Joel <span>S.</span> Brown, PhD
Researcher

Joel S. Brown, PhD

Academic Rank: Senior Member

Overview

To be the leader in applying principles of ecology and evolution to contain and cure cancer while enhancing the length and quality of the patients’ lives.

Discipline

    • Gynecologic Oncology
    • Integrated Mathematical Oncology
    • Cancer Biology and Evolution Program

Education & Training

    • University of Arizona, PhD - Ecology and Evolutionary Biology
Research

As member of the Cancer Biology and Evolution Group and the Department of Integrated Mathematical Oncology, my research and collaborations are multi-disciplinary. I have ongoing collaborations with Drs. Robert Gatenby and Sandy Alexander on applying ecological principles to understanding cancer. In terms of experimental work, I enjoy collaborative work on skin cancer cell culturing with Ken Tsai, competition experiments to explore the cost of resistance with Dr. Robert Gillies and his group, mouse model work on prostate cancer and the evolution of cancer resistance with Drs. Gatenby and Arig Ibrahim. In terms of clinical trials, I have been part of a team led by Jngsong Zhang to examine the efficacy of Adaptive therapy for late stage metastatic castrate resistant cancer (Phase I trial). Currently working with Dr. Christine Chung and her team on a phase II trial for metastatic thyroid cancer. My work is highly collaborative and I look forward to extending and integrating my work to serve the experimentalists, mathematicians and clinicians.I  use a combination of mathematical and experimental approaches to understand how organisms interact with and shape their environments. Squirrels are a particular favorite model system, as they have evolved unique attributes and behaviors for climbing trees, storing acorns and other foods, and avoiding predators. In viewing animals through their ecosystems and adaptations,

Publications

  • Epstein T, Gatenby RA, Brown JS. The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand. PLoS One. 2017 Sep;12(9):e0185085. Pubmedid: 28922380. Pmcid: PMC5602667.
  • Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva AS, Gerlinger M, Yuan Y, Pienta KJ, Anderson KS, Gatenby R, Swanton C, Posada D, Wu CI, Schiffman JD, Hwang ES, Polyak K, Anderson ARA, Brown JS, Greaves M, Shibata D. Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer. 2017 Oct;17(10):605-619. Pubmedid: 28912577.
  • Ibrahim-Hashim A, Robertson-Tessi M, Enrizues-Navas P, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson AR, Gillies RJ, Gatenby RA. Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res. 2017 May;77(9):2242-2254. Pubmedid: 28249898.
  • Brown J, Cunningham JJ, Gatenby RA. Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer. IEEE Trans Biomed Eng. 2017 Mar;64(3):512-518. Pubmedid: 28113286. Pmcid: PMC5438296.
  • Brown JS, Staňková K. Game theory as a conceptual framework for managing insect pests. Curr Opin Insect Sci. 2017 Jun;21:26-32. Pubmedid: 28822485.
  • Gatenby R, Brown J. The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med. 2017 Jul. Pubmedid: 28710258.
  • You L, Brown JS, Thuijsman F, Cunningham JJ, Gatenby RA, Zhang J, Staňková K. Spatial vs. non-spatial eco-evolutionary dynamics in a tumor growth model. J Theor Biol. 2017 Dec;435:78-97. Pubmedid: 28870617.
  • Gatenby RA, Brown J. Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer. Biochim Biophys Acta. 2017 Apr;1867(2):162-166. Pubmedid: 28341421. Pmcid: PMC5441954.
  • Brown JS. Why Darwin would have loved evolutionary game theory. Proc Biol Sci. 2016 Sep;283(1838). Pubmedid: 27605503. Pmcid: PMC5031650.
  • Brown J, Cunningham JJ, Gatenby RA. Aggregation Effects and Population-based dynamics as a source of therapy resistance in cancer. IEEE Trans Biomed Eng. 2016 Nov. Pubmedid: 27831855.
  • Troxell-Smith SM, Tutka MJ, Albergo JM, Balu D, Brown JS, Leonard JP. Foraging decisions in wild versus domestic Mus musculus: What does life in the lab select for?. Behav Processes. 2016 Jan;122:43-50. Pubmedid: 26548716.
  • Amend SR, Roy S, Brown JS, Pienta KJ. Ecological paradigms to understand the dynamics of metastasis. Cancer Lett. 2016 09;380(1):237-242. Pubmedid: 26458994. Pmcid: PMC4826855.
  • Lloyd MC, Cunningham JJ, Bui MM, Gillies RJ, Brown JS, Gatenby RA. Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces. Cancer Res. 2016 06;76(11):3136-3144. Pubmedid: 27009166. Pmcid: PMC5384728.
  • Czupryna AM, Brown JS, Bigambo MA, Whelan CJ, Mehta SD, Santymire RM, Lankester FJ, Faust LJ. Ecology and Demography of Free-Roaming Domestic Dogs in Rural Villages near Serengeti National Park in Tanzania. PLoS One. 2016;11(11):e0167092. Pubmedid: 27893866. Pmcid: PMC5125679.
  • Cunningham JJ, Brown JS, Vincent TL, Gatenby RA. Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites. Evol Med Public Health. 2015 Mar;2015(1):76-87. Pubmedid: 25794501. Pmcid: PMC4404930.
  • Brown JS, Cunningham JJ, Gatenby RA. The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression. Philos Trans R Soc Lond B Biol Sci. 2015 Jul;370(1673). Pubmedid: 26056365. Pmcid: PMC4581026.
  • Lloyd MC, Rejniak KA, Brown JS, Gatenby RA, Minor ES, Bui MM. Pathology to enhance precision medicine in oncology: lessons from landscape ecology. Adv Anat Pathol. 2015 Jul;22(4):267-272. Pubmedid: 26050264. Pmcid: PMC4729443.
  • Brown JS, Aktipis CA. Inclusive fitness effects can select for cancer suppression into old age. Philos Trans R Soc Lond B Biol Sci. 2015 Jul;370(1673). Pubmedid: 26056358. Pmcid: PMC4581037.
  • McNickle GG, Brown JS. When Michaelis and Menten met Holling: towards a mechanistic theory of plant nutrient foraging behaviour. AoB Plants. 2014 Oct;6. Pubmedid: 25341427. Pmcid: PMC4271705.
  • Gatenby RA, Cunningham JJ, Brown JS. Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations. Nat Commun. 2014 Nov;5:5499. Pubmedid: 25407411. Pmcid: PMC4260773.
  • Abu Baker MA, Brown JS. Foraging in space and time structure an African small mammal community. Oecologia. 2014 Jun;175(2):521-535. Pubmedid: 24648024.
  • Cressman R, Křivan V, Brown JS, Garay J. Game-theoretic methods for functional response and optimal foraging behavior. PLoS One. 2014 Feb;9(2):e88773. Pubmedid: 24586390. Pmcid: PMC3938838.
  • Lloyd MC, Alfarouk KO, Verduzco D, Bui MM, Gillies RJ, Ibrahim ME, Brown JS, Gatenby RA. Vascular measurements correlate with estrogen receptor status. BMC Cancer. 2014 Apr;14:279. Pubmedid: 24755315. Pmcid: PMC4012762.
  • Ale SB, Brown JS, Sullivan AT. Evolution of cooperation: combining kin selection and reciprocal altruism into matrix games with social dilemmas. PLoS One. 2014 Apr;8(5):e63761. Pubmedid: 23717479. Pmcid: PMC3661668.
  • Emerson SE, Brown JS. Identifying preferred habitats of samango monkeys (Cercopithecus (nictitans) mitis erythrarchus) through patch use. Behav Processes. 2013 Nov;100:214-221. Pubmedid: 24432361.
  • Howell-Stephens J, Bernier D, Brown JS, Mulkerin D, Santymire RM. Using non-invasive methods to characterize gonadal hormonal patterns of southern three-banded armadillos (Tolypeutes matacus) housed in North American zoos. Anim Reprod Sci. 2013 May;138(3-4):314-323. Pubmedid: 23541612.
  • Orlando PA, Gatenby RA, Brown JS. Tumor evolution in space: the effects of competition colonization tradeoffs on tumor invasion dynamics. Front Oncol. 2013 Mar;3:45. Pubmedid: 23508890. Pmcid: PMC3589695.
  • Alfarouk KO, Ibrahim ME, Gatenby RA, Brown JS. Riparian ecosystems in human cancers. Evol Appl. 2013 Jan;6(1):46-53. Pubmedid: 23396634. Pmcid: PMC3567470.
  • Aktipis CA, Boddy AM, Gatenby RA, Brown JS, Maley CC. Life history trade-offs in cancer evolution. Nat Rev Cancer. 2013 Dec;13(12):883-892. Pubmedid: 24213474. Pmcid: PMC4010142.
  • Orlando PA, Brown JS, Gatenby RA, Giuliano AR. The ecology of human papillomavirus-induced epithelial lesions and the role of somatic evolution in their progression. J Infect Dis. 2013 Aug;208(3):394-402. Pubmedid: 23599315. Pmcid: PMC3698999.
  • Orlando PA, Brown JS, Wise DH. Coexistence and community structure in a consumer resource model with implicit stoichiometry. Theor Popul Biol. 2012 Sep;82(2):77-84. Pubmedid: 22705543.
  • Emerson SE, Brown JS, Whelan CJ, Schmidt KA. Scale-dependent neighborhood effects: shared doom and associational refuge. Oecologia. 2012 Mar;168(3):659-670. Pubmedid: 21987268.
  • Orlando PA, Gatenby RA, Giuliano AR, Brown JS. Evolutionary ecology of human papillomavirus: trade-offs, coexistence, and origins of high-risk and low-risk types. J Infect Dis. 2012 Jan;205(2):272-279. Pubmedid: 22090448. Pmcid: PMC3244363.
  • Orlando PA, Gatenby RA, Brown JS. Cancer treatment as a game: integrating evolutionary game theory into the optimal control of chemotherapy. Phys Biol. 2012 Dec;9(6):065007. Pubmedid: 23197192. Pmcid: PMC3653600.
  • Howell-Stephens JA, Brown JS, Bernier D, Mulkerin D, Santymire RM. Characterizing adrenocortical activity in zoo-housed southern three-banded armadillos (Tolypeutes matacus). Gen Comp Endocrinol. 2012 Aug;178(1):64-74. Pubmedid: 22537671.
  • Cunningham JJ, Gatenby RA, Brown JS. Evolutionary dynamics in cancer therapy. Mol Pharm. 2011 Dec;8(6):2094-2100. Pubmedid: 21815657. Pmcid: PMC3250072.
  • Pintor LM, Brown JS, Vincent TL. Evolutionary game theory as a framework for studying biological invasions. Am Nat. 2011 Apr;177(4):410-423. Pubmedid: 21460564.
  • Kotler BP, Brown J, Mukherjee S, Berger-Tal O, Bouskila A. Moonlight avoidance in gerbils reveals a sophisticated interplay among time allocation, vigilance and state-dependent foraging. Proc Biol Sci. 2010 May;277(1687):1469-1474. Pubmedid: 20053649. Pmcid: PMC2871830.
  • Berger-Tal O, Mukherjee S, Kotler BP, Brown JS. Complex state-dependent games between owls and gerbils. Ecol Lett. 2010 Mar;13(3):302-310. Pubmedid: 20455918.
  • Gatenby RA, Gillies RJ, Brown JS. Evolutionary dynamics of cancer prevention. Nat Rev Cancer. 2010 Aug;10(8):526-527. Pubmedid: 21137109. Pmcid: PMC3744108.
  • Gatenby RA, Brown J, Vincent T. Lessons from applied ecology: cancer control using an evolutionary double bind. Cancer Res. 2009 Oct;69(19):7499-7502. Pubmedid: 19752088.
  • Berger-Tal O, Mukherjee S, Kotler BP, Brown JS. Look before you leap: is risk of injury a foraging cost?. Behav Ecol Sociobiol. 2009 Oct;63(12):1821-1827. Pubmedid: 19779627. Pmcid: PMC2746896.
  • Brown JS, Vincent TL. Evolution of cooperation with shared costs and benefits. Proc Biol Sci. 2008 Sep;275(1646):1985-1994. Pubmedid: 18495622. Pmcid: PMC2596366.
  • Moll JD, Brown JS. Competition and coexistence with multiple life-history stages. Am Nat. 2008 Jun;171(6):839-843. Pubmedid: 18462131.
  • Olsson O, Brown JS, Helf KL. A guide to central place effects in foraging. Theor Popul Biol. 2008 Aug;74(1):22-33. Pubmedid: 18550139.
  • O'Brien EE, Brown JS, Moll JD. Roots in space: a spatially explicit model for below-ground competition in plants. Proc Biol Sci. 2007 Apr;274(1612):929-934. Pubmedid: 17251098. Pmcid: PMC2141669.
  • Howe HF, Zorn-Arnold B, Sullivan A, Brown JS. Massive and distinctive effects of meadow voles on grassland vegetation. Ecology. 2006 Dec;87(12):3007-3013. Pubmedid: 17249225.
  • O'Brien EE, Gersani M, Brown JS. Root proliferation and seed yield in response to spatial heterogeneity of below-ground competition. New Phytol. 2005 Nov;168(2):401-412. Pubmedid: 16219079.
  • Martínez-Garza C, Saha S, Torres V, Brown JS, Howe HF. Planting densities and bird and rodent absence affect size distributions of four dicots in synthetic tallgrass communities. Oecologia. 2004 May;139(3):433-439. Pubmedid: 14986097.
  • Brown JS, Vincent TL. ORGANIZATION OF PREDATOR-PREY COMMUNITIES AS AN EVOLUTIONARY GAME. Evolution. 1992 Oct;46(5):1269-1283. Pubmedid: 28569003.
  • Brown JS. HABITAT SELECTION AS AN EVOLUTIONARY GAME. Evolution. 1990 May;44(3):732-746. Pubmedid: 28567976.
  • Brown JS, Alkon PU. Testing values of crested porcupine habitats by experimental food patches. Oecologia. 1990 Jul;83(4):512-518. Pubmedid: 28313185.
  • Brown JS, Vincent TL. COEVOLUTION AS AN EVOLUTIONARY GAME. Evolution. 1987 Jan;41(1):66-79. Pubmedid: 28563763.
  • Darracq AK, Conner LM, Brown JS, McCleery RA. Cotton Rats Alter Foraging in Response to an Invasive Ant. PLoS One. 11(9):e0163220. Pubmedid: 27655320. Pmcid: PMC5031446.