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Noemi Andor, PhD

Academic Rank: Assistant Member

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Overview

Dr. Andor's research combines computational biology, mathematical modeling and pharmacology to increase odds in the race against tumor evolution.


Discipline

    • Neuro-Oncology
    • Integrated Mathematical Oncology
    • Cancer Biology and Evolution Program

Education & Training

Fellowship:

  • Technical University, PhD - Bioinformatics
  • Ludwig-Maximilians & Technical University, MSc - Bioinformatics
  • Stanford University, -
Research

Dr. Andor's research focuses on the development and integration of methods to quantify the clonal composition of a tumor from different perspectives, including its genome, transcriptome and appearance.  Overall goal is to use these clone characteristics to inform how a tumo's environment can be altered in order to favor certain tumor subclones over others.

Publications

  • Andor N, Lau BT, Catalanotti C, Sathe A, Kubit M, Chen J, Blaj C, Cherry A, Bangs CD, Grimes SM, Suarez CJ, Ji HP. Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution. NAR Genom Bioinform. 2020 Jun.2(2):lqaa016. Pubmedid: 32215369. Pmcid: PMC7079336.
  • Enderling H, Altrock PM, Andor N, Basanta D, Brown JS, Gatenby RA, Marusyk A, Rejniak KA, Silva A, Anderson ARA. High School Internship Program in Integrated Mathematical Oncology (HIP IMO): Five-Year Experience at Moffitt Cancer Center. Bull Math Biol. 2020 Jul.82(7):91. Pubmedid: 32648152.
  • Andor N, Simonds EF, Czerwinski DK, Chen J, Grimes SM, Wood-Bouwens C, Zheng GXY, Kubit MA, Greer S, Weiss WA, Levy R, Ji HP. Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints. Blood. 2019 Mar.133(10):1119-1129. Pubmedid: 30591526. Pmcid: PMC6405336.
  • Chen J, Lau BT, Andor N, Grimes SM, Handy C, Wood-Bouwens C, Ji HP. Single-cell transcriptome analysis identifies distinct cell types and niche signaling in a primary gastric organoid model. Sci Rep. 2019 Mar.9(1):4536. Pubmedid: 30872643. Pmcid: PMC6418230.
  • Vences-Catalán F, Kuo CC, Rajapaksa R, Duault C, Andor N, Czerwinski DK, Levy R, Levy S. CD81 is a novel immunotherapeutic target for B cell lymphoma. J Exp Med. 2019 Jul.216(7):1497-1508. Pubmedid: 31123084. Pmcid: PMC6605745.
  • Daynac M, Chouchane M, Collins HY, Murphy NE, Andor N, Niu J, Fancy SPJ, Stallcup WB, Petritsch CK. Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis. Nat Commun. 2018 Aug.9(1):2862. Pubmedid: 30131568. Pmcid: PMC6104045.
  • Andor N, Maley CC, Ji HP. Genomic Instability in Cancer: Teetering on the Limit of Tolerance. Cancer Res. 2017 May.77(9):2179-2185. Pubmedid: 28432052. Pmcid: PMC5413432.
  • Andor N, Graham TA, Jansen M, Xia LC, Aktipis CA, Petritsch C, Ji HP, Maley CC. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat Med. 2016 Jan.22(1):105-113. Pubmedid: 26618723. Pmcid: PMC4830693.
  • Andor N, Harness JV, Müller S, Mewes HW, Petritsch C. EXPANDS: expanding ploidy and allele frequency on nested subpopulations. Bioinformatics. 2014 Jan.30(1):50-60. Pubmedid: 24177718. Pmcid: PMC3866558.
  • Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec.20(12):1394-1396. Pubmedid: 25401693. Pmcid: PMC4257862.
  • Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep.20(3):328-340. Pubmedid: 21907924. Pmcid: PMC3297490.