Joel Brown, PhD

To be the leader in applying principles of ecology and evolution to contain and cure cancer while enhancing the length and quality of the patients’ lives.

Associations

• Gynecologic Oncology
• Integrated Mathematical Oncology
• Cancer Biology & Evolution Program
• Melanoma & Skin Cancer Center of Excellence
• Center of Excellence for Evolutionary Therapy

Education & Training

Graduate:

• University of Arizona, PhD - Ecology and Evolutionary Biology

As member of the Cancer Biology and Evolution Group and the Department of Integrated Mathematical Oncology, my research and collaborations are multi-disciplinary. I have ongoing collaborations with Drs. Robert Gatenby and Sandy Alexander on applying ecological principles to understanding cancer. In terms of experimental work, I enjoy collaborative work on skin cancer cell culturing with Ken Tsai, competition experiments to explore the cost of resistance with Dr. Robert Gillies and his group, mouse model work on prostate cancer and the evolution of cancer resistance with Drs. Gatenby and Arig Ibrahim. In terms of clinical trials, I have been part of a team led by Jngsong Zhang to examine the efficacy of Adaptive therapy for late stage metastatic castrate resistant cancer (Phase I trial). Currently working with Dr. Christine Chung and her team on a phase II trial for metastatic thyroid cancer. My work is highly collaborative and I look forward to extending and integrating my work to serve the experimentalists, mathematicians and clinicians.I  use a combination of mathematical and experimental approaches to understand how organisms interact with and shape their environments. Squirrels are a particular favorite model system, as they have evolved unique attributes and behaviors for climbing trees, storing acorns and other foods, and avoiding predators. In viewing animals through their ecosystems and adaptations.

• Bukkuri A, Pienta KJ, Austin RH, Hammarlund EU, Amend SR, Brown JS. A mathematical investigation of polyaneuploid cancer cell memory and cross-resistance in state-structured cancer populations. Sci Rep. 2023 Sep.13(1):15027. Pubmedid: 37700000. Pmcid: PMC10497555.
• Pradeu T, Daignan-Fornier B, Ewald A, Germain PL, Okasha S, Plutynski A, Benzekry S, Bertolaso M, Bissell M, Brown JS, Chin-Yee B, Chin-Yee I, Clevers H, Cognet L, Darrason M, Farge E, Feunteun J, Galon J, Giroux E, Green S, Gross F, Jaulin F, Knight R, Laconi E, Larmonier N, Maley C, Mantovani A, Moreau V, Nassoy P, Rondeau E, Santamaria D, Sawai CM, Seluanov A, Sepich-Poore GD, Sisirak V, Solary E, Yvonnet S, Laplane L. Reuniting philosophy and science to advance cancer research. Biol Rev Camb Philos Soc. 2023 Oct.98(5):1668-1686. Pubmedid: 37157910.
• Chahoud J, Anderson ARA, Zhang J, Brown J, Gatenby RA. Evolutionary Dynamics and Intermittent Therapy for Metastatic Cancers. J Clin Oncol. 2023 Oct.41(28):4469-4471. Pubmedid: 37418680. Pmcid: PMC10553063.
• Chancellor S, Grasse B, Sakmar T, Scheel D, Brown JS, Santymire RM. Exploring the Effect of Age on the Reproductive and Stress Physiology of Octopus bimaculoides Using Dermal Hormones. Animals (Basel). 2023 Oct.13(19). Pubmedid: 37835721. Pmcid: PMC10571824.
• Bukkuri A, Pienta KJ, Amend SR, Austin RH, Hammarlund EU, Brown JS. The contribution of evolvability to the eco-evolutionary dynamics of competing species. Ecol Evol. 2023 Oct.13(10):e10591. Pubmedid: 37829179. Pmcid: PMC10565728.
• Welch DL, Fridley BL, Cen L, Teer JK, Yoder SJ, Pettersson F, Xu L, Cheng CH, Zhang Y, Alexandrow MG, Xiang S, Robertson-Tessi M, Brown JS, Metts J, Brohl AS, Reed DR. Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy. Sci Rep. 2023 Nov.13(1):20125. Pubmedid: 37978271. Pmcid: PMC10656496.
• Brown JS, Amend SR, Austin RH, Gatenby RA, Hammarlund EU, Pienta KJ. Updating the Definition of Cancer. Mol Cancer Res. 2023 Nov.21(11):1142-1147. Pubmedid: 37409952. Pmcid: PMC10618731.
• Stein A, Salvioli M, Garjani H, Dubbeldam J, Viossat Y, Brown JS, Staňková K. Stackelberg evolutionary game theory: how to manage evolving systems. Philos Trans R Soc Lond B Biol Sci. 2023 May.378(1876):20210495. Pubmedid: 36934755. Pmcid: PMC10024980.
• El-Kenawi A, Berglund A, Estrella V, Zhang Y, Liu M, Putney RM, Yoder S, Johnson J, Brown J, Gatenby R. Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells. Cancer Res. 2023 Mar.83(5):720-734. Pubmedid: 36480167. Pmcid: PMC9978888.
• West J, Adler F, Gallaher J, Strobl M, Brady-Nicholls R, Brown J, Robertson-Tessi M, Kim E, Noble R, Viossat Y, Basanta D, Anderson ARA. A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation. Elife. 2023 Mar.12. Pubmedid: 36952376. Pmcid: PMC10036119.
• Howell-Stephens J, Potratz EJ, Brown JS, Bernier D, Santymire RM. Integrating Measures of Fecal Glucocorticoid Metabolites and Giving-Up Densities to Assess Adrenocortical Activity and Well-Being in Zoo-Housed Three-Banded Armadillos (Tolypeutes matacus). Animals (Basel). 2023 Jun.13(12). Pubmedid: 37370485. Pmcid: PMC10295497.
• Capp JP, Thomas F, Marusyk A, M Dujon A, Tissot S, Gatenby R, Roche B, Ujvari B, DeGregori J, Brown JS, Nedelcu AM. The paradox of cooperation among selfish cancer cells. Evol Appl. 2023 Jul.16(7):1239-1256. Pubmedid: 37492150. Pmcid: PMC10363833.
• Bukkuri A, Pienta KJ, Hockett I, Austin RH, Hammarlund EU, Amend SR, Brown JS. Modeling cancer's ecological and evolutionary dynamics. Med Oncol. 2023 Feb.40(4):109. Pubmedid: 36853375. Pmcid: PMC9974726.
• Zhang J, Gallaher J, Cunningham JJ, Choi JW, Ionescu F, Chatwal MS, Jain R, Kim Y, Wang L, Brown JS, Anderson AR, Gatenby RA. A Phase 1b Adaptive Androgen Deprivation Therapy Trial in Metastatic Castration Sensitive Prostate Cancer. Cancers (Basel). 2022 Oct.14(21). Pubmedid: 36358643. Pmcid: PMC9656891.
• Bayer P, Brown JS, Dubbeldam J, Broom M. A Markovian decision model of adaptive cancer treatment and quality of life. J Theor Biol. 2022 Nov.551-552:111237. Pubmedid: 35944591.
• Wölfl B, Te Rietmole H, Salvioli M, Kaznatcheev A, Thuijsman F, Brown JS, Burgering B, Staňková K. The Contribution of Evolutionary Game Theory to Understanding and Treating Cancer. Dyn Games Appl. 2022 May.12(2):313-342. Pubmedid: 35601872. Pmcid: PMC9117378.
• Bukkuri A, Gatenby RA, Brown JS. GLUT1 production in cancer cells: a tragedy of the commons. NPJ Syst Biol Appl. 2022 Jun.8(1):22. Pubmedid: 35768428. Pmcid: PMC9243083.
• Zhang J, Cunningham J, Brown J, Gatenby R. Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes. Elife. 2022 Jun.11. Pubmedid: 35762577. Pmcid: PMC9239688.
• Pienta KJ, Hammarlund EU, Austin RH, Axelrod R, Brown JS, Amend SR. Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy. Semin Cancer Biol. 2022 Jun.81:145-159. Pubmedid: 33276091.
• Bukkuri A, Pienta KJ, Austin RH, Hammarlund EU, Amend SR, Brown JS. Stochastic models of Mendelian and reverse transcriptional inheritance in state-structured cancer populations. Sci Rep. 2022 Jul.12(1):13079. Pubmedid: 35906318. Pmcid: PMC9338039.
• Bayer P, Gatenby RA, McDonald PH, Duckett DR, Staňková K, Brown JS. Coordination games in cancer. PLoS One. 2022 Jan.17(1):e0261578. Pubmedid: 35061724. Pmcid: PMC8782377.
• Freischel AR, Teer JK, Luddy K, Cunningham J, Artzy-Randrup Y, Epstein T, Tsai KY, Berglund A, Cleveland JL, Gillies RJ, Brown JS, Gatenby RA. Evolutionary Analysis of TCGA Data Using Over- and Under- Mutated Genes Identify Key Molecular Pathways and Cellular Functions in Lung Cancer Subtypes. Cancers (Basel). 2022 Dec.15(1). Pubmedid: 36612014. Pmcid: PMC9817988.
• Potratz EJ, Brown JS, Rafacz ML, Santymire RM. Designing an assay to evaluate behavioral responses to opposite-sex conspecifics in the endangered black-footed ferret (Mustela nigripes). Zoo Biol. 2022 Dec.42(3):397-406. Pubmedid: 36585919.
• Bukkuri A, Pienta KJ, Austin RH, Hammarlund EU, Amend SR, Brown JS. A life history model of the ecological and evolutionary dynamics of polyaneuploid cancer cells. Sci Rep. 2022 Aug.12(1):13713. Pubmedid: 35962062. Pmcid: PMC9374668.
• Pressley M, Gallaher JA, Brown JS, Tomaszewski MR, Borad P, Damaghi M, Gillies RJ, Whelan CJ. Cycling hypoxia selects for constitutive HIF stabilization. Sci Rep. 2021 Mar.11(1):5777. Pubmedid: 33707510. Pmcid: PMC7952589.
• Freischel AR, Damaghi M, Cunningham JJ, Ibrahim-Hashim A, Gillies RJ, Gatenby RA, Brown JS. Frequency-dependent interactions determine outcome of competition between two breast cancer cell lines. Sci Rep. 2021 Mar.11(1):4908. Pubmedid: 33649456. Pmcid: PMC7921689.
• Artzy-Randrup Y, Epstein T, Brown JS, Costa RLB, Czerniecki BJ, Gatenby RA. Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy. NPJ Breast Cancer. 2021 Mar.7(1):26. Pubmedid: 33707440. Pmcid: PMC7952601.
• Messan MR, Damaghi M, Freischel A, Miao Y, Brown J, Gillies R, Wallace D. Predicting the results of competition between two breast cancer lines grown in 3-D spheroid culture. Math Biosci. 2021 Jun.336:108575. Pubmedid: 33757835.
• Dujon AM, Capp JP, Brown JS, Pujol P, Gatenby RA, Ujvari B, Alix-Panabières C, Thomas F. Is There One Key Step in the Metastatic Cascade?. Cancers (Basel). 2021 Jul.13(15). Pubmedid: 34359593. Pmcid: PMC8345184.
• Ibrahim-Hashim A, Luddy K, Abrahams D, Enriquez-Navas P, Damgaci S, Yao J, Chen T, Bui MM, Gillies RJ, O'Farrelly C, Richards CL, Brown JS, Gatenby RA. Artificial selection for host resistance to tumour growth and subsequent cancer cell adaptations: an evolutionary arms race. Brit J Cancer. 2021 Jan.124(2):455-465. Pubmedid: 33024265. Pmcid: PMC7852689.
• Zhang J, Cunningham JJ, Brown JS, Gatenby RA. Response to Mistry. Nat Commun. 2021 Jan.12(1):329. Pubmedid: 33436553. Pmcid: PMC7804311.
• Salvioli M, Dubbeldam J, Staňková K, Brown JS. Fisheries management as a Stackelberg Evolutionary Game: Finding an evolutionarily enlightened strategy. PLoS One. 2021 Jan.16(1):e0245255. Pubmedid: 33471815. Pmcid: PMC7817040.
• Wirsing AJ, Heithaus MR, Brown JS, Kotler BP, Schmitz OJ. The context dependence of non-consumptive predator effects. Ecol Lett. 2021 Jan.24(1):113-129. Pubmedid: 32990363.
• Strobl MAR, West J, Viossat Y, Damaghi M, Robertson-Tessi M, Brown JS, Gatenby RA, Maini PK, Anderson ARA. Turnover Modulates the Need for a Cost of Resistance in Adaptive Therapy. Cancer Res. 2021 Feb.81(4):1135-1147. Pubmedid: 33172930. Pmcid: PMC8455086.
• Kim E, Brown JS, Eroglu Z, Anderson ARA. Adaptive Therapy for Metastatic Melanoma: Predictions from Patient Calibrated Mathematical Models. Cancers (Basel). 2021 Feb.13(4). Pubmedid: 33669315. Pmcid: PMC7920057.
• Pienta KJ, Hammarlund EU, Brown JS, Amend SR, Axelrod RM. Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells. Proc Natl Acad Sci U S A. 2021 Feb.118(7). Pubmedid: 33504594. Pmcid: PMC7896294.
• Chancellor S, Abbo L, Grasse B, Sakmar T, Brown JS, Scheel D, Santymire RM. Determining the effectiveness of using dermal swabs to evaluate the stress physiology of laboratory cephalopods: A preliminary investigation. Gen Comp Endocrinol. 2021 Dec.314:113903. Pubmedid: 34529999.
• Phan TV, Wang G, Do TK, Kevrekidis IG, Amend S, Hammarlund E, Pienta K, Brown J, Liu L, Austin RH. It doesn't always pay to be fit: success landscapes. J Biol Phys. 2021 Dec.47(4):387-400. Pubmedid: 34709534. Pmcid: PMC8603993.
• Kareva I, Luddy KA, O'Farrelly C, Gatenby RA, Brown JS. Predator-Prey in Tumor-Immune Interactions: A Wrong Model or Just an Incomplete One?. Front Immunol. 2021 Aug.12:668221. Pubmedid: 34531851. Pmcid: PMC8438324.
• Hamdi Y, Abdeljaoued-Tej I, Zatchi AA, Abdelhak S, Boubaker S, Brown JS, Benkahla A. Cancer in Africa: The Untold Story. Front Oncol. 2021 Apr.11:650117. Pubmedid: 33937056. Pmcid: PMC8082106.
• Dujon AM, Aktipis A, Alix-Panabières C, Amend SR, Boddy AM, Brown JS, Capp JP, DeGregori J, Ewald P, Gatenby R, Gerlinger M, Giraudeau M, Hamede RK, Hansen E, Kareva I, Maley CC, Marusyk A, McGranahan N, Metzger MJ, Nedelcu AM, Noble R, Nunney L, Pienta KJ, Polyak K, Pujol P, Read AF, Roche B, Sebens S, Solary E, Staňková K, Swain Ewald H, Thomas F, Ujvari B. Identifying key questions in the ecology and evolution of cancer. Evol Appl. 2021 Apr.14(4):877-892. Pubmedid: 33897809. Pmcid: PMC8061275.
• Gatenby RA, Brown JS. Integrating evolutionary dynamics into cancer therapy. Nat Rev Clin Oncol. 2020 Nov.17(11):675-686. Pubmedid: 32699310.
• Gatenby R, Brown J. Retraction: The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med. 2020 Nov.10(11). Pubmedid: 33139406. Pmcid: PMC7605237.
• Gatenby RA, Brown JS. The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med. 2020 Nov.10(11). Pubmedid: 33139405. Pmcid: PMC7605238.
• Subramanian H, Brown J, Gatenby R. Prebiotic competition and evolution in self-replicating polynucleotides can explain the properties of DNA/RNA in modern living systems. BMC Evol Biol. 2020 Jun.20(1):75. Pubmedid: 32590933. Pmcid: PMC7318430.
• Reed DR, Metts J, Pressley M, Fridley BL, Hayashi M, Isakoff MS, Loeb DM, Makanji R, Roberts RD, Trucco M, Wagner LM, Alexandrow MG, Gatenby RA, Brown JS. An evolutionary framework for treating pediatric sarcomas. Cancer. 2020 Jun.126(11):2577-2587. Pubmedid: 32176331. Pmcid: PMC7318114.
• Pienta KJ, Hammarlund EU, Axelrod R, Amend SR, Brown JS. Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer. Mol Cancer Res. 2020 Jun.18(6):801-810. Pubmedid: 32234827. Pmcid: PMC7272288.
• Miller AK, Brown JS, Basanta D, Huntly N. What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?. Cancer Control. 2020 Jul.27(3). Pubmedid: 32723185. Pmcid: PMC7658723.
• Enderling H, Altrock PM, Andor N, Basanta D, Brown JS, Gatenby RA, Marusyk A, Rejniak KA, Silva A, Anderson ARA. High School Internship Program in Integrated Mathematical Oncology (HIP IMO): Five-Year Experience at Moffitt Cancer Center. Bull Math Biol. 2020 Jul.82(7):91. Pubmedid: 32648152.
• Kotler BP, Brown JS. Cancer Community Ecology. Cancer Control. 2020 Jan.27(1). Pubmedid: 32942911. Pmcid: PMC7503020.
• Gatenby RA, Artzy-Randrup Y, Epstein T, Reed DR, Brown JS. Eradicating Metastatic Cancer and the Eco-Evolutionary Dynamics of Anthropocene Extinctions. Cancer Res. 2020 Feb.80(3):613-623. Pubmedid: 31772037. Pmcid: PMC7771333.
• Makin DF, Kotler BP, Brown JS, Garrido M, Menezes JFS. The Enemy Within: How Does a Bacterium Inhibit the Foraging Aptitude and Risk Management Behavior of Allenby's Gerbils?. Am Nat. 2020 Dec.196(6):717-729. Pubmedid: 33211558.
• Cunningham J, Thuijsman F, Peeters R, Viossat Y, Brown J, Gatenby R, Staňková K. Optimal control to reach eco-evolutionary stability in metastatic castrate-resistant prostate cancer. PLoS One. 2020 Dec.15(12):e0243386. Pubmedid: 33290430. Pmcid: PMC7723267.
• Halloway A, Malone MA, Brown JS. Unstable population dynamics in obligate co-operators. Theor Popul Biol. 2020 Dec.136:1-11. Pubmedid: 33031837.
• Gatenby RA, Avdieiev S, Tsai KY, Brown JS. Integrating genetic and nongenetic drivers of somatic evolution during carcinogenesis: The biplane model. Evol Appl. 2020 Aug.13(7):1651-1659. Pubmedid: 32952610. Pmcid: PMC7484850.
• Pienta KJ, Hammarlund EU, Axelrod R, Brown JS, Amend SR. Poly-aneuploid cancer cells promote evolvability, generating lethal cancer. Evol Appl. 2020 Aug.13(7):1626-1634. Pubmedid: 32952609. Pmcid: PMC7484876.
• Bleicher SS, Kotler BP, Downs CJ, Brown JS. Intercontinental test of constraint-breaking adaptations: Testing behavioural plasticity in the face of a predator with novel hunting strategies. J Anim Ecol. 2020 Aug.89(8):1837-1850. Pubmedid: 32271948.
• West J, You L, Zhang J, Gatenby RA, Brown JS, Newton PK, Anderson ARA. Towards Multidrug Adaptive Therapy. Cancer Res. 2020 Apr.80(7):1578-1589. Pubmedid: 31948939. Pmcid: PMC7307613.
• Flower CE, Dalton JE, Whelan CJ, Brown JS, Gonzalez-Meler MA. Patch use in the arctic ground squirrel: effects of micro-topography and shrub encroachment in the Arctic Circle. Oecologia. 2019 May.190(1):243-254. Pubmedid: 31016381.
• Bleicher SS, Kotler BP, Brown JS. Comparing Plasticity of Response to Perceived Risk in the Textbook Example of Convergent Evolution of Desert Rodents and Their Predators; a Manipulative Study Employing the Landscape of Fear. Front Behav Neurosci. 2019 Mar.13:58. Pubmedid: 30967766. Pmcid: PMC6440367.
• Gatenby RA, Zhang J, Brown JS. First Strike-Second Strike Strategies in Metastatic Cancer: Lessons from the Evolutionary Dynamics of Extinction. Cancer Res. 2019 Jul.79(13):3174-3177. Pubmedid: 31221821. Pmcid: PMC6606376.
• West JB, Dinh MN, Brown JS, Zhang J, Anderson AR, Gatenby RA. Multidrug Cancer Therapy in Metastatic Castrate-Resistant Prostate Cancer: An Evolution-Based Strategy. Clin Cancer Res. 2019 Jul.25(14):4413-4421. Pubmedid: 30992299. Pmcid: PMC6665681.
• Stanková K, Brown JS, Dalton WS, Gatenby RA. Optimizing Cancer Treatment Using Game Theory: A Review. JAMA Oncol. 2019 Jan.5(1):96-103. Pubmedid: 30098166. Pmcid: PMC6947530.
• Kimmel GJ, Gerlee P, Brown JS, Altrock PM. Neighborhood size-effects shape growing population dynamics in evolutionary public goods games. Commun Biol. 2019 Feb.2:53. Pubmedid: 30729189. Pmcid: PMC6363775.
• Gallaher JA, Brown JS, Anderson ARA. The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer. Sci Rep. 2019 Feb.9(1):2425. Pubmedid: 30787363. Pmcid: PMC6382810.
• West J, Robertson-Tessi M, Luddy K, Park DS, Williamson DFK, Harmon C, Khong HT, Brown J, Anderson ARA. The Immune Checkpoint Kick Start: Optimization of Neoadjuvant Combination Therapy Using Game Theory. JCO Clin Cancer Inform. 2019 Feb.3:1-12. Pubmedid: 30742484. Pmcid: PMC6873943.
• Kimmel GJ, Gerlee P, Brown JS, Altrock PM. Neighborhood size-effects shape growing population dynamics in evolutionary public goods games. Commun Biol. 2019 Feb.2(1):53. Pubmedid: 31924922.
• Ujvari B, Jacqueline C, Misse D, Amar V, Fitzpatrick JC, Jennings G, Beckmann C, Rome S, Biro PA, Gatenby R, Brown J, Almeida L, Thomas F. Obesity paradox in cancer: Is bigger really better?. Evol Appl. 2019 Apr.12(6):1092-1095. Pubmedid: 31293625. Pmcid: PMC6597865.
• Gaynor KM, Brown JS, Middleton AD, Power ME, Brashares JS. Landscapes of Fear: Spatial Patterns of Risk Perception and Response. Trends Ecol Evol. 2019 Apr.34(4):355-368. Pubmedid: 30745252.
• Gillies RJ, Brown JS, Anderson ARA, Gatenby RA. Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow. Nat Rev Cancer. 2018 Sep.18(9):576-585. Pubmedid: 29891961. Pmcid: PMC6441333.
• Thomas F, Donnadieu E, Charriere GM, Jacqueline C, Tasiemski A, Pujol P, Renaud F, Roche B, Hamede R, Brown J, Gatenby R, Ujvari B. Is adaptive therapy natural?. PLoS Biol. 2018 Oct.16(10):e2007066. Pubmedid: 30278037. Pmcid: PMC6168119.
• Bayer P, Brown JS, Staňková K. A two-phenotype model of immune evasion by cancer cells. J Theor Biol. 2018 Oct.455:191-204. Pubmedid: 30031001.
• Gatenby R, Brown J. The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med. 2018 Mar.8(3). Pubmedid: 28710258. Pmcid: PMC5830903.
• Cunningham JJ, Brown JS, Gatenby RA, Staňková K. Optimal control to develop therapeutic strategies for metastatic castrate resistant prostate cancer. J Theor Biol. 2018 Dec.459:67-78. Pubmedid: 30243754.
• Bleicher SS, Kotler BP, Shalev O, Dixon A, Embar K, Brown JS. Divergent behavior amid convergent evolution: A case of four desert rodents learning to respond to known and novel vipers. PLoS One. 2018 Aug.13(8):e0200672. Pubmedid: 30125293. Pmcid: PMC6101362.
• Epstein T, Gatenby RA, Brown JS. The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand. PLoS One. 2017 Sep.12(9):e0185085. Pubmedid: 28922380. Pmcid: PMC5602667.
• Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva AS, Gerlinger M, Yuan Y, Pienta KJ, Anderson KS, Gatenby R, Swanton C, Posada D, Wu CI, Schiffman JD, Hwang ES, Polyak K, Anderson ARA, Brown JS, Greaves M, Shibata D. Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer. 2017 Oct.17(10):605-619. Pubmedid: 28912577. Pmcid: PMC5811185.
• Zhang J, Cunningham JJ, Brown JS, Gatenby RA. Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer. Nat Commun. 2017 Nov.8(1):1816. Pubmedid: 29180633. Pmcid: PMC5703947.
• Ibrahim-Hashim A, Robertson-Tessi M, Enrizues-Navas P, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson AR, Gillies RJ, Gatenby RA. Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res. 2017 May.77(9):2242-2254. Pubmedid: 28249898. Pmcid: PMC6005351.
• Brown J, Cunningham JJ, Gatenby RA. Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer. IEEE Trans Biomed Eng. 2017 Mar.64(3):512-518. Pubmedid: 28113286. Pmcid: PMC5438296.
• You L, Brown JS, Thuijsman F, Cunningham JJ, Gatenby RA, Zhang J, Staňková K. Spatial vs. non-spatial eco-evolutionary dynamics in a tumor growth model. J Theor Biol. 2017 Dec.435:78-97. Pubmedid: 28870617.
• Gatenby RA, Brown J. Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer. BBA. Reviews on cancer. 2017 Apr.1867(2):162-166. Pubmedid: 28341421. Pmcid: PMC5441954.
• Brown JS, Staňková K. Game theory as a conceptual framework for managing insect pests. Curr Opin Insect Sci. 2017 06.21:26-32. Pubmedid: 28822485.
• Amend SR, Roy S, Brown JS, Pienta KJ. Ecological paradigms to understand the dynamics of metastasis. Cancer Lett. 2016 Sep.380(1):237-242. Pubmedid: 26458994. Pmcid: PMC4826855.
• Brown J, Cunningham JJ, Gatenby RA. Aggregation Effects and Population-based dynamics as a source of therapy resistance in cancer. IEEE Trans Biomed Eng. 2016 Nov. Pubmedid: 27831855.
• Lloyd MC, Cunningham JJ, Bui MM, Gillies RJ, Brown JS, Gatenby RA. Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces. Cancer Res. 2016 Jun.76(11):3136-3144. Pubmedid: 27009166. Pmcid: PMC5384728.
• Troxell-Smith SM, Tutka MJ, Albergo JM, Balu D, Brown JS, Leonard JP. Foraging decisions in wild versus domestic Mus musculus: What does life in the lab select for?. Behav Processes. 2016 Jan.122:43-50. Pubmedid: 26548716.
• Brown JS. Why Darwin would have loved evolutionary game theory. Proc Biol Sci. 2016 09.283(1838). Pubmedid: 27605503. Pmcid: PMC5031650.
• Czupryna AM, Brown JS, Bigambo MA, Whelan CJ, Mehta SD, Santymire RM, Lankester FJ, Faust LJ. Ecology and Demography of Free-Roaming Domestic Dogs in Rural Villages near Serengeti National Park in Tanzania. PLoS One. 2016.11(11):e0167092. Pubmedid: 27893866. Pmcid: PMC5125679.
• Cunningham JJ, Brown JS, Vincent TL, Gatenby RA. Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites. Evol Med Public Health. 2015 Mar.2015(1):76-87. Pubmedid: 25794501. Pmcid: PMC4404930.
• Brown JS, Cunningham JJ, Gatenby RA. The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression. Philos Trans R Soc Lond B Biol Sci. 2015 Jul.370(1673). Pubmedid: 26056365. Pmcid: PMC4581026.
• Lloyd MC, Rejniak KA, Brown JS, Gatenby RA, Minor ES, Bui MM. Pathology to enhance precision medicine in oncology: lessons from landscape ecology. Adv Anat Pathol. 2015 Jul.22(4):267-272. Pubmedid: 26050264. Pmcid: PMC4729443.
• Brown JS, Aktipis CA. Inclusive fitness effects can select for cancer suppression into old age. Philos Trans R Soc Lond B Biol Sci. 2015 Jul.370(1673). Pubmedid: 26056358. Pmcid: PMC4581037.
• McNickle GG, Brown JS. When Michaelis and Menten met Holling: towards a mechanistic theory of plant nutrient foraging behaviour. AoB Plants. 2014 Oct.6. Pubmedid: 25341427. Pmcid: PMC4271705.
• Gatenby RA, Cunningham JJ, Brown JS. Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations. Nat Commun. 2014 Nov.5:5499. Pubmedid: 25407411. Pmcid: PMC4260773.
• Abu Baker MA, Brown JS. Foraging in space and time structure an African small mammal community. Oecologia. 2014 Jun.175(2):521-535. Pubmedid: 24648024.
• Cressman R, Křivan V, Brown JS, Garay J. Game-theoretic methods for functional response and optimal foraging behavior. PLoS One. 2014 Feb.9(2):e88773. Pubmedid: 24586390. Pmcid: PMC3938838.
• Lloyd MC, Alfarouk KO, Verduzco D, Bui MM, Gillies RJ, Ibrahim ME, Brown JS, Gatenby RA. Vascular measurements correlate with estrogen receptor status. BMC Cancer. 2014 Apr.14:279. Pubmedid: 24755315. Pmcid: PMC4012762.
• Ale SB, Brown JS, Sullivan AT. Evolution of cooperation: combining kin selection and reciprocal altruism into matrix games with social dilemmas. PLoS One. 2014 Apr.8(5):e63761. Pubmedid: 23717479. Pmcid: PMC3661668.
• Emerson SE, Brown JS. Identifying preferred habitats of samango monkeys (Cercopithecus (nictitans) mitis erythrarchus) through patch use. Behav Processes. 2013 Nov.100:214-221. Pubmedid: 24432361.
• Howell-Stephens J, Bernier D, Brown JS, Mulkerin D, Santymire RM. Using non-invasive methods to characterize gonadal hormonal patterns of southern three-banded armadillos (Tolypeutes matacus) housed in North American zoos. Anim Reprod Sci. 2013 May.138(3-4):314-323. Pubmedid: 23541612.
• Orlando PA, Gatenby RA, Brown JS. Tumor evolution in space: the effects of competition colonization tradeoffs on tumor invasion dynamics. Front Oncol. 2013 Mar.3:45. Pubmedid: 23508890. Pmcid: PMC3589695.
• Alfarouk KO, Ibrahim ME, Gatenby RA, Brown JS. Riparian ecosystems in human cancers. Evol Appl. 2013 Jan.6(1):46-53. Pubmedid: 23396634. Pmcid: PMC3567470.
• Aktipis CA, Boddy AM, Gatenby RA, Brown JS, Maley CC. Life history trade-offs in cancer evolution. Nat Rev Cancer. 2013 Dec.13(12):883-892. Pubmedid: 24213474. Pmcid: PMC4010142.
• Orlando PA, Brown JS, Gatenby RA, Giuliano AR. The ecology of human papillomavirus-induced epithelial lesions and the role of somatic evolution in their progression. J Infect Dis. 2013 Aug.208(3):394-402. Pubmedid: 23599315. Pmcid: PMC3698999.
• Orlando PA, Brown JS, Wise DH. Coexistence and community structure in a consumer resource model with implicit stoichiometry. Theor Popul Biol. 2012 Sep.82(2):77-84. Pubmedid: 22705543.
• Emerson SE, Brown JS, Whelan CJ, Schmidt KA. Scale-dependent neighborhood effects: shared doom and associational refuge. Oecologia. 2012 Mar.168(3):659-670. Pubmedid: 21987268.
• Orlando PA, Gatenby RA, Giuliano AR, Brown JS. Evolutionary ecology of human papillomavirus: trade-offs, coexistence, and origins of high-risk and low-risk types. J Infect Dis. 2012 Jan.205(2):272-279. Pubmedid: 22090448. Pmcid: PMC3244363.
• Orlando PA, Gatenby RA, Brown JS. Cancer treatment as a game: integrating evolutionary game theory into the optimal control of chemotherapy. Phys Biol. 2012 Dec.9(6):065007. Pubmedid: 23197192. Pmcid: PMC3653600.
• Howell-Stephens JA, Brown JS, Bernier D, Mulkerin D, Santymire RM. Characterizing adrenocortical activity in zoo-housed southern three-banded armadillos (Tolypeutes matacus). Gen Comp Endocrinol. 2012 Aug.178(1):64-74. Pubmedid: 22537671.
• Cunningham JJ, Gatenby RA, Brown JS. Evolutionary dynamics in cancer therapy. Mol Pharm. 2011 Dec.8(6):2094-2100. Pubmedid: 21815657. Pmcid: PMC3250072.
• Gatenby RA, Gillies RJ, Brown JS. Of cancer and cave fish. Nat Rev Cancer. 2011 Apr.11(4):237-238. Pubmedid: 21548400. Pmcid: PMC3971416.
• Pintor LM, Brown JS, Vincent TL. Evolutionary game theory as a framework for studying biological invasions. Am Nat. 2011 Apr.177(4):410-423. Pubmedid: 21460564.
• Kotler BP, Brown J, Mukherjee S, Berger-Tal O, Bouskila A. Moonlight avoidance in gerbils reveals a sophisticated interplay among time allocation, vigilance and state-dependent foraging. Proc Biol Sci. 2010 May.277(1687):1469-1474. Pubmedid: 20053649. Pmcid: PMC2871830.
• Berger-Tal O, Mukherjee S, Kotler BP, Brown JS. Complex state-dependent games between owls and gerbils. Ecol Lett. 2010 Mar.13(3):302-310. Pubmedid: 20455918.
• Gatenby RA, Gillies RJ, Brown JS. Evolutionary dynamics of cancer prevention. Nat Rev Cancer. 2010 Aug.10(8):526-527. Pubmedid: 21137109. Pmcid: PMC3744108.
• Gatenby RA, Brown J, Vincent T. Lessons from applied ecology: cancer control using an evolutionary double bind. Cancer Res. 2009 Oct.69(19):7499-7502. Pubmedid: 19752088.
• Berger-Tal O, Mukherjee S, Kotler BP, Brown JS. Look before you leap: is risk of injury a foraging cost?. Behav Ecol Sociobiol. 2009 Oct.63(12):1821-1827. Pubmedid: 19779627. Pmcid: PMC2746896.
• Brown JS, Vincent TL. Evolution of cooperation with shared costs and benefits. Proc Biol Sci. 2008 Sep.275(1646):1985-1994. Pubmedid: 18495622. Pmcid: PMC2596366.
• Moll JD, Brown JS. Competition and coexistence with multiple life-history stages. Am Nat. 2008 Jun.171(6):839-843. Pubmedid: 18462131.
• Olsson O, Brown JS, Helf KL. A guide to central place effects in foraging. Theor Popul Biol. 2008 Aug.74(1):22-33. Pubmedid: 18550139.
• O'Brien EE, Brown JS, Moll JD. Roots in space: a spatially explicit model for below-ground competition in plants. Proc Biol Sci. 2007 Apr.274(1612):929-934. Pubmedid: 17251098. Pmcid: PMC2141669.
• Howe HF, Zorn-Arnold B, Sullivan A, Brown JS. Massive and distinctive effects of meadow voles on grassland vegetation. Ecology. 2006 Dec.87(12):3007-3013. Pubmedid: 17249225.
• O'Brien EE, Gersani M, Brown JS. Root proliferation and seed yield in response to spatial heterogeneity of below-ground competition. New Phytol. 2005 Nov.168(2):401-412. Pubmedid: 16219079.
• Martínez-Garza C, Saha S, Torres V, Brown JS, Howe HF. Planting densities and bird and rodent absence affect size distributions of four dicots in synthetic tallgrass communities. Oecologia. 2004 May.139(3):433-439. Pubmedid: 14986097.
• Brown JS, Vincent TL. ORGANIZATION OF PREDATOR-PREY COMMUNITIES AS AN EVOLUTIONARY GAME. Evolution. 1992 Oct.46(5):1269-1283. Pubmedid: 28569003.
• Brown JS. HABITAT SELECTION AS AN EVOLUTIONARY GAME. Evolution. 1990 May.44(3):732-746. Pubmedid: 28567976.
• Brown JS, Alkon PU. Testing values of crested porcupine habitats by experimental food patches. Oecologia. 1990 Jul.83(4):512-518. Pubmedid: 28313185.
• Brown JS, Vincent TL. COEVOLUTION AS AN EVOLUTIONARY GAME. Evolution. 1987 Jan.41(1):66-79. Pubmedid: 28563763.
• Darracq AK, Conner LM, Brown JS, McCleery RA. Cotton Rats Alter Foraging in Response to an Invasive Ant. PLoS One. 11(9):e0163220. Pubmedid: 27655320. Pmcid: PMC5031446.

• Title: The Delta Ecology of NSCLC Treatment
  Sponsor: Nat Institutes of Health
  PI (Contact): Anderson, A., PI (MPI): Gatenby, R., Project PI: Marusyk, A., Core PI/Director: Brown, J.
• Title: Feasibility of Generating Novel Translational and Therapeutic Strategies based on a Multicenter, Pediatric and AYA Evolutionary Tumor Board; pedsETB
  Sponsor: Florida Biomedical Research Program (FBRP)
  PI: Metts, J., CO-PI: Robertson-Tessi, M., CO-PI: Anderson, A., CO-PI: Brown, J., CO-PI: Marusyk, A.
• Title: The Polyaneuploid Cancer Cell State Mediates Multitherapy Resistance in Cancer
  Sponsor: US Army
  PI: Brown, J.
• Title: Eco-Evolutionary Drivers of Clonal Dynamics During UV-Induced Skin Carcinogenesis (PQ3)
  Sponsor: Nat Institutes of Health
  PI (Contact): Tsai, K., PI (MPI): Brown, J.