The Thoracic Program Trial Selection Pre-Screening Protocol expedites the screening process, avoids additional invasive biopsies, and avoids delays in treatment initiation while patients will still have their tumor tissue and blood collected according to the standard practices required by most of the thoracic therapeutic clinical trials
The primary objective of this screening study is to assess the feasibility to identify and match patients to a therapeutic clinical trial and to evaluate the screening success rates for therapeutic clinical trials as measured by number of patients who enroll into a therapeutic clinical trial divided by the number of patients who signed informed consent.This protocol will also evaluate the time between informed consent signature (for a clinical trial) to treatment start on a therapeutic clinical trial. Exploratory objectives are to evaluate the time to enrollment on a subsequent therapeutic clinical trial and to evaluate the utility of circulating tumor DNA (ctDNA) genotyping for screening for clinical trial enrollment.
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