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Jose Alejandro Guevara, MD, PhD

Program: Immunology

Overview

Dr. Guevara-Patiño’s research is focused on identifying signaling cues that can be exploited for the benefit of cancer patients receiving T cell-based immunotherapy, by deeply understanding the immune fertile conditions that are necessary to generate robust anti-tumor T cell responses. José Alejandro is specifically interested in understanding the role of RPS6 as well as the effects of tumor-related hypoxia on anti-tumor T cells. In addition, he is implementing machine learning approaches for the development of immunological predictive biomarkers that will permit the stratification of cancer patients receiving immunotherapies.


Associations

    • Immunology
    • Immuno-Oncology

Education & Training

Fellowship:

  • Memorial Sloan-Kettering Cancer Center, - T Cell Development and tumor Immunology

Medical School:

  • Universidad Central de Venezuela - MD
Research

Dr. Guevara-Patiño’s research is focused on identifying signaling cues that can be exploited for the benefit of cancer patients receiving T cell-based immunotherapy, by deeply understanding the immune fertile conditions that are necessary to generate robust anti-tumor T cell responses. José Alejandro is specifically interested in understanding the role of RPS6 as well as the effects of tumor-related hypoxia on anti-tumor T cells. In addition, he is implementing machine learning approaches for the development of immunological predictive biomarkers that will permit the stratification of cancer patients receiving immunotherapies.

Publications

  • Jaishankar D, Cosgrove C, Ramesh P, Mahon J, Shivde R, Dellacecca ER, Yang SF, Mosenson J, Guevara-Patiño JA, Le Poole IC. HSP70iQ435A to subdue autoimmunity and support anti-tumor responses. Cell Stress Chaperones. 2021 Sep. Pubmedid: 34542825.

Grants

Title: Study of Anti-Tumor Immunity and Tissue Resident Memory Cell Development by NKG2D and Ribosomal Protein S6 Signaling in T cells
Sponsor: Nat Institutes of Health
PI: Guevara, J.