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Jason B. Fleming, MD, FACS

Chair, Gastrointestinal Oncology

Specialty: Surgery
Program: Gastrointestinal Oncology

Call 1-888-MOFFITT
(1-888-663-3488)

or call 1-888-MOFFITT
(1-888-663-3488)

Overview

Dr. Jason Fleming is Chair and Senior Member of the Department of Gastrointestinal Oncology. Dr. Fleming will also be a member of the Chemical Biology and Molecular Medicine Program.  Dr. Fleming completed his medical degree at the University of Tennessee, Center of Health Science, Memphis, and his clinical residency in general surgery at the University of Texas Southwestern Medical Center, Dallas. Dr. Fleming completed two fellowships: a Cancer Research Fellowship at the University of Texas Southwestern Medical Center, Hamon Center for Therapeutic Oncology, Dallas, and a Clinical Fellowship in Surgical Oncology at the University of Texas MD Anderson Cancer Center, Houston. Prior to coming to Moffitt, Dr. Fleming was Professor with Tenure in the Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center in Houston, where he served as Chief of Pancreas Surgery and Executive Director of Perioperative Services. In addition to his academic and administrative responsibilities at MD Anderson, Dr. Fleming was Co-Director of the Pancreatic Cancer Moonshot Program, a Scientific and Medical Advisory board member for the Pancreatic Cancer Action Network (PanCAN), and a consultant for the Society of Abdominal Radiology Disease-Focused Panel. Dr. Fleming has served on numerous committees and holds an impressive array of honors and awards. He has been a Texas Super Doctor in Texas Monthly since 2011, and he has been featured in the Consumer Research Council of America’s Guide to America’s Top Surgeons every year since 2012. Dr. Fleming received the Castle Connolly Top Doctor award every year since 2013. He has been recognized for his outstanding research publications, and in 2016 he received the President’s Faculty Recognition Award for Outstanding Contribution to the University of Texas MD Anderson Cancer Center.

Education & Training

Board Certification:

  • General Surgery

Fellowship:

  • University of Texas Southwestern Medical Center - Oncology Research
  • The University of Texas MD Anderson Cancer Center - Surgical Oncology

Residency:

  • University of Texas Southwestern Medical Center - General Surgery

Medical School:

  • University of Tennessee Center of Health Science - MD
Participating Trials

CLINICAL TRIAL 18941
Preoperative Extended Chemotherapy vs. Chemotherapy Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Head of the Pancreas
Condition: Gastrointestinal Tumor
Intervention: FOLFIRINOX; FOLFOX
Open

If you believe you are eligible for one of these trials or studies, please call
1-888-MOFFITT (1-888-663-3488).

Publications

  • Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 Sep;32(3):392. Pubmedid: 28898700.
  • Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA. Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2017 Sep. Pubmedid: 28864681.
  • Li X, Kang Y, Roife D, Lee Y, Pratt M, Perez MR, Dai B, Koay EJ, Fleming JB. Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth. Oncogene. 2017 Sep;36(38):5432-5438. Pubmedid: 28534517.
  • Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep;357(6356):1156-1160. Pubmedid: 28912244.
  • Okuno M, Goumard C, Mizuno T, Omichi K, Tzeng CD, Chun YS, Aloia TA, Fleming JB, Lee JE, Vauthey JN, Conrad C. Operative and short-term oncologic outcomes of laparoscopic versus open liver resection for colorectal liver metastases located in the posterosuperior liver: a propensity score matching analysis. Surg Endosc. 2017 Sep. Pubmedid: 28917012.
  • Nejati R, Goldstein JB, Halperin DM, Wang H, Hejazi N, Rashid A, Katz MH, Lee JE, Fleming JB, Rodriguez-Canales J, Blando J, Wistuba II, Maitra A, Wolff RA, Varadhachary GR, Wang H. Prognostic Significance of Tumor-Infiltrating Lymphocytes in Patients With Pancreatic Ductal Adenocarcinoma Treated With Neoadjuvant Chemotherapy. Pancreas. 2017 Oct;46(9):1180-1187. Pubmedid: 28902789.
  • Roife D, Kang Y, Wang L, Fang B, Swisher SG, Gershenwald JE, Pretzsch S, Dinney CP, Katz MHG, Fleming JB. Generation of patient-derived xenografts from fine needle aspirates or core needle biopsy. Surgery. 2017 May;161(5):1246-1254. Pubmedid: 28081955. Pmcid: PMC5404969.
  • Roland CL, Starker LF, Kang Y, Chatterjee D, Estrella J, Rashid A, Katz MH, Aloia TA, Lee JE, Dasari A, Yao JC, Fleming JB. Loss of DPC4/SMAD4 expression in primary gastrointestinal neuroendocrine tumors is associated with cancer-related death after resection. Surgery. 2017 Mar;161(3):753-759. Pubmedid: 27816207.
  • Cloyd JM, Wang H, Egger ME, Tzeng CD, Prakash LR, Maitra A, Varadhachary GR, Shroff R, Javle M, Fogelman D, Wolff RA, Overman MJ, Koay EJ, Das P, Herman JM, Kim MP, Vauthey JN, Aloia TA, Fleming JB, Lee JE, Katz MHG. Association of Clinical Factors With a Major Pathologic Response Following Preoperative Therapy for Pancreatic Ductal Adenocarcinoma. JAMA Surg. 2017 Jul. Pubmedid: 28700784.
  • Ngo-Huang A, Parker NH, Wang X, Petzel MQB, Fogelman D, Schadler KL, Bruera E, Fleming JB, Lee JE, Katz MHG. Home-based exercise during preoperative therapy for pancreatic cancer. Langenbecks Arch Surg. 2017 Jul. Pubmedid: 28710540.
  • Cloyd JM, Wang H, Overman M, Zhao J, Denbo J, Prakash L, Kim MP, Shroff R, Javle M, Varadhachary GR, Fogelman D, Wolff RA, Koay EJ, Das P, Maitra A, Aloia TA, Vauthey JN, Fleming JB, Lee JE, Katz MHG. Influence of Preoperative Therapy on Short- and Long-Term Outcomes of Patients with Adenocarcinoma of the Ampulla of Vater. Ann Surg Oncol. 2017 Jul;24(7):2031-2039. Pubmedid: 28124275.
  • Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Sarkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 Jul;32(1):71-87.e7. Pubmedid: 28697344. Pmcid: PMC5533091.
  • Vega EA, Yamashita S, Chun YS, Kim M, Fleming JB, Katz MH, Tzeng CW, Raghav KP, Vauthey JN, Lee JE, Conrad C. Effective Laparoscopic Management Lymph Node Dissection for Gallbladder Cancer. Ann Surg Oncol. 2017 Jul;24(7):1852. Pubmedid: 28168387.
  • Goumard C, Ogiso S, Okuno M, Fleming JB, Kim M, Tzeng CD, Vauthey JN, Lee JE, Conrad C. Tips and tricks of splenic vessel preservation during laparoscopic distal pancreatectomy. Surg Endosc. 2017 Jul. Pubmedid: 28733741.
  • Hoover M, Adamian Y, Brown M, Maawy A, Chang A, Lee J, Gharibi A, Katz MH, Fleming J, Hoffman RM, Bouvet M, Doebler R, Kelber JA. A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts. Oncotarget. 2017 Jan;8(4):5885-5894. Pubmedid: 27602776. Pmcid: PMC5351598.
  • Liu Q, Stewart J, Wang H, Rashid A, Zhao J, Katz MH, Lee JE, Fleming JB, Maitra A, Wolff RA, Varadhachary GR, Krishnan S, Wang H. Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma. PLoS One. 2017 Feb;12(2). Pubmedid: 28187218. Pmcid: PMC5302782.
  • Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, Amin S, Molin MD, Ying H, Kwong LN, Colla S, Takahashi K, Ghosh P, Giuliani V, Muller F, Dey P, Jiang S, Garvey J, Liu CG, Zhang J, Heffernan TP, Toniatti C, Fleming JB, Goggins MG, Wood LD, Sgambato A, Agaimy A, Maitra A, Roberts CW, Wang H, Viale A, DePinho RA, Draetta GF, Chin L. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017 Feb;542(7641):362-366. Pubmedid: 28178232.
  • Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017 Feb;542(7639):119-123. Pubmedid: 28099419. Pmcid: PMC5398413.
  • Chadha AS, Liu G, Chen HC, Das P, Minsky BD, Mahmood U, Delclos ME, Suh Y, Sawakuchi GO, Beddar S, Katz MH, Fleming JB, Javle MM, Varadhachary GR, Wolff RA, Crane CH, Wang X, Thames H, Krishnan S. Does Unintentional Splenic Radiation Predict Outcomes After Pancreatic Cancer Radiation Therapy?. Int J Radiat Oncol Biol Phys. 2017 Feb;97(2):323-332. Pubmedid: 28068240.
  • Chatterjee D, Katz MH, Foo WC, Sundar M, Wang H, Varadhachary GR, Wolff RA, Lee JE, Maitra A, Fleming JB, Rashid A, Wang H. Prognostic Significance of New AJCC Tumor Stage in Patients With Pancreatic Ductal Adenocarcinoma Treated With Neoadjuvant Therapy. Am J Surg Pathol. 2017 Aug;41(8):1097-1104. Pubmedid: 28614206. Pmcid: PMC5527751.
  • Davis CH, Kao LS, Fleming JB, Aloia TA. Multi-Institution Analysis of Infection Control Practices Identifies the Subset Associated with Best Surgical Site Infection Performance: A Texas Alliance for Surgical Quality Collaborative Project. J Am Coll Surg. 2017 Aug. Pubmedid: 28919125.
  • Sun L, Hu L, Cogdell D, Lu L, Gao C, Tian W, Zhang Z, Kang Y, Fleming JB, Zhang W. MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway. Autophagy. 2017 Apr;13(4):703-714. Pubmedid: 28121485. Pmcid: PMC5388243.
  • Dai B, Roife D, Kang Y, Gumin J, Rios Perez MV, Li X, Pratt M, Brekken RA, Fueyo-Margareto J, Lang FF, Fleming JB. Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther. 2017 Apr;16(4):662-670. Pubmedid: 28138026. Pmcid: PMC5512885.
  • Vega EA, Yamashita S, Shin CY, Kim M, Fleming JB, Katz MH, Raghav KP, Vauthey JN, Lee JE, Conrad C. Laparoscopic Partial Splenectomy for Unknown Primary Cancer: A Stepwise Approach. Ann Surg Oncol. 2017 Apr;24(4):1134. Pubmedid: 27942901.
  • Denbo JW, Slack RS, Bruno M, Cloyd JM, Prakash L, Fleming JB, Kim MP, Aloia TA, Vauthey JN, Lee JE, Katz MH. Selective Perioperative Administration of Pasireotide is More Cost-Effective Than Routine Administration for Pancreatic Fistula Prophylaxis. J Gastrointest Surg. 2017 Apr;21(4):636-646. Pubmedid: 28050766.
  • Waragai Y, Suzuki R, Takagi T, Sugimoto M, Asama H, Watanabe K, Kikuchi H, Hikichi T, Masamune A, Kang Y, Fleming JB, Ohira H. Clinical significance of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in pancreatic ductal adenocarcinoma. Pancreatology. 2017 Apr;16(6):1044-1050. Pubmedid: 27665173.
  • Li X, Roife D, Kang Y, Dai B, Pratt M, Fleming JB. Extracellular lumican augments cytotoxicity of chemotherapy in pancreatic ductal adenocarcinoma cells via autophagy inhibition. Oncogene. 2016 Sep;35(37):4881-4890. Pubmedid: 26876211.
  • Cloyd JM, Crane CH, Koay EJ, Das P, Krishnan S, Prakash L, Snyder RA, Varadhachary GR, Wolff RA, Javle M, Shroff RT, Fogelman D, Overman M, Wang H, Maitra A, Lee JE, Fleming JB, Katz MH. Impact of hypofractionated and standard fractionated chemoradiation before pancreatoduodenectomy for pancreatic ductal adenocarcinoma. Cancer. 2016 Sep;122(17):2671-2679. Pubmedid: 27243381. Pmcid: PMC4992463.
  • Pratap A, Fleming JB, Barnett CC. Right hemicolectomy using ileocecal pedicel flap-a new technique for ileocecal sphincter preservation in complex Crohn's disease with right sided colon cancer. Int J Colorectal Dis. 2016 Sep;31(9):1669-1670. Pubmedid: 27234040.
  • Conrad C, Schwarz L, Perrier N, Fleming JB, Katz MH, Aloia TA, Vauthey JN, Lee JE. Spleen and splenic vessel preserving distal pancreatectomy for bifocal PNET in a young patient with MEN1. Surg Endosc. 2016 Oct;30(10):4619. Pubmedid: 26721691.
  • Kang Y, Roife D, Lee Y, Lv H, Suzuki R, Ling J, Rios Perez MV, Li X, Dai B, Pratt M, Truty MJ, Chatterjee D, Wang H, Thomas RM, Wang Y, Koay EJ, Chiao PJ, Katz MH, Fleming JB. Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors. Clin Cancer Res. 2016 Oct;22(19):4934-4946. Pubmedid: 27126993. Pmcid: PMC5127652.
  • Koay EJ, Amer AM, Baio FE, Ondari AO, Fleming JB. Toward stratification of patients with pancreatic cancer: Past lessons from traditional approaches and future applications with physical biomarkers. Cancer Lett. 2016 Oct;381(1):237-243. Pubmedid: 26806807.
  • Gao S, Sun Y, Zhang X, Hu L, Liu Y, Chua CY, Phillips LM, Ren H, Fleming JB, Wang H, Chiao PJ, Hao J, Zhang W. IGFBP2 Activates the NF-κB Pathway to Drive Epithelial-Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2016 Nov;76(22):6543-6554. Pubmedid: 27659045. Pmcid: PMC5315491.
  • Katz MH, Slack R, Bruno M, McMillan J, Fleming JB, Lee JE, Bednarski B, Papadopoulos J, Matin SF. Outpatient virtual clinical encounters after complex surgery for cancer: a prospective pilot study of "TeleDischarge". J Surg Res. 2016 May;202(1):196-203. Pubmedid: 27083967.
  • Wang OH, Azizian N, Guo M, Capello M, Deng D, Zang F, Fry J, Katz MH, Fleming JB, Lee JE, Wolff RA, Hanash S, Wang H, Maitra A. Prognostic and Functional Significance of MAP4K5 in Pancreatic Cancer. PLoS One. 2016 Mar;11(3):e0152300. Pubmedid: 27023625. Pmcid: PMC4811546.
  • Zhuang Z, Ju HQ, Aguilar M, Gocho T, Li H, Iida T, Lee H, Fan X, Zhou H, Ling J, Li Z, Fu J, Wu M, Li M, Melisi D, Iwakura Y, Xu K, Fleming JB, Chiao PJ. IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation. Clin Cancer Res. 2016 Mar;22(6):1432-1444. Pubmedid: 26500238.
  • Krishnan S, Chadha AS, Suh Y, Chen HC, Rao A, Das P, Minsky BD, Mahmood U, Delclos ME, Sawakuchi GO, Beddar S, Katz MH, Fleming JB, Javle MM, Varadhachary GR, Wolff RA, Crane CH. Focal Radiation Therapy Dose Escalation Improves Overall Survival in Locally Advanced Pancreatic Cancer Patients Receiving Induction Chemotherapy and Consolidative Chemoradiation. Int J Radiat Oncol Biol Phys. 2016 Mar;94(4):755-765. Pubmedid: 26972648. Pmcid: PMC4792191.
  • Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Rep. 2016 Jun;16(1):133-147. Pubmedid: 27320920.
  • Conrad C, Passot G, Katz MH, Fleming JB, Kim M, Chun YS, Aloia TA, Vauthey JN, Lee JE. Laparoscopic Insulinoma Enucleation from the Retro-Pancreatic Neck: A Stepwise Approach. Ann Surg Oncol. 2016 Jun;23(6):2001. Pubmedid: 26960928.
  • Fischer LK, Katz MH, Lee SM, Liu L, Wang H, Varadhachary GR, Wolff RA, Lee JE, Maitra A, Roland CL, Fleming JB, Estrella J, Rashid A, Wang H. The number and ratio of positive lymph nodes affect pancreatic cancer patient survival after neoadjuvant therapy and pancreaticoduodenectomy. Histopathology. 2016 Jan;68(2):210-220. Pubmedid: 25945396. Pmcid: PMC4636488.
  • Lee SM, Katz MH, Liu L, Sundar M, Wang H, Varadhachary GR, Wolff RA, Lee JE, Maitra A, Fleming JB, Rashid A, Wang H. Validation of a Proposed Tumor Regression Grading Scheme for Pancreatic Ductal Adenocarcinoma After Neoadjuvant Therapy as a Prognostic Indicator for Survival. Am J Surg Pathol. 2016 Dec;40(12):1653-1660. Pubmedid: 27631521. Pmcid: PMC5178828.
  • Roife D, Dai B, Kang Y, Rios Perez MV, Pratt M, Li X, Fleming JB. Ex Vivo Testing of Patient-Derived Xenografts Mirrors the Clinical Outcome of Patients with Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2016 Dec;22(24):6021-6030. Pubmedid: 27259561. Pmcid: PMC5136340.
  • Wang Y, Hsu JM, Kang Y, Wei Y, Lee PC, Chang SJ, Hsu YH, Hsu JL, Wang HL, Chang WC, Li CW, Liao HW, Chang SS, Xia W, Ko HW, Chou CK, Fleming JB, Wang H, Hwang RF, Chen Y, Qin J, Hung MC. Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. Cancer Res. 2016 Dec;76(23):7049-7058. Pubmedid: 27758883. Pmcid: PMC5135656.
  • Chadha AS, Skinner HD, Gunther JR, Munsell MF, Das P, Minsky BD, Delclos ME, Chatterjee D, Wang H, Clemons M, George G, Singh PK, Katz MH, Fleming JB, Javle MM, Wolff RA, Varadhachary GR, Crane CH, Krishnan S. Phase I Trial of Consolidative Radiotherapy with Concurrent Bevacizumab, Erlotinib and Capecitabine for Unresectable Pancreatic Cancer. PLoS One. 2016;11(6):e0156910. Pubmedid: 27336466. Pmcid: PMC4919049.
  • Marcal LP, Fox PS, Evans DB, Fleming JB, Varadhachary GR, Katz MH, Tamm EP. Analysis of free-form radiology dictations for completeness and clarity for pancreatic cancer staging. Abdom Imaging. 2015 Oct;40(7):2391-2397. Pubmedid: 25906341.
  • Schwarz L, Bruno M, Parker NH, Prakash L, Mise Y, Lee JE, Vauthey JN, Aloia TA, Conrad C, Fleming JB, Katz MH. Active Surveillance for Adverse Events Within 90 Days: The Standard for Reporting Surgical Outcomes After Pancreatectomy. Ann Surg Oncol. 2015 Oct;22(11):3522-3529. Pubmedid: 25694246.
  • Thomas RM, Truty MJ, Kim M, Kang Y, Zhang R, Chatterjee D, Katz MH, Fleming JB. The canary in the coal mine: the growth of patient-derived tumorgrafts in mice predicts clinical recurrence after surgical resection of pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2015 May;22(6):1884-1892. Pubmedid: 25404477. Pmcid: PMC5274872.
  • Hiroshima Y, Maawy AA, Katz MH, Fleming JB, Bouvet M, Endo I, Hoffman RM. Selective efficacy of zoledronic acid on metastasis in a patient-derived orthotopic xenograph (PDOX) nude-mouse model of human pancreatic cancer. J Surg Oncol. 2015 Mar;111(3):311-315. Pubmedid: 25394368.
  • Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, Kapoor A, Yao W, Francesco ME, Petrocchi A, Deem AK, Scott K, Colla S, Mills GB, Fleming JB, Heffernan TP, Jones P, Toniatti C, DePinho RA, Draetta GF. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Res. 2015 Mar;75(6):1091-1101. Pubmedid: 25736685. Pmcid: PMC4446709.
  • Cooper AB, Slack R, Fogelman D, Holmes HM, Petzel M, Parker N, Balachandran A, Garg N, Ngo-Huang A, Varadhachary G, Evans DB, Lee JE, Aloia T, Conrad C, Vauthey JN, Fleming JB, Katz MH. Characterization of Anthropometric Changes that Occur During Neoadjuvant Therapy for Potentially Resectable Pancreatic Cancer. Ann Surg Oncol. 2015 Jul;22(7):2416-2423. Pubmedid: 25519927.
  • Chadha AS, Kocak-Uzel E, Das P, Minsky BD, Delclos ME, Mahmood U, Guha S, Ahmad M, Varadhachary GR, Javle M, Katz MH, Fleming JB, Wolff RA, Crane CH, Krishnan S. Paraneoplastic thrombocytosis independently predicts poor prognosis in patients with locally advanced pancreatic cancer. Acta Oncol. 2015 Jul;54(7):971-978. Pubmedid: 25608822.
  • Kang Y, Zhang R, Suzuki R, Li SQ, Roife D, Truty MJ, Chatterjee D, Thomas RM, Cardwell J, Wang Y, Wang H, Katz MH, Fleming JB. Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype. Lab Invest. 2015 Feb;95(2):207-222. Pubmedid: 25485535. Pmcid: PMC4670045.
  • Rios Perez MV, Dai B, Koay EJ, Wolff RA, Fleming JB. Regression of Stage IV Pancreatic Cancer to Curative Surgery and Introduction of a Novel Ex-Vivo Chemosensitivity Assay. Cureus. 2015 Dec;7(12):e423. Pubmedid: 26848412. Pmcid: PMC4727941.
  • Roland CL, Katz MH, Tzeng CW, Lin H, Varadhachary GR, Shroff R, Javle M, Fogelman D, Wolff RA, Vauthey JN, Crane CH, Lee JE, Fleming JB. The Addition of Postoperative Chemotherapy is Associated with Improved Survival in Patients with Pancreatic Cancer Treated with Preoperative Therapy. Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1221-S1228. Pubmedid: 26350371. Pmcid: PMC5192562.
  • Mise Y, Vauthey JN, Zimmitti G, Parker NH, Conrad C, Aloia TA, Lee JE, Fleming JB, Katz MH. Ninety-day Postoperative Mortality Is a Legitimate Measure of Hepatopancreatobiliary Surgical Quality. Ann Surg. 2015 Dec;262(6):1071-1078. Pubmedid: 25590497. Pmcid: PMC4633391.
  • Roland CL, Yang AD, Katz MH, Chatterjee D, Wang H, Lin H, Vauthey JN, Pisters PW, Varadhachary GR, Wolff RA, Crane CH, Lee JE, Fleming JB. Neoadjuvant therapy is associated with a reduced lymph node ratio in patients with potentially resectable pancreatic cancer. Ann Surg Oncol. 2015 Apr;22(4):1168-1175. Pubmedid: 25352267. Pmcid: PMC5131370.
  • Suzuki R, Kang Y, Li X, Roife D, Zhang R, Fleming JB. Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and autophagy in human pancreatic cancer cells. Anticancer Res. 2014 Sep;34(9):4685-4692. Pubmedid: 25202045. Pmcid: PMC4240628.
  • Kang Y, Ling J, Suzuki R, Roife D, Chopin-Laly X, Truty MJ, Chatterjee D, Wang H, Thomas RM, Katz MH, Chiao PJ, Fleming JB. SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium. PLoS One. 2014 Sep;9(9):e107948. Pubmedid: 25264609. Pmcid: PMC4180072.
  • Foo WC, Wang H, Prieto VG, Fleming JB, Abraham SC. Squamoid cystosis of pancreatic ducts: a variant of a newly-described cystic lesion, with evidence for an obstructive etiology. Rare Tumors. 2014 Sep;6(3):5286. Pubmedid: 25276318. Pmcid: PMC4178271.
  • Suzuki R, Bhutani MS, Shin D, Irisawa A, Fleming JB, Richards-Kortum R, Ohira H. Endoscopic ultrasound-assisted direct peritoneal visualization with a small-caliber scope: A proof of concept study in a swine model. Endosc Ultrasound. 2014 Oct;3(4):226-231. Pubmedid: 25485270. Pmcid: PMC4247530.
  • Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014 Oct;514(7524):628-632. Pubmedid: 25119024. Pmcid: PMC4376130.
  • Koay EJ, Baio FE, Ondari A, Truty MJ, Cristini V, Thomas RM, Chen R, Chatterjee D, Kang Y, Zhang J, Court L, Bhosale PR, Tamm EP, Qayyum A, Crane CH, Javle M, Katz MH, Gottumukkala VN, Rozner MA, Shen H, Lee JE, Wang H, Chen Y, Plunkett W, Abbruzzese JL, Wolff RA, Maitra A, Ferrari M, Varadhachary GR, Fleming JB. Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer. Phys Biol. 2014 Nov;11(6):065002. Pubmedid: 25427073. Pmcid: PMC4266401.
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  • Bose D, Tamm E, Liu J, Marcal L, Balachandran A, Bhosale P, Fleming JB, Lee JE, Evans DB, Hwang RF. Multidisciplinary management strategy for incidental cystic lesions of the pancreas. J Am Coll Surg. 2010 Aug;211(2):205-215. Pubmedid: 20670858. Pmcid: PMC4174396.
  • Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad Sci U S A. 2010 Aug;107(34):15193-15198. Pubmedid: 20696914. Pmcid: PMC2930541.
  • Barnett CC, Beck AW, Holloway SE, Kehler M, Schluterman MK, Brekken RA, Fleming JB, Silliman CC. Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice. Cancer. 2010 Aug;116(16):3862-3874. Pubmedid: 20564095. Pmcid: PMC3400465.
  • Crane CH, Varadhachary GR, Wolff RA, Fleming JB. Challenges in the study of adjuvant chemoradiation after pancreaticoduodenectomy. Ann Surg Oncol. 2010 Apr;17(4):950-952. Pubmedid: 20012500. Pmcid: PMC2840675.
  • Kim MP, Evans DB, Wang H, Abbruzzese JL, Fleming JB, Gallick GE. Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice. Nat Protoc. 2009 Oct;4(11):1670-1680. Pubmedid: 19876027. Pmcid: PMC4203372.
  • Leung KK, Ross WA, Evans D, Fleming J, Lin E, Tamm EP, Lee JH. Pancreatic cystic neoplasm: the role of cyst morphology, cyst fluid analysis, and expectant management. Ann Surg Oncol. 2009 Oct;16(10):2818-2824. Pubmedid: 19536601.
  • Bhutani MS, Verma D, Guha S, Lee JH, Richards-Kortum RR, Fleming JB. Is endoscopic ultrasound "sound" for pancreatic cancer screening?. J Clin Gastroenterol. 2009 Oct;43(9):797-802. Pubmedid: 19652621.
  • Li Z, Chang Z, Chiao LJ, Kang Y, Xia Q, Zhu C, Fleming JB, Evans DB, Chiao PJ. TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation. Cancer Res. 2009 Oct;69(19):7851-7859. Pubmedid: 19773448. Pmcid: PMC3087630.
  • Callender GG, Grubbs EG, Vu T, Hofstetter WL, Fleming JB, Woodburn KL, Lee JE, Evans DB, Perrier ND. The fallen one: the inferior parathyroid gland that descends into the mediastinum. J Am Coll Surg. 2009 May;208(5):887-893. Pubmedid: 19476855.
  • Fleming JB, Gonzalez RJ, Petzel MQ, Lin E, Morris JS, Gomez H, Lee JE, Crane CH, Pisters PW, Evans DB. Influence of obesity on cancer-related outcomes after pancreatectomy to treat pancreatic adenocarcinoma. Arch Surg. 2009 Mar;144(3):216-221. Pubmedid: 19289659.
  • Matsuo Y, Campbell PM, Brekken RA, Sung B, Ouellette MM, Fleming JB, Aggarwal BB, Der CJ, Guha S. K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways. Mol Cancer Res. 2009 Jun;7(6):799-808. Pubmedid: 19509115. Pmcid: PMC4267726.
  • Kim MP, Evans DB, Vu TM, Fleming JB. The recognition and surgical management of heritable lesions of the pancreas. Surg Oncol Clin N Am. 2009 Jan;18(1):99-119, ix. Pubmedid: 19056044.
  • Mummadi RR, Nealon WH, Artifon EL, Fleming JB, Bhutani MS. Pancreatic Schwannoma presenting as a cystic lesion. Gastrointest Endosc. 2009 Feb;69(2):341. Pubmedid: 19185694.
  • Crane CH, Varadhachary G, Settle SH, Fleming JB, Evans DB, Wolff RA. The integration of chemoradiation in the care of patient with localized pancreatic cancer. Cancer Radiother. 2009 Apr;13(2):123-143. Pubmedid: 19167921.
  • Katz MH, Wang H, Fleming JB, Sun CC, Hwang RF, Wolff RA, Varadhachary G, Abbruzzese JL, Crane CH, Krishnan S, Vauthey JN, Abdalla EK, Lee JE, Pisters PW, Evans DB. Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma. Ann Surg Oncol. 2009 Apr;16(4):836-847. Pubmedid: 19194760. Pmcid: PMC3066077.
  • Hwang RF, Wang H, Lara A, Gomez H, Chang T, Sieffert N, Moon Y, Ram S, Zimmerman S, Lee JH, Pisters PW, Tamm EP, Fleming JB, Abbruzzese JL, Evans DB. Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer. Ann Surg Oncol. 2008 May;15(5):1356-1366. Pubmedid: 18256882.
  • Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008 Jun;26(18):3063-3072. Pubmedid: 18565894.
  • Dineen SP, Lynn KD, Holloway SE, Miller AF, Sullivan JP, Shames DS, Beck AW, Barnett CC, Fleming JB, Brekken RA. Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice. Cancer Res. 2008 Jun;68(11):4340-4346. Pubmedid: 18519694.
  • Katz MH, Mortenson MM, Wang H, Hwang R, Tamm EP, Staerkel G, Lee JH, Evans DB, Fleming JB. Diagnosis and management of cystic neoplasms of the pancreas: an evidence-based approach. J Am Coll Surg. 2008 Jul;207(1):106-120. Pubmedid: 18589369.
  • Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, Fleming JB. Current diagnosis and management of unusual pancreatic tumors. Am J Surg. 2008 Jul;196(1):100-113. Pubmedid: 18466869.
  • Blazer DG, Ramirez PT, Wang H, Fleming JB. Distal pancreatectomy for isolated metastasis of endometrial carcinoma to the pancreas. JOP. 2008 Jan;9(1):56-60. Pubmedid: 18182745.
  • Katz MH, Fleming JB, Pisters PW, Lee JE, Evans DB. Anatomy of the superior mesenteric vein with special reference to the surgical management of first-order branch involvement at pancreaticoduodenectomy. Ann Surg. 2008 Dec;248(6):1098-1102. Pubmedid: 19092356.
  • Katz MH, Hwang R, Fleming JB, Evans DB. Tumor-node-metastasis staging of pancreatic adenocarcinoma. CA-Cancer J Clin. 2008 Aug;58(2):111-125. Pubmedid: 18272835.
  • Melisi D, Ishiyama S, Sclabas GM, Fleming JB, Xia Q, Tortora G, Abbruzzese JL, Chiao PJ. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther. 2008 Apr;7(4):829-840. Pubmedid: 18413796. Pmcid: PMC3088432.
  • Korpanty G, Carbon JG, Grayburn PA, Fleming JB, Brekken RA. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res. 2007 Jan;13(1):323-330. Pubmedid: 17200371.
  • Schumacher P, Dineen S, Barnett C, Fleming J, Anthony T. The metastatic lymph node ratio predicts survival in colon cancer. Am J Surg. 2007 Dec;194(6):827-831. Pubmedid: 18005779.
  • Beck AW, Luster TA, Miller AF, Holloway SE, Conner CR, Barnett CC, Thorpe PE, Fleming JB, Brekken RA. Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice. Int J Cancer. 2006 May;118(10):2639-2643. Pubmedid: 16353142.
  • Holloway SE, Beck AW, Shivakumar L, Shih J, Fleming JB, Brekken RA. Selective blockade of vascular endothelial growth factor receptor 2 with an antibody against tumor-derived vascular endothelial growth factor controls the growth of human pancreatic adenocarcinoma xenografts. Ann Surg Oncol. 2006 Aug;13(8):1145-1155. Pubmedid: 16791450.
  • Bell C, Asolati M, Hamilton E, Fleming J, Nwariaku F, Sarosi G, Anthony T. A comparison of complications associated with colostomy reversal versus ileostomy reversal. Am J Surg. 2005 Nov;190(5):717-720. Pubmedid: 16226946.
  • Sarosi GA, Jaiswal KR, Nwariaku FE, Asolati M, Fleming JB, Anthony T. Surgical therapy of peptic ulcers in the 21st century: more common than you think. Am J Surg. 2005 Nov;190(5):775-779. Pubmedid: 16226957.
  • Holloway SE, Beck AW, Girard L, Jaber MR, Barnett CC, Brekken RA, Fleming JB. Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer. J Am Coll Surg. 2005 Mar;200(3):371-377. Pubmedid: 15737847.
  • Fleming JB, Shen GL, Holloway SE, Davis M, Brekken RA. Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy. Mol Cancer Res. 2005 Jul;3(7):413-423. Pubmedid: 16046552.
  • Fleming JB, Barnett CC, Clagett GP. Superficial femoral vein as a conduit for portal vein reconstruction during pancreaticoduodenectomy. Arch Surg. 2005 Jul;140(7):698-701. Pubmedid: 16027337.
  • Villegas L, Jones D, Lindberg G, Chang C, Tesfay S, Fleming JB. Laparoscopic choledochojejunostomy via PTFE-covered stent successfully achieves internal drainage of common bile duct obstruction. HPB (Oxford). 2005 Jan;7(2):149-154. Pubmedid: 18333180. Pmcid: PMC2023941.
  • Eastman AL, Erdman WA, Lindberg GM, Hunt JL, Purdue GF, Fleming JB. Sentinel lymph node biopsy identifies occult nodal metastases in patients with Marjolin's ulcer. J Burn Care Rehabil. 2004 May;25(3):241-245. Pubmedid: 15273464.
  • Wilkiemeyer MB, Bieligk SC, Ashfaq R, Jones DB, Rege RV, Fleming JB. Laparoscopy alone is superior to peritoneal cytology in staging gastric and esophageal carcinoma. Surg Endosc. 2004 May;18(5):852-856. Pubmedid: 15054656.
  • Fleming JB, Brekken RA. Functional imaging of angiogenesis in an orthotopic model of pancreatic cancer. J Cell Biochem. 2003 Oct;90(3):492-501. Pubmedid: 14523983.
  • Kim LT, Fleming JB, Lopez-Guzman C, Nwariaku F. Focal adhesions and associated proteins in medullary thyroid carcinoma cells. J Surg Res. 2003 May;111(2):177-184. Pubmedid: 12850460.
  • Williams NS, Gaynor RB, Scoggin S, Verma U, Gokaslan T, Simmang C, Fleming J, Tavana D, Frenkel E, Becerra C. Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference. Clin Cancer Res. 2003 Mar;9(3):931-946. Pubmedid: 12631590.
  • Jaiswal VR, Baird J, Fleming J, Miller DS, Sharma S, Molberg K. Localized retroperitoneal lymphangioleiomyomatosis mimicking malignancy. A case report and review of the literature. Arch Pathol Lab Med. 2003 Jul;127(7):879-882. Pubmedid: 12823048.
  • Smothers L, Hynan L, Fleming J, Turnage R, Simmang C, Anthony T. Emergency surgery for colon carcinoma. Dis Colon Rectum. 2003 Jan;46(1):24-30. Pubmedid: 12544518.
  • Holloway S, Davis M, Jaber R, Fleming J. A clinically relevant model of human pancreatic adenocarcinoma identifies patterns of metastasis associated with alterations of the TGF-beta/Smad4 signaling pathway. Int J Gastrointest Cancer. 2003 Aug;33(1):61-69. Pubmedid: 12909738.
  • Scott DJ, Fleming JB, Watumull LM, Lindberg G, Tesfay ST, Jones DB. The effect of hepatic inflow occlusion on laparoscopic radiofrequency ablation using simulated tumors. Surg Endosc. 2002 Sep;16(9):1286-1291. Pubmedid: 11984682.
  • Peng B, Fleming JB, Breslin T, Grau AM, Fojioka S, Abbruzzese JL, Evans DB, Ayers D, Wathen K, Wu T, Robertson KD, Chiao PJ. Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. Clin Cancer Res. 2002 Nov;8(11):3628-3638. Pubmedid: 12429655.
  • Fleming JB, Minna JD. Inactivation of tumor suppressor genes by promoter methylation is important in the pathogenesis of pancreatic cancer. Cancer Biol Ther. 2002 May;1(3):297-299. Pubmedid: 12432282.
  • Hamilton EC, Scott DJ, Fleming JB, Rege RV, Laycock R, Bergen PC, Tesfay ST, Jones DB. Comparison of video trainer and virtual reality training systems on acquisition of laparoscopic skills. Surg Endosc. 2002 Mar;16(3):406-411. Pubmedid: 11928017.
  • Scott DJ, Young WN, Watumull LM, Lindberg G, Fleming JB, Huth JF, Rege RV, Jeyarajah DR, Jones DB. Accuracy and effectiveness of laparoscopic vs open hepatic radiofrequency ablation. Surg Endosc. 2001 Feb;15(2):135-140. Pubmedid: 11285955.
  • Fleming JB, Cantor SB, Varma DG, Holst D, Feig BW, Hunt KK, Patel SR, Benjamin RS, Pollock RE, Pisters PW. Utility of chest computed tomography for staging in patients with T1 extremity soft tissue sarcomas. Cancer. 2001 Aug;92(4):863-868. Pubmedid: 11550159.
  • Breslin TM, Cohen L, Sahin A, Fleming JB, Kuerer HM, Newman LA, Delpassand ES, House R, Ames FC, Feig BW, Ross MI, Singletary SE, Buzdar AU, Hortobagyi GN, Hunt KK. Sentinel lymph node biopsy is accurate after neoadjuvant chemotherapy for breast cancer. J Clin Oncol. 2000 Oct;18(20):3480-3486. Pubmedid: 11032588.
  • Scott DJ MD, Young WN, Watumull LM, Lindberg G, Fleming JB, Rege RV, Brown RJ, Jones DB. Development of an in vivo tumor-mimic model for learning radiofrequency ablation. J Gastrointest Surg. 2000 Nov;4(6):620-625. Pubmedid: 11307098.
  • Anthony T, Fleming JB, Bieligk SC, Sarosi GA, Kim LT, Gregorcyk SG, Simmang CL, Turnage RH. Postoperative colorectal cancer surveillance. J Am Coll Surg. 2000 Jun;190(6):737-749. Pubmedid: 10873011.
  • Fleming JB, Berman RS, Cheng SC, Chen NP, Hunt KK, Feig BW, Respondek PM, Yasko AW, Pollack A, Patel SR, Burgess MA, Papadopoulos NE, Plager C, Zagars G, Benjamin RS, Pollock RE, Pisters PW. Long-term outcome of patients with American Joint Committee on Cancer stage IIB extremity soft tissue sarcomas. J Clin Oncol. 1999 Sep;17(9):2772-2780. Pubmedid: 10561352.
  • Fleming JB, Lee JE, Bouvet M, Schultz PN, Sherman SI, Sellin RV, Friend KE, Burgess MA, Cote GJ, Gagel RF, Evans DB. Surgical strategy for the treatment of medullary thyroid carcinoma. Ann Surg. 1999 Nov;230(5):697-707. Pubmedid: 10561095. Pmcid: PMC1420925.
  • Evans DB, Fleming JB, Lee JE, Cote G, Gagel RF. The surgical treatment of medullary thyroid carcinoma. Semin Surg Oncol. 1999 Jan;16(1):50-63. Pubmedid: 9890740.
  • Dackiw AP, Cote GJ, Fleming JB, Schultz PN, Stanford P, Vassilopoulou-Sellin R, Evans DB, Gagel RF, Lee JE. Screening for MEN1 mutations in patients with atypical endocrine neoplasia. Surgery. 1999 Dec;126(6):1097-1103. Pubmedid: 10598193.
  • Hunt KK, Fleming JB, Abramian A, Zhang L, Evans DB, Chiao PJ. Overexpression of the tumor suppressor gene Smad4/DPC4 induces p21waf1 expression and growth inhibition in human carcinoma cells. Cancer Res. 1998 Dec;58(24):5656-5661. Pubmedid: 9865717.
  • Gazdar AF, Bader S, Hung J, Kishimoto Y, Sekido Y, Sugio K, Virmani A, Fleming J, Carbone DP, Minna JD. Molecular genetic changes found in human lung cancer and its precursor lesions. Cold Spring Harb Symp Quant Biol. 1994 Dec;59:565-572. Pubmedid: 7587113.