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Yoga Balagurunathan, PhD

Academic Rank: Assistant Member

Overview

    Dr. Balagurunathan’s research is focused on understanding the physiology of the tumor and its relationship to the underlying genome. His interests include data integration from various modalities (radiology, pathology, genome) to improve clinical decision support, His diseasefoci are prostate cancer, lung cancer and B-cell lymphomas.  


Discipline

    • Biostatistics and Bioinformatics
    • Genitourinary Oncology
    • Diagnostic Imaging and Interventional Radiology
    • Cancer Biology and Evolution Program

Education & Training

Fellowship:

  • Texas A&M University, PhD - Electrical Engineering
  • College of Engineering Guindy, Anna University, ME - Electronics & Communications
Research

    Dr. Balagurunathan’s research is focused on understanding the physiology of the tumor and its relationship to the underlying genome. His interests include data integration from various modalities (radiology, pathology, genome) to improve clinical decision support, His diseasefoci are prostate cancer, lung cancer and B-cell lymphomas.  

Publications

  • Srikumar T, Siegel EM, Gu Y, Balagurunathan Y, Garcia AL, Chen YA, Zhou JM, Zhao X, Gillies R, Clark W, Gamenthaler A, Choi J, Shibata D. Semiautomated Measure of Abdominal Adiposity Using Computed Tomography Scan Analysis. J Surg Res. 2019 May.237:12-21. Pubmedid: 30694786.
  • Paul R, Schabath M, Balagurunathan Y, Liu Y, Li Q, Gillies R, Hall LO, Goldgof DB. Explaining Deep Features Using Radiologist-Defined Semantic Features and Traditional Quantitative Features. Tomography. 2019 Mar.5(1):192-200. Pubmedid: 30854457. Pmcid: PMC6403047.
  • Stringfield O, Arrington JA, Johnston SK, Rognin NG, Peeri NC, Balagurunathan Y, Jackson PR, Clark-Swanson KR, Swanson KR, Egan KM, Gatenby RA, Raghunand N. Multiparameter MRI Predictors of Long-Term Survival in Glioblastoma Multiforme. Tomography. 2019 Mar.5(1):135-144. Pubmedid: 30854451. Pmcid: PMC6403044.
  • Parra NA, Lu H, Choi J, Gage K, Pow-Sang J, Gillies RJ, Balagurunathan Y. Habitats in DCE-MRI to Predict Clinically Significant Prostate Cancers. Tomography. 2019 Mar.5(1):68-76. Pubmedid: 30854444. Pmcid: PMC6403034.
  • Parra NA, Lu H, Li Q, Stoyanova R, Pollack A, Punnen S, Choi J, Abdalah M, Lopez C, Gage K, Park JY, Kosj Y, Pow-Sang JM, Gillies RJ, Balagurunathan Y. Erratum: Predicting clinically significant prostate cancer using DCE-MRI habitat descriptors. Oncotarget. 2019 Mar.10(21):2113. Pubmedid: 31007853. Pmcid: PMC6459347.
  • Balagurunathan Y, Schabath MB, Wang H, Liu Y, Gillies RJ. Quantitative Imaging features Improve Discrimination of Malignancy in Pulmonary nodules. Sci Rep. 2019 Jun;9(1):8528. Pubmedid: 31189944. Pmcid: PMC6561979.
  • Lu H, Mu W, Balagurunathan Y, Qi J, Abdalah MA, Garcia AL, Ye Z, Gillies RJ, Schabath MB. Multi-window CT based Radiomic signatures in differentiating indolent versus aggressive lung cancers in the National Lung Screening Trial: a retrospective study. Cancer Imaging. 2019 Jun;19(1):45. Pubmedid: 31253194. Pmcid: PMC6599273.
  • Li Q, Lu H, Choi J, Gage K, Feuerlein S, Pow-Sang JM, Gillies R, Balagurunathan Y. Radiological semantics discriminate clinically significant grade prostate cancer. Cancer Imaging. 2019 Dec.19(1):81. Pubmedid: 31796094.
  • El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, Berglund A, Visvakarma N, Ibrahim-Hashim A, Choi J, Luddy K, Gatenby R, Pilon-Thomas S, Anderson A, Ruffell B, Gillies R. Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer. Brit J Cancer. 2019 Aug.121(7):556-566. Pubmedid: 31417189. Pmcid: PMC6889319.
  • Li Q, Balagurunathan Y, Liu Y, Qi J, Schabath MB, Ye Z, Gillies RJ. Comparison Between Radiological Semantic Features and Lung-RADS in Predicting Malignancy of Screen-Detected Lung Nodules in the National Lung Screening Trial. Clin Lung Cancer. 2018 Mar;19(2):148-156.e3. Pubmedid: 29137847. Pmcid: PMC5825260.
  • Balagurunathan Y, Beers A, Kalpathy-Cramer J, McNitt-Gray M, Hadjiiski L, Zhao B, Zhu J, Yang H, Yip SSF, Aerts HJWL, Napel S, Cherezov D, Cha K, Chan HP, Flores C, Garcia A, Gillies R, Goldgof D. Semi-automated pulmonary nodule interval segmentation using the NLST data. Med Phys. 2018 Mar;45(3):1093-1107. Pubmedid: 29363773. Pmcid: PMC5952359.
  • Liu Y, Kim J, Balagurunathan Y, Hawkins S, Stringfield O, Schabath MB, Li Q, Qu F, Liu S, Garcia AL, Ye Z, Gillies RJ. Prediction of pathological nodal involvement by CT-based Radiomic features of the primary tumor in patients with clinically node-negative peripheral lung adenocarcinomas. Med Phys. 2018 Jun;45(6):2518-2526. Pubmedid: 29624702. Pmcid: PMC6161827.
  • Balagurunathan Y, Beers A, Kalpathy-Cramer J, McNitt-Gray M, Hadjiiski L, Zhao B, Zhu J, Yang H, Yip SSF, Aerts HJWL, Napel S, Cherezov D, Cha K, Chan HP, Flores C, Garcia A, Gillies R, Goldgof D. Erratum: Semi-automated pulmonary nodule interval segmentation using the NLST data. Med Phys. 2018 Jun.45(6):2689-2690. Pubmedid: 29894564.
  • Paul R, Liu Y, Li Q, Hall L, Goldgof D, Balagurunathan Y, Schabath M, Gillies R. Representation of Deep Features using Radiologist defined Semantic Features. Proc Int Jt Conf Neural Netw. 2018 Jul.2018. Pubmedid: 30443437. Pmcid: PMC6233304.
  • Liu Y, Wang H, Li Q, McGettigan MJ, Balagurunathan Y, Garcia AL, Thompson ZJ, Heine JJ, Ye Z, Gillies RJ, Schabath MB. Radiologic Features of Small Pulmonary Nodules and Lung Cancer Risk in the National Lung Screening Trial: A Nested Case-Control Study. Radiology. 2018 Jan;286(1):298-306. Pubmedid: 28837413. Pmcid: PMC5738292.
  • Cherezov D, Hawkins SH, Goldgof DB, Hall LO, Liu Y, Li Q, Balagurunathan Y, Gillies RJ, Schabath MB. Delta radiomic features improve prediction for lung cancer incidence: A nested case-control analysis of the National Lung Screening Trial. Cancer Med. 2018 Dec.7(12):6340-6356. Pubmedid: 30507033. Pmcid: PMC6308046.
  • Parra AN, Lu H, Li Q, Stoyanova R, Pollack A, Punnen S, Choi J, Abdalah M, Lopez C, Gage K, Park JY, Kosj Y, Pow-Sang JM, Gillies RJ, Balagurunathan Y. Predicting clinically significant prostate cancer using DCE-MRI habitat descriptors. Oncotarget. 2018 Dec.9(98):37125-37136. Pubmedid: 30647849. Pmcid: PMC6324677.
  • Gillies RJ, Balagurunathan Y. Perfusion MR Imaging of Breast Cancer: Insights Using "Habitat Imaging". Radiology. 2018 07;288(1):36-37. Pubmedid: 29714676.
  • Permuth JB, Chen DT, Yoder SJ, Li J, Smith AT, Choi JW, Kim J, Balagurunathan Y, Jiang K, Coppola D, Centeno BA, Klapman J, Hodul P, Karreth FA, Trevino JG, Merchant N, Magliocco A, Malafa MP, Gillies R. Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas. Sci Rep. 2017 Sep;7(1):10484. Pubmedid: 28874676. Pmcid: PMC5585319.
  • Li Q, Kim J, Balagurunathan Y, Qi J, Liu Y, Latifi K, Moros EG, Schabath MB, Ye Z, Gillies RJ, Dilling TJ. CT imaging features associated with recurrence in non-small cell lung cancer patients after stereotactic body radiotherapy. Radiat Oncol. 2017 Sep;12(1):158. Pubmedid: 28946909. Pmcid: PMC5613447.
  • Tunali I, Stringfield O, Guvenis A, Wang H, Liu Y, Balagurunathan Y, Lambin P, Gillies RJ, Schabath MB. Radial gradient and radial deviation radiomic features from pre-surgical CT scans are associated with survival among lung adenocarcinoma patients. Oncotarget. 2017 Nov.8(56):96013-96026. Pubmedid: 29221183. Pmcid: PMC5707077.
  • Ibrahim-Hashim A, Robertson-Tessi M, Enrizues-Navas P, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson AR, Gillies RJ, Gatenby RA. Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res. 2017 May;77(9):2242-2254. Pubmedid: 28249898. Pmcid: PMC6005351.
  • Liu Y, Balagurunathan Y, Atwater T, Antic S, Li Q, Walker RC, Smith G, Massion PP, Schabath MB, Gillies RJ. Radiological Image Traits Predictive of Cancer Status in Pulmonary Nodules. Clin Cancer Res. 2017 Mar;23(6):1442-1449. Pubmedid: 27663588. Pmcid: PMC5527551.
  • Shafiq-Ul-Hassan M, Zhang GG, Latifi K, Ullah G, Hunt DC, Balagurunathan Y, Abdalah MA, Schabath MB, Goldgof DG, Mackin D, Court LE, Gillies RJ, Moros EG. Intrinsic dependencies of CT radiomic features on voxel size and number of gray levels. Med Phys. 2017 Mar;44(3):1050-1062. Pubmedid: 28112418. Pmcid: PMC5462462.
  • Permuth JB, Choi JW, Chen DT, Jiang K, DeNicola G, Li JN, Coppola D, Centeno BA, Magliocco A, Balagurunathan Y, Merchant N, Trevino JG, Jeong D. A pilot study of radiologic measures of abdominal adiposity: weighty contributors to early pancreatic carcinogenesis worth evaluating?. Cancer Biol Med. 2017 Feb.14(1):66-73. Pubmedid: 28443205. Pmcid: PMC5365183.
  • Li Q, Kim J, Balagurunathan Y, Liu Y, Latifi K, Stringfield O, Garcia A, Moros EG, Dilling TJ, Schabath MB, Ye Z, Gillies RJ. Imaging features from pretreatment CT scans are associated with clinical outcomes in nonsmall-cell lung cancer patients treated with stereotactic body radiotherapy. Med Phys. 2017 Aug;44(8):4341-4349. Pubmedid: 28464316. Pmcid: PMC5553698.
  • Chang YC, Ackerstaff E, Tschudi Y, Jimenez B, Foltz W, Fisher C, Lilge L, Cho H, Carlin S, Gillies RJ, Balagurunathan Y, Yechieli RL, Subhawong T, Turkbey B, Pollack A, Stoyanova R. Delineation of Tumor Habitats based on Dynamic Contrast Enhanced MRI. Sci Rep. 2017 Aug;7(1):9746. Pubmedid: 28851989. Pmcid: PMC5575347.
  • Liu Y, Kim J, Balagurunathan Y, Li Q, Garcia AL, Stringfield O, Ye Z, Gillies RJ. Radiomic Features Are Associated With EGFR Mutation Status in Lung Adenocarcinomas. Clin Lung Cancer. 2016 Sep;17(5):441-448.e6. Pubmedid: 27017476. Pmcid: PMC5548419.
  • Cherezov D, Hawkins S, Goldgof D, Hall L, Balagurunathan Y, Gillies RJ, Schabath MB. Improving malignancy prediction through feature selection informed by nodule size ranges in NLST. Conf Proc IEEE Int Conf Syst Man Cybern. 2016 Oct.2016:001939-001944. Pubmedid: 30473607. Pmcid: PMC6251413.
  • Wang H, Schabath MB, Liu Y, Stringfield O, Balagurunathan Y, Heine JJ, Eschrich SA, Ye Z, Gillies RJ. Association Between Computed Tomographic Features and Kirsten Rat Sarcoma Viral Oncogene Mutations in Patients With Stage I Lung Adenocarcinoma and Their Prognostic Value. Clin Lung Cancer. 2016 Jul;17(4):271-278. Pubmedid: 26712103. Pmcid: PMC4887405.
  • Liu Y, Kim J, Qu F, Liu S, Wang H, Balagurunathan Y, Ye Z, Gillies RJ. CT Features Associated with Epidermal Growth Factor Receptor Mutation Status in Patients with Lung Adenocarcinoma. Radiology. 2016 Jul;280(1):271-280. Pubmedid: 26937803. Pmcid: PMC4934516.
  • Hawkins S, Wang H, Liu Y, Garcia A, Stringfield O, Krewer H, Li Q, Cherezov D, Gatenby RA, Balagurunathan Y, Goldgof D, Schabath MB, Hall L, Gillies RJ. Predicting Malignant Nodules from Screening CT Scans. J Thorac Oncol. 2016 Dec;11(12):2120-2128. Pubmedid: 27422797. Pmcid: PMC5545995.
  • Permuth JB, Choi J, Balarunathan Y, Kim J, Chen DT, Chen L, Orcutt S, Doepker MP, Gage K, Zhang G, Latifi K, Hoffe S, Jiang K, Coppola D, Centeno BA, Magliocco A, Li Q, Trevino J, Merchant N, Gillies R, Malafa M, On Behalf Of The Florida Pancreas Collaborative . Combining radiomic features with a miRNA classifier may improve prediction of malignant pathology for pancreatic intraductal papillary mucinous neoplasms. Oncotarget. 2016 Dec;7(52):85785-85797. Pubmedid: 27589689. Pmcid: PMC5349874.
  • Paul R, Hawkins SH, Balagurunathan Y, Schabath MB, Gillies RJ, Hall LO, Goldgof DB. Deep Feature Transfer Learning in Combination with Traditional Features Predicts Survival Among Patients with Lung Adenocarcinoma. Tomography. 2016 Dec.2(4):388-395. Pubmedid: 28066809. Pmcid: PMC5218828.
  • Kalpathy-Cramer J, Mamomov A, Zhao B, Lu L, Cherezov D, Napel S, Echegaray S, Rubin D, McNitt-Gray M, Lo P, Sieren JC, Uthoff J, Dilger SK, Driscoll B, Yeung I, Hadjiiski L, Cha K, Balagurunathan Y, Gillies R, Goldgof D. Radiomics of Lung Nodules: A Multi-Institutional Study of Robustness and Agreement of Quantitative Imaging Features. Tomography. 2016 Dec.2(4):430-437. Pubmedid: 28149958. Pmcid: PMC5279995.
  • Schabath MB, Massion PP, Thompson ZJ, Eschrich SA, Balagurunathan Y, Goldof D, Aberle DR, Gillies RJ. Differences in Patient Outcomes of Prevalence, Interval, and Screen-Detected Lung Cancers in the CT Arm of the National Lung Screening Trial. PLoS One. 2016 Aug;11(8):e0159880. Pubmedid: 27509046. Pmcid: PMC4980050.
  • Stoyanova R, Takhar M, Tschudi Y, Ford JC, Solórzano G, Erho N, Balagurunathan Y, Punnen S, Davicioni E, Gillies RJ, Pollack A. Prostate cancer radiomics and the promise of radiogenomics. Transl Cancer Res. 2016 Aug.5(4):432-447. Pubmedid: 29188191. Pmcid: PMC5703221.
  • Grove O, Berglund AE, Schabath MB, Aerts HJ, Dekker A, Wang H, Velazquez ER, Lambin P, Gu Y, Balagurunathan Y, Eikman E, Gatenby RA, Eschrich S, Gillies RJ. Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma. PLoS One. 2015 Mar;10(3):e0118261. Pubmedid: 25739030. Pmcid: PMC4349806.
  • Verduzco D, Lloyd M, Xu L, Ibrahim-Hashim A, Balagurunathan Y, Gatenby RA, Gillies RJ. Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance. PLoS One. 2015 Mar;10(3):e0120958. Pubmedid: 25811878. Pmcid: PMC4374837.
  • Balagurunathan Y, Gu Y, Wang H, Kumar V, Grove O, Hawkins S, Kim J, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ. Reproducibility and Prognosis of Quantitative Features Extracted from CT Images. Transl Oncol. 2014 Feb;7(1):72-87. Pubmedid: 24772210. Pmcid: PMC3998690.
  • Zhou M, Hall L, Goldgof D, Russo R, Balagurunathan Y, Gillies R, Gatenby R. Radiologically defined ecological dynamics and clinical outcomes in glioblastoma multiforme: preliminary results. Transl Oncol. 2014 Feb;7(1):5-13. Pubmedid: 24772202. Pmcid: PMC3998688.
  • Balagurunathan Y, Kumar V, Gu Y, Kim J, Wang H, Liu Y, Goldgof DB, Hall LO, Korn R, Zhao B, Schwartz LH, Basu S, Eschrich S, Gatenby RA, Gillies RJ. Test-retest reproducibility analysis of lung CT image features. J Digit Imaging. 2014 Dec;27(6):805-823. Pubmedid: 24990346. Pmcid: PMC4391075.
  • Bailey KM, Wojtkowiak JW, Cornnell HH, Ribeiro MC, Balagurunathan Y, Hashim AI, Gillies RJ. Mechanisms of buffer therapy resistance. Neoplasia. 2014 Apr;16(4):354-64.e1. Pubmedid: 24862761. Pmcid: PMC4094835.
  • Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res. 2013 Mar;73(5):1524-1535. Pubmedid: 23288510. Pmcid: PMC3594450.
  • Badie C, Kabacik S, Balagurunathan Y, Bernard N, Brengues M, Faggioni G, Greither R, Lista F, Peinnequin A, Poyot T, Herodin F, Missel A, Terbrueggen B, Zenhausern F, Rothkamm K, Meineke V, Braselmann H, Beinke C, Abend M. Laboratory intercomparison of gene expression assays. Radiat Res. 2013 Aug;180(2):138-148. Pubmedid: 23886340. Pmcid: PMC4117252.
  • Rothkamm K, Beinke C, Romm H, Badie C, Balagurunathan Y, Barnard S, Bernard N, Boulay-Greene H, Brengues M, De Amicis A, De Sanctis S, Greither R, Herodin F, Jones A, Kabacik S, Knie T, Kulka U, Lista F, Martigne P, Missel A, Moquet J, Oestreicher U, Peinnequin A, Poyot T, Roessler U, Scherthan H, Terbrueggen B, Thierens H, Valente M, Vral A, Zenhausern F, Meineke V, Braselmann H, Abend M. Comparison of established and emerging biodosimetry assays. Radiat Res. 2013 Aug;180(2):111-119. Pubmedid: 23862692. Pmcid: PMC4094341.
  • Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Forster K, Aerts HJ, Dekker A, Fenstermacher D, Goldgof DB, Hall LO, Lambin P, Balagurunathan Y, Gatenby RA, Gillies RJ. Radiomics: the process and the challenges. Magn Reson Imaging. 2012 Nov;30(9):1234-1248. Pubmedid: 22898692. Pmcid: PMC3563280.
  • Ariazi EA, Cunliffe HE, Lewis-Wambi JS, Slifker MJ, Willis AL, Ramos P, Tapia C, Kim HR, Yerrum S, Sharma CG, Nicolas E, Balagurunathan Y, Ross EA, Jordan VC. Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. Proc Natl Acad Sci U S A. 2011 Nov;108(47):18879-18886. Pubmedid: 22011582. Pmcid: PMC3223472.
  • Morse DL, Hostetter G, Balagurunathan Y, Gillies RJ, Han H. Identification of pancreatic cancer-specific cell-surface markers for development of targeting ligands. Methods Mol Biol. 2010;624:195-210. Pubmedid: 20217597. Pmcid: PMC4010309.
  • Johnson CD, Balagurunathan Y, Dougherty ER, Afshari CA, He Q, Ramos KS. Insight into redox-regulated gene networks in vascular cells. Bioinformation. 2007 Apr;1(10):379-383. Pubmedid: 17597926. Pmcid: PMC1896051.
  • Hua J, Balagurunathan Y, Chen Y, Lowey J, Bittner ML, Xiong Z, Suh E, Dougherty ER. Normalization benefits microarray-based classification. EURASIP J Bioinform Syst Biol. 2006 Aug;43056. Pubmedid: 18427588. Pmcid: PMC3171318.
  • Seftor EA, Brown KM, Chin L, Kirschmann DA, Wheaton WW, Protopopov A, Feng B, Balagurunathan Y, Trent JM, Nickoloff BJ, Seftor RE, Hendrix MJ. Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment. Cancer Res. 2005 Nov;65(22):10164-10169. Pubmedid: 16288000.
  • Johnson CD, Balagurunathan Y, Tadesse MG, Falahatpisheh MH, Brun M, Walker MK, Dougherty ER, Ramos KS. Unraveling gene-gene interactions regulated by ligands of the aryl hydrocarbon receptor. Environ Health Persp. 2004 Mar;112(4):403-412. Pubmedid: 15033587. Pmcid: PMC1241891.
  • Balagurunathan Y, Wang N, Dougherty ER, Nguyen D, Chen Y, Bittner ML, Trent J, Carroll R. Noise factor analysis for cDNA microarrays. J Biomed Opt. 2004 Jul;9(4):663-678. Pubmedid: 15250753.
  • Johnson CD, Balagurunathan Y, Lu KP, Tadesse M, Falahatpisheh MH, Carroll RJ, Dougherty ER, Afshari CA, Ramos KS. Genomic profiles and predictive biological networks in oxidant-induced atherogenesis. Physiol Genomics. 2003 May;13(3):263-275. Pubmedid: 12657712.
  • Balagurunathan Y, Dougherty ER, Chen Y, Bittner ML, Trent JM. Simulation of cDNA microarrays via a parameterized random signal model. J Biomed Opt. 2002 Jul;7(3):507-523. Pubmedid: 12175304.