Arnold <span>B.</span> Etame
Researcher

Arnold B. Etame

Overview

Dr. Etame's research focuses on enhanced delivery of targeted therapeutics across the blood-brain barrier for malignant and metastatic brain tumors using nanotechnology and focused ultrasound disruption of the blood-brain barrier.  

Discipline

    • Neuro-Oncology
    • Chemical Biology and Molecular Medicine Program

Education & Training

    • University of Iowa College of Medicine, MD
    • University of Toronto, PhD - Laboratory Medicine and Patholobiology
    • Labbatt Brain Tumour Centre, Hospital for Sick Children, Toronto, Research Fellowship - Neurosurgery Oncology
    • University of Michigan Medical Center, Resident - Neurosurgery
Research

He is a principal investigator for clinical trial protocols in patients with malignant brain tumors. 

Publications

  • Ahmed KA, Kim S, Arrington J, Naghavi AO, Dilling TJ, Creelan BC, Antonia SJ, Caudell JJ, Harrison LB, Sahebjam S, Gray JE, Etame AB, Johnstone PA, Yu M, Perez BA. Outcomes targeting the PD-1/PD-L1 axis in conjunction with stereotactic radiation for patients with non-small cell lung cancer brain metastases. J Neurooncol. 2017 Jun;133(2):331-338. Pubmedid: 28466250.
  • Groshev A, Padalia D, Patel S, Garcia-Getting R, Sahebjam S, Forsyth PA, Vrionis FD, Etame AB. Clinical outcomes from maximum-safe resection of primary and metastatic brain tumors using awake craniotomy. Clin Neurol Neurosurg. 2017 Jun;157:25-30. Pubmedid: 28384595.
  • Echevarria M, Ahmed KA, Patel B, Abuodeh YA, Naghavi AO, Sarangkasiri S, Johnstone PA, Etame AB, Yu HM. Clinical Outcomes of Combined BRAF and MEK Inhibition With Stereotactic Radiation for BRAF Mutant Melanoma Brain Metastases. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E115-E116. Pubmedid: 27673816.
  • Fedorenko IV, Evernden B, Kenchappa RS, Sahebjam S, Ryzhova E, Puskas J, McIntosh L, Caceres G, Magliocco A, Etame A, Harbour JW, Smalley KS, Forsyth PA. A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature. Melanoma Res. 2016 Oct;26(5):481-486. Pubmedid: 27285292. Pmcid: PMC5502096.
  • Pisklakova A, McKenzie B, Zemp F, Lun X, Kenchappa RS, Etame AB, Rahman MM, Reilly K, Pilon-Thomas S, McFadden G, Kurz E, Forsyth PA. M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma. Neurooncol. 2016 Mar. Pubmedid: 26962017. Pmcid: PMC4933479.
  • Ahmed KA, Stallworth DG, Kim Y, Johnstone PA, Harrison LB, Caudell JJ, Yu HH, Etame AB, Weber JS, Gibney GT. Clinical outcomes of melanoma brain metastases treated with stereotactic radiation and anti-PD-1 therapy. Ann Oncol. 2016 Mar;27(3):434-441. Pubmedid: 26712903.
  • Abuodeh Y, Ahmed KA, Naghavi AO, Venkat PS, Sarangkasiri S, Johnstone PA, Etame AB, Yu HM. Postoperative Stereotactic Radiosurgery Using 5-Gy × 5 Sessions in the Management of Brain Metastases. World Neurosurg. 2016 Jun;90:58-65. Pubmedid: 26921701.
  • Wang D, Berglund A, Kenchappa RS, Forsyth PA, Mulé JJ, Etame AB. BIRC3 is a novel driver of therapeutic resistance in Glioblastoma. Sci Rep. 2016 Feb;6:21710. Pubmedid: 26888114. Pmcid: PMC4757860.
  • Ahmed KA, Abuodeh YA, Echevarria MI, Arrington JA, Stallworth DG, Hogue C, Naghavi AO, Kim S, Kim Y, Patel BG, Sarangkasiri S, Johnstone PA, Sahebjam S, Khushalani NI, Forsyth PA, Harrison LB, Yu M, Etame AB, Caudell JJ. Clinical outcomes of melanoma brain metastases treated with stereotactic radiosurgery and anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitor, or conventional chemotherapy. Ann Oncol. 2016 Dec;27(12):2288-2294. Pubmedid: 27637745.
  • Patel BG, Ahmed KA, Johnstone PA, Yu HM, Etame AB. Initial experience with combined BRAF and MEK inhibition with stereotactic radiosurgery for BRAF mutant melanoma brain metastases. Melanoma Res. 2016 Aug;26(4):382-386. Pubmedid: 26926151.
  • Ahmed KA, Sarangkasiri S, Chinnaiyan P, Sahebjam S, Yu HH, Etame AB, Rao NG. Outcomes Following Hypofractionated Stereotactic Radiotherapy in the Management of Brain Metastases. Am J Clin Oncol. 2016 Aug;39(4):379-383. Pubmedid: 24755663.
  • Frakes JM, Figura ND, Ahmed KA, Juan TH, Patel N, Latifi K, Sarangkasiri S, Strom TJ, Chinnaiyan P, Rao NG, Etame AB. Potential role for LINAC-based stereotactic radiosurgery for the treatment of 5 or more radioresistant melanoma brain metastases. J Neurosurg. 2015 Nov;123(5):1261-1267. Pubmedid: 26140482.
  • Ahmed KA, Freilich JM, Sloot S, Figura N, Gibney GT, Weber JS, Sarangkasiri S, Chinnaiyan P, Forsyth PA, Etame AB, Rao NG. LINAC-based stereotactic radiosurgery to the brain with concurrent vemurafenib for melanoma metastases. J Neurooncol. 2015 Mar;122(1):121-126. Pubmedid: 25519302.
  • Niknafs YS, Wang AC, Than KD, Etame AB, Thompson BG, Sullivan SE. Hemorrhagic vestibular schwannoma: review of the literature. World Neurosurg. 2014 Nov;82(5):751-756. Pubmedid: 23454397.
  • Ahmed KA, Freilich JM, Abuodeh Y, Figura N, Patel N, Sarangkasiri S, Chinnaiyan P, Yu HH, Etame AB, Rao NG. Fractionated stereotactic radiotherapy to the post-operative cavity for radioresistant and radiosensitive brain metastases. J Neurooncol. 2014 May;118(1):179-186. Pubmedid: 24604750.
  • Diaz RJ, McVeigh PZ, O'Reilly MA, Burrell K, Bebenek M, Smith C, Etame A, Zadeh G, Hynynen K, Wilson BC, Rutka JT. Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors. Nanomedicine. 2014 Jul;10(5):1075-1087. Pubmedid: 24374363. Pmcid: PMC4074278.
  • Kaloostian PE, Yurter A, Etame AB, Vrionis FD, Sciubba DM, Gokaslan ZL. Palliative strategies for the management of primary and metastatic spinal tumors. Cancer Control. 2014 Apr;21(2):140-143. Pubmedid: 24667400.
  • Kaloostian PE, Zadnik PL, Etame AB, Vrionis FD, Gokaslan ZL, Sciubba DM. Surgical management of primary and metastatic spinal tumors. Cancer Control. 2014 Apr;21(2):133-139. Pubmedid: 24667399.
  • Etame AB, Bentley JN, Pandey AS. Acute expansion of an asymptomatic posterior communicating artery aneurysm resulting in oculomotor nerve palsy. BMJ Case Rep. 2013 Jun;2013. Pubmedid: 23761613. Pmcid: PMC3702954.
  • Etame AB, Diaz RJ, O'Reilly MA, Smith CA, Mainprize TG, Hynynen K, Rutka JT. Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound. Nanomedicine. 2012 Oct;8(7):1133-1142. Pubmedid: 22349099. Pmcid: PMC4101537.
  • Sagher O, Thawani JP, Etame AB, Gomez-Hassan DM. Seizure outcomes and mesial resection volumes following selective amygdalohippocampectomy and temporal lobectomy. Neurosurg Focus. 2012 Mar;32(3):E8. Pubmedid: 22380862.
  • Etame AB, Diaz RJ, Smith CA, Mainprize TG, Hynynen K, Rutka JT. Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology. Neurosurg Focus. 2012 Jan;32(1):E3. Pubmedid: 22208896. Pmcid: PMC4106119.
  • Etame AB, Fox WC, Sagher O. Osmotic diuresis paradoxically worsens brain shift after subdural grid placement. Acta Neurochir (Wien). 2011 Mar;153(3):633-637. Pubmedid: 21057826.
  • Etame AB, Smith CA, Chan WC, Rutka JT. Design and potential application of PEGylated gold nanoparticles with size-dependent permeation through brain microvasculature. Nanomedicine. 2011 Dec;7(6):992-1000. Pubmedid: 21616168.
  • Onvani S, Etame AB, Smith CA, Rutka JT. Genetics of medulloblastoma: clues for novel therapies. Expert Rev Neurother. 2010 May;10(5):811-823. Pubmedid: 20420498.
  • Etame AB, Wang AC, Than KD, La Marca F, Park P. Outcomes after surgery for cervical spine deformity: review of the literature. Neurosurg Focus. 2010 Mar;28(3):E14. Pubmedid: 20192659.
  • Etame AB, Wang AC, Than KD, Park P. Clinical and radiographic outcomes after minimally invasive transforaminal lumbar interbody fusion. SAS J. 2010 Jun;4(2):47-53. Pubmedid: 25802649. Pmcid: PMC4365612.
  • Wang AC, Than KD, Etame AB, La Marca F, Park P. Impact of anesthesia on transcranial electric motor evoked potential monitoring during spine surgery: a review of the literature. Neurosurg Focus. 2009 Oct;27(4):E7. Pubmedid: 19795956.
  • Sack JA, Etame AB, Shah GV, La Marca F, Park P. Management and outcomes of patients undergoing surgery for traumatic cervical fracture-subluxation associated with an asymptomatic vertebral artery injury. J Spinal Disord Tech. 2009 Apr;22(2):86-90. Pubmedid: 19342928.
  • Than KD, Wang AC, Etame AB, La Marca F, Park P. Postoperative management of incidental durotomy in minimally invasive lumbar spinal surgery. Minim Invasive Neurosurg. 2008 Oct;51(5):263-266. Pubmedid: 18855289.
  • Etame AB, Than KD, Wang AC, La Marca F, Park P. Surgical management of symptomatic cervical or cervicothoracic kyphosis due to ankylosing spondylitis. Spine (Phila Pa 1976). 2008 Jul;33(16):E559-E564. Pubmedid: 18628698.
  • Sibenaller ZA, Etame AB, Ali MM, Barua M, Braun TA, Casavant TL, Ryken TC. Genetic characterization of commonly used glioma cell lines in the rat animal model system. Neurosurg Focus. 2005 Oct;19(4):E1. Pubmedid: 16241103.