Predicting Progression of Developing Myeloma in a High-Risk Screened Population
The purpose of the PROMISE research study is to analyze blood for precursor conditions to multiple myeloma such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).
To determine clinical/genomic alterations present in individuals with monoclonal gammopathies who are diagnosed though screening of a high-risk population.
To determine clinical/genomic/epigenetic and immune environmental predictors of progression to myeloma in patients with monoclonal gammopathies.
Define the prevalence and incidence of MGUS/SMM in a high-risk population of AAs and family history positive individuals.
Define germline characteristics of MGUS/SMM in AAs and family history positive cases.
Determine the natural history of screen-detected vs. incidentally detected MGUS/SMM. The present study of screened-detected MGUS/SMM can be compared to our PCROWD cohort of MGUS/SMM individuals incidentally diagnosed and longitudinally followed.
Determine the clinical and epidemiological risk factors for progression of MGUS/SMM to MM in a high-risk population of AA and family positive cases.
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