Clinical Trial 21224

• Overview

  Study Title:

  Determining the Structural- and Functional-Level Effects of Diet-specific Interventions on The Gut Microbiota of a Diverse Sample of Southern United States Adults

  Objective:

  Specific Aim 1 - Examine the effect of a diet-specific ( DASH or standard American ) 4-week intervention on the gut microbiota of a racially diverse sample of adults and test for race effects Specific Aim 2 - Evaluate diet-specific effects on functional markers of the gut microbiota including production of secondary bile acids (e.g. lithocholic acid, deoxycholic acid), SCFAs (e.g, acetate, butyrate, propionate), and inflammatory markers (e.g., calprotectin, IL-6) and test for race effects

• Inclusion Criteria

  Inclusion Criteria:
  • Black or white race
  • Non-hispanic ethnicity
  • 19-65 years of age
  • Able to travel to the UAB Bionutrition Unit daily to retrieve meals

• Exclusion Criteria

  Exclusion Criteria:
  • Gastrointestinal (GI) conditions i.e., irritable bowel, diverticulitis, peptic ulcers, Crohn's, GI cancers, and adenatomous polyps
  • Antibiotic or probiotic use in the previous 90 days
  • Smoking/tobacco use
  • Heavy alcohol consumption
  • Major medical conditions (e.g., renal disease, diabetes, cancer

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