Jose Pimiento, MD, FACS
Researcher

Jose Pimiento, MD, FACS

Academic Rank: Assistant Member

Overview

Dr. Pimiento’s research focus is in the treatment of gastrointestinal malignancies, studying the outcomes related with minimally invasive approaches for their treatment, also in identifying clinical, pathologic and molecular factors related to tumor behavior that will impact the response to different treatment modalities. His translational research is focused on chemoprevention of upper gastrointestinal malignancies.

Discipline

    • Gastrointestinal Oncology
    • Tumor Biology
    • Chemical Biology and Molecular Medicine Program

Education & Training

    • Universidad Nacional de Columbia, MD
    • Saint Mary's Health System/Affiliated Yale University School of Medicine, Resident - General Surgery
    • Yale University School of Medicine, Fellow - Surgical Research in Vascular Surgery
    • H. Lee Moffitt Cancer Center and Research Institute, Fellow - Surgical Oncology Research
Research

Dr. Pimiento’s research focus is in the treatment of gastrointestinal malignancies, studying the outcomes related with minimally invasive approaches for their treatment, also in identifying clinical, pathologic and molecular factors related to tumor behavior that will impact the response to different treatment modalities. His translational research is focused on chemoprevention of upper gastrointestinal malignancies.

Publications

  • Walker R, Mejia J, Lee JK, Pimiento JM, Malafa M, Giuliano AR, Coppola D, Enderling H. Personalizing Gastric Cancer Screening With Predictive Modeling of Disease Progression Biomarkers. Appl Immunohistochem Mol Morphol. 2017 Oct. Pubmedid: 29084052.
  • Mirkin KA, Luke FE, Gangi A, Pimiento JM, Jeong D, Hollenbeak CS, Wong J. Sarcopenia related to neoadjuvant chemotherapy and perioperative outcomes in resected gastric cancer: a multi-institutional analysis. J Gastrointest Oncol. 2017 Jun;8(3):589-595. Pubmedid: 28736646. Pmcid: PMC5506267.
  • Walker R, Poleszczuk J, Mejia J, Lee JK, Pimiento JM, Malafa M, Giuliano AR, Enderling H, Coppola D. Toward early detection of Helicobacter pylori-associated gastric cancer. Gastric Cancer. 2017 Jul. Pubmedid: 28725964.
  • Blackham AU, Doepker MP, Centeno BA, Springett G, Pimiento JM, Malafa M, Hodul PJ. Patterns of recurrence and long-term outcomes in patients who underwent pancreatectomy for intraductal papillary mucinous neoplasms with high grade dysplasia: implications for surveillance and future management guidelines. HPB (Oxford). 2017 Jul;19(7):603-610. Pubmedid: 28495434.
  • Glazer ES, Welsh E, Pimiento JM, Teer JK, Malafa MP. TGFβ1 overexpression is associated with improved survival and low tumor cell proliferation in patients with early-stage pancreatic ductal adenocarcinoma. Oncotarget. 2017 Jan;8(1):999-1006. Pubmedid: 27895310. Pmcid: PMC5352213.
  • Glazer ES, Rashid OM, Klapman JB, Harris CL, Hodul PJ, Pimiento JM, Malafa MP. Endoscopic ultrasonography complements computed tomography in predicting portal or superior mesenteric vein resection in patients with borderline resectable pancreatic carcinoma. Pancreatology. 2017 Jan;17(1):130-134. Pubmedid: 28043760.
  • Blackham AU, H Naqvi SM, Schell MJ, Jin W, Gangi A, Almhanna K, Fontaine JP, Hoffe SE, Frakes J, Venkat P, Pimiento JM. Recurrence patterns and associated factors of locoregional failure following neoadjuvant chemoradiation and surgery for esophageal cancer. J Surg Oncol. 2017 Aug. Pubmedid: 28833197.
  • Enomoto LM, Blackham A, Woo Y, Yamamoto M, Pimiento J, Gusani NJ, Wong J. Ratio of intra-operative fluid to anesthesia time and its impact on short term perioperative outcomes following gastrectomy for cancer: A retrospective cohort study. Int J Surg. 2016 Sep;33 Pt A:13-17. Pubmedid: 27394407.
  • Pimiento JM, Neill KG, Henderson-Jackson E, Eschrich SA, Chen DT, Husain K, Shibata D, Coppola D, Malafa MP. Knockdown of CSE1L Gene in Colorectal Cancer Reduces Tumorigenesis in Vitro. Am J Pathol. 2016 Oct;186(10):2761-2768. Pubmedid: 27521996. Pmcid: PMC5222983.
  • Mohammadi H, Abuodeh YA, Jin W, Frakes JM, Friedman M, Biebel B, Choi J, El-Haddad GE, Kis B, Sweeney J, Kim R, Pimiento JM, Malafa MP, Anaya D, Hoffe SE. Using the ALBI Grade as a Prognostic Marker for Radioembolization of Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E194-E195.
  • Glazer ES, Neill KG, Frakes JM, Coppola D, Hodul PJ, Hoffe SE, Pimiento JM, Springett GM, Malafa MP. Systematic Review and Case Series Report of Acinar Cell Carcinoma of the Pancreas. Cancer Control. 2016 Oct;23(4):446-454. Pubmedid: 27842335.
  • Jin W, Mellon EA, Hoffe SE, Frakes JM, Springett GM, Centeno BA, Kim R, Mahipal A, Pimiento JM, Malafa MP, Latifi K. Does Metabolic Tumor Volume Predict Tumor Regression Grade After Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer?. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E195. Pubmedid: 27674030.
  • Pearson AL, Jin W, Mellon EA, Frakes JM, Strom T, Springett GM, Kim R, Mahipal A, Hodul PJ, Pimiento JM, Shridhar R, Malafa MP, Hoffe SE. Post-Stereotactic Body Radiation Therapy (SBRT) Neutrophil-to-Lymphocyte Ratio (NLR) in Patients With Borderline Resectable Pancreatic Cancer (BRPC) May Be a Prognostic Biomarker. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E153. Pubmedid: 27673917.
  • Glazer ES, Rashid OM, Pimiento JM, Hodul PJ, Malafa MP. Increased neutrophil-to-lymphocyte ratio after neoadjuvant therapy is associated with worse survival after resection of borderline resectable pancreatic ductal adenocarcinoma. Surgery. 2016 Nov;160(5):1288-1293. Pubmedid: 27450715. Pmcid: PMC5086285.
  • Pimiento JM, Davis-Yadley AH, Kim RD, Chen DT, Eikman EA, Berman CG, Malafa MP. Metabolic Activity by 18F-FDG-PET/CT Is Prognostic for Stage I and II Pancreatic Cancer. Clin Nucl Med. 2016 Mar;41(3):177-181. Pubmedid: 26673243. Pmcid: PMC4740191.
  • Robinson LA, Tanvetyanon T, Springett G, Fontaine J, Toloza E, Hodul P, Pimiento JM, Malafa M. Pulmonary metastasectomy for suspected pancreaticobiliary cancer. J Thorac Cardiovasc Surg. 2016 Jul;152(1):75-82. Pubmedid: 27050555.
  • Jiang K, Neill K, Cowden D, Klapman J, Eschrich S, Pimiento J, Malafa MP, Coppola D. Expression of CAS/CSE1L, the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in Barrett's Esophagus. Appl Immunohistochem Mol Morphol. 2016 Dec. Pubmedid: 27941559. Pmcid: PMC5466515.
  • Kothari N, Mellon E, Hoffe SE, Frakes J, Shridhar R, Pimiento J, Meredith K, Tran ND, Saeed N, Almhanna K. Outcomes in patients with brain metastasis from esophageal carcinoma. J Gastrointest Oncol. 2016 Aug;7(4):562-569. Pubmedid: 27563446. Pmcid: PMC4963374.
  • Rashid OM, Pimiento JM, Gamenthaler AW, Nguyen P, Ha TT, Hutchinson T, Springett G, Hoffe S, Shridhar R, Hodul PJ, Johnson BL, Illig K, Armstrong PA, Centeno BA, Fulp WJ, Chen DT, Malafa MP. Outcomes of a Clinical Pathway for Borderline Resectable Pancreatic Cancer. Ann Surg Oncol. 2016 Apr;23(4):1371-1379. Pubmedid: 26661409.
  • Davis-Yadley AH, Abbott AM, Pimiento JM, Chen DT, Malafa MP. Increased Expression of the Glucose Transporter Type 1 Gene Is Associated With Worse Overall Survival in Resected Pancreatic Adenocarcinoma. Pancreas. 2016 08;45(7):974-979. Pubmedid: 26692443. Pmcid: PMC4912950.
  • Hall M, Liu H, Malafa M, Centeno B, Hodul PJ, Pimiento J, Pilon-Thomas S, Sarnaik AA. Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors. J Immunother Cancer. 2016;4:61. Pubmedid: 27777771. Pmcid: PMC5067894.
  • Blackham AU, Yue B, Almhanna K, Saeed N, Fontaine JP, Hoffe S, Shridhar R, Frakes J, Coppola D, Pimiento JM. The prognostic value of residual nodal disease following neoadjuvant chemoradiation for esophageal cancer in patients with complete primary tumor response. J Surg Oncol. 2015 Nov;112(6):597-602. Pubmedid: 26394724.
  • Straughan DM, Azoury SC, Bennett RD, Pimiento JM, Fontaine JP, Toloza EM. Robotic-Assisted Esophageal Surgery. Cancer Control. 2015 Jul;22(3):335-339. Pubmedid: 26351890.
  • Rashid OM, Mullinax JE, Pimiento JM, Meredith KL, Malafa MP. Robotic Whipple Procedure for Pancreatic Cancer: The Moffitt Cancer Center Pathway. Cancer Control. 2015 Jul;22(3):340-351. Pubmedid: 26351891.
  • Pimiento JM, Chen DT, Centeno BA, Davis-Yadley AH, Husain K, Fulp WJ, Wang C, Zhang A, Malafa MP. Annexin A8 Is a Prognostic Marker and Potential Therapeutic Target for Pancreatic Cancer. Pancreas. 2015 Jan;44(1):122-127. Pubmedid: 25268673. Pmcid: PMC4262713.
  • Baksh K, Prithviraj G, Kim Y, Hoffe S, Shridhar R, Coppola D, Centeno B, Pimiento J, Meredith K, Almhanna K. Correlation Between Standardized Uptake Value in Preneoadjuvant and Postneoadjuvant Chemoradiotherapy and Tumor Regression Grade in Patients With Locally Advanced Esophageal Cancer. Am J Clin Oncol. 2015 Dec. Pubmedid: 26703814.
  • Chen DT, Davis-Yadley AH, Huang PY, Husain K, Centeno BA, Permuth-Wey J, Pimiento JM, Malafa M. Prognostic Fifteen-Gene Signature for Early Stage Pancreatic Ductal Adenocarcinoma. PLoS One. 2015 Aug;10(8):e0133562. Pubmedid: 26247463. Pmcid: PMC4527782.
  • Pimiento JM, Echeverri S. Pressure ulcers and malnutrition: a devastating and common association. Nutrition. 2014 Mar;30(3):370-371. Pubmedid: 24484686.
  • Toloza E, Sobky C, Pimiento J, Garrett J, Pappas-Politis E, Deneve J, Kim D, Plank D, Smith P, Gonzalez R. Multilevel Costovertebral Reconstruction With the Synthes MatrixRIB Fixation System and Vicryl Mesh After Radical Chest Wall Resection for Sarcoma: A Case Report. Chest. 2014 Mar;145(3 Suppl):34A. Pubmedid: 24638509.
  • McCahill LE, May M, Morrow JB, Khandavalli S, Shabahang B, Kemmeter P, Pimiento JM. Esophagectomy outcomes at a mid-volume cancer center utilizing prospective multidisciplinary care and a 2-surgeon team approach. Am J Surg. 2014 Mar;207(3):380-386. Pubmedid: 24581762.
  • Hodul PJ, Dong Y, Husain K, Pimiento JM, Chen J, Zhang A, Francois R, Pledger WJ, Coppola D, Sebti SM, Chen DT, Malafa MP. Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. PLoS One. 2013 Aug;8(2):e52526. Pubmedid: 23393547. Pmcid: PMC3564846.
  • Pimiento JM, Larkin EM, Smalley KS, Wiersma GL, Monks NR, Fedorenko IV, Peterson CA, Nickoloff BJ. Melanoma genotypes and phenotypes get personal. Lab Invest. 2013 Aug;93(8):858-867. Pubmedid: 23817084.
  • Pimiento JM, Weber J, Hoffe SE, Shridhar R, Almhanna K, Vignesh S, Karl RC, Meredith KL. Outcomes associated with surgery for T4 esophageal cancer. Ann Surg Oncol. 2013 Aug;20(8):2706-2712. Pubmedid: 23504118.
  • Parsons CM, Pimiento JM, Cheong D, Marzban SS, Gonzalez RJ, Johnson D, Letson GD, Zager JS. The role of radical amputations for extremity tumors: a single institution experience and review of the literature. J Surg Oncol. 2012 Feb;105(2):149-155. Pubmedid: 21837679. Pmcid: PMC4504014.
  • Eghbalieh SD, Chowdhary P, Muto A, Ziegler KR, Kudo FA, Pimiento JM, Mirmehdi I, Model LS, Kondo Y, Nishibe T, Dardik A. Age-related neointimal hyperplasia is associated with monocyte infiltration after balloon angioplasty. J Gerontol A-Biol. 2012 Feb;67(2):109-117. Pubmedid: 22016364. Pmcid: PMC3261442.
  • Pimiento JM, Lee MC, Esposito NN, Kiluk JV, Khakpour N, Carter WB, Han G, Laronga C. Role of axillary staging in women diagnosed with ductal carcinoma in situ with microinvasion. J Oncol Pract. 2011 Sep;7(5):309-313. Pubmedid: 22211128. Pmcid: PMC3170064.
  • Pimiento JM, Gadgil PV, Santillan AA, Lee MC, Esposito NN, Kiluk JV, Khakpour N, Hartley TL, Yeh IT, Laronga C. Phyllodes tumors: race-related differences. J Am Coll Surg. 2011 Oct;213(4):537-542. Pubmedid: 21856184.
  • Dudrick SJ, Pimiento JM. Parenteral nutrition and nutritional support of surgical patients: reflections, controversies, and challenges. Surg Clin N Am. 2011 Jun;91(3):675-692. Pubmedid: 21621703.
  • Copeland EM, Pimiento JM, Dudrick SJ. Total parenteral nutrition and cancer: from the beginning. Surg Clin N Am. 2011 Aug;91(4):727-36, vii. Pubmedid: 21787964.
  • Malkan AD, Pimiento JM, Maloney SP, Palesty JA, Scholand SJ. Unusual manifestations of Clostridium difficile infection. Surg Infect (Larchmt). 2010 Jun;11(3):333-337. Pubmedid: 19795991.
  • Muto A, Kondo Y, Pimiento JM, Fitzgerald TN, Dardik A, Nishibe T. Vasodilator response correlates with outcome in chronic critical limb ischemia. J Surg Res. 2010 Jun;161(1):156-161. Pubmedid: 19482314.
  • Westvik TS, Fitzgerald TN, Muto A, Maloney SP, Pimiento JM, Fancher TT, Magri D, Westvik HH, Nishibe T, Velazquez OC, Dardik A. Limb ischemia after iliac ligation in aged mice stimulates angiogenesis without arteriogenesis. J Vasc Surg. 2009 Feb;49(2):464-473. Pubmedid: 19028053. Pmcid: PMC2661623.
  • Pimiento JM, Maloney SP, Tang PC, Muto A, Westvik TS, Fitzgerald TN, Fancher TT, Tellides G, Dardik A. Endothelial nitric oxide synthase stimulates aneurysm growth in aged mice. J Vasc Res. 2008 Jun;45(3):251-258. Pubmedid: 18182824.
  • Fitzgerald TN, Shepherd BR, Asada H, Teso D, Muto A, Fancher T, Pimiento JM, Maloney SP, Dardik A. Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. J Cell Physiol. 2008 Aug;216(2):389-395. Pubmedid: 18247368.
  • Muto A, Fitzgerald TN, Pimiento JM, Maloney SP, Teso D, Paszkowiak JJ, Westvik TS, Kudo FA, Nishibe T, Dardik A. Smooth muscle cell signal transduction: implications of vascular biology for vascular surgeons. J Vasc Surg. 2007 Jun;45 Suppl A:A15-A24. Pubmedid: 17544020. Pmcid: PMC1939976.
  • Kudo FA, Muto A, Maloney SP, Pimiento JM, Bergaya S, Fitzgerald TN, Westvik TS, Frattini JC, Breuer CK, Cha CH, Nishibe T, Tellides G, Sessa WC, Dardik A. Venous identity is lost but arterial identity is not gained during vein graft adaptation. Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1562-1571. Pubmedid: 17463332.
  • Pimiento JM, Teso D, Malkan A, Dudrick SJ, Palesty JA. Cancer of unknown primary origin: a decade of experience in a community-based hospital. Am J Surg. 2007 Dec;194(6):833-837. Pubmedid: 18005780.
  • Paszkowiak JJ, Maloney SP, Kudo FA, Muto A, Teso D, Rutland RC, Westvik TS, Pimiento JM, Tellides G, Sessa WC, Dardik A. Evidence supporting changes in Nogo-B levels as a marker of neointimal expansion but not adaptive arterial remodeling. Vascul Pharmacol. 2007 Apr;46(4):293-301. Pubmedid: 17207665. Pmcid: PMC1839844.
  • Jiang K, Stephen FO, Jeong D, Pimiento JM. Pancreatic and Gastric Heterotopia with Associated Submucosal Lipoma Presenting as a 7-cm Obstructive Tumor of the Ileum: Resection with Double Balloon Enteroscopy. Case Rep Gastroenterol. 9(2):233-240. Pubmedid: 26269700. Pmcid: PMC4520188.
  • Fitzgerald TN, Muto A, Kudo FA, Pimiento JM, Constable RT, Dardik A. Emerging vascular applications of magnetic resonance imaging: a picture is worth more than a thousand words. Vascular. 14(6):366-371. Pubmedid: 17150158.