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Anna Coghill, PhD, MPH

Academic Rank: Assistant Member

Overview

My focus is exploring how the immune environment associated with pathogens such as Epstein-Barr virus (EBV) and Human immunodeficiency virus (HIV) can play a role in both cancer prevention and response to therapy.


Discipline

    • Cancer Epidemiology
    • Cancer Epidemiology Program
    • Melanoma Research Center of Excellence
    • Center for Immunization and Infection Research in Cancer

Education & Training

Fellowship:

  • University of Washington, PhD - Epidemiology
  • Emory University, MPH - Global Health
  • NIH/National Cancer Institute, Fellow - Infections/Immunoepidemiology
Research

Anna E. Coghill, PhD, MPH is an Assistant Member in the Cancer Epidemiology Program at the H. Lee Moffitt Cancer Center & Research Institute.  Her interest in the intersection between infectious agents and cancer began during her dissertation work focusing on HIV as a determinant of cancer patient survival at the UCI/Hutchinson Cancer Center Alliance in Uganda.  This work suggested that HIV was not only related to cancer development but that it also played a role in how patients survived after a cancer diagnosis.  Dr. Coghill’s publications using the HIV/AIDS Cancer Match Study and National Cancer Database, as well as collaborations with the Brazilian National Cancer Institute, have established that HIV-infected cancer patients experience worse stage-specific survival that their HIV-uninfected counterparts.  Dr. Coghill is now focused on identifying both treatment-related and molecular reasons for this survival disparity.  In addition to expanding her HIV and cancer research portfolio, Dr. Coghill is working to characterize the role of Epstein-Barr virus (EBV) in cancer.  EBV is a carcinogen that contributes to nearly 200,000 cancers annually but for which no effective preventive or therapeutic approaches exist.  Dr. Coghill has been pivotal in the development and implementation of a proteome-wide array to characterize the serological immune response to EBV across a range of diseases, including nasopharyngeal carcinoma and both Burkitt and Hodgkin lymphomas.  As a member of the Center for Immunization and Infection Research in Center, she is involved in ongoing collaborations to understand how the dynamics of EBV-based immunity can be used to tailor therapies for malignancies attributable to EBV. 

Publications

  • Liu Z, Jarrett RF, Hjalgrim H, Proietti C, Chang ET, Smedby KE, Yu KJ, Lake A, Troy S, McAulay KA, Pfeiffer RM, Adami HO, Glimelius B, Melbye M, Hildesheim A, Doolan D, Coghill AE. Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma. Int J Cancer. 2019 Oct. Pubmedid: 31618442.
  • Coghill AE, Proietti C, Liu Z, Krause L, Bethony J, Prokunina-Olsson L, Obajemu A, Nkrumah F, Biggar RJ, Bhatia K, Hildesheim A, Doolan DL, Mbulaiteye SM. The Association between the Comprehensive Epstein-Barr Virus Serologic Profile and Endemic Burkitt Lymphoma. Cancer Epidemiol Biomarkers Prev. 2019 Oct. Pubmedid: 31619404.
  • Corrigan KL, Nogueira L, Yabroff KR, Lin CC, Han X, Chino JP, Coghill AE, Shiels M, Jemal A, Suneja G. The impact of the Patient Protection and Affordable Care Act on insurance coverage and cancer-directed treatment in HIV-infected patients with cancer in the United States. Cancer. 2019 Nov. Pubmedid: 31709523.
  • D'Arcy ME, Coghill AE, Lynch CF, Koch LA, Li J, Pawlish KS, Morris CR, Rao C, Engels EA. Survival after a cancer diagnosis among solid organ transplant recipients in the United States. Cancer. 2019 Mar.125(6):933-942. Pubmedid: 30624768. Pmcid: PMC6403005.
  • Coghill AE, Han X, Suneja G, Lin CC, Jemal A, Shiels MS. Advanced stage at diagnosis and elevated mortality among US patients with cancer infected with HIV in the National Cancer Data Base. Cancer. 2019 Aug;125(16):2868-2876. Pubmedid: 31050361. Pmcid: PMC6663596.
  • Coghill AE, Suneja G, Rositch AF, Shiels MS, Engels EA. HIV Infection, Cancer Treatment Regimens, and Cancer Outcomes Among Elderly Adults in the United States. JAMA Oncol. 2019 Aug. Pubmedid: 31369037. Pmcid: PMC6681563.
  • Liu Z, Yu KJ, Coghill AE, Brenner N, Cao SM, Chen CJ, Chen Y, Doolan DL, Hsu WL, Labo N, Middeldorp JM, Miley W, Simon J, Wang CP, Waterboer T, Whitby D, Xie SH, Ye W, Hildesheim A. Multilaboratory Assessment of Epstein-Barr Virus Serologic Assays: the Case for Standardization. J Clin Microbiol. 2019 Aug.57(11). Pubmedid: 31434722. Pmcid: PMC6813000.
  • Coghill AE, Engels EA, Schymura MJ, Mahale P, Shiels MS. Risk of Breast, Prostate, and Colorectal Cancer Diagnoses Among HIV-Infected Individuals in the United States. J Natl Cancer Inst. 2018 Sep;110(9):959-966. Pubmedid: 29529223. Pmcid: PMC6136931.
  • Menon MP, Coghill A, Mutyaba IO, Phipps WT, Okuku FM, Harlan JM, Orem J, Casper C. Association Between HIV Infection and Cancer Stage at Presentation at the Uganda Cancer Institute. J Glob Oncol. 2018 Sep;4:1-9. Pubmedid: 30241147. Pmcid: PMC6180750.
  • Coghill AE, Hsu WL, Yang Q, Wang CP, Lou PJ, Yu KJ, Yu G, Diehl SR, Chen CJ, Goldstein AM, Hildesheim A. Elevated antibodies against Epstein-Barr virus among individuals predicted to carry nasopharyngeal carcinoma susceptibility variants. J Gen Virol. 2018 Sep;99(9):1268-1273. Pubmedid: 29975184. Pmcid: PMC6230770.
  • Coghill AE, Bellizzi AM, Lynch CF, Shiels MS, Selk FR, Gillison M, Hernandez BY, Chan OTM, Engels EA. Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas. Clin Gastroenterol H. 2018 Nov;17(10):2129-2131. Pubmedid: 30448596. Pmcid: PMC6520215.
  • Rositch AF, Jiang S, Coghill AE, Suneja G, Engels EA. Disparities and Determinants of Cancer Treatment in Elderly Americans Living With Human Immunodeficiency Virus/AIDS. Clin Infect Dis. 2018 Nov.67(12):1904-1911. Pubmedid: 29718138. Pmcid: PMC6260168.
  • Liu Z, Coghill AE, Pfeiffer RM, Proietti C, Hsu WL, Chien YC, Lekieffre L, Krause L, Yu KJ, Lou PJ, Wang CP, Mulvenna J, Middeldorp JM, Bethony J, Chen CJ, Doolan DL, Hildesheim A. Patterns of Interindividual Variability in the Antibody Repertoire Targeting Proteins Across the Epstein-Barr Virus Proteome. J Infect Dis. 2018 May;217(12):1923-1931. Pubmedid: 29509907. Pmcid: PMC6279144.
  • Coghill AE, Pfeiffer RM, Proietti C, Hsu WL, Chien YC, Lekieffre L, Krause L, Teng A, Pablo J, Yu KJ, Lou PJ, Wang CP, Liu Z, Chen CJ, Middeldorp J, Mulvenna J, Bethony J, Hildesheim A, Doolan DL. Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan. Clin Cancer Res. 2018 Mar;24(6):1305-1314. Pubmedid: 29301829. Pmcid: PMC5856605.
  • Mahale P, Engels EA, Coghill AE, Kahn AR, Shiels MS. Cancer Risk in Older Persons Living With Human Immunodeficiency Virus Infection in the United States. Clin Infect Dis. 2018 Jun;67(1):50-57. Pubmedid: 29325033. Pmcid: PMC6248478.
  • Coghill AE, Wang CP, Verkuijilen SAWM, Yu KJ, Hsu WL, Middeldorp JM, Hildesheim A. Evaluation of nasal and nasopharyngeal swab collection for the detection of Epstein-Barr virus in nasopharyngeal carcinoma. J Med Virol. 2018 Jan;90(1):191-195. Pubmedid: 28833336.
  • Coghill AE, Schenk JM, Mahkoul Z, Orem J, Phipps W, Casper C. Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda. Aids. 2018 Feb;32(4):505-512. Pubmedid: 29381560. Pmcid: PMC5872837.
  • Menon M, Coghill A, Mutyaba I, Okuku F, Phipps W, Harlan J, Orem J, Casper C. Whom to treat? Factors associated with chemotherapy recommendations and outcomes among patients with NHL at the Uganda Cancer Institute. PLoS One. 2018 Feb;13(2):e0191967. Pubmedid: 29389998. Pmcid: PMC5794100.
  • Coghill AE, Bu W, Hsu WL, Nguyen H, Yu KJ, Chien YC, Chen CJ, Cohen JI, Hildesheim A. Evaluation of Total and IgA-Specific Antibody Targeting Epstein-Barr Virus Glycoprotein 350 and Nasopharyngeal Carcinoma Risk. J Infect Dis. 2018 Aug;218(6):886-891. Pubmedid: 29718378. Pmcid: PMC6093398.
  • Coghill AE, Strickler HD. Survival Deficit for HIV-Infected Lymphoma Patients in the National Cancer Database. Cancer Epidemiol Biomarkers Prev. 2017 Mar;26(3):289-290. Pubmedid: 28254955. Pmcid: PMC5340270.
  • Coghill AE, Pfeiffer RM, Shiels MS, Engels EA. Excess Mortality among HIV-Infected Individuals with Cancer in the United States. Cancer Epidemiol Biomarkers Prev. 2017 Jul;26(7):1027-1033. Pubmedid: 28619832. Pmcid: PMC5500417.
  • Suneja G, Coghill A. Cancer care disparities in people with HIV in the United States. Curr Opin HIV AIDS. 2017 Jan;12(1):63-68. Pubmedid: 27753654. Pmcid: PMC6424354.
  • Ferreira MP, Coghill AE, Chaves CB, Bergmann A, Thuler LC, Soares EA, Pfeiffer RM, Engels EA, Soares MA. Outcomes of cervical cancer among HIV-infected and HIV-uninfected women treated at the Brazilian National Institute of Cancer. Aids. 2017 Feb;31(4):523-531. Pubmedid: 28060014. Pmcid: PMC5263104.
  • Yanik EL, Achenbach CJ, Gopal S, Coghill AE, Cole SR, Eron JJ, Moore RD, Mathews WC, Drozd DR, Hamdan A, Ballestas ME, Engels EA. Changes in Clinical Context for Kaposi's Sarcoma and Non-Hodgkin Lymphoma Among People With HIV Infection in the United States. J Clin Oncol. 2016 Sep;34(27):3276-3283. Pubmedid: 27507879. Pmcid: PMC5024548.
  • Coghill AE, Bu W, Nguyen H, Hsu WL, Yu KJ, Lou PJ, Wang CP, Chen CJ, Hildesheim A, Cohen JI. High Levels of Antibody that Neutralize B-cell Infection of Epstein-Barr Virus and that Bind EBV gp350 Are Associated with a Lower Risk of Nasopharyngeal Carcinoma. Clin Cancer Res. 2016 Jul;22(14):3451-3457. Pubmedid: 26920891. Pmcid: PMC4947430.
  • Coghill AE, Shiels MS, Rycroft RK, Copeland G, Finch JL, Hakenewerth AM, Pawlish KS, Engels EA. Rectal squamous cell carcinoma in immunosuppressed populations: is this a distinct entity from anal cancer?. Aids. 2016 Jan;30(1):105-112. Pubmedid: 26372482. Pmcid: PMC4703472.
  • Coghill AE, Johnson LG, Berg D, Resler AJ, Leca N, Madeleine MM. Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. Am J Transplant. 2016 Feb;16(2):565-573. Pubmedid: 26824445. Pmcid: PMC5500236.
  • Coghill AE, Shiels MS, Suneja G, Engels EA. Reply to L. Dal Maso et al. J Clin Oncol. 2016 Feb;34(4):390-391. Pubmedid: 26598741.
  • Liu Z, Coghill AE, Pfeiffer RM, Hsu WL, Lou PJ, Wang CP, Yu KJ, Niwa S, Brotzman M, Ye W, Chen CJ, Hildesheim A. Birth order and risk of nasopharyngeal carcinoma in multiplex families from Taiwan. Int J Cancer. 2016 Dec;139(11):2467-2473. Pubmedid: 27537611.
  • Shiels MS, Kreimer AR, Coghill AE, Darragh TM, Devesa SS. Anal Cancer Incidence in the United States, 1977-2011: Distinct Patterns by Histology and Behavior. Cancer Epidemiol Biomarkers Prev. 2015 Oct;24(10):1548-1556. Pubmedid: 26224796. Pmcid: PMC4592448.
  • Pyakurel R, Sharma N, Paudel D, Coghill A, Sinden L, Bost L, Larkin M, Burrus CJ, Roy K. Cause of Death in Women of Reproductive Age in Rural Nepal Obtained Through Community-Based Surveillance: Is Reducing Maternal Mortality the Right Priority for Women's Health Programs?. Health Care Women Int. 2015 Oct;36(6):655-662. Pubmedid: 24690028.
  • Coghill AE, Shiels MS, Suneja G, Engels EA. Elevated Cancer-Specific Mortality Among HIV-Infected Patients in the United States. J Clin Oncol. 2015 Jul;33(21):2376-2383. Pubmedid: 26077242. Pmcid: PMC4500831.
  • Coghill AE, Engels EA. Are cancer outcomes worse in the presence of HIV infection?. Cancer Epidemiol Biomarkers Prev. 2015 Aug;24(8):1165-1166. Pubmedid: 26240170. Pmcid: PMC4527081.
  • Coghill AE, Hildesheim A. Epstein-Barr virus antibodies and the risk of associated malignancies: review of the literature. Am J Epidemiol. 2014 Oct;180(7):687-695. Pubmedid: 25167864. Pmcid: PMC4271109.
  • Coghill AE, Hsu WL, Pfeiffer RM, Juwana H, Yu KJ, Lou PJ, Wang CP, Chen JY, Chen CJ, Middeldorp JM, Hildesheim A. Epstein-Barr virus serology as a potential screening marker for nasopharyngeal carcinoma among high-risk individuals from multiplex families in Taiwan. Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1213-1219. Pubmedid: 24769890. Pmcid: PMC4082438.
  • Scherer D, Koepl LM, Poole EM, Balavarca Y, Xiao L, Baron JA, Hsu L, Coghill AE, Campbell PT, Kleinstein SE, Figueiredo JC, Lampe JW, Buck K, Potter JD, Kulmacz RJ, Jenkins MA, Hopper JL, Win AK, Newcomb PA, Ulrich CM, Makar KW. Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: colon cancer family registry. Gene Chromosome Canc. 2014 Jul;53(7):568-578. Pubmedid: 24677636. Pmcid: PMC4326223.
  • Coghill AE, Newcomb PA, Madeleine MM, Richardson BA, Mutyaba I, Okuku F, Phipps W, Wabinga H, Orem J, Casper C. Contribution of HIV infection to mortality among cancer patients in Uganda. Aids. 2013 Nov;27(18):2933-2942. Pubmedid: 23921614. Pmcid: PMC4319357.
  • Passarelli MN, Phipps AI, Potter JD, Makar KW, Coghill AE, Wernli KJ, White E, Chan AT, Hutter CM, Peters U, Newcomb PA. Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women. Cancer Res. 2013 Jan;73(2):767-775. Pubmedid: 23149914. Pmcid: PMC3588850.
  • Kraus S, Hummler S, Toriola AT, Poole EM, Scherer D, Kotzmann J, Makar KW, Kazanov D, Galazan L, Naumov I, Coghill AE, Duggan D, Gigic B, Arber N, Ulrich CM. Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study. Pharmacogenet Genomics. 2013 Aug;23(8):428-437. Pubmedid: 23778325. Pmcid: PMC4435676.
  • Phipps AI, Buchanan DD, Makar KW, Burnett-Hartman AN, Coghill AE, Passarelli MN, Baron JA, Ahnen DJ, Win AK, Potter JD, Newcomb PA. BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics. Cancer Epidemiol Biomarkers Prev. 2012 Oct;21(10):1792-1798. Pubmedid: 22899730. Pmcid: PMC3467328.
  • Coghill AE, Phipps AI, Bavry AA, Wactawski-Wende J, Lane DS, LaCroix A, Newcomb PA. The association between NSAID use and colorectal cancer mortality: results from the women's health initiative. Cancer Epidemiol Biomarkers Prev. 2012 Nov;21(11):1966-1973. Pubmedid: 22933426. Pmcid: PMC3493711.
  • Newcomb PA, Savu A, Phipps AI, Coghill AE, Yasui Y. Impact of colon cancer screening on family history phenotype. Epidemiology. 2012 Mar;23(2):308-310. Pubmedid: 22252410. Pmcid: PMC3299289.
  • Coghill AE, Newcomb PA, Poole EM, Hutter CM, Makar KW, Duggan D, Potter JD, Ulrich CM. Genetic variation in inflammatory pathways is related to colorectal cancer survival. Clin Cancer Res. 2011 Nov;17(22):7139-7147. Pubmedid: 21976545. Pmcid: PMC3218294.
  • Passarelli MN, Coghill AE, Hutter CM, Zheng Y, Makar KW, Potter JD, Newcomb PA. Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: a population-based study of postmenopausal women. Gene Chromosome Canc. 2011 Nov;50(11):875-886. Pubmedid: 21910156. Pmcid: PMC3201720.
  • Coghill AE, Newcomb PA, Chia VM, Zheng Y, Wernli KJ, Passarelli MN, Potter JD. Pre-diagnostic NSAID use but not hormone therapy is associated with improved colorectal cancer survival in women. Brit J Cancer. 2011 Mar;104(5):763-768. Pubmedid: 21304527. Pmcid: PMC3048198.
  • Coghill AE, Hansen S, Littman AJ. Risk factors for eclampsia: a population-based study in Washington State, 1987-2007. Am J Obstet Gynecol. 2011 Dec;205(6):553.e1-553.e7. Pubmedid: 21855842.
  • Coghill AE, Newcomb PA, Potter JD. Aspirin use, colorectal cancer survival, and loss to follow-up. Jama. 2009 Dec;302(23):2549. Pubmedid: 20009049.