Meningioma Clinical Trials

Meningioma clinical trials provide valuable information about how to diagnose, treat, prevent and ultimately cure these complex tumors. Most of these studies are designed to compare two or more treatments: the best option currently available and a novel therapy that has the potential to produce better survival outcomes and quality of life, or cause fewer side effects. Other trials are designed to learn more about how or why the condition develops, determine how to reduce the likelihood of recurrence or study new options for screening and prevention.

Some of the most recent clinical trials for meningioma have evaluated:

  • What role chemotherapy can play in meningioma treatment and which chemo medications are most effective
  • How tumor markers can help predict which patients will respond most favorably to specific treatments
  • Whether carbon ion-based treatments can be more effective than traditional postoperative radiation
  • Various options for addressing chronic, meningioma-induced neurological defects and cognitive impairment

At Moffitt Cancer Center, our clinical trials program has contributed to many key developments in brain cancer research. In fact, today’s most effective meningioma treatments were once only available through clinical trials – and a number of those trials took place at Moffitt. Through our clinical research program, patients have unique opportunities to access the latest therapies before those options are available in other settings, and opportunities continue to open up as our researchers steadily work toward finding a brain cancer cure.

For more information about our meningioma clinical trials, call 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form online. No referral is necessary to make an appointment.

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Open Clinical Trials:

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CLINICAL TRIAL 18752

ACTION Trial- Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas (Phase I)

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 19970

A Pilot Trial of Intratumorally-Administered Topotecan using Convection-Enhanced Delivery (CED) in Patients with Suspected Recurrent/Progressive WHO Grade III or IV (High Grade) Glioma Undergoing Stereotactic Biopsy (IND 117,240)

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 20487

Phase I/II Study of Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in the Management of HER2+ Breast Leptomeningeal Disease

Disease Site: Brain and Nervous System, Breast, Leptomeningeal (LMD)

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CLINICAL TRIAL 20899

Phase I/II Study of Stereotactic Radiation and Abemaciclib in the Management of Hormone Receptor Positive HER2 Negative Breast Cancer Brain Metastases

Disease Site: Brain and Nervous System, Breast

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CLINICAL TRIAL 20964

A Phase 2 Basket Study of Tucatinib in Combination with Trastuzumab in Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Disease Site: Brain and Nervous System, Breast, Ill-Defined Sites, Lung, Other Digestive Organ, Urinary Bladder, Brain metastasis, Leptomeningeal (LMD)

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CLINICAL TRIAL 21039

A Pivotal Randomized, Open-Label Study Of OPTUNE(R)(TTFIELDS, 200KHZ) Concomitant With Radiation Therapy And Temozolomide For The Treatment Of Newly Diagnosed Glioblastoma

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 19731

Electronic Social Network Assessment Program (eSNAP) + Caregiver Navigator Intervention for Neuro-Oncology Couples

Disease Site: Brain and Nervous System, Brain metastasis, Gliomas, Leptomeningeal (LMD), Meningiomas

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CLINICAL TRIAL 21737

A Pilot Study of Advanced Multi-parametric MRI to Evaluate De Novo Glioblastoma Tumors Prior to Surgical Resection

Disease Site: Brain and Nervous System, Gliomas

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