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TIL (tumor-infiltrating lymphocyte) therapy is a type of cellular immunotherapy that may be used to treat head and neck squamous cell carcinoma, melanoma, lung cancer, genitourinary cancers and a growing list of other malignancies. Cellular immunotherapy leverages components of the patient’s own immune system to seek out and attack specific cancer cells.
How does TIL therapy work?
TIL therapy essentially uses altered tumor cells to destroy the tumor itself. TILs, or tumor-infiltrating lymphocytes, are special immune system cells (T cells) that are naturally present inside some tumors. In TIL therapy, TILs are collected from the tumor during a biopsy, or surgical resection, and grown to very large numbers in a laboratory with interleukin-2 (IL-2), a protein that promotes rapid TIL growth. Once successfully grown to billions in number, the TILs are infused back into the patient, where they actively attack cancer cells while leaving healthy cells alone. A brief course of chemotherapy is required prior to the TIL infusion to help the TIL attack the tumor.
TIL therapy at Moffitt Cancer Center
Moffitt Cancer Center is helping revolutionize the way cancers are treated through TIL therapy and many other innovative treatments. With established physician scientists and clinicians, our center is actively exploring cellular immunotherapies by spearheading ambitious research initiatives and a groundbreaking clinical trial program. Thanks in part to our dedication to improving patient outcomes and quality of life through research, Moffitt is designated by the National Cancer Institute as a Comprehensive Cancer Center. We are the only Florida-based cancer center to hold this distinction.
If you would like to learn about Moffitt’s approach to cellular immunotherapy, treatment options for your specific type of cancer or whether or not you are a candidate for TIL therapy, contact us at 1-888-663-3488 or complete a new patient registration form online. We make advanced cancer treatment accessible by providing clinical and supportive care services in one location and accepting patients with or without referrals.