Conor Lynch
Researcher

Conor Lynch

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Overview

Discipline

    • Tumor Biology
    • Genitourinary Oncology
    • Cancer Biology and Evolution Program
    • Myeloma

Education & Training

    • Dublin City University, Ireland, PhD - Cancer Biology,Molecular Biology
Research

The goal of our laboratory is to understand how metastatic prostate cancer cells interact with the bone microenvironment to establish and grow as secondary cancers using in vivo and in vitro techniques. The lab has made major inroads into defining how matrix metalloproteinases (MMPs) contribute the prostate cancer progression in bone.

Publications

  • Tauro M, Shay G, Sansil SS, Laghezza A, Tortorella P, Neuger AM, Soliman H, Lynch CC. Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth. Mol Cancer Ther. 2017 Mar;16(3):494-505. Pubmedid: 28069877. Pmcid: PMC5337166.
  • Shay G, Tauro M, Loiodice F, Tortorella P, Sullivan DM, Hazlehurst LA, Lynch CC. Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment. Oncotarget. 2017 Jun;8(26):41827-41840. Pubmedid: 28611279. Pmcid: PMC5522031.
  • Ember SW, Lambert QT, Berndt N, Gunawan S, Ayaz M, Tauro M, Zhu JY, Cranfill PJ, Greninger P, Lynch CC, Benes CH, Lawrence HR, Reuther GW, Lawrence NJ, Schonbrunn E. Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics. Mol Cancer Ther. 2017 Jun;16(6):1054-1067. Pubmedid: 28336808. Pmcid: PMC5457702.
  • Bankaitis K, Borriello L, Cox T, Lynch C, Zijlstra A, Fingleton B, Gužvić M, Anderson R, Neman J. Meeting report: Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis. Clin Exp Metastas. 2017 Apr;34(3-4):203-213. Pubmedid: 28260197.
  • Cook LM, Araujo A, Pow-Sang JM, Budzevich MM, Basanta D, Lynch CC. Predictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer. Sci Rep. 2016 Jul;6:29384. Pubmedid: 27411810. Pmcid: PMC4944130.
  • Yu D, Kahen E, Cubitt CL, McGuire J, Kreahling J, Lee J, Altiok S, Lynch CC, Sullivan DM, Reed DR. Identification of Synergistic, Clinically Achievable, Combination Therapies for Osteosarcoma. Sci Rep. 2015 Nov;5:16991. Pubmedid: 26601688. Pmcid: PMC4658502.
  • Shay G, Lynch CC, Fingleton B. Moving targets: Emerging roles for MMPs in cancer progression and metastasis. Matrix Biol. 2015 Mar;44-46:200-206. Pubmedid: 25652204. Pmcid: PMC4564058.
  • Frieling JS, Basanta D, Lynch CC. Current and emerging therapies for bone metastatic castration-resistant prostate cancer. Cancer Control. 2015 Jan;22(1):109-120. Pubmedid: 25504285. Pmcid: PMC4673894.
  • Luhach I, Idiyatullin D, Lynch CC, Corum C, Martinez GV, Garwood M, Gillies RJ. Rapid ex vivo imaging of PAIII prostate to bone tumor with SWIFT-MRI. Magn Reson Med. 2014 Sep;72(3):858-863. Pubmedid: 24155275. Pmcid: PMC3997623.
  • Cook LM, Shay G, Aruajo A, Lynch CC. Integrating new discoveries into the "vicious cycle" paradigm of prostate to bone metastases. Cancer Metastasis Rev. 2014 Sep;33(2-3):511-525. Pubmedid: 24414228. Pmcid: PMC4096318.
  • Araujo A, Cook LM, Lynch CC, Basanta D. An integrated computational model of the bone microenvironment in bone-metastatic prostate cancer. Cancer Res. 2014 May;74(9):2391-2401. Pubmedid: 24788098. Pmcid: PMC4023121.
  • Cook LM, Shay G, Araujo A, Lynch CC. Erratum to: Integrating new discoveries into the "vicious cycle" paradigm of prostate to bone metastases. Cancer Metastasis Rev. 2014 Dec;33(4):1125. Pubmedid: 25096218.
  • Gallaher J, Cook LM, Gupta S, Araujo A, Dhillon J, Park JY, Scott JG, Pow-Sang J, Basanta D, Lynch CC. Improving treatment strategies for patients with metastatic castrate resistant prostate cancer through personalized computational modeling. Clin Exp Metastas. 2014 Dec;31(8):991-999. Pubmedid: 25173680. Pmcid: PMC5399888.
  • Tauro M, McGuire J, Lynch CC. New approaches to selectively target cancer-associated matrix metalloproteinase activity. Cancer Metastasis Rev. 2014 Dec;33(4):1043-1057. Pubmedid: 25325988.
  • Thiolloy S, Edwards JR, Fingleton B, Rifkin DB, Matrisian LM, Lynch CC. An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. PLoS One. 2012 May;7(1):e29862. Pubmedid: 22238668. Pmcid: PMC3251607.
  • Shah M, Huang D, Blick T, Connor A, Reiter LA, Hardink JR, Lynch CC, Waltham M, Thompson EW. An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer. PLoS One. 2012 May;7(1):e29615. Pubmedid: 22253746. Pmcid: PMC3256168.
  • Halpern JL, Kilbarger A, Lynch CC. Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor. Cancer Lett. 2011 Sep;308(1):91-99. Pubmedid: 21601983. Pmcid: PMC3311035.
  • Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O'Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR. Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone. J Bone Miner Res. 2011 Jun;26(6):1252-1260. Pubmedid: 21611966. Pmcid: PMC3312757.
  • Lynch CC, Vargo-Gogola T, Matrisian LM, Fingleton B. Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA. J Oncol. 2011 Jul;2010:530745. Pubmedid: 20628524. Pmcid: PMC2902104.
  • Bi X, Patil CA, Lynch CC, Pharr GM, Mahadevan-Jansen A, Nyman JS. Raman and mechanical properties correlate at whole bone- and tissue-levels in a genetic mouse model. J Biomech. 2011 Jan;44(2):297-303. Pubmedid: 21035119. Pmcid: PMC3019269.
  • Lynch CC. Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis. Bone. 2011 Jan;48(1):44-53. Pubmedid: 20601294.
  • Fingleton B, Lynch CC. A new dress code for MMPs: cleavage optional. Dev Cell. 2010 Jan;18(1):3-4. Pubmedid: 20152171.
  • Fowler JA, Mundy GR, Lwin ST, Lynch CC, Edwards CM. A murine model of myeloma that allows genetic manipulation of the host microenvironment. Dis Model Mech. 2010 Feb;2(11-12):604-611. Pubmedid: 19779066. Pmcid: PMC2776114.
  • Min Y, Ren X, Vaught DB, Chen J, Donnelly E, Lynch CC, Lin PC. Tie2 signaling regulates osteoclastogenesis and osteolytic bone invasion of breast cancer. Cancer Res. 2010 Apr;70(7):2819-2828. Pubmedid: 20233869. Pmcid: PMC2848896.
  • Bruni-Cardoso A, Johnson LC, Vessella RL, Peterson TE, Lynch CC. Osteoclast-derived matrix metalloproteinase-9 directly affects angiogenesis in the prostate tumor-bone microenvironment. Mol Cancer Res. 2010 Apr;8(4):459-470. Pubmedid: 20332212. Pmcid: PMC2946627.
  • Schoenecker J, Mignemi N, Stutz C, Liu Q, Edwards J, Lynch C, Holt G, Schwartz H, Mencio G, Hamm H. 2010 Young Investigator Award winner: Therapeutic aprotinin stimulates osteoblast proliferation but inhibits differentiation and bone matrix mineralization. Spine (Phila Pa 1976). 2010 Apr;35(9):1008-1016. Pubmedid: 20407341.
  • Martin MD, Fingleton B, Lynch CC, Wells S, McIntyre JO, Piston DW, Matrisian LM. Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth. Clin Exp Metastas. 2009 Jan;25(8):877-885. Pubmedid: 18787962. Pmcid: PMC2588650.
  • Thiolloy S, Halpern J, Holt GE, Schwartz HS, Mundy GR, Matrisian LM, Lynch CC. Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Cancer Res. 2009 Aug;69(16):6747-6755. Pubmedid: 19679556. Pmcid: PMC2745595.
  • Welch DR, Cooper CR, Hurst DR, Lynch CC, Martin MD, Vaidya KS, VanSaun MN, Mastro AM. Metastasis Research Society-American Association For Cancer Research Joint Conference on Metastasis. Cancer Res. 2008 Dec;68(23):9578-9582. Pubmedid: 19047132. Pmcid: PMC2741417.
  • Holt GE, Halpern JL, Lynch CC, Devin CJ, Schwartz HS. Imaging analysis of the in vivo bioreactor: a preliminary study. Clin Orthop Relat Res. 2008 Aug;466(8):1890-1896. Pubmedid: 18506563. Pmcid: PMC2584254.
  • Martin MD, Carter KJ, Jean-Philippe SR, Chang M, Mobashery S, Thiolloy S, Lynch CC, Matrisian LM, Fingleton B. Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res. 2008 Aug;68(15):6251-6259. Pubmedid: 18676849. Pmcid: PMC2789265.
  • Halpern J, Lynch CC, Fleming J, Hamming D, Martin MD, Schwartz HS, Matrisian LM, Holt GE. The application of a murine bone bioreactor as a model of tumor: bone interaction. Clin Exp Metastas. 2007 Mar;23(7-8):345-356. Pubmedid: 17136574.
  • Lynch CC, Vargo-Gogola T, Martin MD, Fingleton B, Crawford HC, Matrisian LM. Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor. Cancer Res. 2007 Jul;67(14):6760-6767. Pubmedid: 17638887.
  • Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK, Vargo-Gogola TC, Begtrup JL, Peterson TE, Fingleton B, Shirai T, Matrisian LM, Futakuchi M. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell. 2005 May;7(5):485-496. Pubmedid: 15894268.
  • Lynch CC, Crawford HC, Matrisian LM, McDonnell S. Epidermal growth factor upregulates matrix metalloproteinase-7 expression through activation of PEA3 transcription factors. Int J Oncol. 2004 Jun;24(6):1565-1572. Pubmedid: 15138601.
  • McIntyre JO, Fingleton B, Wells KS, Piston DW, Lynch CC, Gautam S, Matrisian LM. Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem J. 2004 Feb;377(Pt 3):617-628. Pubmedid: 14556651. Pmcid: PMC1223892.
  • Harmey JH, Bucana CD, Lu W, Byrne AM, McDonnell S, Lynch C, Bouchier-Hayes D, Dong Z. Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion. Int J Cancer. 2002 Oct;101(5):415-422. Pubmedid: 12216068.
  • Lynch CC, Matrisian LM. Matrix metalloproteinases in tumor-host cell communication. Differentiation. 2002 Dec;70(9-10):561-573. Pubmedid: 12492497.
  • Lynch CC, McDonnell S. The role of matrilysin (MMP-7) in leukaemia cell invasion. Clin Exp Metastasis. 2000;18(5):401-406. Pubmedid: 11467772.
  • McDonnell S, Morgan M, Lynch C. Role of matrix metalloproteinases in normal and disease processes. Biochem Soc Trans. 1999 Aug;27(4):734-740. Pubmedid: 10917674.