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Transdisciplinary Research in Colorectal Cancer: The ColoCare Study
This is a research study of colorectal cancer. Our long-term goals are to learn how to improve treatment success in future patients and what future patients can do to improve their health after diagnosis. For example, testing may be done to find new ways to tailor therapy, or to evaluate a patient's health status after a colorectal cancer diagnosis.
This study will establish a cohort of 250 colorectal cancer patients with a comprehensive assessment of quality of life, health behaviors and medical history, study collected blood samples at baseline (surgery) and during follow-up (6 and 12 months), and TCC generated gene expression analysis. The central hypothesis of this research is that colorectal cancer patients with elevated levels of IGF and insulin/glucose biomarkers will demonstrate distinct gene expression alterations in IGF-related signaling pathways and will have both altered systemic inflammation and worse quality of life.