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Sanjay Premi, PhD

Program: Tumor Biology


    Dr. Premi is interested in exploring the pathophysiology of melanin-chemiexcitation pathway in skin cancer development, progression, and drug-resistance.  


    • Tumor Biology
    • Cutaneous Oncology
    • Molecular Medicine Program
    • Melanoma Research Center of Excellence
    • Molecular Medicine Program

Education & Training


  Dr. Premi’s lab is interested in investigating the contradictory role of skin-pigmentation in skin-carcinogenesis. Major projects in the lab are: 1) Melanin-chemiexcitation and its role in inducing resistance against targeted therapies in melanoma, 2) Adducts of melanin-carbonyls with biomolecules and the role of such adducts in regulating skin homeostasis and carcinogenesis, and 3) the role of 1 and 2 in modulating immune response against melanoma.                 


  • Amente S, Scala G, Majello B, Azmoun S, Tempest HG, Premi S, Cooke MS. Genome-wide mapping of genomic DNA damage: methods and implications. Cell Mol Life Sci. 2021 Aug. Pubmedid: 34463773.
  • Chaudhuri RK, Meyer T, Premi S, Brash D. Acetyl zingerone: An efficacious multifunctional ingredient for continued protection against ongoing DNA damage in melanocytes after sun exposure ends. Int J Cosmet Sci. 2020 Feb.42(1):36-45. Pubmedid: 31538664. Pmcid: PMC7004018.
  • Premi S. Role of Melanin Chemiexcitation in Melanoma Progression and Drug Resistance. Front Oncol. 2020 Aug.10:1305. Pubmedid: 32850409. Pmcid: PMC7425655.
  • Premi S, Han L, Mehta S, Knight J, Zhao D, Palmatier MA, Kornacker K, Brash DE. Genomic sites hypersensitive to ultraviolet radiation. Proc Natl Acad Sci U S A. 2019 Nov.116(48):24196-24205. Pubmedid: 31723047. Pmcid: PMC6883822.
  • Premi S, Brash DE. Unanticipated role of melanin in causing carcinogenic cyclobutane pyrimidine dimmers. Mol Cell Oncol. 2016 Jan.3(1):e1033588. Pubmedid: 27308551. Pmcid: PMC4845191.
  • Premi S, Brash DE. Chemical excitation of electrons: A dark path to melanoma. DNA Repair (Amst). 2016 Aug.44:169-177. Pubmedid: 27262612. Pmcid: PMC4958542.
  • Premi S, Wallisch S, Mano CM, Weiner AB, Bacchiocchi A, Wakamatsu K, Bechara EJ, Halaban R, Douki T, Brash DE. Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. Science. 2015 Feb.347(6224):842-847. Pubmedid: 25700512. Pmcid: PMC4432913.
  • Zhang R, Premi S, Kilic SS, Bacchiocchi A, Halaban R, Brash DE. Clonal growth of human melanocytes using cell-free extracellular matrix. Pigment Cell Melanoma Res. 2013 Nov.26(6):925-927. Pubmedid: 24034857. Pmcid: PMC4086752.
  • Muthusamy V, Premi S, Soper C, Platt J, Bosenberg M. The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma. J Invest Dermatol. 2013 Jul.133(7):1827-1833. Pubmedid: 23364479. Pmcid: PMC3683103.
  • Premi S, Srivastava J, Epplen JT, Ali S. AZFc region of the Y chromosome shows singular structural organization. Chromosome Res. 2010 Jun.18(4):419-430. Pubmedid: 20373140.
  • Premi S, Srivastava J, Panneer G, Ali S. Startling mosaicism of the Y-chromosome and tandem duplication of the SRY and DAZ genes in patients with Turner Syndrome. PLoS One. 2009 Jun.3(11):e3796. Pubmedid: 19030103. Pmcid: PMC2582957.
  • Srivastava J, Premi S, Kumar S, Ali S. Expressional dynamics of minisatellite 33.15 tagged spermatozoal transcriptome in Bubalus bubalis. BMC Genomics. 2009 Jul.10:303. Pubmedid: 19583837. Pmcid: PMC2713999.
  • Premi S, Srivastava J, Chandy SP, Ali S. Unique signatures of natural background radiation on human Y chromosomes from Kerala, India. PLoS One. 2009 Apr.4(2):e4541. Pubmedid: 19242544. Pmcid: PMC2644265.
  • Srivastava J, Premi S, Kumar S, Ali S. Organization and differential expression of the GACA/GATA tagged somatic and spermatozoal transcriptomes in Buffalo Bubalus bubalis. BMC Genomics. 2008 Mar.9:132. Pubmedid: 18366692. Pmcid: PMC2346481.
  • Srivastava J, Premi S, Kumar S, Parwez I, Ali S. Characterization of Smoc-1 uncovers two transcript variants showing differential tissue and age specific expression in Bubalus bubalis. BMC Genomics. 2007 Nov.8:436. Pubmedid: 18042303. Pmcid: PMC2235864.
  • Premi S, Srivastava J, Chandy SP, Ali S. AZFc somatic microdeletions and copy number polymorphism of the DAZ genes in human males exposed to natural background radiation. Hum Genet. 2007 May.121(3-4):337-346. Pubmedid: 17308897.
  • Srivastava J, Premi S, Garg LC, Ali S. Organizational and expressional uniqueness of a testis-specific mRNA transcript of protooncogene c-kit receptor in water buffalo Bubalus bubalis. DNA Cell Biol. 2006 Sep.25(9):501-513. Pubmedid: 16989573.
  • Pathak D, Premi S, Srivastava J, Chandy SP, Ali S. Genomic instability of the DYZ1 repeat in patients with Y chromosome anomalies and males exposed to natural background radiation. DNA Res. 2006 Jun.13(3):103-109. Pubmedid: 16980714.
  • Srivastava J, Premi S, Pathak D, Ahsan Z, Tiwari M, Garg LC, Ali S. Transcriptional status of known and novel genes tagged with consensus of 33.15 repeat loci employing minisatellite-associated sequence amplification (MASA) and real-time PCR in water buffalo, Bubalus bubalis. DNA Cell Biol. 2006 Jan.25(1):31-48. Pubmedid: 16405399.
  • Premi S, Srivastava J, Chandy SP, Ahmad J, Ali S. Tandem duplication and copy number polymorphism of the SRY gene in patients with sex chromosome anomalies and males exposed to natural background radiation. Mol Hum Reprod. 2006 Feb.12(2):113-121. Pubmedid: 16510537.
  • Pathak D, Srivastava J, Premi S, Tiwari M, Garg LC, Kumar S, Ali S. Chromosomal localization, copy number assessment, and transcriptional status of BamHI repeat fractions in water buffalo Bubalus bubalis. DNA Cell Biol. 2006 Apr.25(4):206-214. Pubmedid: 16629593.


Title: Nitrosylation mediated resistance to targeted therapy and immunotherapy in NRAS mutant Melanoma
Sponsor: Moffitt Cancer Center
PI: Premi, S.