Bob Keenan, MD, FACS, MMM

Cancer Focus:
Lung Cancer, Mesothelioma, Pancoast Tumor, Thymoma

Dr. Keenan was born in Ontario, Canada and lived in many places in the province and country. As an undergraduate, he was balancing passions for medicine and wildlife ecology until medicine won out. He received his medical degree from the University of Alberta then moved to Toronto to complete a residency in general surgery and a fellowship in thoracic surgery. In between, Dr. Keenan spent two years at the University of Pittsburgh where he conducted research on lung transplantation. He returned to Pittsburgh, in 1992, for a faculty position after completing his thoracic surgical fellowship. During his time at the University of Pittsburgh, Dr. Keenan became Director of Thoracic Surgery and then Vice-Chair of the Division of Cardiothoracic Surgery. He was also the Director of the Lung Transplant and Lung Volume Reduction programs. In 2000, Dr. Keenan moved to the West Penn Allegheny Health System (now Allegheny Health Network) where he was System Director of Thoracic Surgery and Chief Quality Officer for two of the major hospitals. In 2015, he was recruited to join Moffitt Cancer Center as the Chief Medical Officer and Vice-President of Quality. He is a Senior Member in the Department of Thoracic Oncology and a Professor of Oncologic Sciences at the University of South Florida. He is a Fellow of the American College of Surgeons and of the Royal College of Surgeons of Canada. Dr. Keenan’s clinical research activities include being a Principal Investigator for the National Emphysema Treatment Trial, a site Principal Investigator for numerous thoracic oncology cooperative group trials through ACOSOG, CALGB and ECOG and a national Co-Investigator for a randomized trial for early stage lung cancers. He is the author or co-author of over 230 scientific articles and book chapters. In the area of quality, Dr. Keenan has been an Examiner for the Malcolm Baldrige National Quality Award and holds a Healthcare Lean Certificate from the University of Michigan.

Education & Training

Board Certification:

• Surgery - General Surgery

Fellowship:

• University of Pittsburgh - Lung Transplant Research
• University of Toronto - Thoracic Surgery

Residency:

• University of Toronto - General Surgery

Medical School:

• The University of Alberta - MD

• Altorki N, Wang X, Damman B, Mentlick J, Landreneau R, Wigle D, Jones DR, Conti M, Ashrafi AS, Liberman M, de Perrot M, Mitchell JD, Keenan R, Bauer T, Miller D, Stinchcombe TE. Lobectomy, segmentectomy, or wedge resection for peripheral clinical T1aN0 non-small cell lung cancer: A post hoc analysis of CALGB 140503 (Alliance). J Thorac Cardiovasc Surg. 2024 Jan.167(1):338-347.e1. Pubmedid: 37473998. Pmcid: PMC10794519.
• Stinchcombe TE, Wang X, Damman B, Mentlick J, Landreneau R, Wigle D, Jones DR, Conti M, Ashrafi AS, Liberman M, de Perrot M, Mitchell JD, Keenan R, Bauer T, Miller D, Altorki N. Secondary Analysis of the Rate of Second Primary Lung Cancer From Cancer and Leukemia Group B 140503 (Alliance) Trial of Lobar Versus Sublobar Resection for T1aN0 Non-Small-Cell Lung Cancer. J Clin Oncol. 2024 Apr.42(10):1110-1113. Pubmedid: 38215351.
• Rollison DE, Gonzalez BD, Turner K, Jim HSL, Zhao Y, Amorrortu RP, Howard R, Ghia KM, Ngo B, Reisman P, Moore C, Perkins R, Keenan RJ, Sallman DA, Naso CM, Robinson EJ, Vadaparampil ST, Simmons VN, Schabath MB, Gilbert SM. Examining disparities in large-scale patient-reported data capture using digital tools among cancer patients at clinical intake. Cancer Med. 2023 Sep.12(18):19033-19046. Pubmedid: 37596773. Pmcid: PMC10557830.
• Amorrortu RP, Zhao Y, Keenan RJ, Gilbert SM, Rollison DE. Factors Associated with Self-reported COVID-19 Infection and Hospitalization among Patients Seeking Care at a Comprehensive Cancer Center. J Racial Ethn Health Disparities. 2023 Nov. Pubmedid: 37917235.
• Altorki N, Wang X, Kozono D, Watt C, Landrenau R, Wigle D, Port J, Jones DR, Conti M, Ashrafi AS, Liberman M, Yasufuku K, Yang S, Mitchell JD, Pass H, Keenan R, Bauer T, Miller D, Kohman LJ, Stinchcombe TE, Vokes E. Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer. N Engl J Med. 2023 Feb.388(6):489-498. Pubmedid: 36780674. Pmcid: PMC10036605.
• Giuliano AR, Lancet JE, Pilon-Thomas S, Dong N, Jain AG, Tan E, Ball S, Tworoger SS, Siegel EM, Whiting J, Mo Q, Cubitt CL, Dukes CW, Hensel JA, Keenan RJ, Hwu P. Evaluation of Antibody Response to SARS-CoV-2 mRNA-1273 Vaccination in Patients With Cancer in Florida. JAMA Oncol. 2022 May.8(5):748-754. Pubmedid: 35266953. Pmcid: PMC8914884.
• Spiess PE, Greene J, Keenan RJ, Paculdo D, Letson GD, Peabody JW. Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer. Cancer. 2020 Jul.126(14):3174-3175. Pubmedid: 32324273. Pmcid: PMC7264676.
• Robinson LA, Tanvetyanon T, Grubbs D, Antonia S, Creelan B, Fontaine J, Toloza E, Keenan R, Dilling T, Stevens CW, Sommers KE, Vrionis F. Reply to Dickhoff et al. from authors of 'Induction chemoradiotherapy versus chemotherapy alone for superior sulcus lung cancer'. Lung Cancer. 2018 Oct.124:322-323. Pubmedid: 30193907.
• Tanvetyanon T, Keenan RJ. Recovery of lung function after segmentectomy versus lobectomy for early-stage lung cancer. J Thorac Dis. 2018 Jul.10(Suppl 18):S2144-S2146. Pubmedid: 30123544. Pmcid: PMC6072929.
• Altorki NK, Wang X, Wigle D, Gu L, Darling G, Ashrafi AS, Landrenau R, Miller D, Liberman M, Jones DR, Keenan R, Conti M, Wright G, Veit LJ, Ramalingam SS, Kamel M, Pass HI, Mitchell JD, Stinchcombe T, Vokes E, Kohman LJ. Perioperative mortality and morbidity after sublobar versus lobar resection for early-stage non-small-cell lung cancer: post-hoc analysis of an international, randomised, phase 3 trial (CALGB/Alliance 140503). Lancet Respir Med. 2018 Dec.6(12):915-924. Pubmedid: 30442588. Pmcid: PMC6396275.
• Baldonado JJAR, Amaral M, Garrett J, Moodie C, Robinson L, Keenan R, Toloza EM, Fontaine JP. Credentialing for robotic lobectomy: what is the learning curve? A retrospective analysis of 272 consecutive cases by a single surgeon. J Robot Surg. 2018 Dec.13(5):663-669. Pubmedid: 30560496.
• Robinson LA, Tanvetyanon T, Grubbs D, Antonia S, Creelan B, Fontaine J, Toloza E, Keenan R, Dilling T, Stevens CW, Sommers KE, Vrionis F. Induction chemoradiotherapy versus chemotherapy alone for superior sulcus lung cancer. Lung Cancer. 2018 Aug.122:206-213. Pubmedid: 30032833.
• Srivistava R, Zalisko BE, Keenan RJ, Howell SH. The GET System Inserts the Tail-Anchored Protein, SYP72, into Endoplasmic Reticulum Membranes. Plant Physiol. 2017 Feb.173(2):1137-1145. Pubmedid: 27923985. Pmcid: PMC5291014.
• Nguyen DT, Fontaine JP, Robinson LA, Keenan RJ, Toloza EM. P1.22: Temporal Survival Improvement for Stage-II (T3N0M0) Lung Adenocarcinoma After Pulmonary Lobectomy: Track: Early Stage NSCLC (Stage I - III). J Thorac Oncol. 2016 Oct.11(10S):S195. Pubmedid: 27676508.
• Nguyen DT, Fontaine JP, Robinson LA, Keenan RJ, Toloza EM. P1.17: Improved Survival for Stage-2 (N1) Pulmonary Adenocarcinoma and Squamous Cell Carcinoma After Pulmonary Lobectomy: Track: Early Stage NSCLC (Stage I - III). J Thorac Oncol. 2016 Oct.11(10S):S191-S192. Pubmedid: 27676503.
• Sharma P, Keenan RJ, Sexton WJ. Mass in Solitary Intrathoracic Kidney Within Bochdalek Hernia. Urology. 2016 Nov.97:e15-e16. Pubmedid: 27554626.
• Bang D, Xu J, Keenan R, Pike V, Lehmann R, Tenner C, Crittenden D, Pillinger M, Krasnokutsky S. Cardiovascular Disease Prevalence in Patients with Osteoarthritis, Gout, or Both. Bull Hosp Jt Dis (2013). 2016 Jun.74(2):113-118. Pubmedid: 27281314.
• Dominik PK, Borowska MT, Dalmas O, Kim SS, Perozo E, Keenan RJ, Kossiakoff AA. Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs. Structure. 2016 Feb.24(2):300-309. Pubmedid: 26749445. Pmcid: PMC4740257.
• Borowska MT, Dominik PK, Anghel SA, Kossiakoff AA, Keenan RJ. A YidC-like Protein in the Archaeal Plasma Membrane. Structure. 2015 Sep.23(9):1715-1724. Pubmedid: 26256539. Pmcid: PMC4558205.
• Svensson E, Culig MH, Keenan RJ, Song T, Biederman R. Left ventricular aneurysm with herniation through the chest wall. Ann Thorac Surg. 2012 Sep.94(3):e63-e64. Pubmedid: 22916781.
• Sherrill J, Mariappan M, Dominik P, Hegde RS, Keenan RJ. A conserved archaeal pathway for tail-anchored membrane protein insertion. Traffic. 2011 Sep.12(9):1119-1123. Pubmedid: 21658170. Pmcid: PMC3155638.
• Hegde RS, Keenan RJ. Tail-anchored membrane protein insertion into the endoplasmic reticulum. Nat Rev Mol Cell Biol. 2011 Nov.12(12):787-798. Pubmedid: 22086371. Pmcid: PMC3760496.
• Mariappan M, Mateja A, Dobosz M, Bove E, Hegde RS, Keenan RJ. The mechanism of membrane-associated steps in tail-anchored protein insertion. Nature. 2011 Aug.477(7362):61-66. Pubmedid: 21866104. Pmcid: PMC3760497.
• Mariappan M, Li X, Stefanovic S, Sharma A, Mateja A, Keenan RJ, Hegde RS. A ribosome-associating factor chaperones tail-anchored membrane proteins. Nature. 2010 Aug.466(7310):1120-1124. Pubmedid: 20676083. Pmcid: PMC2928861.
• Meyers BF, Downey RJ, Decker PA, Keenan RJ, Siegel BA, Cerfolio RJ, Landreneau RJ, Reed CE, Balfe DM, Dehdashti F, Ballman KV, Rusch VW, Putnam JB. The utility of positron emission tomography in staging of potentially operable carcinoma of the thoracic esophagus: results of the American College of Surgeons Oncology Group Z0060 trial. J Thorac Cardiovasc Surg. 2007 Mar.133(3):738-745. Pubmedid: 17320575.
• Hartman MS, Epstein DM, Geyer SJ, Keenan RJ. Alveolar adenoma. Ann Thorac Surg. 2004 Nov.78(5):1842-1843. Pubmedid: 15511494.
• Andujar JJ, Papasavas PK, Birdas T, Robke J, Raftopoulos Y, Gagné DJ, Caushaj PF, Landreneau RJ, Keenan RJ. Laparoscopic repair of large paraesophageal hernia is associated with a low incidence of recurrence and reoperation. Surg Endosc. 2004 Mar.18(3):444-447. Pubmedid: 14752653.
• Santos RS, Raftopoulos Y, Keenan RJ, Halal A, Maley RH, Landreneau RJ. Bronchoscopic palliation of primary lung cancer: single or multimodality therapy?. Surg Endosc. 2004 Jun.18(6):931-936. Pubmedid: 15108108.
• Szwerc MF, Landreneau RJ, Santos RS, Keenan RJ, Murray GF. Minithoracotomy combined with mechanically stapled bronchial and vascular ligation for anatomical lung resection. Ann Thorac Surg. 2004 Jun.77(6):1904-1909. Pubmedid: 15172234.
• Raftopoulos Y, Papasavas P, Landreneau R, Hayetian F, Santucci T, Gagné D, Caushaj P, Keenan R. Clinical outcome of laparoscopic antireflux surgery for patients with irritable bowel syndrome. Surg Endosc. 2004 Apr.18(4):655-659. Pubmedid: 15026924.
• Santos R, Colonias A, Parda D, Trombetta M, Maley RH, Macherey R, Bartley S, Santucci T, Keenan RJ, Landreneau RJ. Comparison between sublobar resection and 125Iodine brachytherapy after sublobar resection in high-risk patients with Stage I non-small-cell lung cancer. Surgery. 2003 Oct.134(4):691-697. Pubmedid: 14605631.
• Papasavas PK, Keenan RJ, Yeaney WW, Caushaj PF, Gagné DJ, Landreneau RJ. Prediction of postoperative gas bloating after laparoscopic antireflux procedures based on 24-h pH acid reflux pattern. Surg Endosc. 2003 Mar.17(3):381-385. Pubmedid: 12457222.
• Coxson HO, Whittall KP, Nakano Y, Rogers RM, Sciurba FC, Keenan RJ, Hogg JC. Selection of patients for lung volume reduction surgery using a power law analysis of the computed tomographic scan. Thorax. 2003 Jun.58(6):510-514. Pubmedid: 12775863. Pmcid: PMC1746695.
• Papasavas PK, Keenan RJ, Yeaney WW, Caushaj PF, Gagné DJ, Landreneau RJ. Effectiveness of laparoscopic fundoplication in relieving the symptoms of gastroesophageal reflux disease (GERD) and eliminating antireflux medical therapy. Surg Endosc. 2003 Aug.17(8):1200-1205. Pubmedid: 12739117.
• Burns KE, Keenan RJ, Grgurich WF, Manzetti JD, Zenati MA. Outcomes of lung volume reduction surgery followed by lung transplantation: a matched cohort study. Ann Thorac Surg. 2002 May.73(5):1587-1593. Pubmedid: 12022555.
• Scheidler MG, Keenan RJ, Maley RH, Wiechmann RJ, Fowler D, Landreneau RJ. "True" parahiatal hernia: a rare entity radiologic presentation and clinical management. Ann Thorac Surg. 2002 Feb.73(2):416-419. Pubmedid: 11845852.
• Vilchez R, McCurry K, Dauber J, Iacono A, Keenan R, Griffith B, Kusne S. Influenza and parainfluenza respiratory viral infection requiring admission in adult lung transplant recipients. Transplantation. 2002 Apr.73(7):1075-1078. Pubmedid: 11965034.
• Luketich JD, Fernando HC, Christie NA, Buenaventura PO, Keenan RJ, Ikramuddin S, Schauer PR. Outcomes after minimally invasive esophagomyotomy. Ann Thorac Surg. 2001 Dec.72(6):1909-1912. Pubmedid: 11789770.
• Nakano Y, Coxson HO, Bosan S, Rogers RM, Sciurba FC, Keenan RJ, Walley KR, Paré PD, Hogg JC. Core to rind distribution of severe emphysema predicts outcome of lung volume reduction surgery. Am J Respir Crit Care Med. 2001 Dec.164(12):2195-2199. Pubmedid: 11751187.
• Luketich JD, Schauer PR, Christie NA, Weigel TL, Raja S, Fernando HC, Keenan RJ, Nguyen NT. Minimally invasive esophagectomy. Ann Thorac Surg. 2000 Sep.70(3):906-911. Pubmedid: 11016332.
• Rogers RM, Coxson HO, Sciurba FC, Keenan RJ, Whittall KP, Hogg JC. Preoperative severity of emphysema predictive of improvement after lung volume reduction surgery: use of CT morphometry. Chest. 2000 Nov.118(5):1240-1247. Pubmedid: 11083670.
• Coxson HO, Whittall KP, Rogers RM, Sciurba FC, Keenan RJ, Hogg JC. A cluster analysis of CT scans predicts patients who respond to lung volume reduction surgery. Chest. 2000 May.117(5 Suppl 1):247S-248S. Pubmedid: 10843932.
• Naunheim KS, Hazelrigg SR, Kaiser LR, Keenan RJ, Bavaria JE, Landreneau RJ, Osterloh J, Keller CA. Risk analysis for thoracoscopic lung volume reduction: a multi-institutional experience. Eur J Cardiothorac Surg. 2000 Jun.17(6):673-679. Pubmedid: 10856858.
• Lowdermilk GA, Keenan RJ, Landreneau RJ, Hazelrigg SR, Bavaria JE, Kaiser LR, Keller CA, Naunheim KS. Comparison of clinical results for unilateral and bilateral thoracoscopic lung volume reduction. Ann Thorac Surg. 2000 Jun.69(6):1670-1674. Pubmedid: 10892904.
• Orons PD, Amesur NB, Dauber JH, Zajko AB, Keenan RJ, Iacono AT. Balloon dilation and endobronchial stent placement for bronchial strictures after lung transplantation. J Vasc Interv Radiol. 2000 Jan.11(1):89-99. Pubmedid: 10693719.
• Pham SM, Rao AS, Zeevi A, McCurry KR, Keenan RJ, Vega JD, Kormos RL, Hattler BG, Fung JJ, Starzl TE, Griffith BP. Effects of donor bone marrow infusion in clinical lung transplantation. Ann Thorac Surg. 2000 Feb.69(2):345-350. Pubmedid: 10735661. Pmcid: PMC2981807.
• Landreneau RJ, De Giacomo T, Mack MJ, Hazelrigg SR, Ferson PF, Keenan RJ, Luketich JD, Yim AP, Coloni GF. Therapeutic video-assisted thoracoscopic surgical resection of colorectal pulmonary metastases. Eur J Cardiothorac Surg. 2000 Dec.18(6):671-676. Pubmedid: 11113674.
• Luketich JD, Meehan M, Nguyen NT, Christie N, Weigel T, Yousem S, Keenan RJ, Schauer PR. Minimally invasive surgical staging for esophageal cancer. Surg Endosc. 2000 Aug.14(8):700-702. Pubmedid: 10954812.
• Luketich JD, Meehan MA, Landreneau RJ, Christie NA, Close JM, Ferson PF, Keenan RJ, Belani CP. Total videothoracoscopic lobectomy versus open thoracotomy for early-stage non small-cell lung cancer. Clin Lung Cancer. 2000 Aug.2(1):56-60. Pubmedid: 14731340.
• Luketich JD, Friedman DM, Weigel TL, Meehan MA, Keenan RJ, Townsend DW, Meltzer CC. Evaluation of distant metastases in esophageal cancer: 100 consecutive positron emission tomography scans. Ann Thorac Surg. 1999 Oct.68(4):1133-1136. Pubmedid: 10543468.
• Lin JC, Wiechmann RJ, Szwerc MF, Hazelrigg SR, Ferson PF, Naunheim KS, Keenan RJ, Yim AP, Rendina E, DeGiacomo T, Coloni GF, Venuta F, Macherey RS, Bartley S, Landreneau RJ. Diagnostic and therapeutic video-assisted thoracic surgery resection of pulmonary metastases. Surgery. 1999 Oct.126(4):636-641. Pubmedid: 10520909.
• Stilley CS, Dew MA, Stukas AA, Switzer GE, Manzetti JD, Keenan RJ, Griffith BP. Psychological symptom levels and their correlates in lung and heart-lung transplant recipients. Psychosomatics. 1999 Nov.40(6):503-509. Pubmedid: 10581979.
• Nunley DR, Grgurich WF, Keenan RJ, Dauber JH. Empyema complicating successful lung transplantation. Chest. 1999 May.115(5):1312-1315. Pubmedid: 10334145.
• Nunley DR, Hattler B, Keenan RJ, Iacono AT, Yousem S, Ohori NP, Dauber JH. Lung transplantation for end-stage pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 1999 Mar.16(1):93-100. Pubmedid: 10207947.
• Thistlethwaite PA, Luketich JD, Ferson PF, Keenan RJ, Jamieson SW. Ablation of persistent air leaks after thoracic procedures with fibrin sealant. Ann Thorac Surg. 1999 Feb.67(2):575-577. Pubmedid: 10197706.
• Naunheim KS, Kaiser LR, Bavaria JE, Hazelrigg SR, Magee MJ, Landreneau RJ, Keenan RJ, Osterloh JF, Boley TM, Keller CA. Long-term survival after thoracoscopic lung volume reduction: a multiinstitutional review. Ann Thorac Surg. 1999 Dec.68(6):2026-2031. Pubmedid: 10616971.
• Gammie JS, Stukus DR, Pham SM, Hattler BG, McGrath MF, McCurry KR, Griffith BP, Keenan RJ. Effect of ischemic time on survival in clinical lung transplantation. Ann Thorac Surg. 1999 Dec.68(6):2015-2019. Pubmedid: 10616969.
• Thaete FL, Peterson MS, Plunkett MB, Ferson PF, Keenan RJ, Landreneau RJ. Computed tomography-guided wire localization of pulmonary lesions before thoracoscopic resection: results in 101 cases. J Thorac Imaging. 1999 Apr.14(2):90-98. Pubmedid: 10210479.
• Stilley CS, Miller DJ, Manzetti JD, Marino IR, Keenan RJ. Optimism and coping styles: A comparison of candidates for liver transplantation with candidates for lung transplantation. Psychother Psychosom. 1999.68(6):299-303. Pubmedid: 10559709.
• Kassis ES, Belani CP, Ferson PF, Keenan RJ, Luketich JD. Hodgkin's disease presenting with a bronchoesophageal fistula. Ann Thorac Surg. 1998 Oct.66(4):1409-1410. Pubmedid: 9800846.
• Landreneau RJ, Wiechmann RJ, Hazelrigg SR, Mack MJ, Keenan RJ, Ferson PF. Effect of minimally invasive thoracic surgical approaches on acute and chronic postoperative pain. Chest Surg Clin N Am. 1998 Nov.8(4):891-906. Pubmedid: 9917931.
• Nunley DR, Ohori P, Grgurich WF, Iacono AT, Williams PA, Keenan RJ, Dauber JH. Pulmonary aspergillosis in cystic fibrosis lung transplant recipients. Chest. 1998 Nov.114(5):1321-1329. Pubmedid: 9824009.
• Nunley DR, Grgurich W, Iacono AT, Yousem S, Ohori NP, Keenan RJ, Dauber JH. Allograft colonization and infections with pseudomonas in cystic fibrosis lung transplant recipients. Chest. 1998 May.113(5):1235-1243. Pubmedid: 9596300.
• Zaldonis DB, Keenan RJ, Pham SM, Kormos RL, Griffith BP. Neoral conversion in stable thoracic transplant patients leads to dose reduction. Transplant P. 1998 Jun.30(4):1158-1159. Pubmedid: 9636468.
• Kapucu LO, Meltzer CC, Townsend DW, Keenan RJ, Luketich JD. Fluorine-18-fluorodeoxyglucose uptake in pneumonia. J Nucl Med. 1998 Jul.39(7):1267-1269. Pubmedid: 9669408.
• Zenati M, Keenan RJ, Courcoulas AP, Griffith BP. Lung volume reduction or lung transplantation for end-stage pulmonary emphysema?. Eur J Cardiothorac Surg. 1998 Jul.14(1):27-31. Pubmedid: 9726611.
• Landreneau RJ, Mack MJ, Dowling RD, Luketich JD, Keenan RJ, Ferson PF, Hazelrigg SR. The role of thoracoscopy in lung cancer management. Chest. 1998 Jan.113(1 Suppl):6S-12S. Pubmedid: 9438683.
• Zaldonis DB, Keenan RJ, Pham SM, Kormos RL, Griffith BP. Neoral conversion in stable thoracic transplant patients leads to dose reduction. Transplant P. 1998 Aug.30(5):1898-1899. Pubmedid: 9723325.
• Luketich JD, Schauer PR, Meltzer CC, Landreneau RJ, Urso GK, Townsend DW, Ferson PF, Keenan RJ, Belani CP. Role of positron emission tomography in staging esophageal cancer. Ann Thorac Surg. 1997 Sep.64(3):765-769. Pubmedid: 9307471.
• Pigula FA, Griffith BP, Zenati MA, Dauber JH, Yousem SA, Keenan RJ. Lung transplantation for respiratory failure resulting from systemic disease. Ann Thorac Surg. 1997 Dec.64(6):1630-1634. Pubmedid: 9436547.
• Luketich JD, Schauer P, Urso K, Townsend DW, Belani CP, Cidis Meltzer C, Ferson PF, Keenan RJ. Minimally invasive surgical biopsy confirms PET findings in esophageal cancer. Surg Endosc. 1997 Dec.11(12):1213-1215. Pubmedid: 9373297.
• Belani CP, Luketich JD, Landreaneau RJ, Kim R, Ramanathan RK, Day R, Ferson PF, Keenan RJ, Posner M, Seeger J, Lembersky B. Efficacy of cisplatin, 5-fluorouracil, and paclitaxel regimen for carcinoma of the esophagus. Semin Oncol. 1997 Dec.24(6 Suppl 19):S19-S89. Pubmedid: 9427275.
• Sommers KE, Griffith BP, Hardesty RL, Keenan RJ. Early lung allograft function in twin recipients from the same donor: risk factor analysis. Ann Thorac Surg. 1996 Sep.62(3):784-790. Pubmedid: 8784009.
• Boujoukos AJ, Keenan RJ. Use of bronchial blocker to improve gas exchange in respiratory failure and differential lung disease. Chest. 1996 Oct.110(4):1110-1111. Pubmedid: 8874278.
• Lee KH, Martich GD, Boujoukos AJ, Keenan RJ, Griffith BP. Predicting ICU length of stay following single lung transplantation. Chest. 1996 Oct.110(4):1014-1017. Pubmedid: 8874262.
• Rogers RM, Sciurba FC, Keenan RJ. Lung reduction surgery in chronic obstructive lung disease. Med Clin North Am. 1996 May.80(3):623-644. Pubmedid: 8637307.
• Luketich JD, Westkaemper J, Sommers KE, Ferson PF, Keenan RJ, Landreneau RJ. Bronchoesophagopleural fistula after photodynamic therapy for malignant mesothelioma. Ann Thorac Surg. 1996 Jul.62(1):283-284. Pubmedid: 8678664.
• Landreneau RJ, Keenan RJ, Hazelrigg SR, Mack MJ, Naunheim KS. Thoracoscopy for empyema and hemothorax. Chest. 1996 Jan.109(1):18-24. Pubmedid: 8549184.
• Luketich JD, Sommers KE, Griffith BP, Boujoukos A, Landreneau RJ, Ferson PF, Keenan RJ. Successful management of secondary aortoesophageal fistula. Ann Thorac Surg. 1996 Dec.62(6):1852-1854. Pubmedid: 8957407.
• Holbert JM, Brown ML, Sciurba FC, Keenan RJ, Landreneau RJ, Holzer AD. Changes in lung volume and volume of emphysema after unilateral lung reduction surgery: analysis with CT lung densitometry. Radiology. 1996 Dec.201(3):793-797. Pubmedid: 8939233.
• Naunheim KS, Landreneau RJ, Andrus CH, Ferson PF, Zachary PE, Keenan RJ. Laparoscopic fundoplication: a natural extension for the thoracic surgeon. Ann Thorac Surg. 1996 Apr.61(4):1062-1065. Pubmedid: 8607656.
• Mitruka S, Landreneau RJ, Mack MJ, Fetterman LS, Gammie J, Bartley S, Sutherland SR, Bowers CM, Keenan RJ, Ferson PF. Diagnosing the indeterminate pulmonary nodule: percutaneous biopsy versus thoracoscopy. Surgery. 1995 Oct.118(4):676-684. Pubmedid: 7570322.
• Pham SM, Keenan RJ, Rao AS, Fontes PA, Kormos RL, Abu-Elmagd K, Zeevi A, Kawai A, Hattler BG, Hardesty RL. Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients. Ann Thorac Surg. 1995 Oct.60(4):1015-1020. Pubmedid: 7574940. Pmcid: PMC2967193.
• Sonett JR, Keenan RJ, Ferson PF, Griffith BP, Landreneau RJ. Endobronchial management of benign, malignant, and lung transplantation airway stenoses. Ann Thorac Surg. 1995 Jun.59(6):1417-1422. Pubmedid: 7539606.
• Zenati M, Keenan RJ, Landreneau RJ, Paradis IL, Ferson PF, Griffith BP. Lung reduction as bridge to lung transplantation in pulmonary emphysema. Ann Thorac Surg. 1995 Jun.59(6):1581-1583. Pubmedid: 7771852.
• Schwarz RE, Posner MC, Plunkett MB, Ferson PF, Keenan RJ, Landreneau RJ. Needle-localized thoracoscopic resection of indeterminate pulmonary nodules: impact on management of patients with malignant disease. Ann Surg Oncol. 1995 Jan.2(1):49-55. Pubmedid: 7834454.
• O'Riordan TG, Iacono A, Keenan RJ, Duncan SR, Burckart GJ, Griffith BP, Smaldone GC. Delivery and distribution of aerosolized cyclosporine in lung allograft recipients. Am J Respir Crit Care Med. 1995 Feb.151(2 Pt 1):516-521. Pubmedid: 7842214.
• Pigula FA, Keenan RJ, Naunheim KS, Ferson PF, Landreneau RJ. Diagnosis of postpneumonectomy bronchopleural fistula using ventilation scintigraphy. Ann Thorac Surg. 1995 Dec.60(6):1812-1814. Pubmedid: 8787494.
• Landreneau FE, Landreneau RJ, Keenan RJ, Ferson PF. Diagnosis and management of spinal metastases from breast cancer. J Neurooncol. 1995.23(2):121-134. Pubmedid: 7643148.
• Siegfried JM, Davis AL, Testa JR, Hunt JD, Keenan RJ, Yousem SA, Ritter PS, Ferson PF, Landreneau RJ. Ability to culture resectable non-small cell lung carcinomas is correlated with recurrence. Ann Thorac Surg. 1994 Sep.58(3):662-666. Pubmedid: 7944686.
• Bando K, Keenan RJ, Paradis IL, Konishi H, Komatsu K, Hardesty RL, Griffith BP. Impact of pulmonary hypertension on outcome after single-lung transplantation. Ann Thorac Surg. 1994 Nov.58(5):1336-1342. Pubmedid: 7979655.
• Griffith BP, Bando K, Hardesty RL, Armitage JM, Keenan RJ, Pham SM, Paradis IL, Yousem SA, Komatsu K, Konishi H. A prospective randomized trial of FK506 versus cyclosporine after human pulmonary transplantation. Transplantation. 1994 Mar.57(6):848-851. Pubmedid: 7512292. Pmcid: PMC2975521.
• Griffith BP, Magee MJ, Gonzalez IF, Houel R, Armitage JM, Hardesty RL, Hattler BG, Ferson PF, Landreneau RJ, Keenan RJ. Anastomotic pitfalls in lung transplantation. J Thorac Cardiovasc Surg. 1994 Mar.107(3):743-753. Pubmedid: 8127104.
• Iacono AT, Masciangelo TN, Grgurich WF, Ohori NP, Keenan RJ, Paradis IL, Griffith BP. A new complication related to laser bronchoscopy in a single lung transplant recipient. Chest. 1994 Jul.106(1):311-313. Pubmedid: 8020302.
• Kawai A, Paradis IL, Keenan RJ, Hardesty RL, Hattler BG, Pham SM, Griffith BP. Lung transplantation at the University of Pittsburgh: 1982 to 1994. Clin Transpl. 1994 Feb.111-120. Pubmedid: 7547530.
• Bando K, Armitage JM, Paradis IL, Keenan RJ, Hardesty RL, Konishi H, Komatsu K, Stein KL, Shah AN, Bahnson HT. Indications for and results of single, bilateral, and heart-lung transplantation for pulmonary hypertension. J Thorac Cardiovasc Surg. 1994 Dec.108(6):1056-1065. Pubmedid: 7983875.
• Landreneau RJ, Mack MJ, Hazelrigg SR, Naunheim K, Dowling RD, Ritter P, Magee MJ, Nunchuck S, Keenan RJ, Ferson PF. Prevalence of chronic pain after pulmonary resection by thoracotomy or video-assisted thoracic surgery. J Thorac Cardiovasc Surg. 1994 Apr.107(4):1079-1085. Pubmedid: 8159030.
• Magee MJ, Klain M, Ferson PF, Keenan RJ, Landreneau RJ. Nasotracheal jet ventilation for rigid endoscopy. Ann Thorac Surg. 1994 Apr.57(4):1031-1032. Pubmedid: 8166507.
• Landreneau RJ, Keenan RJ, Hazelrigg SR, Dowling RD, Mack MJ, Ferson PF. VATS wedge resection of the lung using the neodymium:yttrium-aluminum garnet laser. Ann Thorac Surg. 1993 Sep.56(3):758-761. Pubmedid: 8379789.
• Landreneau RJ, Mack MJ, Keenan RJ, Hazelrigg SR, Dowling RD, Ferson PF. Strategic planning for video-assisted thoracic surgery. Ann Thorac Surg. 1993 Sep.56(3):615-619. Pubmedid: 8379753.
• Dowling RD, Keenan RJ, Ferson PF, Landreneau RJ. Video-assisted thoracoscopic resection of pulmonary metastases. Ann Thorac Surg. 1993 Sep.56(3):772-775. Pubmedid: 8379792.
• Worsey J, Ferson PF, Keenan RJ, Julian TB, Landreneau RJ. Thoracoscopic pancreatic denervation for pain control in irresectable pancreatic cancer. Br J Surg. 1993 Aug.80(8):1051-1052. Pubmedid: 7691373.
• Zeevi A, Uknis ME, Spichty KJ, Tector M, Keenan RJ, Rinaldo C, Yousem S, Duncan S, Paradis I, Dauber J. Proliferation of cytomegalovirus-primed lymphocytes in bronchoalveolar lavages from lung transplant patients. Transplantation. 1992 Oct.54(4):635-639. Pubmedid: 1329281.
• Aeba R, Killinger WA, Keenan RJ, Yousem SA, Hamamoto I, Hardesty RL, Griffith BP. Lazaroid U74500A as an additive to University of Wisconsin solution for pulmonary grafts in the rat transplant model. J Thorac Cardiovasc Surg. 1992 Nov.104(5):1333-1339. Pubmedid: 1434715.
• Keenan RJ, Duncan AJ, Yousem SA, Zenati M, Schaper M, Dowling RD, Alarie Y, Burckart GJ, Griffith BP. Improved immunosuppression with aerosolized cyclosporine in experimental pulmonary transplantation. Transplantation. 1992 Jan.53(1):20-25. Pubmedid: 1733067.
• Aeba R, Keenan RJ, Hardesty RL, Yousem SA, Hamamoto I, Griffith BP. University of Wisconsin solution for pulmonary preservation in a rat transplant model. Ann Thorac Surg. 1992 Feb.53(2):240-245. Pubmedid: 1531007.
• Keenan RJ, Uknis ME, Pham SM, Spichty K, Duquesnoy RJ, Griffith BP, Zeevi A. Mitogen responses of lymphocytes from lung transplant recipients--correlation with rejection and infection. Transplantation. 1992 Aug.54(2):241-245. Pubmedid: 1496536.
• Keenan RJ, Eiras G, Burckart GJ, Stuart RS, Hardesty RL, Vogelsang G, Griffith BP, Zeevi A. Immunosuppressive properties of thalidomide. Inhibition of in vitro lymphocyte proliferation alone and in combination with cyclosporine or FK506. Transplantation. 1991 Nov.52(5):908-910. Pubmedid: 1719668.
• Keenan RJ, Lega ME, Dummer JS, Paradis IL, Dauber JH, Rabinowich H, Yousem SA, Hardesty RL, Griffith BP, Duquesnoy RJ. Cytomegalovirus serologic status and postoperative infection correlated with risk of developing chronic rejection after pulmonary transplantation. Transplantation. 1991 Feb.51(2):433-438. Pubmedid: 1847251.
• Keenan RJ, Armitage JM, Trento A, Siewers RD, Hardesty RL, Bahnson HT, Griffith BP. Clinical experience with the Medtronic-Hall valve prosthesis. Ann Thorac Surg. 1990 Nov.50(5):748-753. Pubmedid: 2241336.
• Keenan RJ, Todd TR, Demajo W, Slutsky AS. Effects of hypercarbia on arterial and alveolar oxygen tensions in a model of gram-negative pneumonia. J Appl Physiol Respir Environ Exerc Physiol. 1990 May.68(5):1820-1825. Pubmedid: 2113901.
• Kaufman CL, Zeevi A, Kormos RL, Zerbe TR, Keenan RJ, Uretsky BF, Griffith BP, Hardesty RL, Duquesnoy RJ. Propagation of infiltrating lymphocytes and graft coronary disease in cardiac transplant recipients. Hum Immunol. 1990 Jun.28(2):228-236. Pubmedid: 2351570.
• Gammie JS, Banks MC, Fuhrman CR, Pham SM, Griffith BP, Keenan RJ, Luketich JD. The pigtail catheter for pleural drainage: a less invasive alternative to tube thoracostomy. JSLS. 3(1):57-61. Pubmedid: 10323171. Pmcid: PMC3015347.
• Raftopoulos Y, Landreneau RJ, Hayetian F, Papasavas P, Naunheim KS, Hazelrigg SR, Santos R, Gagné D, Caushaj P, Keenan RJ. Factors affecting quality of life after minimally invasive Heller myotomy for achalasia. J Gastrointest Surg. 8(3):233-239. Pubmedid: 15019914.