Exploring Men s Prostate Cancer Genetic Risk Perceptions and Willingness to Give a Biospecimen for Genetic Risk Testing
The purpose of this study is to assess prostate cancer genetic risk and susceptibility beliefs among men without prostate cancer who are considering undergoing prostate cancer screening, as well as to assess willingness of men to provide a biospecimen (saliva sample) and test the samples for prostate cancer aggressiveness
Aim 1: Assess prostate cancer genetic risk and susceptibility beliefs among unaffected men of diverse races/ethnicities who are considering undergoing prostate cancer screening (N=100). This will be achieved through a variety of community-based recruitment methods and collection of risk, beliefs and behavioral data by questionnaire.
Aim 2: Assess willingness of men to provide a biospecimen (saliva sample) and test the samples for prostate cancer aggressiveness, and determine risk category based on SNP genetic profile. This will be achieved by collecting (opt-in approach) saliva samples for genetic risk testing to generate a SNP risk profile. We will assess the proportion of consented men who will provide a saliva sample. Once sample is received, the SNP profile will be categorized into a genetic risk category (very low, low, average, high or very high risk) for developing prostate cancer.
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