Phase 2, Single Arm Study of CG0070 Combined with Pembrolizumab in Patients with Non Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG)

Disease Site: Urinary Bladder

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CLINICAL TRIAL 20840

An Exploratory, Open-label, Multicenter Phase 1b Trial to Evaluate Safety and Efficacy of Sym021 (Anti-PD-1) in Combination with Either Sym022 (Anti-LAG-3) or Sym023 (Anti-TIM-3) or Sym023 and Irinotecan in Patients with Recurrent Advanced Biliary Tract Carcinomas

Disease Site: Liver, Lung, Other Female Genital, Urinary Bladder

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CLINICAL TRIAL 20943

Combination of Ipi/Nivo Plus Sacituzumab Govitecan in Metastatic Cisplatin Ineligible Urothelial Carcinoma Patients

Disease Site: Other Urinary, Urinary Bladder, Urothelial Cancer

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CLINICAL TRIAL 20964

A Phase 2 Basket Study of Tucatinib in Combination with Trastuzumab in Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Disease Site: Brain and Nervous System, Breast, Ill-Defined Sites, Lung, Other Digestive Organ, Urinary Bladder

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CLINICAL TRIAL 19733

Motivating a Spectrum of Cancer Patients to Quit Smoking: Intervention Development and Feasibility

Disease Site: Breast, Colon, Colorectal, Melanoma, skin, Other Female Genital, Rectum, Urinary Bladder, Uterus, Vaginal, Vulva, Ovary

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CLINICAL TRIAL 21375

A Multicenter Validation of Genomic Subtyping and Whole Transcriptome Profiling for Predicting Non-Organ Confined Disease in Patients with Clinical T1/T2 Urothelial Carcinoma of the Bladder

Disease Site: Urinary Bladder

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