Clinical Trial 21378

• Overview

  Study Title:

  Phase 1 Study of Adoptive T Cell Therapy Following HER2-Pulsed Dendritic Cell Vaccine and Pepinemab / Trastuzumab in Patients with Metastatic HER2-Positive Breast Cancer

  Summary:

  The purpose of this study is to test the safety of Adoptive T-Cell therapy following the Dendritic Cell (DC1) study vaccine given in combination with pepinemab added to standard of care therapy, trastuzumab to help people with HER2 positive breast cancer.

  Objective:

  Primary Objective: To evaluate the safety of infusing escalating doses of expanded HER2 specific T cells into patients with HER2+ metastatic breast cancer. Secondary Objectives: 1. To assess the safety, tolerability of DC1 and pepinemab/trastuzumab treatment 2. To evaluate to what extent HER2 specific T cell immunity can be generated in patients after infusion of HER2 specific T cells 3. To investigate how long T cell immune augmentation persists in vivo after adoptive transfer of HER2 specific T cells 4. To evaluate the preliminary efficacy of HER2 specific T cell therapy in patients with metastatic HER2+ breast cancer 5. To assess the subtype for CD4 T cell helper response generated in patients in response to this therapy 6. To determine whether inhibitory responses such as MDSC, Th2 and Treg influence the response. 7. To evaluate the pharmacokinetics, pharmacodynamics markers and immunogenicity of pepinemab 8. To identify potential predictive biomarkers

• Treatments

  Therapies:

  Cell Therapy; Chemotherapy (NOS)

  Medications:

  CD4+ T Cells (); DC1 Vaccine (); Herceptin (Trastuzumab); Pepinemab (VX15/2503); Trastuzumab (); cyclophosphamide (); cytoxan (cyclophosphamide); rhuMAb HER2 (Trastuzumab)

• Inclusion Criteria

  Inclusion Criteria:
  • Must have a histologically confirmed HER2 positive breast cancer and must be candidates for trastuzumab therapy as per current standard of care. Note: HER2 positive breast cancer is defined by tumor tissue HER2 overexpression and or tumor HER2 amplification per ASCO/CAP criteria.
  • Patients will be eligible regardless of ER/PR status which will be determined per 2020 ASCO/CAP guideline and hormonal therapy will be allowed to continue for patients with ER/PR positive disease.
  • Must have evaluable disease, defined as at least one lesion that can be accurately measured ≥ 10 mm by standard imaging techniques that can be include but not limited to CT, PET, PET/CT, MRI. Skeletal disease which is measurable by PET/CT or bone scan will also be allowed.
  • Must have had disease progression while on trastuzumab for the treatment of HER2+ MBC and received no more than 3 lines of cytotoxic chemotherapy in the setting of metastatic disease.
  • ECOG performance status 0 or 1.
  • Must have normal organ and marrow function as defined in protocol within 14 days of registration.
  • Left ventricular ejection fraction above institutional lower limit of normal (by echocardiogram or MUGA scan)
  • Female patients of childbearing potential must agree to use dual methods of contraception and have a negative serum or urine pregnancy test at screening, and male patients must use an effective barrier method of contraception if sexually active with a female of child-bearing potential. Acceptable methods of contraception are condoms with contraceptive foam, oral, implantable or injectable contraceptives, contraceptive patch, intrauterine device, diaphragm with spermicidal gel, or a sexual partner who is surgically sterilized or post-menopausal. For both male and female patients, effective methods of contraception must be used throughout the study and for 3 months following the last dose. To be considered of not to be of childbearing potential, postmenopausal women must be amenorrheic for at least 12 months naturally (not in the setting of post chemotherapy) or patients must be surgically sterile.
  • Must have the ability to understand and the willingness to sign a written informed consent prior to registration on study.
  • Must have a life expectancy of at least 12 weeks.

• Exclusion Criteria

  Exclusion Criteria:
  • Patients who have had chemotherapy or radiotherapy within 14 days prior to beginning protocol therapy.
  • Patients may not be receiving any other investigational agents within 14 days or 5 half-lives (whichever is longer) prior to beginning protocol therapy.
  • Patients with uncontrolled brain metastases or leptomeningeal disease
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
  • Patients with active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including chronic prolonged systemic corticosteroids (defined as corticosteroid use of duration one month or greater), should be excluded.
  • Female patients who are pregnant or nursing are not eligible.
  • Second invasive malignancy requiring active treatment
  • Known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) is not permitted.
  • Any known positive test for Hepatitis B or Hepatitis C virus indicating acute or chronic infection is not permitted.
  • Patients who have received a live attenuated vaccine ≤30 days of registration are not eligible.
  • Patients not able to comply with the treatment schedule and study procedures for any reason are not eligible.
  • Patients previously treated with any form of adoptive cell transfer therapy.

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