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Clinical Trials for Testicular Cancer

The majority of clinical trials for testicular cancer are used to compare new therapies to existing ones. Through these trials, oncologists can find the most effective treatments, determine the optimum dosages, look for potential drug interactions and discover the best ways to help manage side effects. At the same time, patients can access the most innovative options in testicular cancer treatment, including new combinations of chemotherapy drugs and advanced surgical techniques. A smaller percentage of clinical trials are also used to investigate other testicular cancer-related topics. These include:

  • Predictive factors (including genetic and environmental factors) that could help oncologists determine who is more at risk for developing the disease
  • Diagnostic techniques and screening methods (such as biomarker-based blood tests) that can help increase the likelihood of early detection
  • DNA mutations that cause the cancer to develop

At Moffitt Cancer Center, our clinical trials are supervised by a team of oncologists and researchers who follow each patient’s progress to ensure maximum safety and comfort. Patients are never required to participate in a clinical trial, and those who do may stop at any time. Most importantly, because our multispecialty tumor board meets weekly to review each patient’s progress, we can make individualized adjustments as necessary to ensure the best possible outcome and quality of life.

Moffitt emphasizes research because we believe that every clinical trial gets us one step closer to a cure – and we won’t be satisfied until there is one. Because of our research efforts, we have been named a Comprehensive Cancer Center by the National Cancer Institute – the only such center based in Florida.  To learn more about our clinical trials for testicular cancer,  call 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form online.

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Open Clinical Trials:

Showing of 50

CLINICAL TRIAL 19319

InPACT- International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)

Disease Site: Penis / penile cancer, Other Male Genital

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CLINICAL TRIAL 19435

Combination of Nivolumab Immunotherapy with Radiation Therapy and Androgen Deprivation Therapy in the Management of Gleason Group 5 Prostate Cancer

Disease Site: Prostate

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CLINICAL TRIAL 19867

A Phase 1b/2 Study of BXCL701, a Small Molecule Inhibitor of Dipeptidyl Peptidases (DPP), Administered in Combination with the Anti-Programmed Cell Death 1 (PD-1) Monoclonal Antibody Pembrolizumab (PEMBRO; Keytruda®) in Patients with Small Cell Neuroendocrine Prostate Cancer (SCNC; NEPC)

Disease Site: Prostate

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CLINICAL TRIAL 19873

A Phase II Open Label Single Arm Study of Adjuvant Nivolumab following Chemo-Radiation in localized Muscle-Invasive Bladder Cancer (NEXT)

Disease Site: Urinary Bladder

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CLINICAL TRIAL 19981

A Randomized Phase II Study of Atezolizumab (MPDL3280A) plus Recombinant Human IL-7 (CYT107) in patients with locally advanced or metastatic urothelial carcinoma

Disease Site: Urinary Bladder, Urothelial Cancer

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CLINICAL TRIAL 20050

QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination with ALT-803 in Patients with BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer

Disease Site: Urinary Bladder

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CLINICAL TRIAL 20056

Phase II Clinical Trial of Green Tea Catechins in Men on Active Surveillance (AS)

Disease Site: Prostate

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CLINICAL TRIAL 20117

A Phase 1/2 Study of Regn5678 (Anti-psmaxcd28) with Cemiplimab (Anti-pd-1) in Patients with Metastatic Castration-Resistant Prostate Cancer

Disease Site: Prostate

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CLINICAL TRIAL 20345

Phase I/II Trial of Pre-Operative Image Guided Intensity Modulated Proton Radiation Therapy (IMPT) or Photon (IMRT) with Simultaneously Integrated Boost to the High Margin for Retroperitoneal Sarcomas

Disease Site: Anal, Colon, Kidney, Other genitourinary, Pancreas, Rectum, Sarcoma

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CLINICAL TRIAL 20353

S1806, Phase III Randomized Trial of Concurrent Chemoradiotherapy with or without Atezolizumab in Localized Muscle Invasive Bladder Cancer

Disease Site: Urinary Bladder

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CLINICAL TRIAL 20377

A Phase 2 Multicohort Study of Nivolumab in Combination with Docetaxel and Androgen Deprivation Therapy in Metastatic Hormone Sensitive Prostate Cancer Patients with DNA Damage Repair Defects or Inflamed Tumors

Disease Site: Prostate

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CLINICAL TRIAL 20832

A Phase II Study to Evaluate the Safety and Efficacy of Prostatic Artery Embolization in Patients with Localized Prostate Carcinoma and Obstructive Lower Urinary Tract Symptoms

Disease Site: Prostate

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CLINICAL TRIAL 20943

Combination of Ipi/Nivo Plus Sacituzumab Govitecan in Metastatic Cisplatin Ineligible Urothelial Carcinoma Patients

Disease Site: Other Urinary, Urinary Bladder, Urothelial Cancer

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CLINICAL TRIAL 21082

SPLASH: Study Evaluating Metastatic Castrate Resistant Prostate Cancer Treatment Using 177Lu-PNT2002 PSMA Therapy After Second-line Hormonal Treatment

Disease Site: Prostate

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CLINICAL TRIAL 21083

A Phase 2b Randomized Trial of Autologous Dendritic Cell Immunotherapy (CMN-001) Plus Standard Treatment of Advanced Renal Cell Carcinoma

Disease Site: Other

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CLINICAL TRIAL 21117

A Phase 1 Multicenter Study Evaluating the Safety and Efficacy of ALLO-316 Following ALLO-647 Containing Conditioning Regimen in Subjects with Advanced or Metastatic Clear Cell Renal Cell Carcinoma (ccRCC)

Disease Site: Kidney

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CLINICAL TRIAL 21139

A Phase IIA Study of Sequential ("first strike, second strike") Therapies, Modeled on Evolutionary Dynamics of Anthropocene Extinctions, for High Risk Metastatic Castration Sensitive Prostate Cancer

Disease Site: Prostate

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CLINICAL TRIAL 21433

A Phase 1 and 2a open-label trial to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and antitumor activity of LAVA-1207, a PSMA-targeting bispecific γδ-T cell engager, in patients with therapy refractory metastatic castration resistant prostate cancer

Disease Site: Other

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CLINICAL TRIAL 21460

Phase Ib Trial of Erdafitinib Combined with Enfortumab Vedotin Following Platinum and PD1/L1 Inhibitors for Metastatic Urothelial Carcinoma with FGFR2/3 Genetic Alterations

Disease Site: Other Urinary

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CLINICAL TRIAL 21913

A Phase 3 Study of CG0070 In Patients with Non- Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG)

Disease Site: Urinary Bladder

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CLINICAL TRIAL 19291

The Utility of PSMA-PET Imaging for Detecting Early Metastatic Prostate Cancer in Men with High GC Decipher® Test Scores: A Sub-aim of the VANDAAM Study (MCC #18523)

Disease Site: Prostate

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CLINICAL TRIAL 18523

A Validation Study on the Impact of Decipher® Testing on Treatment Recommendations in African-American and Non-African American Men with Prostate Cancer (VANDAAM Study)

Disease Site: Prostate

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CLINICAL TRIAL 20010

IRONMAN: International Registry for Men with Advanced Prostate Cancer

Disease Site: Prostate

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CLINICAL TRIAL 21353

A Prospective Randomized Trial Comparing Pre-Anesthesia Evaluation Remotely via Telemedicine Versus in Person for Surgical Patients at H. Lee Moffitt Cancer Center

Disease Site: Any Site

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CLINICAL TRIAL 50428

Metabolite Consumption in Patient-Derived Explants to Predict Therapeutic Response in Aggressive and Oligometastatic Prostate Cancer in African American Men

Disease Site: Prostate

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